CN1544018A - Yinzhihuang powder injection and its preparation process - Google Patents
Yinzhihuang powder injection and its preparation process Download PDFInfo
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- CN1544018A CN1544018A CNA2003101087184A CN200310108718A CN1544018A CN 1544018 A CN1544018 A CN 1544018A CN A2003101087184 A CNA2003101087184 A CN A2003101087184A CN 200310108718 A CN200310108718 A CN 200310108718A CN 1544018 A CN1544018 A CN 1544018A
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- salt
- injection
- extract
- cape jasmine
- bloom
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Abstract
The invention relates to a medicament for heat-clearing, detoxification and removing dampness, which comprises capilary Artemisia extractive or its salt, cape jasmine extract or its salt, baicalin or its salt, honeysuckle flower extract or its salt and water-soluble medicinal findings.
Description
Technical field
The invention belongs to medical technical field, be specifically related to a kind of pharmaceutical preparation of mattress Cape jasmine Huang,, the invention still further relates to the preparation method of said preparation simultaneously more specifically to a kind of mattress Cape jasmine bloom injection.
Background technology
" mattress Cape jasmine Huang " is a name side of China's traditional Chinese medical science, and heat clearing away is arranged on the Chinese medicine, detoxifcation, dampness removing, the function of jaundice eliminating.Be used for dampness-heat in the liver and gallbladder, appearance is known Huang, distending pain in the chest and hypochondrium, nausea and vomiting, yellowish or reddish urine, diseases such as acute, delay property, chronic hepatitis.The preparation of " mattress Cape jasmine Huang " mainly contains water for injection injection and tablet at present clinically.Aqueous injection technology is more backward, and stable effective ingredients is poor, and the impurity content height causes untoward reaction more.Therefore, adopting the modern crafts means that " mattress Cape jasmine Huang " carried out secondary development, is the needs of the modernization of Chinese medicine.
Summary of the invention
The object of the present invention is to provide a kind of steady quality, impurity content is few, untoward reaction is little mattress Cape jasmine bloom injection and preparation method thereof.
According to tcm prescription, in conjunction with the modern Chinese medicine preparation method, mattress Cape jasmine bloom injection is made by Herba Artemisiae Scopariae extract or its salt, Fructus Gardeniae extract or its salt, baicalin or its salt, Flos Lonicerae extract or its salt and water-soluble injection adjuvant.The ratio range by weight of its Herba Artemisiae Scopariae extract or its salt, Fructus Gardeniae extract or its salt, baicalin or its salt, Flos Lonicerae extract or its salt and water-soluble injection adjuvant is: (1～100): (1～10): (0.1～100): (1～10): (1～100).More suitable weight proportion scope is: (3～8): (2～4): (15～25): (2～6): (10～30).
Above-mentioned water-soluble injection adjuvant is one or more in meglumine, mannitol, 30 POVIDONE K 30 BP/USP 30, glucose, the lactose, and it act as hydrotropy, shaping etc.
The salt of four kinds of used main components can be acceptable salt on sodium salt, potassium salt, calcium salt, magnesium salt or other physiology in the prescription.
The preparation method of above-mentioned injectable powder is as follows:
1, the preparation of lyophilized injectable powder: adopt freeze-drying.Concrete steps are: get Herba Artemisiae Scopariae extract or its salt, Fructus Gardeniae extract or its salt, baicalin or its salt, Flos Lonicerae extract or its salt of recipe quantity, add the water for injection of 60% recipe quantity, dissolve with 10%NaOH, transfer pH to dissolve fully to extract, add injection supplementary material, dissolving adds activated carbon adsorption, filter, standardize solution, fine straining, packing, lyophilizing, sealing by fusing are promptly.
2, the preparation of spray drying injectable powder: adopt spray drying method, concrete steps are: get Herba Artemisiae Scopariae extract or its salt, Fructus Gardeniae extract or its salt, baicalin or its salt, Flos Lonicerae extract or its salt of recipe quantity, add the water for injection of 60% recipe quantity, with the 10%NaOH dissolving, transfer pH to dissolve fully, the adding injection supplementary material to extract, dissolving, add activated carbon adsorption, filter standardize solution, fine straining, spray drying, packing, sealing by fusing is promptly.
The present invention adopts modern crafts, makes the mattress Cape jasmine bloom injection that stability is high, impurity content is few, untoward reaction is little, complies with the requirement of the modernization of Chinese medicine.
The specific embodiment
The invention is further illustrated by the following examples.
Embodiment 1
Herba Artemisiae Scopariae extract or its salt 12g
Fructus Gardeniae extract or its salt 6.4g
Baicalin or its salt 40g
Flos Lonicerae extract or its salt (in chlorogenic acid) 8g
Mannitol 66.4g
Make 1000 altogether
Preparation method: get baicalin or its salt and add an amount of moistening of water, dissolve with sodium hydroxide solution; Three flavors such as all the other Herba Artemisiae Scopariae extract are dissolved in water respectively, and other gets mannitol and is dissolved in water, and mixing is regulated pH value, is diluted to 2000ml with water for injection, adds activated carbon adsorption, filter, and packing, lyophilizing, sealing by fusing is promptly.
Annotate: 1. Herba Artemisiae Scopariae extract is 90% ethanol percolation extract of Herba Artemisiae Scopariae, removes grease such as chlorophyll, the solid extract that makes through drying under reduced pressure.
2. Fructus Gardeniae extract is the 70% alcohol reflux liquid of Fructus Gardeniae, uses 95% ethanol precipitation, the solid extract that makes through drying under reduced pressure.
3. baicalin is the decocting liquid of Radix Scutellariae, and multiple acid out is made with extra care and got behind hydrochloric acid, contains baicalin (C21H18O11) and should be more than 90%.
4. Flos Lonicerae extract: extracting honeysuckle decocts with water secondary, and each 2 hours, collecting decoction filtered, and filtrate adds lime cream and is adjusted to pH value to 10～12, leave standstill, the leaching precipitation adds suitable quantity of water, adds sulphuric acid and regulates pH value to 6～7, stirs evenly, filter, filtrate is concentrated into the thick paste shape, oven dry, promptly.Containing chlorogenic acid should be more than 18%.
Embodiment 2
Herba Artemisiae Scopariae extract or its salt 22g
Fructus Gardeniae extract or its salt 6.4g
Baicalin or its salt 40g
Flos Lonicerae extract or its salt (in chlorogenic acid) 16g
Adjuvant 0
Make 1000 altogether
Preparation method: get four flavor extracts, it is an amount of to add water, with the sodium hydroxide solution dissolving, regulates pH value, is diluted to 2000ml with water for injection, adds activated carbon adsorption, filters, and spray drying, packing, sealing by fusing is promptly.
Embodiment 3
Herba Artemisiae Scopariae extract or its salt 80g
Fructus Gardeniae extract or its salt 12g
Baicalin or its salt 5g
Flos Lonicerae extract or its salt (in chlorogenic acid) 7g
Adjuvant 32g
Embodiment 4
Herba Artemisiae Scopariae extract or its salt 100g
Fructus Gardeniae extract or its salt 2g
Baicalin or its salt 1g
Flos Lonicerae extract or its salt (in chlorogenic acid) 10g
Adjuvant 60g
Embodiment 5
Herba Artemisiae Scopariae extract or its salt 10g
Fructus Gardeniae extract or its salt 10g
Baicalin or its salt 100g
Flos Lonicerae extract or its salt (in chlorogenic acid) 5g
Adjuvant 80g
Among the embodiment 2-4, the extract of four kinds of Main Ingredients and Appearances is with example 1.Preparation method can adopt freeze-drying or spray drying method etc.Preparation process is with example 1.Prepared mattress Cape jasmine bloom injection all has good performance.
Claims (7)
1, a kind ofly is used for heat clearing away, detoxifcation, dampness removing, the injection mattress Cape jasmine bloom injection of jaundice eliminating, it is characterized in that being formed by Herba Artemisiae Scopariae extract or its salt, Fructus Gardeniae extract or its salt, baicalin or its salt, Flos Lonicerae extract or its salt and the assembly of water-soluble injection adjuvant, wherein the weight proportion scope of 5 kinds of component Herba Artemisiae Scopariae extract or its salt, Fructus Gardeniae extract or its salt, baicalin or its salt, Flos Lonicerae extract or its salt and water-soluble injection adjuvant is: (1～100): (1～10): (0.1～100): (1～10): (0～100).
2, mattress Cape jasmine bloom injection according to claim 1 is characterized in that the weight proportion scope of 5 kinds of components is: (3-8): (2-4): (1 5-25): (2-6): (10-30).
3, mattress Cape jasmine bloom injection according to claim 1 and 2 is characterized in that the water-soluble injection adjuvant is one or more in meglumine, mannitol, 30 POVIDONE K 30 BP/USP 30, glucose, the lactose.
4, mattress Cape jasmine bloom injection according to claim 1 and 2, the salt that it is characterized in that four main components can be acceptable salt on sodium salt, potassium salt, calcium salt, magnesium salt or other physiology.
5, the preparation method of injection mattress Cape jasmine bloom injection according to claim 1 and 2 is characterized in that adopting freeze-drying or spray drying method for preparation.
6, the preparation method of injection mattress Cape jasmine bloom injection according to claim 5 is characterized in that adopting freeze-drying, and concrete steps are: Herba Artemisiae Scopariae extract or its salt, Fructus Gardeniae extract or its salt, baicalin or its salt, Flos Lonicerae extract or its salt of getting recipe quantity, the water for injection that adds 60% recipe quantity with 10%NaOH dissolving, transfers pH to dissolve fully to extract, add injection supplementary material, dissolving adds activated carbon adsorption, filter, standardize solution, fine straining, packing, lyophilizing, sealing by fusing are promptly.
7, the preparation method of injection mattress Cape jasmine bloom injection according to claim 5, it is characterized in that adopting spray drying method, concrete steps are: Herba Artemisiae Scopariae extract or its salt, Fructus Gardeniae extract or its salt, baicalin or its salt, Flos Lonicerae extract or its salt of getting recipe quantity, the water for injection that adds 60% recipe quantity, dissolve with 10%NaOH, transfer pH to dissolve fully to extract, add injection supplementary material, dissolving adds activated carbon adsorption, filter, standardize solution, fine straining, spray drying, packing, sealing by fusing are promptly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2003101087184A CN1544018A (en) | 2003-11-19 | 2003-11-19 | Yinzhihuang powder injection and its preparation process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2003101087184A CN1544018A (en) | 2003-11-19 | 2003-11-19 | Yinzhihuang powder injection and its preparation process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1544018A true CN1544018A (en) | 2004-11-10 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2003101087184A Pending CN1544018A (en) | 2003-11-19 | 2003-11-19 | Yinzhihuang powder injection and its preparation process |
Country Status (1)
| Country | Link |
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| CN (1) | CN1544018A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102770150A (en) * | 2009-11-26 | 2012-11-07 | 株式会社爱茉莉太平洋 | Composition for promoting the activity of peroxisome proliferator-activated receptor-delta |
-
2003
- 2003-11-19 CN CNA2003101087184A patent/CN1544018A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102770150A (en) * | 2009-11-26 | 2012-11-07 | 株式会社爱茉莉太平洋 | Composition for promoting the activity of peroxisome proliferator-activated receptor-delta |
| CN102770150B (en) * | 2009-11-26 | 2015-06-10 | 株式会社爱茉莉太平洋 | Composition for promoting the activity of peroxisome proliferator-activated receptor-delta |
| US10183048B2 (en) | 2009-11-26 | 2019-01-22 | Amorepacific Corporation | Composition for promoting the activity of peroxisome proliferator-activated receptor-delta |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |