CN1076365A - " medicine for endometriosis " manufacturing process - Google Patents
" medicine for endometriosis " manufacturing process Download PDFInfo
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- CN1076365A CN1076365A CN 92106441 CN92106441A CN1076365A CN 1076365 A CN1076365 A CN 1076365A CN 92106441 CN92106441 CN 92106441 CN 92106441 A CN92106441 A CN 92106441A CN 1076365 A CN1076365 A CN 1076365A
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Abstract
" medicine for endometriosis " manufacturing process is the manufacture method that belongs to the Chinese medicine electuary of treatment gynaecopathia endometriosis.Purpose is to overcome that the existing medicine of this disease of treatment can produce toxic and side effects and shortcoming such as cost an arm and a leg.Decocting with water twice → concentrating filter liquor after the present invention adopts Chinese medicine Rhizoma Cyperi, Rhizoma Corydalis, Ramulus Cinnamomi, Radix Salviae Miltiorrhizae, rhizoma sparganic, Rhizoma Curcumae to fill a prescription according to a certain percentage again make with extra care → is condensed into thick paste and adds adjuvant → sieve and make granule, through granulate, promptly make " medicine for endometriosis " electuary.Advantage is the curative effect height, and relapse rate is low, more back pregnancy rate height; Nontoxic, side effect; Raw material is easy to get, and method is simple, and price is low, is ideal medicine.
Description
" medicine for endometriosis " treats a kind of Chinese medicine electuary of gynaecopathia endometriosis, the invention belongs to the manufacture method of this Chinese medicine electuary.
Endometriosis is common gynecological disease, frequently-occurring disease, and its sickness rate accounts for women's in reproduction period 5~20%, and this disease not only endangers WomanHealth, also is one of main pathogenic factor of dysmenorrhea, infertility.Cause very big body, pained hardship to the women.None ideal medicament still at present aspect the treatment of this disease.At present the medicine that uses in the world has danazol, and this medicine is domestic not to be produced, and cost an arm and a leg from external import, and poison, side reaction is bigger, as feeling sick vomiting, amenorrhea etc.A kind of medicine is also used in the home and abroad in addition: tamoxifen, and price is more cheap slightly than danazol, but dosage is difficult to grasp to everyone, and dosage is slightly little, then renders a service deficiency, is difficult for removing misery, and dosage is big slightly, amenorrhea and some toxic and side effects promptly occur.
The objective of the invention is to improve curative effect, reduce price, a kind of Chinese medicine electuary " medicine for endometriosis " manufacturing process of conveniently taking is provided in order to overcome the poison that produced with above-mentioned Drug therapy endometriosis, to pay effect.
The manufacturing process technology feature of " medicine for endometriosis " is as follows: prescription is got six kinds of Chinese crude drugs in accordance with regulations earlier, → add twice of decocting Zhu → concentrating filter liquor make with extra care → to be condensed into thick paste and to add adjuvant, → system granule, granulate, each composition ratio of paying of institute's material of getting it filled is: Rhizoma Cyperi 6~15 grams, Rhizoma Corydalis 8~22 restrains, Ramulus Cinnamomi 3~10 grams, Radix Salviae Miltiorrhizae 8~25 grams, rhizoma sparganic 3~10 grams, Rhizoma Curcumae 3~10 grams, according to what of pharmacy amount each time, the quantity of the material of getting it filled increases exponentially according to each pair formula proportion.
In six kinds of medical materials being got, Rhizoma Cyperi, Rhizoma Corydalis are through vinegar system, and vinegar system method is pressed the regulation of Chinese Pharmacopoeia nineteen ninety version, and Rhizoma Curcumae is through parch, and frying production method also is the regulation by Chinese Pharmacopoeia nineteen ninety version.
According to what of pharmacy amount, how many medical materials decision gets, the composition of six kinds of medical materials than will with each composition of paying six kinds of medical materials in the prescription of regulation than identical, add decocting Zhu secondary.After the medical material mixing, put into and fry in shallow oil the Zhu container, add water and make the water surface surpass 7~15 centimetres of powder, soak after two hours, heating Zhu boils, Zhu is 1.5~2.5 hours first, and the leaching medicinal liquid adds water for the second time, the water surface surpasses 4~6 centimetres of powder, Zhu 1~2 hour, the leaching medicinal liquid, and merge frying in shallow oil Zhu gained medicinal liquid for twice.
The concentration process of twice being fried in shallow oil Zhu gained medicinal liquid is as follows: medicinal liquid is heated to boiling, allow water evaporates, medicinal liquid constantly concentrates, treat that medicinal liquid is concentrated to: surveying proportion at 100 ℃ of intermittent fever is 1.02~1.04, be that Bo Meishi meter reading is 3~6 o'clock, after medicinal liquid is cooled to room temperature, limit Stir mixes the limit, and to add concentration be that 90~98% ethanol is 45~55% to containing the alcohol amount, left standstill again 20~28 hours, with filter paper or filter cloth leaching supernatant, in water-bath, reclaim ethanol again, surplus pure heated volatile is to the greatest extent, reheat is concentrated into: surveying proportion at 80 ℃ of intermittent fever is 1.25~1.30, and promptly Bo Meishi meter reading is 29~33.5.
When the medicinal liquid that is condensed into is cooled to 28~32 ℃, become paste, add adjuvant: each is paid medical material and adds dextrin 10~14 grams, stevioside 0.02~0.04 gram according to pharmacy amount each time what, increases the adjuvant amount exponentially, the medicinal liquid that becomes paste is with after adjuvant mixes, cross 16 mesh sieves and make granule,, divide the Chinese medicine electuary " medicine for endometriosis " of packed treatment gynaecopathia endometriosis through granulate.The dissolved granule that one pair of medicine is made is distributed into 2 parcels.
Patient obeys three every day, obeys a bag at every turn, and every clothes stopped one day in five days, and logotype was a course of treatment in three months, extends the period of treatment and can improve curative effect.
The advantage that adopts Chinese medicine to make electuary treatment gynaecopathia endometriosis is the curative effect height, and relapse rate is low, women's pregnancy rate height after treating: safety, have no side effect, and can not cause amenorrhea; Processing method is simple, and raw material is easy to get, and price is lower, meets China's actual conditions, and is easy for patients to accept; Easy to carry and use being beneficial to promoted the use of.It is a kind of comparatively ideal medicine of treatment endometriosis.
In clinical observation on the therapeutic effect, observed 110 routine patients altogether, wherein 34 examples are observed by hospital for gynaecology and obstetrics of Shanghai Medical Univ, 76 examples are observed by Qingdao Hospital of Traditional Chinese Medicine Combined with Western Medicine,, partly patient has used peritoneoscope, and through treatment in 3-6 month, total effective rate was 91%, and stochastic sampling is observed 34 examples with leading position peace treatment, treat 26 examples with tamoxifen, be 3 months the course of treatment, and effective percentage is respectively 82.35% and 92.39%, learn by statistics and handle two groups of effective percentage no significant differences (P>0.05).In clinical observation treatment,, confirm that " medicine for endometriosis " has tangible activating blood circulation to dissipate blood stasis, warming the meridian for promoting the flow of YANG QI, the effect of regulating QI to relieve pain with the index contrast of hemorheology and pelvic blood flow diagram.In clinical practice, also find no toxicity, side effect, through following up a case by regular visits to, pregnancy rate is 53%, recurrence rate after healing only is 4%, and the relapse rate after curing with danazol is 20%, and the relapse rate after curing with tamoxifen is 10~30%, relapse rate reduces greatly.
Embodiment:
One, gets 10 kilograms of the Rhizoma Cyperi (processed with vinegar) that cook by the processing of pharmacopeia regulation, 15 kilograms of vinegar Rhizoma Corydalis, 6 kilograms of Ramulus Cinnamomi, 15 kilograms of Radix Salviae Miltiorrhizaes, 6 kilograms of rhizoma sparganic are fried 6 kilograms of Rhizoma Curcumae, add water and surpass 12 centimetres of powder, soak after two hours, boil in logical being steam heated to of rustless steel jacketed pan.The Zhu two hours leaching filtrate of boiling.Slag adds water again and surpasses 5 centimetres of powder, and logical again being steam heated to boiled, and Zhu boiled 1.5 hours, and leaching filtrate is removed slag, and merges filtrate twice.Logical Steam Heating in jacketed pan, make water evaporates, during to about 30,000 milliliters, it is 1.03 that 100 ° of heat are surveyed proportion, stops heating, is chilled to room temperature and adds 95% ethanol 35000ml, and survey with alcoholometer reach that to contain the alcohol amount be that 50%(mixes with adding with Stir), left standstill 24 hours, and filtered, reclaim the surplus alcohol of ethanol (reclaiming 20000ml approximately) logical Steam Heating in jacketed pan in alcohol distillation column and wave to the greatest extent, and continue heating and be concentrated into heat to survey (80 ℃) proportion be 1.29, stop logical steam, wait to be chilled to 30 ° and add stevioside 30 grams, add 13 kilograms of mixings of dextrin of K cryogenic treatment again and cross 16 mesh sieves and make granule, behind natural draft drying, granulate is distributed into 2000 pouches, gets final product.
Two, get Rhizoma Cyperi (processed with vinegar) 900 grams that cooked by the processing of pharmacopeia regulation, vinegar Rhizoma Corydalis 900 grams, Ramulus Cinnamomi 500 grams, Radix Salviae Miltiorrhizae 1000 grams, rhizoma sparganic 500 grams, Rhizoma Curcumae 500 grams add water and surpass 10 centimetres of powder, soak after 1.5 hours in cauldron electric furnace and be heated to and boil, Zhu boiled two hours first, leaching filtrate.Slag adds water again and surpasses 4 centimetres of powder, is heated to and boils, and Zhu boiled 1.5 hours, leaching filtrate is removed slag, and merges medicinal liquid twice, continuing heating makes water evaporates to about: 2700ml, and room temperature to be chilled to adds 95% ethanol 3000ml and left standstill the leaching supernatant 24 hours, electric furnace is flung to ethanol to using up and being concentrated into about 300ml, waits to be chilled to 30 ℃, adds stevioside 3 grams, the dextrin 1300 of K cryogenic treatment restrains, cross 16 mesh sieves behind the mixing and make granule, behind 40 ° of oven dryings, granulate is distributed into 200 pouches and gets final product.
Three, get Rhizoma Cyperi (processed with vinegar) 150 grams that cooked by the processing of pharmacopeia regulation, vinegar Rhizoma Corydalis 100 grams, Ramulus Cinnamomi 100 grams, Radix Salviae Miltiorrhizae 200 grams, rhizoma sparganic 100 grams, Rhizoma Curcumae 100 grams add water and surpass 6 centimetres of powder, soak after 2.5 hours in cauldron electric furnace and are heated to and boil.Zhu boiled two hours first, leaching filtrate.Slag adds water again and surpasses 5 centimetres of powder, is heated to and boils.Boiled leaching filtrate 1.5 hours.Remove slag, merge medicinal liquid twice, continue heating and make water evaporates to about 500ml.Room temperature to be chilled to adds 95% ethanol 550ml.Left standstill 24 hours, the leaching supernatant is flung to ethanol to the greatest extent, and is concentrated into about 50 grams, treat cold rnning stevioside 0.3 gram and the dextrin 80 gram mixings handled after cross 16 mesh sieves and make granule, granulate is distributed into 20 pouches and gets final product behind 40 ° of oven dryings.
Claims (5)
1, a kind of Chinese medicine electuary " medicine for endometriosis " manufacturing process for the treatment of the gynaecopathia endometriosis, earlier prescription is got twice → concentrating filter liquor of six kinds of Chinese crude drugs → decoct with water and make with extra care → is condensed into thick paste and adds adjuvant → system granule in accordance with regulations, granulate, it is characterized in that each composition ratio of paying of Chinese crude drug is: Rhizoma Cyperi 6~15 grams, Rhizoma Corydalis 8~22 grams, Ramulus Cinnamomi 3~10 grams, Radix Salviae Miltiorrhizae 8~25 grams, rhizoma sparganic 3~10 grams, Rhizoma Curcumae 3~10 grams, according to what of a pharmacy amount, the quantity of the material of getting it filled increases exponentially according to each pair formula proportion.
2, according to claim 1 described " medicine for endometriosis " manufacturing process, the Rhizoma Cyperi in six kinds of Chinese crude drugs that it is characterized in that writes out a prescription is in accordance with regulations got, Rhizoma Corydalis is through vinegar system, and Rhizoma Curcumae is through parch.
3, according to claim 1 described " medicine for endometriosis " manufacturing process, it is characterized in that adding that decocting Zhu is performed such for twice, add water after six kinds of Chinese crude drugs are mixed, make the water surface surpass 7~15 centimetres of powder, soak after two hours, boil first Zhu 1.5~2.5 hours of heating Zhu, the leaching medicinal liquid adds water for the second time, the water surface surpasses 4~6 centimetres of powder, Zhu 1~2 hour, the leaching medicinal liquid, and merge frying in shallow oil Zhu gained medicinal liquid for twice.
4, according to claim 1 described " medicine for endometriosis " manufacturing process, it is characterized in that the concentrating filter liquor process is as follows: medicinal liquid is heated to boiling, allow water evaporates, be concentrated to: surveying proportion at 100 ℃ of intermittent fever is 1.02~1.04, be that Bo Meishi meter reading is 3~6, after medicinal liquid is cooled to room temperature, limit Stir mixes the limit, and to add concentration be that 90~98% ethanol is 45~55% to containing the alcohol amount, left standstill again 20~28 hours, with filter paper or filter cloth leaching supernatant, in water-bath, reclaim ethanol, surplus pure heated volatile is to the greatest extent, reheat is concentrated into: surveying proportion at 80 ℃ of intermittent fever is 1.25~1.30, and promptly Bo Meishi meter reading is 29~33.5.
5, according to claim 1 described " medicine for endometriosis " manufacturing process, it is characterized in that the medicinal liquid that will be condensed into is cooled to 25 ℃~35 ℃, promptly become paste, add adjuvant: each is paid medical material and adds dextrin 10~14 grams, stevioside 0.02~0.04 gram mixes the back and crosses 16 mesh sieves, makes granule, through granulate, divide pack to get final product.
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
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CN 92106441 CN1076365A (en) | 1992-03-16 | 1992-03-16 | " medicine for endometriosis " manufacturing process |
CN 93110326 CN1081107A (en) | 1992-03-16 | 1993-03-15 | Medicine for endometriosis and manufacturing process thereof |
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CN 92106441 CN1076365A (en) | 1992-03-16 | 1992-03-16 | " medicine for endometriosis " manufacturing process |
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CN 92106441 Pending CN1076365A (en) | 1992-03-16 | 1992-03-16 | " medicine for endometriosis " manufacturing process |
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Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1091607C (en) * | 1998-03-05 | 2002-10-02 | 陈寿熙 | Jingshutong soluble granules |
CN1304016C (en) * | 2003-12-29 | 2007-03-14 | 袁洪 | Compound red sage root spray |
CN1332703C (en) * | 2005-03-14 | 2007-08-22 | 徐究竟 | Medicine for treating endometriosis and its preparing process |
CN103386077A (en) * | 2012-05-08 | 2013-11-13 | 四川滇虹医药开发有限公司 | Compound traditional Chinese medicine used for treating dysmenorrhoea and endometriosis, and preparation method thereof |
CN105362962A (en) * | 2015-12-18 | 2016-03-02 | 钟柏根 | Herb composition for treating endometriosis and application thereof |
-
1992
- 1992-03-16 CN CN 92106441 patent/CN1076365A/en active Pending
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1091607C (en) * | 1998-03-05 | 2002-10-02 | 陈寿熙 | Jingshutong soluble granules |
CN1304016C (en) * | 2003-12-29 | 2007-03-14 | 袁洪 | Compound red sage root spray |
CN1332703C (en) * | 2005-03-14 | 2007-08-22 | 徐究竟 | Medicine for treating endometriosis and its preparing process |
CN103386077A (en) * | 2012-05-08 | 2013-11-13 | 四川滇虹医药开发有限公司 | Compound traditional Chinese medicine used for treating dysmenorrhoea and endometriosis, and preparation method thereof |
CN103386077B (en) * | 2012-05-08 | 2015-09-23 | 四川滇虹医药开发有限公司 | A kind ofly be used for the treatment of herbal mixture of dysmenorrhea and endometriosis and preparation method thereof |
CN105362962A (en) * | 2015-12-18 | 2016-03-02 | 钟柏根 | Herb composition for treating endometriosis and application thereof |
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