CN1546136A - Baras camphor, chuanxiong rhizome headache treating medicine and its oral preparation and its preparing process - Google Patents
Baras camphor, chuanxiong rhizome headache treating medicine and its oral preparation and its preparing process Download PDFInfo
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Abstract
The invention relates to a traditional Chinese pharmaceutical composition for treating cephalodynia, its oral administration preparation and process for preparation, wherein the preparation is prepared from boneol, grassleaved sweetflag rhizome, Ligusticum wallichii1, and root of Dahurain angelica.
Description
[technical field] the present invention relates to treat a kind of medicine that modern medicine migraine, tension headache, vascular headache and traumatic headache etc. belong to expectorant stasis of bloods retardance brain networks, oral formulations and preparation method thereof.
[background technology] headache is a kind of clinically modal frequently-occurring disease, up-to-date sorting technique by international headache association (HIS), headache is divided into migraine, tension headache, cluster headache and chronic paroxysmal hemicrania etc., wherein common with migraine.The general migrainous incidence rate of crowd is 15~19%, and the U.S. has 2,300 ten thousand people migraineurs every year approximately, European countries and world's most countries, and migrainous prevalence is broadly similar also.About 2.4 hundred million migraineurs in the whole world will stand 1,400,000,000 migrainous torments every year, there is the annual natural law of suffering from various headaches of 5% women and 2.8% male to be no less than 180 days, there are every year 90% male and 95% women to have a headache, only have 1% people to escape by luck throughout one's life.We can say that headache almost invades and everyone.
Its clinical manifestation of the patient of migraine, tension headache and cluster headache and degree are not quite similar, Most patients is except that having headache in various degree, toward the change of contact with hallucination, colour vision, vision, or nasal obstruction, watery nasal discharge, nausea,vomiting,diarrhea, perspiration, cardiopalmus, even facial paralysis, neural mental symptom etc. appear.Therefore, have every year numerous headache patients to seek medical advice and medicine everywhere, he (she) in have many people to suffer untold misery because of the headache that prolonged difficulty heals, seriously influence work and life, therefore, remove vast headache patient's misery, also just become medical worker's important duty.
Recent studies confirms, causes that the reason of headache is very complicated, except that physical factor, chemical factor, endocrine factors, goes back multiple factors such as spiritedness and nerve.Because its pathogenesis is complicated and not fully aware of, implement the specific aim treatment with chemical drugs, can only be the verification treatment mostly, late result is relatively poor.
The Chinese patent medicine and the characteristics thereof that are usually used in treating headache in the market are as follows:
1. the exceedingly high liquid of Tai Ji: lay particular stress on headache due to invasion of exogenous pathogens;
2. ZHENGTIAN WAN: focus on blood circulation promoting and blood stasis dispelling, expelling wind and dampness;
3. brain Yiganning capsule: focus on calming wind and dredging collateral, better to the headache due to hyperactivity of liver-YANG effect;
4. QUANTIANMA JIAONANG: form with single medicinal material, cure mainly liver wind headache;
5. Cornu Saigae Tataricae capsule: form with single medicinal material, cure mainly the liver-fire liver wind headache;
6. Chuanxiong Chatiao San: function is a dispelling wind and relieving, cures mainly the headache of diseases caused by exogenous pathogenic factor ailment said due to cold or exposure;
7. headache is peaceful: dispelling wind and relieving, the circulation of qi promoting blood stasis dispelling cures mainly migraine, vascular headache, nervous headache.
8. headache magical effect pellet: form by Rhizoma Chuanxiong, Flos Carthami, Semen Persicae, Ramulus Uncariae Cum Uncis, Herba Asari, the Radix Angelicae Dahuricae, Radix Angelicae Sinensis, Radix Paeoniae, Radix Aconiti Lateralis Preparata.The function nourshing blood and promoting blood circulation, dispelling wind and relieving.Cure mainly various headaches such as migraine, tension headache.
9. brain-strengthening infusion: form by Radix Et Caulis Acanthopanacis Senticosi, Fructus Schisandrae Chinensis, caffeine.The function brain-nourishing refreshing nourishes Fructus Alpiniae Oxyphyllae.Cure mainly the neurasthenia, neurosis, nervous headache.
10. control inclined to one side spirit: form by Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, the Radix Paeoniae Alba, Semen Sinapis Albae, Radix Bupleuri, Rhizoma Cyperi, Semen Pruni, Radix Glycyrrhizae.Function is soothing the liver, regulate the flow of vital energy, pain relieving.Cure mainly migraine.Hypertension etc.
11. the cranium pain is peaceful: be made up of Scorpio, Herba Asari, Scolopendra, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Radix Paeoniae Rubra, Flos Carthami, the Radix Angelicae Dahuricae, Radix Glycyrrhizae.The function dispelling wind is invigorated blood circulation, relieving spasm to stop pain.Cure mainly vascular headache.
12. Pain-Stopping Pill: form by Rhizoma Gastrodiae, Bulbus Fritillariae Cirrhosae, system Arisaema Cum Bile, the Rhizoma Pinelliae, Pericarpium Citri Reticulatae, Poria cum Radix Pini, Bombyx Batryticatus, Scolopendra, Scorpio, succinum.The function wind-expelling pain-stopping, nourshing blood and promoting blood circulation.Cure mainly ailment said due to cold or exposure headache card.
According to disclosed No. 1358505 patents on July 17 " capsule for treating headache " in 2002 introduction, this invention has adopted four flavor Chinese medicines such as Rhizoma Arisaematis (processed), Herba Asari, Flos Chrysanthemi and Borneolum Syntheticum to form, through more than ten years clinical verification determined curative effect.Though wherein Borneolum Syntheticum belongs to the medicine of hot waking up the patient from unconsciousness by clearing away heat key, yet its status is not a monarch drug and only using as accessory drugs.
In view of present modern medicine to having a headache the pathogenetic level of understanding and be based upon chemotherapy method on this aspect, still be not enough to satisfy hundreds of millions of headache patients' treatment demand, therefore, be necessary the medicine of research, the more efficiently treatment headache of exploitation.And used historical Chinese medicine in several thousand as having, aspect the understanding and diagnosis and treatment of this disease of having a headache, original opinion and treatment experience are all arranged, for China medicine worker has accumulated extremely abundant valuable wealth, make that with the modern medicine technological means active drug of research and development treatment headache disease has had solid foundation and wide space.
[summary of the invention] purpose of the present invention, be to remedy the deficiency of existing product, technology, providing a kind of Borneolum Syntheticum with refrigerant inducing resuscitation to extensive patients and medical personnel is monarch drug, and three flavors such as Rhizoma Acori Graminei, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae are the glacier Dimetothiazine of ministerial drug and its oral formulations (granule, capsule, tablet, drop pill) and preparation method thereof altogether.
Can obtain glacier Dimetothiazine involved in the present invention and different oral formulations respectively by following method:
The preparation method of glacier Dimetothiazine raw material medicated powder
One. prescription
Borneolum Syntheticum (1~3 part), Rhizoma Acori Graminei (25~35 parts), Rhizoma Chuanxiong (25~35 parts), the Radix Angelicae Dahuricae (25~35 parts).
This prescription is a monarch drug with the Borneolum Syntheticum of refrigerant inducing resuscitation, and its acrid in the mouth is cool in nature, focuses on diffusing stagnated fire, sensiblely satisfies, and ends headache.Rhizoma Acori Graminei acrid in the mouth flavor temperature, inducing resuscitation eliminating phlegm, the logical merit of auxiliary Borneolum Syntheticum a surname.The hot perfume (or spice) of Rhizoma Chuanxiong is walked string, is apt to reach the mountain peak item, and blood-activating and qi-promoting is the key medicine of treatment headache.Radix Angelicae Dahuricae property and flavor of peppery and warm, kind dispelling wind evil, ending above three flavors of headache is ministerial drug altogether.All medicines share, with the inducing resuscitation eliminating phlegm, and fluent QI and blood, wind-expelling pain-stopping is a purport, holds on to the pathogenesis key, so multiple headache is had preferably curative effect.On the property of medicine, Borneolum Syntheticum is cooler, and Rhizoma Acori Graminei, Rhizoma Chuanxiong and the Radix Angelicae Dahuricae be temperature partially, share its property of medicine of back belong to substantially hot and agent, so be beneficial to oral.
Two. preparation method
The first step is extracted volatile oil
Method 1: water vapour distillation method
(1) get Rhizoma Acori Graminei, Rhizoma Chuanxiong, Radix Angelicae Dahuricae decoction pieces and add the above water logging bubble of 5 times of amounts more than 1 hour, steam distillation separates, and it is standby to collect volatile oil;
(2) separate the volatile oil after-filtration, get medicinal residues and filtrate I, other device of filtrate I is stored for future use;
Method 2:CO
2Super critical extraction
(1) Rhizoma Acori Graminei supercritical extraction: CO
2→ refrigeration system → high-pressure pump → extraction kettle → extraction-container I → extraction-container II → circulation.Condition: extracting pressure 20~25MPa, extraction-container I pressure 10~13MPa, extraction-container II pressure 6~8MPa, 48~58 ℃ of extraction temperature, 55~65 ℃ of extraction-container I temperature, extraction-container temperature II45~50 ℃, circulation time 3~4h, oil-collecting ratio 3~6%.
(2) Rhizoma Chuanxiong supercritical extraction condition: extracting pressure 25~35MPa, 45~55 ℃ of extraction temperature are resolved pressure 8~12MPa, 55~65 ℃ of resolution temperatures.
(3) Radix Angelicae Dahuricae supercritical extraction condition: extracting pressure 20~30MPa, 30~45 ℃ of extraction temperature are resolved pressure 10~20MPa, 40~50 ℃ of resolution temperatures.
The medicinal residues that second step will extract behind the volatile oil add water more than 3 times, decoct once or more than, be no less than 1h at every turn, filtrate and the filtrate I that decocts several times merged, filtration gets filtrate II;
The 3rd step concentrated filtrate II, and drying is pulverized, and sieves, and it is standby to get dry powder;
The 4th step Borneolum Syntheticum is pulverized, and sieves, and adds in the above dry powder and stirs;
The 5th step was dissolved in the volatile oil of carrying in an amount of ethanol, evenly was sprayed in the above dry powder, stirred, and got glacier Dimetothiazine raw material medicated powder.
The preparation method of glacier Dimetothiazine granule
One. prescription
Glacier Dimetothiazine raw material medicated powder---by the preparation method gained medicated powder of glacier Dimetothiazine raw material medicated powder;
Starch, Pulvis Talci are an amount of.
Two. preparation technology
The first step adds certain proportion of starch and Pulvis Talci, and stirs on the basis that obtains glacier Dimetothiazine raw material medicated powder;
Second step, the equipment of selecting to adapt was made granule with above material according to determined granulating process, get final product glacier Dimetothiazine granule raw material;
The 3rd step promptly got glacier Dimetothiazine granule with above gained granule raw material packing.
The preparation method of glacier capsule for treating headache
To incapsulate by the preparation method resulting granules of glacier Dimetothiazine granule, get final product the glacier capsule for treating headache.
The preparation method of glacier Dimetothiazine tablet
Will be by the preparation method resulting granules tabletting of glacier Dimetothiazine granule, get final product glacier Dimetothiazine tablet.
The preparation method of glacier Dimetothiazine drop pill
One. prescription
Glacier Dimetothiazine raw material medicated powder---by the preparation method gained medicated powder of glacier Dimetothiazine raw material medicated powder;
Substrate---Polyethylene Glycol
1500~20000, in the substrate such as stearic acid, sodium stearate, glycerin gelatine, glyceryl monostearate, Lac, polyoxyethylene monostearate, polyethers, carboxymethyl starch sodium any one or a few mix mutually;
The ratio of glacier Dimetothiazine raw material medicated powder and substrate counts 1 by weight: (1~8).
Two. preparation technology
The first step is according to the weight portion meter, with 1: the ratio of (1~8) with glacier Dimetothiazine raw material medicated powder and substrate mix homogeneously, places and heats while stirring in the heating container until fusion;
Second step was adopted special-purpose drop pill machine (as the DW-35 type drop pill machine of Taixing, Jiangsu second pharmaceutical machine factory production), and the temperature control system of adjustment drop pill machine, make the water dropper temperature of drop pill machine remain on (70~100) ℃, and the thermograde that makes condensing agent in the condensation column is (40~10) ℃ for (40~10) ℃ → (5~-15) ℃-be condensation column upper temp, and bottom temp is (5~-15) ℃;
The 3rd step treated that the temperature of condensing agent in dropping-pill machine head and the condensation column is stable respectively and was in for second step during desired state of temperature, and fused material is splashed in the condensing agent with suitable speed by the water dropper of drop pill machine.Condensing agent can be any one in liquid paraffin, methyl-silicone oil, the vegetable oil;
The drop pill that the 4th step will be shunk molding by the outlet of drop pill machine takes out, and removes the surface condensation agent, and drying promptly gets glacier Dimetothiazine drop pill.
By positive QI-insufficiency, essence and blood loses empty [beneficial effect] headache because of how, and liver-yang is high contrary, the clear key of phlegm-turbidity and blood stasis stasis plug, QI and blood can not be fluent due to, wherein the clear key of phlegm-turbidity and blood stasis stasis plug is its main pathology.In view of the above, we cube focus on inducing resuscitation eliminating phlegm, removing obstruction in the collateral to relieve pain.Former side controls headache side based on " Shen Liangfang of Soviet Union " Borneolum Syntheticum radish Juice collunarium, cuts radish Juice, is monarch drug with the Borneolum Syntheticum, adds Rhizoma Acori Graminei, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae new side of four Chinese medicine composition altogether.
This prescription is updated in the clinical practice of several years, is finally determined.The Herba Asari and the Radix Paeoniae Alba are arranged in the former prescription, and do not have the Radix Angelicae Dahuricae.The capsule that adopts former prescription to make, once the hospital of traditional Chinese hospital, Guangdong Province was used for the clinical observation of curative effect of doing.From therapeutic outcome, the improve significantly effect of cerebral vasospasm of capsule for treating headache.After 10 days, vasospasmotic headache patient's cerebral vasospasm situation is significantly improved through the Dimetothiazine treatment.Handle through pairing T test statistics, significant difference is arranged.Now, in former prescription, removed Herba Asari, simultaneously the Radix Paeoniae Alba has been changed to the Radix Angelicae Dahuricae, finally be defined as prescription disclosed in this invention through constantly experiment improvement.
This prescription is a monarch drug with the Borneolum Syntheticum of refrigerant inducing resuscitation, and its acrid in the mouth is cool in nature, focuses on diffusing stagnated fire, sensiblely satisfies, and ends headache.Rhizoma Acori Graminei acrid in the mouth flavor temperature, inducing resuscitation eliminating phlegm, the logical merit of auxiliary Borneolum Syntheticum a surname.The hot perfume (or spice) of Rhizoma Chuanxiong is walked string, is apt to reach the mountain peak item, and blood-activating and qi-promoting is the key medicine of treatment headache.Radix Angelicae Dahuricae property and flavor of peppery and warm, kind dispelling wind evil, ending above three flavors of headache is ministerial drug altogether.All medicines share, with the inducing resuscitation eliminating phlegm, and fluent QI and blood, wind-expelling pain-stopping is a purport, holds on to the pathogenesis key, so multiple headache is had preferably curative effect.On the property of medicine, Borneolum Syntheticum is cooler, and Rhizoma Acori Graminei, Rhizoma Chuanxiong and the Radix Angelicae Dahuricae be temperature partially, share its property of medicine of back belong to substantially hot and agent, so be beneficial to oral.
From the modern pharmacology analysis, Borneolum Syntheticum has antiinflammatory (significantly to suppress the rat paw edema due to the Ovum Gallus domesticus album, suppress mice auricle swelling in the side
(1)), antalgic and sedative and anti-hypoxia
(2)(can prolong the length of one's sleep of mice, improve the mice threshold of pain and hypoxia endurance time), antibiotic
(3)(golden yellow streptococcus, beta hemolytic streptococcus, Streptococcus viridans, streptococcus pneumoniae, escherichia coli are all had inhibitory action), can also strengthen the laboratory animal blood-brain barrier permeability
(4) (5), tool sees through blood brain barrier rapidly
(6) (7)Deng pharmacological action.Rhizoma Chuanxiong has tangible sedation, movable inhibited to animal brain when Rhizoma Chuanxiong volatile oil is a small amount of; The Rhizoma Chuanxiong decoct can press down big spontaneous activity in mice, prolongs the length of one's sleep of mice.Contained ferulic acid cnidium lactone has spasmolysis to smooth muscle in the Rhizoma Chuanxiong; Ligustrazine can suppress anoxia and cause the lung vasoconstriction, and microcirculation disturbance is also had more sure improvement effect, and anticoagulant stops thrombosis, reduces pharmacological actions such as blood viscosity
(8)Rhizoma Acori Graminei
(9)Have calmness, convulsion, alleviation smooth muscle spasm and improve the effect of learning and memory of little mouse function.The Radix Angelicae Dahuricae
(10)Have antiinflammatory, analgesic, analgesia, spasmolytic, pharmacological action such as antibiotic.
Animal experiment study is the result show, the glacier Dimetothiazine reacts bitterly the mice due to thermostimulation and the acetic acid and has the obvious suppression effect; And can improve Mice Auricle microcirculation and blood flow thereof, make the expansion of arteriole and venule, the blood capillary opening amount increases.Also can obviously reduce blood viscosity and the cerebral vascular resistance of dog, cerebral blood flow increasing amount, and be good dose-effect reaction relation, and SBP, DBP and HR are not all had obvious influence, Electrocardiographic P ripple, P-R interval, QRS ripple, S-T section and T ripple also no abnormality seen change; The effect of antagonism mouse brain ischemia is still arranged, can breathe the persistent period behind the kind white mice broken end of significant prolongation Kunming, significant difference is relatively arranged with the normal saline matched group.Results suggest: glacier Dimetothiazine medicine involved in the present invention, by pain relieving, microcirculation improvement, reduction cerebral vascular resistance, reduce whole blood viscosity, the cerebral blood flow increasing amount is to anti-cerebral ischemia and the effect of tool treatment angioneurotic headache.This provides theoretical basis for clinical practice.
In order to make glacier Dimetothiazine involved in the present invention really be useful for clinical, and can adapt to different situations patient's demand, we have succeeded in developing corresponding practical dosage form again on the basis of extracting glacier Dimetothiazine raw material medicated powder---glacier Dimetothiazine granule, glacier capsule for treating headache and glacier Dimetothiazine drop pill.
It is simple and convenient that granule, capsule and sheet have production technology, and characteristics with low cost become a kind of domestic and clinical dosage form that extensive patients is taken like a shot already; Drop pill is a kind of new dosage form, and it is compared with traditional oral formulations, and tangible advantage is arranged.
Glacier Dimetothiazine drop pill involved in the present invention; utilize surfactant polyethylene etc. to be substrate; be refined into solid dispersion with glacier Dimetothiazine raw material medicated powder; making medicine be molecule, colloid or microcrystalline state is scattered in the substrate; the total surface area of medicine increases, and substrate is hydrophilic, and medicine is had wetting action; can make that medicine is rapidly molten to loose into microgranule or solution, thereby make the dissolving of medicine and absorb and accelerate.Thereby improved bioavailability, brought into play efficient, quick-acting effects etc.
Compare with the administering mode of traditional oral formulations, exist essential distinction.Drop pill with the solid dispersion technology preparation can adopt oral and sublingual administration, and effective ingredient is fully contacted with mucomembranous surface, absorbs by mucomembranous epithelial cell, directly enters blood circulation.Especially sublingual administration administration can directly enter blood circulation without gastrointestinal tract and liver, has avoided first pass effect effectively, has also avoided gastrointestinal irritation, thereby it is rapid to have an onset, bioavailability height, characteristics such as side effect is little, and medication is convenient.
This preparation is by after the heating of solid drugs and substrate, being melt into liquid state, splashes into to make in the not miscible condensed fluid.Therefore, the stability of drug height, not facile hydrolysis, oxidation, and the operation be under liquid state, to carry out, no dust pollution is not subject to the influence of crystal formation, thereby has guaranteed the quality of medicine, has increased stability.
Again by the embodiment of two specific embodiment,, be described further below [specific embodiment] glacier Dimetothiazine involved in the present invention, glacier Dimetothiazine tablet, glacier Dimetothiazine drop pill and corresponding preparation method.(because of granule, sheet and capsular preparation method are comparatively simple, technology is comparative maturity also, so do not introduce embodiment):
The preparation and the experimental result of specific embodiment one glacier Dimetothiazine raw material medicated powder
One. prescription
1 part of Borneolum Syntheticum, 30 parts of Rhizoma Acori Graminei, 30 parts of Rhizoma Chuanxiongs, 30 parts of the Radixs Angelicae Dahuricae.
Two. preparation method
The first step is extracted volatile oil---steam distillation
1. get Rhizoma Acori Graminei, Rhizoma Chuanxiong, Radix Angelicae Dahuricae decoction pieces and add 10 times of amounts of water, soak 4h, steam distillation separates, collects volatile oil, approximately 0.5ml~2.5ml/100g medical material;
2. the medicinal residues behind the above extraction volatile oil are filtered, get medicinal residues and filtrate I, other device of filtrate I is stored for future use;
Second step will be extracted medicinal residues behind the volatile oil and be added 10 times of decoctings and boil 3 times, and each 4 hours, filter, merge with filtrate I, must filtrate II;
The 3rd step concentrated filtrate II, and drying is pulverized, and sieves, and it is standby to get dry powder;
The 4th step Borneolum Syntheticum is pulverized, and sieves, and adds in the above dry powder and stirs;
The 5th step was dissolved in the volatile oil of carrying in an amount of ethanol, evenly was sprayed in the above dry powder, stirred, and got glacier Dimetothiazine raw material medicated powder.
Three. experimental result
By this experiment gained result: the volatile oil yield has reached more than 80%, and the yield of glacier Dimetothiazine raw material medicated powder is also comparatively approaching with theoretical value.
The preparation method and the experimental result of specific embodiment two glacier Dimetothiazine drop pill
One. prescription
Glacier Dimetothiazine raw material medicated powder---by preparation method one resulting raw material powder of the present invention;
Substrate---polyethylene glycol 6000;
The ratio of glacier Dimetothiazine raw material medicated powder and substrate is counted 1: 3 by weight.
Two. preparation technology
The first step,, places and heats while stirring in the heating container until fusion glacier Dimetothiazine raw material medicated powder and substrate mix homogeneously with 1: 3 ratio according to the weight portion meter;
Second step was adopted homemade drop pill machine, and the temperature control system of adjustment drop pill machine, make the water dropper temperature of drop pill machine remain on (70~75) ℃, and the thermograde that makes condensing agent in the condensation column is (25~15) ℃ for (25~15) ℃ → (5~-5) ℃-be condensation column upper temp, and bottom temp is (5~-5) ℃;
The 3rd step treated that the temperature of condensing agent in dropping-pill machine head and the condensation column is stable respectively and was in for second step during desired state of temperature, with the water dropper of fused material, splash into (this example condensing agent uses methyl-silicone oil) in the methyl-silicone oil with suitable speed by the drop pill machine;
The drop pill that the 4th step will be shunk molding by the outlet of drop pill machine takes out, and removes the surface condensation agent, and drying promptly gets glacier Dimetothiazine drop pill.
Three. result of the test
Experiment one selects different substrates to carry out the experiment of prescription
Experimental design: carry out the influence of prescription to product involved in the present invention in order to observe glacier Dimetothiazine raw material medicated powder and different substrates, respectively with polyethylene glycol 6000, stearic acid, sodium stearate, glycerin gelatine, glyceryl monostearate, Lac, the polyoxyethylene monostearate, polyethers, carboxymethyl starch sodium is a substrate, glacier Dimetothiazine raw material medicated powder is even with 1: 3 mixed with different substrate, other is all according to the step of stipulating in [specific embodiment], adopt electrically heated mode that each group prepared materials is heated to fusion respectively, utilize homemade drop pill machine, regulate the requirement that its temperature control system makes second step of preparation technology in satisfied [specific embodiment], with the methyl-silicone oil is condensing agent, the technical process given according to [specific embodiment] is prepared, can obtain the prescription experiment of 9 glacier Dimetothiazine raw material medicated powder and different substrates, and obtain 9 groups of different experimental results and see attached list one.
Test the experiment of two glacier Dimetothiazine raw material medicated powder and the different proportionings of substrate
Experimental design: carry out the influence of prescription with substrate with different ratios to product involved in the present invention in order to observe glacier Dimetothiazine raw material medicated powder, respectively with 1: 1/1: 2/1: 3/1: 4/1: 5/1: 6/1: 7/1: 8 ratio, with glacier Dimetothiazine raw material medicated powder and substrate mix homogeneously, substrate is selected polyethylene glycol 6000 for use, other is all according to defined terms and step in [specific embodiment], adopt electrically heated mode that each group prepared materials is heated to fusion respectively, utilize homemade drop pill machine, regulate the requirement that its temperature control system makes second step of preparation technology in satisfied [specific embodiment], with the methyl-silicone oil is condensing agent, the technical process given according to [specific embodiment] is prepared, can obtain the prescription experiment of 8 glacier Dimetothiazine raw material medicated powder and different substrates, and obtain 8 groups of different experimental results and see attached list two.
Test the experiment of selecting different water dropper temperature in three preparation process
Experimental design: in order to observe of the influence of the different water dropper temperature of selection in the preparation process to product involved in the present invention, utilize homemade drop pill machine, regulate its temperature control system, make the water dropper temperature remain on 50 ℃ respectively, 60 ℃, 70 ℃, 80 ℃, 90 ℃, 100 ℃, temperature error<2%, and making condensate temperature satisfy the requirement in second step of preparation technology in [specific embodiment], all according to defined terms and step in [specific embodiment], substrate is selected polyethylene glycol 6000 for use for other, glacier Dimetothiazine raw material medicated powder and substrate is even with 1: 3 mixed, adopting electrically heated mode that the material that configures is heated to fusion, is condensing agent with the methyl-silicone oil, is prepared respectively according to the given technology in front [specific embodiment], can obtain the experiment of 6 different water dropper temperature, and obtain 6 groups of different experimental datas and see attached list three.
Test the experiment of selecting different condensing agents in four preparation process
Experimental design: select of the influence of different condensing agents in the preparation process to product involved in the present invention in order to observe, respectively with liquid paraffin, methyl-silicone oil, vegetable oil as condensing agent, all according to defined terms and step in [specific embodiment], substrate is selected Polyethylene Glycol for use for other
6000Glacier Dimetothiazine raw material medicated powder and substrate is even with 1: 3 mixed, adopt electrically heated mode that the material that configures is heated to fusion, utilize homemade drop pill machine, regulate the requirement that its temperature control system makes second step of preparation technology in satisfied [specific embodiment], be prepared respectively according to the given technology in front [specific embodiment] again, can obtain 3 experiments of selecting different condensing agents for use, and obtain 3 groups of different experimental datas and see attached list four.
Test the experiment of selecting different condensing agent temperature in five preparation process
Experimental design: select of the influence of different condensing agent temperature in the preparation process to product involved in the present invention in order to observe, regulate the refrigeration control system of drop pill machine, make in the post thermograde of condensing agent remain on (20~10) ℃ → (5~-5) ℃ respectively, (30~20) ℃ → (0~-10) ℃, (40~30) ℃ → (5~-15) ℃, temperature error<5%, all according to defined terms and step in [specific embodiment], substrate is selected Polyethylene Glycol for use for other
6000Glacier Dimetothiazine raw material medicated powder and substrate is even with 1: 3 mixed, adopt electrically heated mode that the material that configures is heated to fusion, utilize homemade drop pill machine, regulating its temperature control system makes the temperature of dropping-pill machine head satisfy the requirement in second step of preparation technology in [specific embodiment], with the methyl-silicone oil is condensing agent, be prepared respectively according to the given technology in front [specific embodiment] again, can obtain the experiment of 3 different condensing agent temperature, and obtain 3 groups of different experimental datas and see attached list five.
Table one glacier Dimetothiazine raw material medicated powder and the mutually blended experiment of different substrates
The substrate title | Effective ingredient (%) | Rounding rate (%) | Dissolve scattered time limit (minute) | The ball method of double differences different (%) | Hardness |
Polyethylene Glycol 6000 | ??25.0 | ??93 | ??<30 | ??<10 | +++ |
Stearic acid | ??25.0 | ??62 | ??>30 | ??>10 | ++ |
Sodium stearate | ??25.0 | ??57 | ??<30 | ??>10 | + |
Glycerin gelatine | ??25.0 | ??41 | ??<30 | ??>10 | + |
Glyceryl monostearate | ??25.0 | ??46 | ??<30 | ??>10 | + |
Lac | ??25.0 | ??25 | ??>30 | ??>10 | + |
The polyoxyethylene monostearate | ??25.0 | ??88 | ??<30 | ??<10 | +++ |
Polyethers | ??25.0 | ??82 | ??<30 | ??<10 | +++ |
Carboxymethyl starch sodium | ??25.0 | ??81 | ??<30 | ??<10 | ++ |
Result by table one can see: in an embodiment, when selecting different substrate or substrate combination, to the rounding rate, the ball method of double differences is different and index influence such as hardness is bigger, and dissolve scattered time limit institute is influenced not obvious.
The experiment of table two glacier Dimetothiazine raw material medicated powder and the different proportionings of substrate
Raw material medicated powder: substrate | Effective ingredient (%) | Rounding rate (%) | Dissolve scattered time limit (minute) | The ball method of double differences different (%) | Hardness |
1∶1 | ??50.0 | 62 | ??>30 | ??>10 | + |
1∶2 | ??33.3 | 81 | ??>30 | ??<10 | ++ |
1∶3 | ??25.0 | 94 | ??<30 | ??<10 | +++ |
1∶4 | ??20.0 | 94 | ??<30 | ??<10 | +++ |
1∶5 | ??16.7 | 96 | ??<30 | ??<10 | +++ |
1∶6 | ??14.3 | 96 | ??<30 | ??<10 | +++ |
1∶7 | ??12.5 | 95 | ??<30 | ??<10 | +++ |
1∶8 | ??11.1 | 93 | ??<30 | ??<10 | +++ |
Result by table two can see: in an embodiment, when the mixed proportion of raw material and substrate was 1: 4, rounding rate index had reached level preferably, and other index also enters a preferable scope accordingly.
Table three is selected the experiment of different water dropper temperature
The water dropper temperature | Effective ingredient (%) | The rounding rate | Dissolve scattered time limit | The ball method of double differences is different | Hardness |
50℃ | ??25.0 | ????55 | ??<30 | ??>10 | + |
60℃ | ??25.0 | ????72 | ??<30 | ??>10 | + |
70℃ | ??25.0 | ????95 | ??<30 | ??<10 | +++ |
80℃ | ??25.0 | ????93 | ??<30 | ??<10 | +++ |
90℃ | ??25.0 | ????80 | ??<30 | ??<10 | ++ |
100℃ | ??25.0 | ????73 | ??<30 | ??>10 | + |
Result by table three can see: in an embodiment, when selecting different water dropper temperature, to the rounding rate, the ball method of double differences is different and the hardness number influence is bigger, and dissolve scattered time limit is not had obvious influence.
Table four is selected the experiment of different condensing agents
Condensing agent | Effective ingredient (%) | Rounding rate (%) | Dissolve scattered time limit (minute) | The ball method of double differences different (%) | Hardness |
Liquid paraffin | ??25.0 | ??86 | ??<30 | ??<10 | +++ |
Methyl-silicone oil | ??25.0 | ??94 | ??<30 | ??<10 | +++ |
Vegetable oil | ??25.0 | ??71 | ??<30 | ??>10 | ++ |
Result by table four can see: bigger to the influence of rounding rate index when selecting different condensing agents in an embodiment, and with hardness certain influence is arranged to the ball method of double differences is different, and dissolve scattered time limit is not had obvious influence.
Table five is selected the experiment of different condensing agent temperature
The gradient scope of condensing agent temperature | Effective ingredient (%) | Rounding rate (%) | Dissolve scattered time limit (minute) | The ball method of double differences different (%) | Hardness |
(20~10)→(5~-5)℃ | ??25.0 | ????94 | ??<30 | ??<10 | +++ |
(30~20)→(0~-10)℃ | ??25.0 | ????93 | ??<30 | ??<10 | ++ |
(40~30)→(-5~-15)℃ | ??25.0 | ????81 | ??<30 | ??>10 | ++ |
Result by table five can see: in an embodiment, when selecting different condensing agent temperature, rounding rate index is had certain influence, and to dissolve scattered time limit, the ball method of double differences is different and index influence such as hardness is less.
(annotate: the hardness method for expressing in the subordinate list, adopt drop pill is placed on the glass plate, press...with one's finger it, observe its metamorphosis."+" expression flicking promptly is out of shape, " ++ " expression distortion of firmly pressing, and " +++" expression is indeformable by it.)
The partial reference data is as follows:
1. Luo Xiao east. the clinical research of capsule for treating headache treatment vasospasmotic headache. traditional Chinese medical science research 1998,10-11 (5) is P.3-4
2. old preciousness. capsule for treating headache. the patent No. 00134079.4
3. the beautiful Rong of beam etc. the pharmacokinetics feature of Borneolum Syntheticum in rat blood serum and cerebral tissue. new Chinese medicine and clinical pharmacology 1993,4 (4) are P.38
4. the beautiful Rong of beam etc. Borneolum Syntheticum is to the observation of rabbit, rat cerebral tissue's azovan blue coloration. and Guangzhou Traditional Chinese Medicine College's journal 1993,10 (4) is P.211
5. Xie Ming edits. the tcm prescription modern study. Xueyuan Press 1997 (front page)
Description attached sheet: description of drawings
1. this accompanying drawing is a process chart, by Borneolum Syntheticum, the raw material powder preparation of Rhizoma Chuanxiong Dimetothiazine and Borneolum Syntheticum, two parts of Rhizoma Chuanxiong Dimetothiazine formulation preparation.
2. feedstock production is divided again and is done that volatile oil extracts and two parts of dry powder preparation, and wherein: volatile oil provides two kinds of methods, and the one, traditional vapor distillation extraction method, the 2nd, than advanced person's CO
2Super critical extraction.
3. after making Dimetothiazine dry powder, adopt preparation method two, three, four, five respectively, can obtain four different dosage forms such as Borneolum Syntheticum, Rhizoma Chuanxiong Dimetothiazine granule, capsule, tablet and drop pill respectively.
Claims (12)
1. one kind is used for the treatment of the medicine that modern medicine migraine, tension headache, vascular headache and traumatic headache etc. belong to expectorant stasis of blood retardance brain network, form prescription by four flavor Chinese medicines, again by different preparation methoies, can make raw material medicated powder and different oral formulations respectively, it is characterized in that: constituting prescription of the present invention is Borneolum Syntheticum (1~3 part), Rhizoma Acori Graminei (25~35 parts), Rhizoma Chuanxiong (25~35 parts), the Radix Angelicae Dahuricae (25~35 parts); Can make glacier Dimetothiazine raw material medicated powder and glacier Dimetothiazine granule, capsule, tablet, drop pill respectively.
2. the prescription of addressing according to claim 1, it is characterized in that: the optimal proportion of prescription is 1 part of a Borneolum Syntheticum, 30 parts of Rhizoma Acori Graminei, 30 parts of Rhizoma Chuanxiongs, 30 parts of the Radixs Angelicae Dahuricae.
3. preparation method that is used for the described glacier of claim 1 Dimetothiazine raw material medicated powder, it is characterized in that: this preparation method is made up of following processing step:
The first step is extracted volatile oil
Method 1: water vapour distillation method
(1) get Rhizoma Acori Graminei, Rhizoma Chuanxiong, Radix Angelicae Dahuricae decoction pieces and add the above water logging bubble of 5 times of amounts more than 1 hour, steam distillation separates, and it is standby to collect volatile oil;
(2) separate the volatile oil after-filtration, get medicinal residues and filtrate I, other device of filtrate I is stored for future use;
Method 2:CO
2Super critical extraction
(1) Rhizoma Acori Graminei supercritical extraction: CO
2→ refrigeration system → high-pressure pump → extraction kettle → extraction-container I → extraction-container II → circulation.Condition: extracting pressure 20~25MPa, extraction-container I pressure 10~13MPa, extraction-container II pressure 6~8MPa, 48~58 ℃ of extraction temperature, 55~65 ℃ of extraction-container I temperature, extraction-container temperature II45~50 ℃, circulation time 3~4h, oil-collecting ratio 3~6%.
(2) Rhizoma Chuanxiong supercritical extraction condition: extracting pressure 25~35MPa, 45~55 ℃ of extraction temperature are resolved pressure 8~12MPa, 55~65 ℃ of resolution temperatures.
(3) Radix Angelicae Dahuricae supercritical extraction condition: extracting pressure 20~30MPa, 30~45 ℃ of extraction temperature are resolved pressure 10~20MPa, 40~50 ℃ of resolution temperatures.
The medicinal residues that second step will extract behind the volatile oil add water more than 3 times, decoct once or more than, be no less than 1h at every turn, filtrate and the filtrate I that decocts several times merged, filtration gets filtrate II;
The 3rd step concentrated filtrate II, and drying is pulverized, and sieves, and it is standby to get dry powder;
The 4th step Borneolum Syntheticum is pulverized, and sieves, and adds in the above dry powder and stirs;
The 5th step was dissolved in the volatile oil of carrying in an amount of ethanol, evenly was sprayed in the above dry powder, stirred, and got glacier Dimetothiazine raw material medicated powder.
4. according to the first step in the described preparation method of claim 2, it is characterized in that: when adopting the water vapour distillation method to extract volatile oil, more preferably, add the above immersion of 8 times of amounts of water 2~4 hours.
5. according to the step of the 3rd in the described preparation method of claim 2, it is characterized in that: more preferably add 8~10 times in water, decoct 2~3 times, each 2h~4h.
6. preparation method that is used for the described glacier of claim 1 Dimetothiazine granule, it is characterized in that: this preparation method is made up of following processing step:
The glacier Dimetothiazine raw material medicated powder that the first step will obtain by the described preparation method of claim 3 adds an amount of starch and Pulvis Talci, and stirs;
Second step, the equipment of selecting to adapt was made granule with above material according to determined granulating process, get final product glacier Dimetothiazine granule raw material;
The 3rd step promptly got glacier Dimetothiazine granule with above gained granule raw material packing.
7. preparation method that is used for the described glacier of claim 1 capsule for treating headache is characterized in that: will incapsulate by the glacier Dimetothiazine granule that the described preparation method of claim 6 obtains, get final product the glacier capsule for treating headache.
8. preparation method that is used for the described glacier of claim 1 Dimetothiazine tablet is characterized in that: the glacier Dimetothiazine granule tabletting that will obtain by the described preparation method of claim 6, get final product glacier Dimetothiazine tablet.
9. preparation method that is used for the described glacier of claim 1 Dimetothiazine drop pill, it is characterized in that: this preparation method is made up of following processing step:
The first step is according to the weight portion meter, with 1: the ratio of (1~8), and the glacier Dimetothiazine raw material medicated powder and the substrate mix homogeneously that will obtain by the described preparation method of claim 3 place and heat while stirring in the heating container until fusion;
Substrate can be selected Polyethylene Glycol
1500~20000, any one or two or more mixture in the tween such as stearic acid, sodium stearate, glycerin gelatine, glyceryl monostearate, Lac, polyoxyethylene monostearate, polyethers, carboxymethyl starch sodium;
Second step was adopted special-purpose drop pill machine (as the DW-35 type drop pill machine of Taixing, Jiangsu second pharmaceutical machine factory production), and the temperature control system of adjustment drop pill machine, make the water dropper temperature of drop pill machine remain on (70~100) ℃, and the thermograde that makes condensing agent in the condensation column is (40~10) ℃ for (40~10) ℃ → (5~-15) ℃-be condensation column upper temp, and bottom temp is (5~-15) ℃;
The 3rd step treated that the temperature of condensing agent in dropping-pill machine head and the condensation column is stable respectively and was in for second step during desired state of temperature, and fused material is splashed in the condensing agent with suitable speed by the water dropper of drop pill machine.Condensing agent can be any one in liquid paraffin, methyl-silicone oil, the vegetable oil;
The drop pill that the 4th step will be shunk molding by the outlet of drop pill machine takes out, and removes the surface condensation agent, and drying promptly gets glacier Dimetothiazine drop pill.
10. according to the first step of the described preparation method of claim 9, it is characterized in that: the ratio of glacier Dimetothiazine raw material medicated powder and substrate, more preferably 1: (2~6), more preferred substrate is polyoxyethylene monostearate, Polyethylene Glycol
4000~10000, a kind of in four kinds of polyethers, carboxymethyl starch sodium etc.
11. according to second in the described preparation method of claim 9 step, it is characterized in that: the preferred scope of temperature of dripping dropping-pill machine head in the system process is (60~90) ℃.
12. according to second in the described preparation method of claim 9 step, it is characterized in that: the preferred scope of thermograde of dripping condensing agent in the system process is (25~15) ℃ → (5~-5) ℃.
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
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CN100405323C (en) * | 2005-09-20 | 2008-07-23 | 中国科学院计算技术研究所 | Method for realizing supporting of EJTAG detection in instruction grade random detection |
CN1872250B (en) * | 2005-06-01 | 2010-09-29 | 天津天士力制药股份有限公司 | Composition of medication for treating headache |
CN102309470A (en) * | 2010-07-08 | 2012-01-11 | 谭友标 | Cold oil and preparation process thereof |
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2003
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1872250B (en) * | 2005-06-01 | 2010-09-29 | 天津天士力制药股份有限公司 | Composition of medication for treating headache |
CN100405323C (en) * | 2005-09-20 | 2008-07-23 | 中国科学院计算技术研究所 | Method for realizing supporting of EJTAG detection in instruction grade random detection |
CN102309470A (en) * | 2010-07-08 | 2012-01-11 | 谭友标 | Cold oil and preparation process thereof |
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