CN100594921C - Traditional Chinese medicine compound preparations for treating chronic hepatitis B and cirrhosis - Google Patents

Abstract

The invention provides a Chinese medicine compound preparation for treating chronic hepatitis B and liver cirrhosis and includes drug materials according to the weight potions of 10 to 80 portion of aralia, 10 to 80 portion of white notopodium root, 10 to 80 portion of downy myrtle, 5 to 60 portion of phonm penh dubie, 5 to 80 portion of panax notoginseng, 10 to 70 portion of phyllanthus urinariz,10 to 80 portion of peach flower, 10 to 80 portion of radix pseudotellaria, 5 to 60 portion of tabanus, 10 to 80 portion of werbenaceae and 10 to 80 portion of sanzi herb. The preparation has the effects of retracting a liver and a spleen, leading to complex constant aminotransferase, increasing albumin, transferring HBV-DNA from positive to negative and , and resulting in an antiphlogistic and cholagogic action and has good and fast curative effects and short cure course for treating chronic hepatitis B and liver cirrhosis.

Description

A kind of compound Chinese medicinal preparation for the treatment of chronic hepatitis B and liver cirrhosis

One, technical field

The present invention relates to a kind of medicine for the treatment of hepatopathy, a kind of especially Chinese medicine composition for the treatment of chronic hepatitis B and liver cirrhosis.

Two, background technology

Chronic hepatitis, liver cirrhosis, the 80%th, cause by hepatitis B virus (HBV), belong to the general chronic disease.According to statistics, there are hepatitis B virus carriers 1.2 hundred million people in China, now suffer from chronic hepatitis B 2,000 ten thousand people, and 1/3rd people can develop into liver cirrhosis or hepatocarcinoma.So chronic hepatitis B, liver cirrhosis are a kind of diseases of serious harm human health.

Treat chronic hepatitis B at present, the western medical treatment of liver cirrhosis mainly is antiviral, immunomodulating, improve Comprehensive Treatments such as liver function and anti-hepatic fibrosis, medicine has He Puting, Dai Ting, adefovir ester, interferon etc., but easily cause the state of an illness repeatedly, particularly the transaminase bounces easily, and liver, spleen can not bounce back to normally, and HBV fails thoroughly to remove.

According to bibliographical information, gallbladder infection is one of reason that causes chronic hepatitis B, liver cirrhosis, and when finding that clinically 98% patient does ultrasound diagnosis, gallbladder wall is crude or thicken, and gallbladder wall is smooth after treating, and sb.'s illness took a favorable turn, stable.We think that the Chinese traditional treatment of chronic hepatitis B, liver cirrhosis is identical, and clinically without pathological section, also difficulty is distinguished, and liver cirrhosis is the inevitable outcome of development of chronic hepatitis, so have only the healing chronic hepatitis, could stop the development of liver cirrhosis.

At present, treatment does not still have specific medicament for chronic hepatitis B, the curative effect of existing medicine still can not be satisfactory, therefore, people better treat chronic hepatitis B pharmaceutical preparation to curative effect and still exist demand, particularly curative effect is reliable, the clinical symptoms recovery is fast, cure rate height, the Chinese medicine preparation that toxicity, side effect is little.

Three, summary of the invention

Purpose of the present invention just provides a kind of short treating period, rapid-action, and effecting a permanent cure, treating both the principal and secondary aspects of a disease and be difficult for recurrence particularly more has the treatment chronic hepatitis B and the liver cirrhosis compound Chinese medicinal preparation of outstanding effect to chronic sympton.

Treatment chronic hepatitis B of the present invention and liver cirrhosis compound Chinese medicinal preparation are made up of following raw materials by weight proportions:

Cortex araliae chinensis 10-80 weight portion, Radix Malloti Apelitae 10--80 weight portion, Fructus Rhodomyrti 10--80 weight portion, Eupolyphaga Seu Steleophaga 5--60 weight portion, Radix Notoginseng 5--80 weight portion, Cacumen Securinegae Suffruticosae 10--70 weight portion, Flos persicae 10--80 Radix Pseudostellariae 10--80 weight portion, Tabanus 5--60 weight portion, Herba Verbenae 10--80 weight portion, Rhizoma Saururi (Herba Saururi) 10--80 weight portion.

Each raw material function of the present invention cures mainly as follows:

Put down in writing according to " Chinese medicine voluminous dictionary " (in March, 2006 second edition) and relevant document:

Radix Malloti Apelitae is the root of Euphorbiaceae Mallotus plant Folium Malloti Apeltae (Mallotus apelta (Lour) Muell-Arg), the property of medicine: little puckery, little hardship of distinguishing the flavor of, and property is flat, and function cures mainly: heat clearing away, damp eliminating, astringent therapy is invigorated blood circulation.Cure mainly hepatitis, hepatosplenomegaly etc.

Radix araliae chinensis (Cortex Araliae Chinensis) is five to add the root and the root bark of section's Aralia fogfruit Cortex araliae chinensis (Arulia chinensisL.).The property of medicine: hot, bitter, flat.Return spleen, kidney channel.Effect cures mainly: expelling wind and removing dampness, dissipating blood stasis for subsidence of swelling.Cure mainly edema, tympanites, jaundice etc.

Fructus Rhodomyrti is the fruit of Myrtaceae Fructus Rhodomyrti (Fructus Rhodo myrti Tomentosae) platymiscium.Nature and flavor: sweet, puckery, flat.Return liver, spleen channel.Function cures mainly: nourishing blood and hemoslasis, astringing intestine to stop diarrhea controlling nocturnal emission with astringent drugs.It is weak to be mainly used in blood deficiency.

Cacumen Securinegae Suffruticosae is the herb of (phyllamhus.urinaria L.), the property of medicine: little hardship, cold.Function cures mainly: heat clearing away, diuresis make eye bright, removing food stagnancy.Cure mainly jaundice, venom etc.

Flos persicae is the flower of Rosaceae peach family plant seed peach (Amygadlus Persicu L.), the property of medicine: bitter flat, and GUIXIN, liver, large intestine channel.Function cures mainly: diuretic relieving constipation, blood circulation promoting and blood stasis dispelling.Cure mainly dysuria, edema, phlegm retention etc.

Rhizoma Saururi (Herba Saururi) is the ground part of Saururaceae Rhizoma Saururi (Herba Saururi) platymiscium Rhizoma Saururi (Herba Saururi) (Sanrurus Chinensis (Lour) Baill).The property of medicine: Gan Xin, cold.Return spleen, kidney, gallbladder, urinary bladder channel.Function cures mainly: heat-clearing and toxic substances removing, inducing diuresis to remove edema.Cure mainly edema, jaundice etc.

Herba Verbenae is Herba Verbenae (Verbena officinalisL.) herb of Verenaceae verbena.The property of medicine: toil is slightly cold.Return liver, spleen channel.Function cures mainly: heat-clearing and toxic substances removing, promoting blood circulation to restore menstrual flow, inducing diuresis to remove edema, preventing the attack (or recurrence) of malaria.Cure mainly jaundice due to damp-heat, edema, dysuria.

The compound Chinese medicinal preparation that the present invention treats chronic hepatitis B and liver cirrhosis is that the medical herbs folk prescription sanction arrangement of collecting treatment among the people " dropsy " forms, and it is main using Chinese herbal medicine, and Chinese herbal medicine medicine source, rural area is extensive, easily gathers, and belongs to wild medicine, so good effect.Through clinical practice and pharmacological testing, filter out the compound Chinese medicinal preparation of forming You Cortex araliae chinensis, Fructus Rhodomyrti, Herba Verbenae etc. treatment chronic hepatitis B, liver cirrhosis are had good curative effect.Have retraction liver spleen, multiple normal transaminase, raising albumin, the HBV-DNA sun is turned out cloudy, the effect of anti-inflammatory and choleretic.

Four, the specific embodiment

The concrete prescription that below will illustrate compound Chinese medicinal preparation of the present invention is formed and preparation method:

Preparation of the present invention is mainly made the oral powder mode, has characteristics such as be convenient for carrying, dose is few, instructions of taking is simple, is called " soft liver eliminating stagnation is loose " in the use, can also explore other dosage forms in process of production.

Embodiment 1: select: Cortex araliae chinensis 20g Radix Malloti Apelitae 20g Fructus Rhodomyrti 20g Eupolyphaga Seu Steleophaga 10g Radix Notoginseng 20g Cacumen Securinegae Suffruticosae 30g Flos persicae 20g Radix Pseudostellariae 20g Tabanus 10g Herba Verbenae 30g Rhizoma Saururi (Herba Saururi) 30g for use

Above medicine is air-dry, be ground into 300 order powders, obtain the powder (soft liver eliminating stagnation is loose) of preparation of the present invention, obey every day 2 times, obey 5 grams at every turn, boiled water takes.

Embodiment 2: select: Cortex araliae chinensis 10g Radix Malloti Apelitae 10g Fructus Rhodomyrti 10g Eupolyphaga Seu Steleophaga 5g Radix Notoginseng 5g Cacumen Securinegae Suffruticosae 10g Flos persicae 10g Radix Pseudostellariae 10g Tabanus 5g Herba Verbenae 10g Rhizoma Saururi (Herba Saururi) 10g for use.

Above medicine is contained in marmite, added cold water and soaked powder 1-2cm, soaked 15-30 minute, add water again and slowly boil twice, boiled 30-50 minute for the first time, boiled 40-70 minute for the second time, twice fried liquid merges, and shakes up the decoction that promptly obtains preparation of the present invention, divides and takes for three times.

Embodiment 3: select: Cortex araliae chinensis 80g Radix Malloti Apelitae 80g Fructus Rhodomyrti 80g Eupolyphaga Seu Steleophaga 60g Radix Notoginseng 80g Cacumen Securinegae Suffruticosae 70g Flos persicae 80g Radix Pseudostellariae 80g Tabanus 60g Herba Verbenae 80g Rhizoma Saururi (Herba Saururi) 80g for use.

Said medicine was soaked 2 hours, add water and boil twice in right amount, merge twice solution and filter, filtrate concentrates, and drying under reduced pressure gets dry extract, and adds an amount of antiseptic and essence, granulate, and drying, granulate, packing, sterilization, the solid particle agent of making preparation of the present invention is taken after mixing it with water.

Implement 4: select: Cortex araliae chinensis 50g Radix Malloti Apelitae 50g Fructus Rhodomyrti 50g Eupolyphaga Seu Steleophaga 30g Radix Notoginseng 50g Cacumen Securinegae Suffruticosae 50g Flos persicae 50g Radix Pseudostellariae 50g Tabanus 25g Herba Verbenae 80g Rhizoma Saururi (Herba Saururi) 80g for use.

Above medicine is air-dry, be ground into 300 order powders, add a certain amount of heat refining honey, stir, round is cut in rubbing, makes the pill of preparation of the present invention, part vic.

Below further specify the curative effect of preparation for treating chronic viral hepatitis B of the present invention, liver cirrhosis by clinical observation material:

The case data:

1, sweet * *, man, 27 years old, bright people from village of muscle bamboo town, Cenxi City, Guangxi will, factory works in the Dongguan, Guangdong, shows in the ultrasound diagnosis of the Humen, Dongguan hospital on August 17th, 2003: leftlobe of liver 5.6 * 5.3cm, lobus dexter 12 * 9cm, echo light point obviously increases thick enhancing in the liver, and it is clear that blood vessel is owed, inner diameter of portal vein 1.3cm, gallbladder 5.1 * 2.1cm, wall thickness 3mm is coarse, the thick 4.4cm of spleen meets the liver cirrhosis performance; October 14 is in the eastern thickness of pipe street examination in hospital HBV-DNA positive: 4.63 * 10 ⁶Copies, liver function ALT56U/L.JIUYUE was gone to a doctor on the 2nd in 2003, gave soft liver eliminating stagnation diffusing 5 grams, and every day, 2 boiled water were taken after mixing it with water, taken altogether 3 months in the Dongguan peaceful the People's Hospital's check B ultrasonic shows: hepatic portal vein internal diameter 1.1cm, gallbladder wall is smooth, the thick 3.2cm of spleen, chemical examination HBV-DNA feminine gender, liver function ALT43U/L.

2, patient's Tan * *, people from Cenxi City, Guangxi.Show in Cenxi City epidemic prevention station ultrasound diagnosis in December in 2006 29 days: leftlobe of liver size 7.4 * 6.9cm, lobus dexter 11.9 * 9.0cm, liver face owe level and smooth, vasoganglion is fuzzy slightly, and hepatic tissue echo luminous point increases slightly, comparatively dense, inner diameter of portal vein 1.4cm, gallbladder are crude slightly, the thick 4.8cm of spleen.Chemical examination liver function total protein 71g/L, albumin 35g/L, globulin 36g/L, the plain 51.9 μ mol/L of total gallbladder meridian, the plain μ 28.6mol/L of direct gallbladder meridian, thymol turbidity test 14U, alanine aminotransferase 281U, hepatitis b surface antigen positive; In the fluorescence quantitative PCR detection HBV-DNA of Cenxi City healthcare hospital for women ﹠ children concentration 3.02 * 10 ⁵Copies/ml.On January 5th, 2007 went to a doctor, and gave diffusing 5 grams of soft liver eliminating stagnation, and every day, 2 boiled water were taken after mixing it with water, and took in June, 2007 always.On February 7th, 2007 is at the liver function test total protein 77g/L of Cenxi City Disease Control and Prevention Center, albumin 44g/L, globulin 29g/L, the plain 10.7 μ mol/L of total gallbladder meridian, the direct plain μ 4.5mol/L of gallbladder meridian, thymol turbidity test 4U, alanine aminotransferase 17U; Showed on June 6th, 2007 in the ultrasound diagnosis of Cenxi City institute of traditional Chinese medicine: leftlobe of liver size 5.6 * 3.5cm, the maximum clino-diagonal 10.7cm of lobus dexter, the liver face is level and smooth, and vasoganglion is clear, and hepatic tissue echo luminous point increases slightly intensive slightly, inner diameter of portal vein 1.4cm, gallbladder is smooth, the thick 4.2cm of spleen; On June 7th, 2007 is in the check HBV-DNA of Cenxi City healthcare hospital for women ﹠ children concentration＜1.00 * 10 ³Copies/ml.This example is taken soft liver eliminating stagnation and was loose 2 months, and liver function is recovered normally to take half a year fully, and ultrasound diagnosis and HBV-DNA check and recover normal fully.

3, the patient old * *, man, 43 years old, new people from street in Gui Yi town, Cenxi City, Guangxi.Because of " suffer from hepatitis B, liver cirrhosis 13 years is surplus, malaise edema 15 days " goes into my institute's hospitalization on July 7th, 2007.Hydrosarca when being admitted to hospital, the chemical examination liver function is normal substantially; B ultrasonic shows: leftlobe of liver size 6.4 * 7.5cm, and the maximum clino-diagonal 13.2cm of lobus dexter, the liver face is level and smooth, and vasoganglion is clear, and hepatic tissue echo luminous point increases slightly intensive, inner diameter of portal vein 1.3cm, gallbladder is crude, the thick 4.6cm of spleen.Ultrasound diagnosis on August 1 in 2007 is shown: leftlobe of liver size 5.6 * 3.5cm, and the maximum clino-diagonal 10.7cm of lobus dexter, the liver face is level and smooth, and vasoganglion is clear, and hepatic tissue echo luminous point increases slightly intensive slightly, inner diameter of portal vein 1.4cm, gallbladder is smooth, the thick 4.2cm of spleen.Diffusing 5 grams of the soft liver eliminating stagnation of doctor's advice, every day, 2 boiled water were taken after mixing it with water, and cooperated to suit the medicine to the illness and other auxiliary treatment, and malaise, edema symptom disappear gradually.Check on August 18 B ultrasonic shows: leftlobe of liver size 6.9 * 3.5cm, and the maximum clino-diagonal 12.3cm of lobus dexter, the liver face is level and smooth, and vasoganglion is clear, and hepatic tissue echo luminous point increases slightly intensive slightly, and inner diameter of portal vein 1.1c m, gallbladder, spleen recover normal fully.The complete obiteration of symptom such as malaise, edema.The patient is almost recovered and leaves hospital.Advise and continue to take soft liver eliminating stagnation after leaving hospital and loose and do the steadiness treatment.

Claims (1)

1, a kind of compound Chinese medicinal preparation for the treatment of chronic hepatitis B and liver cirrhosis is characterized in that it is made up of following raw materials by weight proportions:

Cortex araliae chinensis 10-80 weight portion, Radix Malloti Apelitae 10--80 weight portion, Fructus Rhodomyrti 10--80 weight portion, Eupolyphaga Seu Steleophaga 5--60 weight portion, Radix Notoginseng 5--80 weight portion, Cacumen Securinegae Suffruticosae 10--70 weight portion, Flos persicae 10--80 Radix Pseudostellariae 10--80 weight portion, Tabanus 5--60 weight portion, Herba Verbenae 10--80 weight portion, Rhizoma Saururi (Herba Saururi) 10--80 weight portion.