CN1087534A

CN1087534A - " Yiganping " oral liquid

Info

Publication number: CN1087534A
Application number: CN 93110444
Authority: CN
Inventors: 眭勋华
Original assignee: Individual
Current assignee: Individual
Priority date: 1992-12-03
Filing date: 1993-02-03
Publication date: 1994-06-08

Abstract

" Yiganping " oral liquid belongs to the medicament preparation for the treatment of hepatitis B.This medicine be by Radix Et Rhizoma Rhei, the Radix Astragali, Typhonium flagelliforme (Lodd.) Blume, Herba Rabdosiae Lophanthoidis, Herba Hyperici Japonici, Fructus Mume disappear, ∴ wood, Herba Artemisiae Anomalae, Radix Wikstroemae cooperates in certain proportion with the Radix Rosae Cymosae root, the oral liquid that the water heating extraction is made, through 338 routine clinical treatment tests are shown, treatment obvious effective rate to chronic hepatitis can reach more than 80%, and short treating period, simultaneously liver cirrhosis, early hepatocarcinoma also there are curative effect preferably.

Description

" Yiganping " oral liquid

" Yiganping " oral liquid belongs to the medicament preparation for the treatment of hepatitis B.

Type B viral hepatitis is a kind of frequently-occurring disease, the commonly encountered diseases of China, and the hepatitis B virus carrying rate of no disease is 8.83% in the population of China at present, and some area is up to 15.86%; The Type B viral hepatitis course of disease is longer, and the pathogeny complexity easily transfers chronic hepatitis to, even easily develops into liver cirrhosis, and is closely related with the hepatocarcinoma generation, is a kind of to the very serious disease of human body harm.Modern medicine has had more deep research to its cause of disease and morbidity, immune mechanism, and proposed antiviral, regulation and control immunologic function and promoted therapeutic schemes such as liver cell regeneration, the hepatitis B of China's treatment by Chinese herbs in recent years also makes encouraging progress, peaceful as the liver benefiting, fall Chinese medicines such as enzyme spirit, manyzoned polypore gantai, multiple liver energy, liver-protecting tablet hepatitis B all had certain curative effect, but medicine time is oversize, some medicine patient takes more than 1 year at least, and the curative effect instability, and obvious effective rate is low.

The present invention is intended to develop a kind of course of treatment of the Chinese medicine preparation of treatment hepatitis B long but evident in efficacy not.

Technical scheme of the present invention is: " Yiganping " oral liquid is by Radix Et Rhizoma Rhei, the Radix Astragali, Typhonium flagelliforme (Lodd.) Blume, Herba Rabdosiae Lophanthoidis, Herba Hyperici Japonici, Fructus Mume disappears, wood, Herba Artemisiae Anomalae, a few flavor Chinese medicines of Radix Wikstroemae and Radix Rosae Cymosae root are made, the proportioning of its Chinese medicine of respectively distinguishing the flavor of is: Radix Et Rhizoma Rhei 3-5%, Radix Astragali 10-12%, Typhonium flagelliforme (Lodd.) Blume 3-5%, Herba Rabdosiae Lophanthoidis 10-12%, Herba Hyperici Japonici 9-11%, the Fructus Mume 10-12% that disappears, wood 10-12%, Herba Artemisiae Anomalae 3-5%, Radix Wikstroemae 10-12%, Radix Rosae Cymosae root 18-21%, with above-mentioned respectively distinguish the flavor of Chinese medicine by prescription weigh the back roguing, the water that adds two times of weight, slow fire boiling 30-40 minute, medicinal residues behind the taking-up medicinal liquid add the above water of one times of weight again, continue with slow fire boiling 45-60 minute, take out medicinal liquid, the secondary medicinal liquid mixes reuse slow fire after the coarse filtration and is concentrated into half that be equivalent to amount of water for the first time and gets final product.

Relevant pharmacopeia record, Radix Et Rhizoma Rhei tool heat-clearing and toxic substances removing, cooling blood and removing stasis, regulating QI diuretic, the effect of eliminating stagnation relieving constipation; Radix Astragali sweet in the mouth acid tepor, length for tonic, tool QI invigorating, yang invigorating, benefiting QI for strengthening the superficies, effects such as promoting pus discharge and tissue regeneration strengthening, and the function of regulating the whole body internal organs is arranged and improve immune function of human body, strengthen reticuloendothelial system, prevent that liver glycogen from reducing, reduce the oxygen consumption of liver cell mitochondria, promote the generation of body internal interference element; The Herba Hyperici Japonici bitter but sweet flavor, cold, clearing away heat-damp and promoting diuresis, subduing swelling and detoxicating, treating acute and chronic hepatitis; Typhonium flagelliforme (Lodd.) Blume is gone into liver, stomach, large intestine channel, and the hemostasis dissipating blood stasis is arranged, and the merit of subduing swelling and relieving pain cures mainly hepatosplenomegaly, liver cirrhosis and early stage hepatocarcinoma; The bitter temperature of Herba Artemisiae Anomalae nature and flavor is gone into Liver and kidney two warps, and removing blood stasis stimulates the menstrual flow, healing up sore and subduing swelling, and treating acute and chronic hepatitis, effects such as tool transaminase lowering, recovery liver function, and do not have the effect of paying; Radix Wikstroemae nature and flavor toil, cold, tool heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, the effect of blood-activating analgetic; The Cortex araliae chinensis nature and flavor are hot flat, wind-damp dispelling, and diuresis, dissipating blood stasis blood, detumescence poison cure mainly rheumatic arthritis, oedema due to nephritis, cirrhotic ascites, acute, chronic hepatitis, stranguria with turbid discharge leukorrhagia, diseases such as diabetes; The Fructus Mume nature and flavor that disappear are bitter flat, control haematemesis, metrorrhagia, hemorrhoidal bleeding, stranguria with turbid discharge leukorrhagia, enteritis and dysentery, and premature ejacuation emission, Herba Hyperici Japonici, Fructus Mume disappear, Herba Rabdosiae Lophanthoidis, Radix Wikstroemae etc. all have the effect of the hepatoprotective of invigorating blood circulation.Motherland's medical science thinks that hepatopathy must lie in stomach, and the spleen-stomach disease must lie in liver, and taste are hindered then the liver self inflicted injury, thereby causes the mechanism of qi retardance, and is strongly fragrant and be heat, and calentura is for wet, and then hepatopathy becomes; Because the wet liver-heat of spleen is basis of hepatopathy, so soothing the liver blood stasis dispelling, Tonghua QI and blood meridian then is its main principle of treatment, and the hepatitis B " Cuochuang jin " oral liquor is then developed through the science compatibility according to above-mentioned principle.

From in March, 1988 to 1991 year December with the hepatitis B " Cuochuang jin " oral liquor 338 routine hepatitis Bs are carried out clinical treatment observation, the result is as follows:

Male 155 examples in the 338 routine cases, women 183 examples, the age minimum is 14 years old, is 52 years old to the maximum; The course of disease 1 year is with interior person's 137 examples, 1-2 person's 152 examples, 2-5 person's 34 examples, person's 15 examples more than 5 years; Wherein belong to chronic active hepatitis 225 examples, chronic persistent hepatitis 113 examples.

Medication dose is each 80ml, every day three times, (medicine) being taken before meal usefulness, 30 days each courses of treatment; After taking medicine 3-6 month, produce effects reaches 297 examples, accounts for 87.9%, is 41 examples effectively, accounts for 12.1%, and through visiting 1-2, patient's all biochemical indicator all keeps stable.

The hepatitis B " Cuochuang jin " oral liquor has remarkable result to reducing S-GPT, and above-mentioned 338 examples are fallen ill after taking the hepatitis B " Cuochuang jin " oral liquor, and S-GPT recovers to have normally 297 examples; Therapeutic effect to chronic hepatitis is better than other medicines, according to both at home and abroad in recent years, the obvious effective rate of general treatment only is 26-54.9%, and the treatment obvious effective rate of this medicine can reach more than 80%, pharmacology and zoopery also prove the effect of falling enzyme preferably, fall wadding, recovering liver function, so the hepatitis B " Cuochuang jin " oral liquor is the comparatively ideal medicine of current treatment hepatitis B, liver cirrhosis and early stage hepatocarcinoma, and production technology is simple, drug resource spreads all over the country, and is worth Application and Development.

Example:

1, take by weighing the Chinese herbal medicine of respectively distinguishing the flavor of by following prescription earlier:

Radix Et Rhizoma Rhei 100g Radix Astragali 300g Typhonium flagelliforme (Lodd.) Blume 100g

The Herba Rabdosiae Lophanthoidis 300g Herba Hyperici Japonici 250g Fructus Mume 300g that disappears

Cortex araliae chinensis 300g Herba Artemisiae Anomalae 100 Radix Wikstroemae 300g

Radix Rosae Cymosae root 500g

2, said medicine is removed most foreign material, add water 500ml, slow fire boiling 40 minutes, take out medicinal liquid, add water 3000ml again in former medicinal residues jar, continuation slow fire boils fries in shallow oil 50 minutes, the secondary medicinal liquid simmers in water after coarse filtration again and fries in shallow oil, and is concentrated into about 2400ml, and the cooling back is bottled standby.

Model case:

The week * *, the woman, 32 years old, first menstruation in 1989 * * hospital's chemical examination, be diagnosed as " chronic active hepatitis ", peaceful through the liver benefiting for oral administration, fall enzyme spirit, manyzoned polypore gantai, multiple liver can and ATP, inosine sheet etc., curative effect does not show, GPT fluctuation (reitman-frankel method) about 300 units always, TTT20-25 unit, TFT++++, the HBsAg positive, anti--the HBc positive.After in March, 89, conscious nauseating, poor appetite is detested oil and is increased the weight of, and dull pain is often accompanied in the hepatic region, abdominal distention, limbs fatigue, big loose stool.The liver spleen can be laid one's hand on and about two fingers on inspection, and body of the tongue is deep red, the few Tianjin of yellow and thin fur, and thready and rapid pulse, liver function test is: TTT20 unit, TTT++++, GPT422 unit, the HBsAg positive, anti--the HBc positive.

Through taking the hepatitis B " Cuochuang jin " oral liquor after 30 days, check liver function, GPT recovers normally substantially, but it is turbid still undesired to wad a quilt with cotton; Continuous taking medicine 60 days looked into the liver size and recovered normal, and the patient is conscious, and all diseases disappear, and follow up a case by regular visits to after 1 year, check its biochemical indicator all in normal range.

Claims

1, a kind of have the Chinese medicine preparation-hepatitis B " Cuochuang jin " oral liquor of significant curative effect to hepatitis B, it is characterized in that being made by Radix Et Rhizoma Rhei, the Radix Astragali, Typhonium flagelliforme (Lodd.) Blume, Herba Rabdosiae Lophanthoidis, Herba Hyperici Japonici, Fructus Mume Xiao, Cortex araliae chinensis, Herba Artemisiae Anomalae, Radix Wikstroemae and a few flavor Chinese medicines of Radix Rosae Cymosae root.

2, by the described hepatitis B " Cuochuang jin " oral liquor of claim 1.The proportioning that it is characterized in that above-mentioned a few flavor Chinese medicines is as follows:

Radix Et Rhizoma Rhei 3-5% Radix Astragali 10-12%

Typhonium flagelliforme (Lodd.) Blume 3-5% Herba Rabdosiae Lophanthoidis 10-12%

The Herba Hyperici Japonici 9-11% Fructus Mume 10-12% that disappears

Cortex araliae chinensis 10-12% Herba Artemisiae Anomalae 3-5%

Radix Wikstroemae 10-12% Radix Rosae Cymosae root 18-21%

3, by claim 1 or 2 described hepatitis B " Cuochuang jin " oral liquors, it is characterized in that the processing method of hepatitis B " Cuochuang jin " oral liquor is:

After the above-mentioned Chinese medicine roguing of respectively distinguishing the flavor of, the water that adds two times of weight, slow fire boiling 30-40 minute, medicinal residues behind the taking-up medicinal liquid add the above water of one times of weight again, continue with slow fire boiling 45-60 minute, take out medicinal liquid, the secondary medicinal liquid mixes after the coarse filtration once more and to be concentrated into half that be equivalent to amount of water for the first time with slow fire and to get final product.