CN1542428A - Multiple input rotational flow field minisize agitator - Google Patents
Multiple input rotational flow field minisize agitator Download PDFInfo
- Publication number
- CN1542428A CN1542428A CNA2003101084646A CN200310108464A CN1542428A CN 1542428 A CN1542428 A CN 1542428A CN A2003101084646 A CNA2003101084646 A CN A2003101084646A CN 200310108464 A CN200310108464 A CN 200310108464A CN 1542428 A CN1542428 A CN 1542428A
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- hybrid chamber
- flow field
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- mixing cavity
- cylindrical hybrid
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- 239000011159 matrix material Substances 0.000 claims description 20
- 238000005530 etching Methods 0.000 claims description 6
- 239000011521 glass Substances 0.000 claims description 4
- 229910021419 crystalline silicon Inorganic materials 0.000 claims description 2
- 229920002379 silicone rubber Polymers 0.000 claims description 2
- 238000002156 mixing Methods 0.000 abstract description 16
- 239000012530 fluid Substances 0.000 abstract description 12
- 238000009792 diffusion process Methods 0.000 abstract description 7
- 239000003153 chemical reaction reagent Substances 0.000 abstract description 6
- 238000005728 strengthening Methods 0.000 abstract description 2
- 239000000758 substrate Substances 0.000 abstract 3
- 230000000694 effects Effects 0.000 description 7
- 239000000126 substance Substances 0.000 description 5
- 230000003068 static effect Effects 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 2
- 230000005684 electric field Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 230000009471 action Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 230000008676 import Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
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Abstract
The miniature multiple-input rotary flow field mixer includes the first mixing cavity in the first substrate with several connected inlet pipes, the second mixing cavity in the second substrate and outlet pipes connect to the second mixing cavity said the exhaust joint. Three substrates are bonded and the second mixing cavity has its lower end communicated with the first mixing cavity and the upper end communicated with the exhaust pipe. The reagents or samples of different components enters the first mixing cavity via the inlet pipes to form upward rotary flow field entering the second mixing cavity, and the fluid elements are stretched to become thinner inside the two mixing cavities while strengthening the molecule diffusion driven by the concentration gradient to realize efficient mixing.
Description
Affiliated technical field
The present invention relates to microfluid chemical analysis system device, particularly a kind of many input rotational flow field micro-mixers.
Background technology
Microfluid system can be defined as handling microlitre so that receive the MEMS system of upgrading fluid.The microfluid chemical analysis system has following advantage: short response time, less reagent and sample consumption, be easy to characteristics such as miniaturization and robotization, efficient height.The function of little chemical analysis system comprises sampling, pre-service, mixing, chemical reaction, separation, aftertreatment and identification etc.The purpose of hybrid processing is to be used for reducing heterogeneity, for example is used for dilution, perhaps is used for strengthening chemical reaction rate, and it is very important therefore realizing mixing fast and efficiently.
According to application of mixture theory, the main cause of produce mixing is the redistribution of relative position between the different fluid that forms of the convection action owing to the flow field, thus the process that causes various fluids to mix mutually; At molecular scale, because the Brownian movement of molecule produces diffusion, the drive fluid molecule, impels fluid to reach molecular level and evenly mixes to the diffusion of concentration lower from the concentration eminence simultaneously.
For microfluid system, because existing micro-processing technology is used in the restriction of yardstick, be difficult to adopt rotation stirring structure with movable member, equally also be difficult to process the complex three-dimensional structure that is similar to conventional static mixer form.And for microfluid system, its flow belongs to microlitre even receives upgrading, and volume is little, and speed is low, and it is moving to belong to low Reynolds number flow, if no strong external disturbance, fluid maintenance laminar condition.Therefore under the microscale condition, for reaching the mixed uniformly purpose of molecular level, the design of micro-mixer should be strengthened the molecular diffusion effect.Therefore domestic and international at present quiet, the dynamic micro mixer of studying, mainly be to utilize the principle that strengthens the molecular diffusion effect, increase the contact area between the different liquids by the structural design of runner, disturbance machinery or other modes, reduce the volume of fluid element, reach the purpose that realizes mixing.
Desirable micro-mixer should have following characteristics: fast, flow is adjustable, volume is little, concentration is adjustable, it is integrated to be easy to.Existing micro-mixer, because the restriction of processing technology, majority is a planar structure, the micro-mixer that for example utilizes a plurality of intersection microchannels to form, such micro-mixer takes up room greatly, and efficient is lower; Complicated processing technology is adopted in also having of other, for example by piezoelectric crystalline film, applies alternating electric field generation ultrasonic vibration simultaneously and mixes; Or adopt and to apply electric field and magnetic field simultaneously, by Lorentz force electrolytical effect being reached the purpose of mixing, such structure not only takes up room greatly, and processed complex, is difficult to integratedly, and cost is also higher.
Summary of the invention
The objective of the invention is to overcome above-mentioned the deficiencies in the prior art and defective, and the normal need mixing plurality of reagents that occurs, the requirement of sample in the satisfied reality, a kind of miniature static mixer that is applicable to the multichannel input of little chemical analysis system is provided.
In order to achieve the above object, the technical solution used in the present invention is that it comprises: at first matrix upper surface etching first cylindrical hybrid chamber, one end is with first cylindrical hybrid chamber is tangent is communicated with, the input channel that several five equilibriums of another termination input interface are arranged, the second cylindrical hybrid chamber is arranged on second matrix, be communicated with the second cylindrical hybrid chamber at the 3rd matrix lower surface etching one end, the output channel of another termination output interface, first matrix that is etched with input channel one side successively with second matrix and the 3rd matrix being etched with output channel one side bonding mutually, the second cylindrical hybrid chamber lower end is communicated with the first cylindrical hybrid chamber, and the second cylindrical hybrid chamber upper end is communicated with output channel.
The xsect of said input channel and output channel is rectangle.
The internal diameter of the second cylindrical hybrid chamber is less than the internal diameter of the first cylindrical hybrid chamber.
Said matrix material is organic glass or crystalline silicon or glass or pottery or silicon rubber;
The present invention compares with background technology, and the useful effect that has is:
1, import the rotational flow field micro-mixer more and adopt the 3-D solid structure design, compact overall structure, simple belongs to static mixer;
2, input channel and hybrid chamber are tangent, so after fluid enters hybrid chamber, can form rotation rising flow field within it; Delivery outlet is positioned at the top of hybrid chamber, and reagent or sample can be owing to the effect of gravity do not flowed out fast, and keep certain hour in hybrid chamber, are beneficial to the molecular diffusion effect;
3, an end of output channel is a column type, as with the interface of hybrid chamber, loss can reduce pressure.
Micro-mixer provided by the invention can be used for mixing polytype reagent or sample, can be used as the reactor of little chemical analysis system simultaneously.
Description of drawings
The invention will be further described below in conjunction with drawings and Examples.
Fig. 1 is a structural principle synoptic diagram of the present invention;
Fig. 2 is the sectional view of Fig. 1 along the A-A plane.
Embodiment
As Fig. 1, shown in Figure 2, the present invention includes: at first matrix A upper surface etching first cylindrical hybrid chamber 3, one end and first cylindrical 3 tangent connections of hybrid chamber, the input channel 2 that several five equilibriums of another termination input interface 1 are arranged, the processing second cylindrical hybrid chamber 4 on second matrix B, be communicated with the second cylindrical hybrid chamber 4 at the 3rd matrix C lower surface etching one end, the output channel 5 of another termination output interface 6, the first matrix A that is etched with input channel 2 one side successively with second matrix B and the 3rd matrix C being etched with output channel 2 one sides bonding mutually, the second cylindrical hybrid chamber, 4 lower ends are communicated with the first cylindrical hybrid chamber 3, and the second cylindrical hybrid chamber, 4 upper ends are communicated with output channel 5.
When many inputs rotational flow field micro-mixer is connected with high precision micro syringe pump or other micropumps by input interface 1, the reagent of heterogeneity or sample just enter in the first cylindrical hybrid chamber 3 by input channel 2, because input channel 2 is tangential with 3 one-tenth of the first cylindrical hybrid chambers, just form rotational flow field in the first cylindrical hybrid chamber 3, fluid upwards flows simultaneously, rotate into the second cylindrical hybrid chamber 4, because the existence of rotational flow field, each fluid element all can be stretched and attenuation, and since the internal diameter of the second cylindrical hybrid chamber 4 less than the internal diameter of the first cylindrical hybrid chamber 3, flow velocity also can be accelerated, further stretching fluid infinitesimal, the molecular diffusion effect of concentration gradient driving is simultaneously also strengthened greatly, and final the realization mixed fast and efficiently.
Claims (4)
1, a kind of many input rotational flow field micro-mixers, it is characterized in that it comprises: at first matrix (A) upper surface etching first cylindrical hybrid chamber (3), one end and first tangent connection of cylindrical hybrid chamber (3), the input channel (2) that several five equilibriums of another termination input interface (1) are arranged, the second cylindrical hybrid chamber (4) is arranged on second matrix (B), be communicated with the second cylindrical hybrid chamber (4) at the 3rd matrix (C) lower surface etching one end, the output channel (5) of another termination output interface (6), first matrix (A) that is etched with input channel (2) one side is successively with second matrix (B) be etched with output channel (2) the 3rd matrix (C) simultaneously bonding mutually, second cylindrical hybrid chamber (4) lower end is communicated with the first cylindrical hybrid chamber (3), and the second cylindrical hybrid chamber (4) upper end is communicated with output channel (5).
2, a kind of many input rotational flow field micro-mixers according to claim 1, it is characterized in that: said input channel (2) is rectangle with the xsect of output channel (5).
3, a kind of many input rotational flow field micro-mixers according to claim 1, it is characterized in that: the internal diameter of the second cylindrical hybrid chamber (4) is less than the internal diameter of the first cylindrical hybrid chamber (3).
4, a kind of many input rotational flow field micro-mixers according to claim 1, it is characterized in that: said matrix material is organic glass or crystalline silicon or glass or pottery or silicon rubber.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2003101084646A CN1542428A (en) | 2003-11-04 | 2003-11-04 | Multiple input rotational flow field minisize agitator |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2003101084646A CN1542428A (en) | 2003-11-04 | 2003-11-04 | Multiple input rotational flow field minisize agitator |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1542428A true CN1542428A (en) | 2004-11-03 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2003101084646A Pending CN1542428A (en) | 2003-11-04 | 2003-11-04 | Multiple input rotational flow field minisize agitator |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1542428A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101708439B (en) * | 2009-11-05 | 2012-04-25 | 浙江大学 | Chaotic microfluidic chip mixer and mixing method thereof |
| CN104155463A (en) * | 2014-08-27 | 2014-11-19 | 南京大学 | Device and method for producing and measuring droplet on micro-fluidic chip |
| CN113063779A (en) * | 2021-03-15 | 2021-07-02 | 埃妥生物科技(杭州)有限公司 | Sampler and mixing device of sample and reagent |
| CN113908744A (en) * | 2021-11-08 | 2022-01-11 | 常州大学 | Microfluidic mixer and application thereof |
-
2003
- 2003-11-04 CN CNA2003101084646A patent/CN1542428A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101708439B (en) * | 2009-11-05 | 2012-04-25 | 浙江大学 | Chaotic microfluidic chip mixer and mixing method thereof |
| CN104155463A (en) * | 2014-08-27 | 2014-11-19 | 南京大学 | Device and method for producing and measuring droplet on micro-fluidic chip |
| CN104155463B (en) * | 2014-08-27 | 2016-01-20 | 南京大学 | The device and method that a kind of microfluidic chip liquid drop produces and measures |
| CN113063779A (en) * | 2021-03-15 | 2021-07-02 | 埃妥生物科技(杭州)有限公司 | Sampler and mixing device of sample and reagent |
| CN113908744A (en) * | 2021-11-08 | 2022-01-11 | 常州大学 | Microfluidic mixer and application thereof |
| WO2023077764A1 (en) * | 2021-11-08 | 2023-05-11 | 常州大学 | Micro-fluidic mixer and use thereof |
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| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |