CN1545502A - 吲哚衍生物的制备方法 - Google Patents

吲哚衍生物的制备方法 Download PDF

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Publication number
CN1545502A
CN1545502A CNA028164350A CN02816435A CN1545502A CN 1545502 A CN1545502 A CN 1545502A CN A028164350 A CNA028164350 A CN A028164350A CN 02816435 A CN02816435 A CN 02816435A CN 1545502 A CN1545502 A CN 1545502A
Authority
CN
China
Prior art keywords
unsubstituted
substituted
general formula
hydrogen
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA028164350A
Other languages
English (en)
Chinese (zh)
Inventor
H���ֶ��²�
H·沃尔德布
ղ���
A·沃尔勒布
�ɳ��
P·A·范德沙亚夫
R·科利
N·恩德
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BASF Schweiz AG
Original Assignee
Ciba Spezialitaetenchemie Holding AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Spezialitaetenchemie Holding AG filed Critical Ciba Spezialitaetenchemie Holding AG
Publication of CN1545502A publication Critical patent/CN1545502A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an alkyl or cycloalkyl radical attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Catalysts (AREA)
CNA028164350A 2001-08-22 2002-08-13 吲哚衍生物的制备方法 Pending CN1545502A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01810817.5 2001-08-22
EP01810817 2001-08-22

Publications (1)

Publication Number Publication Date
CN1545502A true CN1545502A (zh) 2004-11-10

Family

ID=8184102

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA028164350A Pending CN1545502A (zh) 2001-08-22 2002-08-13 吲哚衍生物的制备方法

Country Status (7)

Country Link
US (1) US20050032875A1 (cg-RX-API-DMAC7.html)
EP (1) EP1423365A1 (cg-RX-API-DMAC7.html)
JP (1) JP2005503393A (cg-RX-API-DMAC7.html)
CN (1) CN1545502A (cg-RX-API-DMAC7.html)
CA (1) CA2455842A1 (cg-RX-API-DMAC7.html)
IL (1) IL160043A0 (cg-RX-API-DMAC7.html)
WO (1) WO2003018555A1 (cg-RX-API-DMAC7.html)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110944965A (zh) * 2017-07-28 2020-03-31 隆萨有限公司 非均相钴催化制备烷基化或氟代烷基化、氯代烷基化、和氟代氯代烷基化化合物的方法
CN118772052A (zh) * 2024-09-10 2024-10-15 湖南九维生物医药有限公司 一种医药中间体及其制备方法

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1417180E (pt) 2001-07-13 2007-03-30 Astrazeneca Uk Ltd Preparação de compostos de aminopirimidina
EP2335700A1 (en) * 2001-07-25 2011-06-22 Boehringer Ingelheim (Canada) Ltd. Hepatitis C virus polymerase inhibitors with a heterobicylic structure
GB0218781D0 (en) 2002-08-13 2002-09-18 Astrazeneca Ab Chemical process
US7223785B2 (en) * 2003-01-22 2007-05-29 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
US7098231B2 (en) * 2003-01-22 2006-08-29 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
WO2004080963A1 (en) * 2003-03-13 2004-09-23 Ciba Specialty Chemicals Holding Inc. Process for the preparation of indole derivatives by enzymatic acylation
GB0312896D0 (en) 2003-06-05 2003-07-09 Astrazeneca Ab Chemical process
UY28501A1 (es) 2003-09-10 2005-04-29 Astrazeneca Uk Ltd Compuestos químicos
WO2005037787A1 (en) * 2003-10-16 2005-04-28 Ciba Specialty Chemicals Holding Inc. Crystalline form of fluvastatin sodium
GB0324791D0 (en) 2003-10-24 2003-11-26 Astrazeneca Ab Chemical process
UY28758A1 (es) * 2004-02-20 2005-09-30 Boehringer Ingelheim Int Inhibidores de polimerasa viral
WO2006030304A2 (en) * 2004-09-17 2006-03-23 Ranbaxy Laboratories Limited Novel forms of fluvastatin sodium, processes for preparation and pharmaceutical compositions thereof
GB0428328D0 (en) * 2004-12-24 2005-02-02 Astrazeneca Uk Ltd Chemical process
JP5036567B2 (ja) * 2005-02-11 2012-09-26 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ２，３−ジ置換インドール類の製造方法
JP5015154B2 (ja) * 2005-08-12 2012-08-29 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ウイルスポリメラーゼインヒビター
WO2012098049A1 (en) * 2011-01-18 2012-07-26 Dsm Sinochem Pharmaceuticals Netherlands B.V. Process for the preparation of statins in the presence of base

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4739073A (en) * 1983-11-04 1988-04-19 Sandoz Pharmaceuticals Corp. Intermediates in the synthesis of indole analogs of mevalonolactone and derivatives thereof
US5354772A (en) * 1982-11-22 1994-10-11 Sandoz Pharm. Corp. Indole analogs of mevalonolactone and derivatives thereof
US4808621A (en) * 1986-07-07 1989-02-28 Warner-Lambert Company Trans-6-[2-(N-heteroaryl-3,5-disubstituted)pyrazol-4-yl)-ethyl]- or ethenyl]tetrahydro-4-hydroxypyran-2-one inhibitors of cholesterol biosynthesis
US5102893A (en) * 1986-07-07 1992-04-07 Warner-Lambert Company Trans-6-(2-(n-heteroaryl-3,5-disubstituted)pyrazol-4-yl)-ethyl- or ethenyl)tetrahydro-4-hydroxypyran-2-one inhibitors of cholesterol biosynthesis
CA2285455A1 (en) * 1997-04-09 1998-10-15 Sebastian Mario Marcuccio Process for covalently coupling organic compounds utilizing diboron derivatives
EP1064243B1 (en) * 1998-03-18 2002-10-23 Ciba SC Holding AG Coupling reactions with palladium catalysts
CA2407862A1 (en) * 2000-05-26 2001-12-06 Ciba Specialty Chemicals Holding Inc. Process for the preparation of indole derivatives and intermediates of the process

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110944965A (zh) * 2017-07-28 2020-03-31 隆萨有限公司 非均相钴催化制备烷基化或氟代烷基化、氯代烷基化、和氟代氯代烷基化化合物的方法
CN118772052A (zh) * 2024-09-10 2024-10-15 湖南九维生物医药有限公司 一种医药中间体及其制备方法

Also Published As

Publication number Publication date
WO2003018555A1 (en) 2003-03-06
CA2455842A1 (en) 2003-03-06
JP2005503393A (ja) 2005-02-03
EP1423365A1 (en) 2004-06-02
IL160043A0 (en) 2004-06-20
US20050032875A1 (en) 2005-02-10

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C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication