CN1554414A

CN1554414A - Compound red sage root spray

Info

Publication number: CN1554414A
Application number: CNA2003101208174A
Authority: CN
Inventors: 洪袁; 袁洪; 陽国平
Original assignee: Individual
Current assignee: Individual
Priority date: 2003-12-29
Filing date: 2003-12-29
Publication date: 2004-12-15
Anticipated expiration: 2023-12-29
Also published as: CN1304016C

Abstract

The compound red sage spray is prepared with red sage, notoginseng and borneol in certain proportion. The preparation process includes twice alcohol reflux extraction of red sage pieces and notoginseng grains and filtering, once water reflux extraction of red sage pieces and notoginseng grains and filtering, merging the filtrate, concentration, adding surfactant via stirring, dissolving borneol in alcohol, mixing the concentrated liquid, borneol solution, essence and water via stirring, and packing. The present invention alters traditional medicine administrating mode and the medicine spray can fast remit the symptom of dyspnea and angina pectoris patient.

Description

Compound red sage root spray

Technical field:

The present invention relates to a kind of Chinese medicine preparation, be specifically related to a kind of treat in the heart feel oppressed, anginal medicine-compound red sage root spray and preparation technology.

Background technology:

Coronary heart disease, angina pectoris are a kind of cardiovascular disease of serious threat human health.In American-European countries, its sickness rate occupies the first place of various diseases.In China, its sickness rate, mortality rate continue over nearly 30 years to rise, and according to statistics, the cardiovascular rate of dying of illness accounts for crude death rate's 40% in recent years, has every year 2000000 people to die from the cardiovascular diseases approximately, and its acute attack is again the main cause that causes patient death.Along with the prolongation of human longevity, population is aging day by day, and coronary heart disease, anginal sickness rate still can continue to increase.Therefore, the task of top priority that anginal acute attack is current the world of medicine is particularly controlled in the development of control primary disease.

FUFANG DANSHEN PIAN is to treat in the heart to feel oppressed, anginal classical Chinese patent medicine, and its curative effect is very sure.But because this medicine is a tablet, onset is slow, and taking neither be too convenient, can not be used for anginal acute attack.And to feeling oppressed in the heart, anginal patient, rapid-action is vital.

Summary of the invention:

Technical problem to be solved by this invention is the defective that overcomes above-mentioned prior art, and a kind of rapid-action, good effect, easy to use is provided, and anginal medicine is felt oppressed in treatment in the heart.

Technical problem of the present invention is to solve by following technical scheme.It is characterized in that it is to make with following weight percentages and method: its raw material is Radix Salviae Miltiorrhizae 70%～80%, Radix Notoginseng 18%～28%, Borneolum Syntheticum 1%～2%.Its preparation method is that the salvia piece of said ratio, Radix Notoginseng coarse granule are distinguished mixed extraction three times, adds alcohol reflux 1～2 hour for the first time, filters; Refluxing for the second time adds 50% alcohol reflux 1～2 hour, filters; Add water for the third time and refluxed 2～2.5 hours, filtration merges second and third time filtrate, reclaims ethanol then and also concentrates, and with this medicinal liquid and the medicinal liquid merging of reflux, extract, for the first time, leaves standstill its filtrate of filtration back and adds surfactant again, stirs evenly; Other gets the Borneolum Syntheticum of said ratio, adds dissolve with ethanol, and this liquid and last liquid are merged, and adds an amount of essence and water, stirs evenly the back packing.

The present invention adopts Radix Salviae Miltiorrhizae and panax mixed to extract, vacuum concentration, need not be dry, avoided being heated for a long time of medicine, can effective ingredient is damaged, in addition, this product have added appropriate amount of auxiliary materials, make Borneolum Syntheticum be liquid condition evenly, stably be distributed in the preparation, thereby guaranteed the quality of preparation.The present invention has changed traditional administering mode by medication preparation is become spray, makes drug effect rapidly, fast, and is easy to use, can very fast alleviation feel oppressed anginal patient symptom in the heart.

Description of drawings:

Fig. 1 is preparation technology's flow chart of the present invention.

The specific embodiment:

The applicant finds through for many years test and observation, FUFANG DANSHEN PIAN is that Radix Salviae Miltiorrhizae extractum feeds intake, and the Radix Salviae Miltiorrhizae extractum quality is uneven, can cause compound Salviae Miltiorrhizae tablet quality instability like this, reduces content of effective in the Radix Salviae Miltiorrhizae Tabellae, Radix Salviae Miltiorrhizae Tabellae is an oral agents in addition, onset is slow, and for feeling oppressed anginal patient in the heart, relief of symptoms is of paramount importance as early as possible, can save a people's life sometimes.The medicine Radix Salviae Miltiorrhizae that the present invention will treat coronary heart disease changes route of administration, absorbs fast, good effectiveness according to oral mucosa, makes oral spray, like this, can accelerate greatly the drug absorption time, and onset is rapid, uses also very convenient.It is characterized in that it comprises following weight percentages: Radix Salviae Miltiorrhizae 70%～80%, Radix Notoginseng 18%～28%, Borneolum Syntheticum 1%～2%.Wherein Radix Salviae Miltiorrhizae can repose sedate, tonneau GUAN-pulse, invigorate blood circulation, logical percardium, be treatment coronary heart disease and anginal good medicine, but the Radix Notoginseng promoting blood circulation to remove blood stasis, Borneolum Syntheticum can be had one's ideas straightened out, refreshment, above-mentioned three flavor Chinese medicines by certain proportioning prescription, had activating blood circulation to dissipate blood stasis, the effect of regulating QI to relieve pain.

Preparation method of the present invention is that the salvia piece of said ratio, Radix Notoginseng coarse granule are distinguished mixed extraction three times, adds alcohol reflux 1～2 hour for the first time, filters; Refluxing for the second time adds 50% alcohol reflux 1～2 hour, filters; Add water for the third time and refluxed 2～2.5 hours, filtration merges second and third time filtrate, reclaims ethanol then and also concentrates, and with this medicinal liquid and the medicinal liquid merging of reflux, extract, for the first time, leaves standstill its filtrate of filtration back and adds surfactant tween 80 again, stirs evenly; Other gets the Borneolum Syntheticum of said ratio, add dissolve with ethanol after, this liquid and last liquid are merged, add an amount of essence and water again, stir evenly the back packing, make spray.In the above-mentioned preparation process, adopt the stability of ethanol extracting can increasing solution, adopt surfactant can increase the dissolubility of solute,, can make the mobile better of spray simultaneously, be convenient to absorb to improve the drug effect of preparation.

Embodiment:

Get Radix Salviae Miltiorrhizae (decoction pieces) 600g, Radix Notoginseng (coarse granule) 188g mixed extraction three times, added alcohol reflux 1.5 hours for the first time, filter, filtrate recycling ethanol is to a certain amount of (medicinal liquid I); Refluxing for the second time adds 50% alcohol reflux 1.5 hours, filters; Add water for the third time and refluxed 2 hours, filter, merge second and third time filtrate, reclaim ethanol and be concentrated into a certain amount of (medicinal liquid II), merge medicinal liquid I, II, leave standstill, filter, filtrate adds the surfactant tween 80, stirs evenly; Other gets Borneolum Syntheticum 11g, adds dissolve with ethanol, and this liquid and last liquid are merged, and adds an amount of essence, adds water to ormal weight, stirs evenly, and by every bottle of 20ml packing, promptly gets product of the present invention.

Therefore the present invention is a liquid preparation, sprays into the oral cavity after the atomizing, absorbs very soon, both can be used for anginal acute attack, can take for a long time again, obviously is being better than FUFANG DANSHEN PIAN aspect the curative effect of treatment angina pectoris.

Medicine effect of the present invention is learned experimental result:

1, medicine of the present invention has good anti-tentative myocardial ischemia effect, improves the ischemic electrocardiogram and changes, the incidence rate of the chamber arrhythmia that the minimizing ischemia causes.

2, obvious coronary blood flow increasing lowers myocardial oxygen consumption.

3, can obviously suppress the inductive platelet aggregation of ADP, reduce the whole blood viscosity of blood stasis model rabbit, change the hemorheology situation.

Claims

1, a kind of compound red sage root spray is characterized in that it is to make with following weight percentages and method:

Its raw material is Radix Salviae Miltiorrhizae 70%～80%, Radix Notoginseng 18%～28%, Borneolum Syntheticum 1%～2%;

Its preparation method is that the salvia piece of said ratio, Radix Notoginseng coarse granule are distinguished mixed extraction three times, adds alcohol reflux 1～2 hour for the first time, filters; Refluxing for the second time adds 50% alcohol reflux 1～2 hour, filters; Add water for the third time and refluxed 2～2.5 hours, filtration merges second and third time filtrate, reclaims ethanol then and also concentrates, and with this medicinal liquid and the medicinal liquid merging of reflux, extract, for the first time, leaves standstill its filtrate of filtration back and adds surfactant again, stirs evenly; Other gets the Borneolum Syntheticum of said ratio, adds dissolve with ethanol, and this liquid and last liquid are merged, and adds an amount of essence and water, stirs evenly the back packing.

2, compound red sage root spray according to claim 1 is characterized in that surfactant is a tween 80.