CN1091607C - Jingshutong soluble granules - Google Patents

Abstract

The present invention relates to a hemagogic soluble granular preparation which is prepared from 12 kinds of traditional Chinese medicine, such as ginseng, Chinese angelica root, red sage root, safflower, notoginseng, earthworm, honeysuckle flower, wild chrysanthemum flower, etc. and an auxiliary agent by means of the procedures of drying, pulverization, volatile oil extraction, decoction, extraction, concentration, drying, granulation, packaging, etc. The preparation is mainly used for treating endometriosis and has the advantages of wide adaptability, convenience for taking, no toxic or side effect, quick and long therapeutic effect, etc.

Description

Jingshutong soluble granules

The present invention relates to a kind of Chinese medicine preparation, is to be used for the treatment of endometriotic Jingshutong soluble granules.

Endometriosis is because the caused a kind of disease of endometrium of long body part beyond cavity of uterus.Endometriosis belongs to Chinese medicine " dysmenorrhea " and waits the disease category, and its morbidity is many because of deficiency of the liver and kindey, qi depression to blood stasis, due to the stagnation of phlegm-damp, the many disease meetings of primary disease color is sallow or dark and gloomy, Light-headedness, distension and fullness of the chest and abdomen, lower abdomen pain, by do not subtract or counter exacerbating, many strings of arteries and veins or stringy and thready pulse, belong to the disease of stasis deficiency in origin and excess in superficiality, stasis should be led to.In a word, primary disease with undermine Liver and kidney, depression of liver-QI, stasis is not all right, dash to appoint to be obstructed, the vessels of the uterus obturation is relevant.

At present, the main usability glandular hormone of western medical treatment endometriosis is to prehypophyseal negative feedback, and the inhibition ovary is ovulated and adopted a pregnant estrogen conjoint therapy; Or utilize danazol, Testosterone etc., to eliminating the caused pain of endometriosis certain curative effect is arranged all, extensively by clinical employing.Clinical proof: hormone plays an important role to keeping intravital balance, still, if a certain parahormone supersecretion of human body or very few will cause the body disfunction, and influences the function of other endocrine gland, stiff reaction can occur when serious.Too much use hormone may damage liver, causes the confusion of the menstrual cycle, and the women is slight manlike etc., can bring certain psychic trauma to the patient, and the function of ovary is suppressed, and estrogen level reduces, and consumption is big more, and side effect is heavy more.Secondly, another kind of treatment means is to take operative treatment, and the method often can not once be eradicated, and also need perform the operation once more, easily brings bigger misery to the patient.Therefore say that treatment endometriosis doctor trained in Western medicine does not still have positive radical cure method at present.

The purpose of this invention is to provide a kind of Jingshutong soluble granules, be mainly used in the treatment endometriosis, have wide adaptability, taking convenience, have no side effect, curative effect is rapid, characteristics such as lasting.

Prescription of the present invention is made up of following medicine and weight range:

Radix Ginseng 1500～2000 g, Radix Angelicae Sinensis 2000～3000 g, Radix Salviae Miltiorrhizae 3000～3500 g,

Flos Carthami 2000～2500 g, Radix Notoginseng 300～400 g, Pheretima 1000～2000 g,

Flos Lonicerae 2000～2500 g, Flos Chrysanthemi Indici 2000～2500 g, the Radix Aucklandiae 1000～1500 g,

Sanguis Draxonis 300～500 g, Hirudo 1000～1500 g, Fructus Gleditsiae Abnormalis 1000～1500 g.

Its preparation method is to make granule with conventional pharmaceutical methods, specifically:

One, drying and crushing: earlier Hirudo, Pheretima (removing its earth) are added respectively propagandize hotly to coke yellow standby.Get Sanguis Draxonis, Radix Notoginseng, Hirudo, Pheretima and put into the hothouse drying by the prescription predetermined weight, being ground into particle diameter with pulverizer respectively then is that 0.125～0.106mm fine powder is stand-by;

Two, extract volatile oil and decoction: earlier with Radix Angelicae Sinensis, Flos Carthami, Flos Lonicerae, Flos Chrysanthemi Indici, the Radix Aucklandiae, that Fructus Gleditsiae Abnormalis extracts volatile oil is standby.After the heat said medicine and Radix Ginseng, Radix Salviae Miltiorrhizae are decocted with water twice by the weight of prescription regulation, each amount of water is 5 times of said medicine total amount.Decocted (opening the back) for the first time 2.0～2.5 hours; Decocted (opening the back) for the second time 1.5～2.0 hours, and decocted the medicinal liquid merging with twice again and filter, remove medicinal residues:

Three, extraction concentrates: with the multi-function extractor extracted twice of the medicinal liquid after the above-mentioned decoction filtering, remove moisture, make it to be concentrated into relative density and be 1.30 ± 0.02 (60 ℃) extractum, and standby;

Four, granulate dry: the fine drug powder that will extract after extractum and the pulverizing after concentrating mixes, add adjuvant: sugar and starch, wherein sugar accounts for medicine total amount 20～25%, starch accounts for medicine total amount 5～10%, mix homogeneously, the preparation granulating is evenly sprayed the volatile oil of extraction after the drying, be dissolved granule:

Five, packing: pack with masking foil, every bag of net weight 6g is a dose, 28 bags in every box.

Storage: place the moon to dry in the air and preserve in dry place.

Usage and consumption: become human oral one time a bag (6g), boiled water is taken after mixing it with water, a twice-daily, and 14 days is a course of treatment.

Jingshutong soluble granules has the merit of drastically removing blood stasis and resolving static blood, blood circulation promoting and blood stasis dispelling, promoting the circulation of QI to relieve pain, cures mainly endometriosis.

Radix Angelicae Sinensis, Flos Carthami have blood circulation promoting and blood stasis dispelling, analgesic effect in this prescription; Radix Salviae Miltiorrhizae, Radix Notoginseng cooling blood and removing stasis, the stasis of blood go then blood must return through; Ginseng qi-tonifying, QI can promote blood circulation, the operation of blood depends on the compress of gas, i.e. so-called " the capable then blood of gas is capable "; The Pheretima the meridian dredging, " stasis of blood is gone into network for a long time " can strengthen function of promoting blood circulation to disperse blood clots; Flos Lonicerae, Flos Chrysanthemi Indici heat-clearing and toxic substances removing, blood are heated and then decoct in bulk, and disease the working as of knot used it to the hot stasis of blood mutually; Radix Aucklandiae promoting the circulation of QI to relieve pain, the QI and blood mutual dependence for existence, the capable then blood of gas is capable, and the stagnation of QI is blood stasis then; Hirudo has removing blood stasis, removing blood stasis, and the merit of collateral dredging is particularly useful for blood stasis amenorrhea person; But Sanguis Draxonis, Radix Notoginseng dissipating blood stasis tissue regeneration promoting, promoting blood circulation and stopping pain.All medicine compatibilities, not only promoting the circulation of blood divides the stasis of blood to stagnate, and the pent-up of the branch of venting one's spleen is again invigorated blood circulation and not hematozemia, blood stasis dispelling and tissue regeneration promoting it.The characteristics of we's compatibility: be that biochemical function pass with the internal organs meridians with QI and blood is a foundation, not only promoting the circulation of blood divides the stasis of blood to stagnate, the pent-up of the kind branch of venting one's spleen again.It has following three characteristics: one, QI and blood is taken into account.Blood circulation promoting and blood stasis dispelling is joined depressed liver-energy dispersing and QI regulating, and based on blood stasis dispelling, it is auxilliary regulating the flow of vital energy, and the residence circulation of qi promoting is among invigorating blood circulation; Joining QI regulating medicine is the QI and blood biochemical relationship of " the capable then blood of gas is capable "; Its two, residence is supported in living.Be that blood circulation promoting regulates qi resides in the tonifying YIN that nourishes blood, make the stasis of blood go just not hinder, regulate the flow of vital energy and do not consume the moon, in promptly invigorating blood circulation and do not have the worry of hematozemia, regulate the flow of vital energy and do not have the fraud of impairment of YIN; Its three, lifting is with using.Radix Ginseng, Flos Lonicerae in the side, the effectiveness that smooth mechanism of qi is declared in one rise and one drop, makes QI and blood lifting and accent, thereby produces " dredge its QI and blood, make its accent reach, and it is flat to make peace ".

Curative effect: this Jingshutong soluble granules, observe through hospitalizes such as Hospital Attached to Liaoning Inst. of Traditional Chinese Medicine 278 example endometriosis disease patients, wherein cure (pain disappearance, all disease recoveries from illness) 249 examples, effective (big disappearance of pain, all diseases obviously alleviate) 27 examples, invalid (pain no change, all disease nothings alleviate) 2 examples, total effective rate 96%.This shows that Jingshutong soluble granules has the effect of very strong blood circulation promoting and blood stasis dispelling, promoting the circulation of QI to relieve pain; And treating both the principal and secondary aspects of a disease, and the circulatory disturbance of improvement is arranged, human body immunity improving power is recovered normal physiological function, is removed remarkable efficacy such as pain, and have taking convenience, have no side effect, pure Chinese medicinal preparation, easily by advantages such as the patient accept.

Embodiment

One, drying and crushing: trematodiasis 1000g fetches water earlier, Pheretima (removing its earth) 1500g adds respectively and propagandizes hotly to coke yellow standbyly, gets Sanguis Draxonis 400g, Radix Notoginseng 90g, put into the hothouse inner drying together with the Hirudo after the parch, Pheretima, and it is standby to be ground into particle diameter 0.125～0.106mm fine powder with pulverizer respectively:

Two, extract volatile oil and decoction: earlier with Radix Angelicae Sinensis 2500g, Flos Carthami 2000g, Flos Lonicerae 2500g, Flos Chrysanthemi Indici 2500g, Radix Aucklandiae 1200g, it is standby that Fructus Gleditsiae Abnormalis 1200g extracts volatile oil, then with said medicine and Radix Ginseng 1500g, Radix Salviae Miltiorrhizae 3200g decocts with water twice, each amount of water is 5 times of said medicine total amount, decocts (opening the back) for the first time 2.0 hours, decocts (opening the back) for the second time 1.5 hours, again twice decoction liquor merged and filter, remove medicinal residues;

Three, extraction concentrates: with the multi-function extractor extracted twice of the medicinal liquid after the decoction filtering, remove moisture, making it to be concentrated into relative density is that 1.30 ± 0.02 (60 ℃) extractum is standby;

Four, granulation is dry: fine drug powder mixes after extractum after at last said extracted being concentrated and the above-mentioned pulverizing, every 4g adds the 250g adjuvant: sugared 150g and starch 100g, mix homogeneously is made granule, evenly spray after the drying extraction volatile oil this dissolved granule:

Five, packing: pack with masking foil, every bag of net weight 6g is a dose, and every box is (14 a days) dosing course of treatment for 28 bags.

Claims (1)

1. one kind is used for the treatment of endometriotic dissolved granule, it is characterized in that: it is made up of following medicine and weight range:

Radix Ginseng 1500～2000 g, Radix Angelicae Sinensis 2000～3000 g, Radix Salviae Miltiorrhizae 3000～3500 g,

Flos Carthami 2000～2500 g, Radix Notoginseng 300～400 g, Pheretima 1000～2000 g,

Flos Lonicerae 2000～2500 g, Flos Chrysanthemi Indici 2000～2500 g, the Radix Aucklandiae 1000～1500 g,

Sanguis Draxonis 300～500 g, Hirudo 1000～1500 g, Fructus Gleditsiae Abnormalis 1000～1500 g.