CN1546074A - Chinese herbal granule for treating viral myocarditis and its preparing process - Google Patents
Chinese herbal granule for treating viral myocarditis and its preparing process Download PDFInfo
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- CN1546074A CN1546074A CNA2003101052518A CN200310105251A CN1546074A CN 1546074 A CN1546074 A CN 1546074A CN A2003101052518 A CNA2003101052518 A CN A2003101052518A CN 200310105251 A CN200310105251 A CN 200310105251A CN 1546074 A CN1546074 A CN 1546074A
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Abstract
The invention relates to a traditional Chinese granule preparation for treating viral myocarditis, wherein the weight ratio of the constituents of the raw material in preparing the granule are, bupleurum root 1-200 parts, baikal skullcap root 1-300 parts, root of American ginseng 1-100 parts, root of red rooted saliva 1-400 parts, licorice root 1-200 parts, and ophiopogon root 1-300 parts.
Description
(1) technical field
The present invention relates to a kind of Chinese medicine, particularly a kind of Chinese medicine granules for the treatment of viral myocarditis and preparation method thereof.
(2) background technology
Viral myocarditis (VMC) is to invade heart by multiple virus, cause focal or diffusivity myocardium between matter inflammatory exudation and myofibrosis cordis, necrosis or dissolved disease, what have can be with pericardium or the change of endocardium inflammation.Can cause myocardial damage, cardiac dysfunction, arrhythmia and whole body symptom.Can betide any age, incidence rate has the trend that increases in recent years, is one of clinical common heart disease.State of an illness weight great disparity clinically, course of disease varying length, prognosis is good mostly.But severe arrhythmia, heart failure, cardiogenic shock can take place in minority, even sudden death; But also course of disease protracted course of disease, cardiac hypertrophy, losing has myocardium permanent lesion, and because immunoreation develops into cardiomyopathy gradually.According to national nine provinces and cities " viral myocarditis cooperative groups " investigation, its sickness rate is occupied 5.97% of the sick child of institute sum, accounts for 0.14% of outpatient's sum.At present, both at home and abroad clinical treatment VMC there is no the definite effective antiviral drugs, and selectivity suppresses virus and to the harmless chemical synthetic drug of host also seldom.Sick just to try out terminations such as virazole, interferon, immune ribonucleic acid or disturb the malicious medicine that duplicates and the medicine of cardiac nutrition such as Energy mixture, fructose, but recover curative effect uncertainly for clinical symptoms and sign, and Chinese medicine is preponderated relatively for the treatment viral myocarditis, the peaceful granule of carditis proves all that by clinical observation and zoopery we are as a kind of Chinese traditional compound medicine, have the effect that improves clinical symptoms and sign preferably, treat viral myocarditis clinically and have broad application prospects.
(3) summary of the invention
The technical problem to be solved in the present invention provides a kind of Chinese medicine granules that has obvious curative effects at viral myocarditis and preparation method thereof.
The technical scheme that adopts is:
A kind of Chinese medicine granules for the treatment of viral myocarditis, comprise Radix Bupleuri, Radix Scutellariae, Radix Panacis Quinquefolii, Radix Glycyrrhizae Preparata, Radix Salviae Miltiorrhizae, Radix Ophiopogonis Chinese medicine component, be on the basis of Herba Sidae Rhombifoliae soup in traditional classical prescription treatise on Febrile Diseases, form in conjunction with clinical experience and multinomial provincial, national subject study change sanction as a result.Its material combination is: Radix Bupleuri 1-200 part, Radix Scutellariae 1-300 part, Radix Panacis Quinquefolii 1-100 part, Radix Salviae Miltiorrhizae 1-400 part, Radix Glycyrrhizae Preparata 1-200 part, Radix Ophiopogonis 1-300 part.
The preparation method of the Chinese medicine granules of treatment viral myocarditis is:
Radix Panacis Quinquefolii powder becomes fine powder (crossing 80 mesh sieves), and is standby.The Radix Bupleuri powder becomes coarse powder, adopts supercritical CO
2Extraction method at pressure 10-30MPa, under temperature 30-40 ℃, was extracted 2-4 hour, and extract adds beta-cyclodextrin inclusion compound, makes inclusion complex, dry (50 ℃).With Radix Scutellariae, Radix Salviae Miltiorrhizae and through CO
2Radix Bupleuri after the supercritical extraction merges, and adds 60-80% ethanol 6-9 and doubly measures, reflux, extract, 2 times, each 1-3 hour, medicinal liquid filtered with 120 order filter clothes while hot, merges filtrate twice, decompression recycling ethanol is concentrated into the clear paste of relative density 1.15-1.20 (55-60 ℃), and is standby.Medicinal residues merge after getting Radix Ophiopogonis, Radix Glycyrrhizae Preparata and Radix Scutellariae, Radix Salviae Miltiorrhizae, Radix Bupleuri alcohol extraction, add water 6-9 and doubly measure decoction 2 times, each 2 hours, medicinal liquid filters with 120 order filter clothes, merges filtrate twice, leaves standstill 10-13 hour, get supernatant, be concentrated into relative density 1.15-1.20 (55-60 ℃) clear paste.With above twice gained clear paste spray-dried separately (75～80 ℃ of air outlet temperature).Get above-mentioned Radix Ginseng Rubra fine powder, spray drying powder and beta-cyclo dextrin included compound, adding starch is an amount of, crosses 80 mesh sieves, and mixing is granulated, promptly.
Medicine side separates:
The medicine of existing eliminating evil heat clearing away among the we has the product of the tonify deficiency of setting upright again, but both relieving accumulation of pathogens of Radix Bupleuri, again can be eliminating evil, the pathogenesis that hits, Xie Shaoyang make the evil of half table separate from foreign promotion at the pathogenic factor in the exterior of warp; Radix Scutellariae lacks the hot and suffocating of sun clearly, kind water flowing blood constipation of YIN type, and Xie Shaoyang is in the interior-heat at mansion, and making the evil of half lining must be monarch drug from interior thorough altogether; Radix Panacis Quinquefolii strengthening vital QI to eliminate pathogenic factors, and the heresy of anti-half lining is deeply, Radix Salviae Miltiorrhizae is hot and suffocating clearly, and the stasis that can separate QI and blood is ministerial drug; Radix Ophiopogonis, the compatibility Radix Ginseng was with the moon that nourishes heart, and the Radix Glycyrrhizae Preparata coordinating the actions of various ingredients in a prescription is an adjuvant, all medicines mutually 5, and three warmers tonneau then, mechanism of qi and smooth, so hot and suffocating as to separate, mechanism of qi must be capable, ataraxia.
Effect: heat-clearing and toxic substances removing, supplementing QI and nourishing YIN.
The present invention cures mainly: viral myocarditis.
Usage: boiled water is taken after mixing it with water, the adult: 10g/ time, children's: children's below 7 years old 5g/ time, children's is 10g/ time more than 7 years old, every day 2 times, early, late respectively once, 1 month is a course of treatment.
Clinical treatment 331 routine patients of the present invention, the summary situation is as follows:
1, routine number is selected and observed to case: 331 examples are Hospital Attached to Liaoning Inst. of Traditional Chinese Medicine viral myocarditis inpatient in April, 1996-May calendar year 2001.Case is selected to meet the diagnostic criteria that the academic meeting of the 6th heart disease of in May, 1994 whole nation is formulated, and does not use any immune formulation.Chinese medical discrimination adopts the viral myocarditis Chinese medical discrimination standard of Ministry of Health of the People's Republic of China's formulation in 1993.To possess cardiopalmus, uncomfortable in chest or chest pain, shortness of breath and fatigue, spontaneous perspiration or night sweat, vexation and vomiting, reluctant to speak and eat, or dry throat and mouth, red tongue, clinical main symptoms such as thready and rapid pulse or knot or generation are included the object of observation in.
2, observation index:
(1) the clinical symptoms integration is observed: with the pareordia discomfort is cardinal symptom, weak, breathe hard, hyperhidrosis, complexion, metatrophia etc. are minor symptom, cardinal symptom full marks 4 minutes, minor symptom full marks 2 minutes.The symptom of initiatively saying and obviously continuing to exist keeps a perfect score; Heavy or be interrupted the person of appearance and remember half mark when light during symptom; Symptom the person gentlier or only once in a while do not occur and remembers 1/4 mark; Asymptomatic person remembers 0 fen.Each symptom score adds up, and total points is 20 minutes, and＜10 fens persons are that the I level is slight, and 10-15 is divided into II level moderate, and＞15 are divided into III level severe.From before the medication when medication finishes till, observe the variation of each symptom of patient every day, keep the score by above standard, with the unified table record of observing.
(2) all case is all had an electro-cardiogram or 24 hr Ambulatory EKG Monitoring before treatment, check after month.
3, clinical efficacy evaluation criteria: the middle clinical efficacy evaluation criteria of " the new Chinese medicine clinical research guideline " that adopts Ministry of Health of the People's Republic of China to formulate.Cure: treatment back symptom disappears fully, and the symptom total mark is 0; Produce effects: treatment back symptom total mark obviously descends＞2/3 before the treatment; Effectively: treatment back symptom total mark is the preceding decline 1/3-2/3 of treatment; Invalid: treatment back symptom total mark descends＜1/3.
4, therapeutic outcome: 189 examples are organized in treatment, cure 95 examples, produce effects 65 examples, effective 22 examples, invalid 7 examples, cure-remarkable-effectiveness rate 84.6%, total effective rate 96.2%; Matched group 142 examples are cured 69 examples, produce effects 36 examples, effective 18 examples, invalid 19 examples, cure-remarkable-effectiveness rate 74.4%, total effective rate 87.2%.Two groups relatively have notable difference (t check, P＜0.01), and treatment group curative effect is better than matched group.
Clinical practice proves: after the peaceful granule input of carditis is clinical, firmly get numerous doctors and patients' favorable comment.It is evident in efficacy, has obtained remarkable economic efficiency and social benefit, but large tracts of land promote the use of, prospect is considerable.
(4) description of drawings
Fig. 1 is the technological process of production figure of a kind of Chinese medicine granules for the treatment of viral myocarditis of the present invention and preparation method thereof.
(5) specific embodiment
Embodiment one
The Chinese medicine granules of treatment viral myocarditis comprises Radix Bupleuri, Radix Scutellariae, Radix Panacis Quinquefolii, Radix Salviae Miltiorrhizae, Radix Glycyrrhizae Preparata, Radix Ophiopogonis Six-element Chinese medicine component, and its compatibility is: 200 parts of Radix Bupleuri, 300 parts of Radix Scutellariaes, 100 parts of Radix Panacis Quinquefoliis, 400 parts of Radix Salviae Miltiorrhizaes, 200 parts of Radix Glycyrrhizae Preparatas, 300 parts of Radix Ophiopogonis.
Its preparation method is: Radix Panacis Quinquefolii powder becomes fine powder (crossing 80 mesh sieves), and is standby.The Radix Bupleuri powder becomes coarse powder, adopts supercritical CO
2Extraction method at pressure 20MPa, under 35 ℃ of the temperature, was extracted 3 hours, and extract adds beta-cyclodextrin inclusion compound, makes inclusion complex, dry (50 ℃).With Radix Scutellariae, Radix Salviae Miltiorrhizae and through CO
2Radix Bupleuri after the supercritical extraction merges, and adds 8 times of amounts of 70% ethanol, reflux, extract, 2 times, and each 1.5 hours, medicinal liquid with the filtration of 120 order filter clothes, merged filtrate twice while hot, and decompression recycling ethanol is concentrated into the clear paste of relative density 1.15-1.20 (55-60 ℃), and is standby.Medicinal residues merge after getting Radix Ophiopogonis, Radix Glycyrrhizae Preparata and Radix Salviae Miltiorrhizae, Radix Scutellariae, Radix Bupleuri alcohol extraction, add 8 times of amounts of water and decoct each 2 hours 2 times, medicinal liquid filters with 120 order filter clothes, merges filtrate twice, leaves standstill 12 hours, get supernatant, be concentrated into relative density 1.15-1.20 (55-60 ℃) clear paste.With above twice gained clear paste spray-dried separately (75～80 ℃ of air outlet temperature).Get above-mentioned Radix Panacis Quinquefolii fine powder, spray drying powder and beta-cyclo dextrin included compound, adding starch is an amount of, crosses 80 mesh sieves, and mixing is granulated, promptly.
Embodiment two
A kind of Chinese medicine granules for the treatment of viral myocarditis, comprise Radix Bupleuri, Radix Scutellariae, Radix Panacis Quinquefolii, Radix Salviae Miltiorrhizae, Radix Glycyrrhizae Preparata, Radix Ophiopogonis Six-element Chinese medicine component, its material combination is: 1 part of Radix Bupleuri, 1 part of Radix Scutellariae, 1 part of Radix Panacis Quinquefolii, 1 part of Radix Salviae Miltiorrhizae, 1 part of Radix Glycyrrhizae Preparata, 1 part of Radix Ophiopogonis.
Its preparation method is: Radix Panacis Quinquefolii powder becomes fine powder (crossing 80 mesh sieves), and is standby.The Radix Bupleuri powder becomes coarse powder, adopts supercritical CO
2Extraction method at pressure 10MPa, under 30 ℃ of the temperature, was extracted 2 hours, and extract adds beta-cyclodextrin inclusion compound, makes inclusion complex, dry (50 ℃).With Radix Scutellariae, Radix Salviae Miltiorrhizae and through CO
2Radix Bupleuri after the supercritical extraction merges, and add 60% ethanol 6-9 and doubly measure, reflux, extract, 2 times, each 1 hour, medicinal liquid with the filtration of 120 order filter clothes, merged filtrate twice while hot, and decompression recycling ethanol is concentrated into the clear paste of relative density 1.15-1.20 (55-60 ℃), and is standby.Medicinal residues merge after getting Radix Ophiopogonis, Radix Glycyrrhizae Preparata and Radix Salviae Miltiorrhizae, Radix Scutellariae, Radix Bupleuri alcohol extraction, add 6 times of amounts of water and decoct each 2 hours 2 times, medicinal liquid filters with 120 order filter clothes, merges filtrate twice, leaves standstill 10 hours, get supernatant, be concentrated into relative density 1.15-1.20 (55-60 ℃) clear paste.With above twice gained clear paste spray-dried separately (75～80 ℃ of air outlet temperature).Get above-mentioned Radix Ginseng Rubra fine powder, spray drying powder and beta-cyclo dextrin included compound, adding starch is an amount of, crosses 80 mesh sieves, and mixing is granulated, promptly.
Embodiment three
A kind of Chinese medicine granules for the treatment of viral myocarditis, comprise Radix Bupleuri, Radix Scutellariae, Radix Panacis Quinquefolii, Radix Salviae Miltiorrhizae, Radix Glycyrrhizae Preparata, Radix Ophiopogonis Chinese medicine component, be on the basis of Herba Sidae Rhombifoliae soup in traditional classical prescription treatise on Febrile Diseases, form in conjunction with clinical experience and multinomial provincial, national subject study change sanction as a result.Its material combination is: 100 parts of Radix Bupleuri, 100 parts of Radix Scutellariaes, 50 parts of Radix Panacis Quinquefoliis, 200 parts of Radix Salviae Miltiorrhizaes, 100 parts of Radix Glycyrrhizae Preparatas, 200 parts of Radix Ophiopogonis.
Its preparation method is: Radix Panacis Quinquefolii powder becomes fine powder (crossing 80 mesh sieves), and is standby.The Radix Bupleuri powder becomes coarse powder, adopts supercritical CO
2Extraction method at pressure 30MPa, under 40 ℃ of the temperature, was extracted 4 hours, and extract adds beta-cyclodextrin inclusion compound, makes inclusion complex, dry (50 ℃).With Radix Scutellariae, Radix Salviae Miltiorrhizae and through CO
2Radix Bupleuri after the supercritical extraction merges, and adds 9 times of amounts of 80% ethanol, reflux, extract, 2 times, and each 3 hours, medicinal liquid with the filtration of 120 order filter clothes, merged filtrate twice while hot, and decompression recycling ethanol is concentrated into the clear paste of relative density 1.15-1.20 (55-60 ℃), and is standby.Medicinal residues merge after getting Radix Ophiopogonis, Radix Glycyrrhizae Preparata and Radix Scutellariae, Radix Bupleuri alcohol extraction, add 9 times of amounts of water and decoct each 2 hours 2 times, medicinal liquid filters with 120 order filter clothes, merges filtrate twice, leaves standstill 13 hours, get supernatant, be concentrated into relative density 1.15-1.20 (55-60 ℃) clear paste.With above twice gained clear paste spray-dried separately (75～80 ℃ of air outlet temperature).Get above-mentioned Radix Ginseng Rubra fine powder, spray drying powder and beta-cyclo dextrin included compound, adding starch is an amount of, crosses 80 mesh sieves, and mixing is granulated, promptly.
Claims (3)
1, a kind of Chinese medicine granules for the treatment of viral myocarditis is characterized in that the proportioning raw materials for preparing this Chinese medicine granules is: Radix Bupleuri 1-200 part, Radix Scutellariae 1-300 part, Radix Panacis Quinquefolii 1-100 part, Radix Salviae Miltiorrhizae 1-400 part, Radix Glycyrrhizae Preparata 1-200 part, Radix Ophiopogonis 1-300 part.
2, a kind of Chinese medicine granules for the treatment of viral myocarditis according to claim 1 is characterized in that the proportioning raw materials for preparing this Chinese medicine granules is: 200 parts of Radix Bupleuri, 300 parts of Radix Scutellariaes, 100 parts of Radix Panacis Quinquefoliis, 400 parts of Radix Salviae Miltiorrhizaes, 200 parts of Radix Glycyrrhizae Preparatas, 300 parts of Radix Ophiopogonis.
3, a kind of preparation method for the treatment of the Chinese medicine granules of viral myocarditis is characterized in that:
A, get Radix Panacis Quinquefolii powder, Radix Bupleuri powder, Radix Scutellariae, Radix Glycyrrhizae Preparata by charge ratio, preserve separately is standby;
B, the Radix Bupleuri powder is adopted supercritical CO
2Extraction method at pressure 10-30MPa, under temperature 30-40 ℃, was extracted 2-4 hour, and extract adds beta-cyclodextrin inclusion compound, makes inclusion complex, and is dry under 50 ℃ of temperature;
C, get Radix Scutellariae, Radix Salviae Miltiorrhizae and through CO
2Radix Bupleuri after the supercritical extraction merges, and adds 60-80% ethanol 6-9 and doubly measures, reflux, extract, 2 times, each 1-3 hour, medicinal liquid filtered with 120 order filter clothes while hot, merges filtrate twice, decompression recycling ethanol is concentrated into the clear paste of relative density 1.15-1.20 (55-60 ℃), and is standby;
D, get that medicinal residues merge after Radix Ophiopogonis, Radix Glycyrrhizae Preparata and Radix Salviae Miltiorrhizae, Radix Scutellariae, the Radix Bupleuri alcohol extraction, add water 6-9 and doubly measure and decoct each 2 hours 2 times, medicinal liquid filters with 120 order filter clothes, merges filtrate twice, leaves standstill 10-13 hour, get supernatant, be concentrated into relative density 1.15-1.20 (55-60 ℃) clear paste;
E, with above-mentioned twice gained clear paste spray-dried separately (75～80 ℃ of air outlet temperature);
F, get Radix Panacis Quinquefolii fine powder and above-mentioned spray drying powder and beta-cyclo dextrin included compound, it is an amount of to add starch, crosses 80 mesh sieves, is mixed, granulates, and gets product.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103977391A (en) * | 2014-06-11 | 2014-08-13 | 云南云龙制药股份有限公司 | Preparation method and applications of bupleurum tenue capsule |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1054984C (en) * | 1995-08-24 | 2000-08-02 | 傅鹤年 | Xinshouling capsule for treating heart diseases |
| CN1124153C (en) * | 2001-08-31 | 2003-10-15 | 石家庄以岭药业股份有限公司 | Medicinal composition for restoring cardiac collaterals and its application |
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2003
- 2003-12-02 CN CNB2003101052518A patent/CN100333769C/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103977391A (en) * | 2014-06-11 | 2014-08-13 | 云南云龙制药股份有限公司 | Preparation method and applications of bupleurum tenue capsule |
| CN103977391B (en) * | 2014-06-11 | 2016-06-01 | 云南云龙制药股份有限公司 | The preparation method of a kind of Xiao chaihu capsule and application |
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| CN100333769C (en) | 2007-08-29 |
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