CN1081107A - Medicine for endometriosis and manufacturing process thereof - Google Patents
Medicine for endometriosis and manufacturing process thereof Download PDFInfo
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- CN1081107A CN1081107A CN 93110326 CN93110326A CN1081107A CN 1081107 A CN1081107 A CN 1081107A CN 93110326 CN93110326 CN 93110326 CN 93110326 A CN93110326 A CN 93110326A CN 1081107 A CN1081107 A CN 1081107A
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Abstract
Medicine for endometriosis and manufacturing process thereof are Chinese medicine electuary and the manufacture methods thereof that belongs to treatment gynecological endometriosis.Its constituent has 6～15 parts of Rhizoma Cyperis, 8～22 parts of Rhizoma Corydalis, 3～10 parts of Ramulus Cinnamomi, 8～25 parts of Radix Salviae Miltiorrhizaes, 3～10 parts of rhizoma sparganic, 3～10 parts of Rhizoma Curcumae, 10～14 parts in dextrin, 0.02～0.04 part of stevioside.Through steaming and decocting, filtration, the concentrated granule of making, granulate.Advantage be curative effect height, relapse rate low, safely, have no side effect, processing technique is simple, raw material is easy to get, price is lower, and is easy to utilize.
Description
The present invention relates to a kind of Chinese medicine electuary and manufacturing process thereof for the treatment of gynecological's endometriosis, concrete is medicine for endometriosis and manufacturing process thereof.
Endometriosis is common gynecological disease, frequently-occurring disease, and its sickness rate accounts for women's in reproduction period 5～20%, and this disease not only endangers WomanHealth, also is one of main pathogenic factor of dysmenorrhea, infertility, causes very big body, pained hardship to the women.None ideal medicament still at present aspect the treatment of this disease.At present the medicine that uses in the world has danazol, and this medicine is domestic not to be produced, cost an arm and a leg from external import, and poison, side reaction are bigger, as feel sick, vomiting, amenorrhea etc.A kind of medicine is also used in the home and abroad in addition: tamoxifen, and price is more cheap slightly than danazol, but dosage is difficult to grasp to everyone, and dosage is slightly little, then renders a service deficiency, is difficult for removing misery, and dosage is big slightly, amenorrhea and some toxic and side effects promptly occur.
To the objective of the invention is the toxicity, side effect that produced with above-mentioned Drug therapy endometriosis in order overcoming, to improve curative effect, reduce price, a kind of Chinese medicine electuary medicine for endometriosis and manufacturing process thereof of conveniently taking is provided.
The constituent of medicine for endometriosis electuary is as follows:
6～15 parts of Rhizoma Cyperis
8～22 parts of Rhizoma Corydalis
3～10 parts of Ramulus Cinnamomi
8～25 parts of Radix Salviae Miltiorrhizaes
3～10 parts of rhizoma sparganic
3～10 parts of Rhizoma Curcumae
10～14 parts in dextrin
0.02～0.04 part of stevioside
In above-mentioned constituent, Rhizoma Cyperi, Rhizoma Corydalis are through vinegar system, and Rhizoma Curcumae is through parch.
The manufacturing process of medicine for endometriosis is as follows: the constituent by medicine for endometriosis is got
6～15 parts of Rhizoma Cyperis
8～22 parts of Rhizoma Corydalis
3～10 parts of Ramulus Cinnamomi
8～25 parts of Radix Salviae Miltiorrhizaes
3～10 parts of rhizoma sparganic
3～10 parts of Rhizoma Curcumae
After adding twice of water steaming and decocting, filter, concentrating filter liquor is refined into thick paste, adds dextrin, stevioside, makes granule, behind the granulate.
Rhizoma Cyperi in mentioned component, Rhizoma Corydalis are elder generation's process vinegar systems, and Rhizoma Curcumae is earlier through parch.Vinegar system method and frying production method are all undertaken by the regulation of Chinese Pharmacopoeia nineteen ninety version.
Adding the water steaming and decocting is undertaken by following process: after taking out by the component content of six kinds of Chinese medicines in the prescription, mix and add water, make 7～15 centimetres of horizontal exceeding powder, soak after two hours, heated and boiled was boiled the leaching medicinal liquid first 1.5～2.5 hours; Add for the second time water, the water surface surpasses 4～6 centimetres of powder, boiled 1～2 hour, and the leaching medicinal liquid, and with the merging of twice decoction gained medicinal liquid.
The concentration process that twice is decocted the gained medicinal liquid is as follows: medicinal liquid is heated to boiling, allow water evaporates, medicinal liquid constantly concentrates, treat that medicinal liquid is concentrated to: surveying proportion at 100 ℃ of intermittent fever is 1.02～1.04, be that Bo Meishi meter reading is 3～6 o'clock, after medicinal liquid is cooled to room temperature, adding concentration while stirring and be 90～98% ethanol is 45～55% to containing the alcohol amount, left standstill again 20～28 hours, with filter paper or filter cloth leaching supernatant, in water-bath, reclaim ethanol again, surplus pure heated volatile is to the greatest extent, reheat is concentrated into: surveying proportion at 80 ℃ of intermittent fever is 1.25～1.30, and promptly Bo Meishi meter reading is 29～33.5.
When the medicinal liquid that is condensed into is cooled to 28～32 ℃, become paste, promptly add 10～14 parts in dextrin, 0.02～0.04 part of stevioside, the medicinal liquid that becomes paste is with after adjuvant mixes, cross 16 mesh sieves and make granule,, divide the Chinese medicine electuary " medicine for endometriosis " of packed treatment gynaecopathia endometriosis through granulate.
Patient obeys three every day, and every clothes stopped one day in five days, and logotype was a course of treatment in three months, extends the period of treatment and can improve curative effect.
The advantage that adopts this Chinese medicine to make electuary treatment gynaecopathia endometriosis is the curative effect height, and relapse rate is low, women's pregnancy rate height after treating; Safely, have no side effect, can not cause amenorrhea; Processing method is simple, and raw material is easy to get, and price is lower, meets China's actual conditions, and is easy for patients to accept; Easy to carry and use being beneficial to promoted the use of.It is a kind of comparatively ideal medicine of treatment endometriosis.
In clinical observation on the therapeutic effect, observed 110 routine patients altogether, wherein 34 examples are observed by hospital for gynaecology and obstetrics of Shanghai Medical Univ, 76 examples are observed by Qingdao Hospital of Traditional Chinese Medicine Combined with Western Medicine,, part patient has used peritoneoscope, and through treatment in 3～6 months, total effective rate was 91%, and stochastic sampling is observed 34 examples with the medicine for endometriosis treatment, treat 26 examples with tamoxifen, be 3 months the course of treatment, and effective percentage is respectively 82.35% and 92.39%, learn by statistics and handle two groups of effective percentage no significant differences (P＞0.05).In clinical observation treatment,, confirm that dystopy is equipped with the effect of tangible activating blood circulation to dissipate blood stasis, warming the meridian for promoting the flow of YANG QI, regulating QI to relieve pain with the index contrast of hemorheology and pelvic blood flow diagram.In clinical practice, also find no toxicity, side effect, through following up a case by regular visits to, pregnancy rate is 53%, recurrence rate after healing only is 4%, and the relapse rate after curing with danazol is 20%, and the relapse rate after curing with tamoxifen is 10～30%, relapse rate reduces greatly.
Embodiment:
One, get 10 kilograms of the Rhizoma Cyperi (processed with vinegar) that cook by the processing of pharmacopeia regulation, 15 kilograms of vinegar Rhizoma Corydalis, 6 kilograms of Ramulus Cinnamomi, 15 kilograms of Radix Salviae Miltiorrhizaes, 6 kilograms of rhizoma sparganic add water and surpass 12 centimetres of powder, soak after two hours, lead to be steam heated in the rustless steel jacketed pan and boil.Boil two hours leaching filtrate.Slag adds water again and surpasses 5 centimetres of powder, and logical again being steam heated to boiled, and boils 1.5 hours, and leaching filtrate is removed slag, and merges filtrate twice.Logical Steam Heating in jacketed pan, make water evaporates, during to about 30,000 milliliters, it is 1.03 that 100 ℃ of heat are surveyed proportion, stops heating, is chilled to room temperature and adds 95% ethanol 35000ml, and survey with alcoholometer reach that to contain the alcohol amount be that 50%(is with adding with stirring), left standstill 24 hours, and filtered, reclaim the surplus alcohol of ethanol (reclaiming 20000ml approximately) logical Steam Heating in jacketed pan in alcohol distillation column and wave to the greatest extent, and continue heating and be concentrated into heat to survey (80 ℃) proportion be 1.29, stop logical steam, wait to be chilled to 30 ℃ and add stevioside 30 grams, add 13 kilograms of mixings of dextrin of K cryogenic treatment again and cross 16 mesh sieves and make granule, behind natural draft drying, granulate is distributed into 2000 pouches, gets final product.When taking, every day three times, each one bag.
Two, get Rhizoma Cyperi (processed with vinegar) 900 grams that cooked by the processing of pharmacopeia regulation, vinegar Rhizoma Corydalis 900 grams, Ramulus Cinnamomi 500 grams, Radix Salviae Miltiorrhizae 1000 grams, rhizoma sparganic 500 grams, Rhizoma Curcumae 500 grams, add water and surpass 10 centimetres of powder, soak after 1.5 hours in cauldron electric furnace and be heated to and boil, boiled leaching filtrate first two hours, slag adds water again and surpasses 4 centimetres of powder, be heated to and boil, boiled leaching filtrate 1.5 hours, remove slag, merge medicinal liquid twice, continue heating and make water evaporates to about: 2700ml, room temperature to be chilled to adds 95% ethanol 3000ml and left standstill 24 hours, the leaching supernatant, electric furnace is flung to ethanol to using up and being concentrated into about 300ml, waits to be chilled to 30 ℃, adds stevioside 3 grams, the dextrin 1300 of K cryogenic treatment restrains, cross 16 mesh sieves behind the mixing and make granule, behind 40 ℃ of oven dryings, granulate is distributed into 200 pouches and gets final product.When taking, every day three times, each one bag.
Three, get Rhizoma Cyperi (processed with vinegar) 150 grams that cooked by the processing of pharmacopeia regulation, vinegar Rhizoma Corydalis 100 grams, Ramulus Cinnamomi 100 grams, Radix Salviae Miltiorrhizae 200 grams, rhizoma sparganic 100 grams, Rhizoma Curcumae 100 grams add water and surpass 6 centimetres of powder, soak after 2.5 hours in cauldron electric furnace and are heated to and boil.Boiled leaching filtrate first two hours.Slag adds water again and surpasses 5 centimetres of powder, is heated to and boils.Boiled leaching filtrate 1.5 hours.Remove slag, merge medicinal liquid twice, continue heating and make water evaporates to about 500ml.Room temperature to be chilled to adds 95% ethanol 550ml.Left standstill 24 hours, the leaching supernatant is flung to ethanol to the greatest extent, and is concentrated into about 50 grams, treat cold rnning stevioside 0.3 gram and the dextrin 80 gram mixings handled after cross 16 mesh sieves and make granule, granulate is distributed into 20 pouches and gets final product behind 40 ℃ of oven dryings.When taking, every day three times, each one bag.
Claims (7)
1, a kind of Chinese medicine electuary medicine for endometriosis that is used for the treatment of gynecological's endometriosis is characterized in that its constituent is as follows:
6～15 parts of Rhizoma Cyperis
8～22 parts of Rhizoma Corydalis
3～10 parts of Ramulus Cinnamomi
8～25 parts of Radix Salviae Miltiorrhizaes
3～10 parts of rhizoma sparganic
3～10 parts of Rhizoma Curcumae
10～14 parts in dextrin
0.02～0.04 part of stevioside
2, according to the described medicine for endometriosis of claim 1, it is characterized in that Rhizoma Cyperi, Rhizoma Corydalis in the constituent through vinegar system, Rhizoma Curcumae is through parch.
3, a kind of Chinese medicine electuary medicine for endometriosis manufacturing process that is used for the treatment of gynecological's endometriosis is characterized in that getting by the constituent of medicine for endometriosis:
6～15 parts of Rhizoma Cyperis
8～22 parts of Rhizoma Corydalis
3～10 parts of Ramulus Cinnamomi
8～25 parts of Radix Salviae Miltiorrhizaes
3～10 parts of rhizoma sparganic
3～10 parts of Rhizoma Curcumae
After adding twice of water steaming and decocting, filter, concentrating filter liquor is refined into thick paste, adds dextrin, stevioside, makes granule, behind the granulate.
4, according to the described medicine for endometriosis manufacturing process of claim 3, it is characterized in that Rhizoma Cyperi, the Rhizoma Corydalis in the medicine for endometriosis constituent is elder generation's process vinegar system, Rhizoma Curcumae is earlier through parch.
5, according to the described medicine for endometriosis manufacturing process of claim 3, it is characterized in that decocting with water and be performed such for twice, add water after will six kinds of Chinese crude drugs mixing, make the water surface surpass 7～15 centimetres of powder, soak after two hours, heated and boiled was boiled 1.5～2.5 hours first, the leaching medicinal liquid, add for the second time water, the water surface surpasses 4～6 centimetres of powder, boils 1～2 hour, the leaching medicinal liquid, and with the merging of twice decoction gained medicinal liquid.
6, according to the described medicine for endometriosis manufacturing process of claim 3, it is characterized in that the concentrating filter liquor process is as follows: medicinal liquid is heated to boiling, allow water evaporates, be concentrated to: surveying proportion at 100 ℃ of intermittent fever is 1.02～1.04, be that Bo Meishi meter reading is 3～6, after medicinal liquid is cooled to room temperature, adding concentration while stirring and be 90～98% ethanol is 45～55% to containing the alcohol amount, left standstill again 20～28 hours, with filter paper or filter cloth leaching supernatant, in water-bath, reclaim ethanol, surplus pure heated volatile is to the greatest extent, reheat is concentrated into: surveying proportion at 80 ℃ of intermittent fever is 1.25～1.30, and promptly Bo Meishi meter reading is 29～33.5.
7,, it is characterized in that the medicinal liquid that will be condensed into is cooled to 25 ℃～35 ℃, promptly becomes paste according to the described medicine for endometriosis manufacturing process of claim 3, add 10～14 parts in dextrin, 0.02～0.04 part of stevioside mixes the back and crosses 16 mesh sieves, make granule,, divide pack to get final product through granulate.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 93110326 CN1081107A (en) | 1992-03-16 | 1993-03-15 | Medicine for endometriosis and manufacturing process thereof |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN92106441.1 | 1992-03-16 | ||
| CN 92106441 CN1076365A (en) | 1992-03-16 | 1992-03-16 | " medicine for endometriosis " manufacturing process |
| CN 93110326 CN1081107A (en) | 1992-03-16 | 1993-03-15 | Medicine for endometriosis and manufacturing process thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1081107A true CN1081107A (en) | 1994-01-26 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 93110326 Pending CN1081107A (en) | 1992-03-16 | 1993-03-15 | Medicine for endometriosis and manufacturing process thereof |
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| Country | Link |
|---|---|
| CN (1) | CN1081107A (en) |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1057936C (en) * | 1995-04-20 | 2000-11-01 | 裴玉环 | "Neiyisan" traditional Chinese medicine for treatment of adenomyosis and its preparing process |
| CN1078078C (en) * | 1997-12-05 | 2002-01-23 | 蔡利珊 | Traditional Chinese medicinal preparation for curing gynecopathy |
| CN1091607C (en) * | 1998-03-05 | 2002-10-02 | 陈寿熙 | Jingshutong soluble granules |
| CN1332703C (en) * | 2005-03-14 | 2007-08-22 | 徐究竟 | Medicine for treating endometriosis and its preparing process |
| CN100364516C (en) * | 2004-12-20 | 2008-01-30 | 叶耀良 | Dan e Fukang preparation and preparing method |
| CN100421718C (en) * | 2004-04-21 | 2008-10-01 | 广州中医药大学第二附属医院 | Chinese medicinal composition for treating endometriosis and its preparation method |
| CN102614340A (en) * | 2012-02-15 | 2012-08-01 | 罗苓 | Medicinal powder for promoting pregnancy |
| CN103386077A (en) * | 2012-05-08 | 2013-11-13 | 四川滇虹医药开发有限公司 | Compound traditional Chinese medicine used for treating dysmenorrhoea and endometriosis, and preparation method thereof |
| CN104013914A (en) * | 2014-06-13 | 2014-09-03 | 陈筠 | Traditional Chinese medicine for treating endometriosis and preparation method of traditional Chinese medicine |
| CN113491739A (en) * | 2021-08-20 | 2021-10-12 | 重庆市中医院 | Pain-relieving and stasis-eliminating traditional Chinese medicine for treating endometriosis and preparation method thereof |
-
1993
- 1993-03-15 CN CN 93110326 patent/CN1081107A/en active Pending
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1057936C (en) * | 1995-04-20 | 2000-11-01 | 裴玉环 | "Neiyisan" traditional Chinese medicine for treatment of adenomyosis and its preparing process |
| CN1078078C (en) * | 1997-12-05 | 2002-01-23 | 蔡利珊 | Traditional Chinese medicinal preparation for curing gynecopathy |
| CN1091607C (en) * | 1998-03-05 | 2002-10-02 | 陈寿熙 | Jingshutong soluble granules |
| CN100421718C (en) * | 2004-04-21 | 2008-10-01 | 广州中医药大学第二附属医院 | Chinese medicinal composition for treating endometriosis and its preparation method |
| CN100364516C (en) * | 2004-12-20 | 2008-01-30 | 叶耀良 | Dan e Fukang preparation and preparing method |
| CN1332703C (en) * | 2005-03-14 | 2007-08-22 | 徐究竟 | Medicine for treating endometriosis and its preparing process |
| CN102614340A (en) * | 2012-02-15 | 2012-08-01 | 罗苓 | Medicinal powder for promoting pregnancy |
| CN103386077A (en) * | 2012-05-08 | 2013-11-13 | 四川滇虹医药开发有限公司 | Compound traditional Chinese medicine used for treating dysmenorrhoea and endometriosis, and preparation method thereof |
| CN103386077B (en) * | 2012-05-08 | 2015-09-23 | 四川滇虹医药开发有限公司 | A kind ofly be used for the treatment of herbal mixture of dysmenorrhea and endometriosis and preparation method thereof |
| CN104013914A (en) * | 2014-06-13 | 2014-09-03 | 陈筠 | Traditional Chinese medicine for treating endometriosis and preparation method of traditional Chinese medicine |
| CN113491739A (en) * | 2021-08-20 | 2021-10-12 | 重庆市中医院 | Pain-relieving and stasis-eliminating traditional Chinese medicine for treating endometriosis and preparation method thereof |
| CN113491739B (en) * | 2021-08-20 | 2022-09-13 | 重庆市中医院 | Pain-relieving and stasis-eliminating traditional Chinese medicine for treating endometriosis and preparation method thereof |
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