CN1535159A - 包含抗人精浆蛋白单链抗体/人羧钛酶a融合蛋白及前体药物的药盒 - Google Patents

包含抗人精浆蛋白单链抗体/人羧钛酶a融合蛋白及前体药物的药盒 Download PDF

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Publication number
CN1535159A
CN1535159A CNA018233376A CN01823337A CN1535159A CN 1535159 A CN1535159 A CN 1535159A CN A018233376 A CNA018233376 A CN A018233376A CN 01823337 A CN01823337 A CN 01823337A CN 1535159 A CN1535159 A CN 1535159A
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CN
China
Prior art keywords
human
chain antibody
carboxypeptidase
fusion protein
fusion
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CNA018233376A
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English (en)
Other versions
CN1278739C (zh
Inventor
郝晓柯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fourth Military Medical University FMMU
Original Assignee
Fourth Military Medical University FMMU
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fourth Military Medical University FMMU filed Critical Fourth Military Medical University FMMU
Publication of CN1535159A publication Critical patent/CN1535159A/zh
Application granted granted Critical
Publication of CN1278739C publication Critical patent/CN1278739C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

本发明涉及抗体导向的酶－前体药物疗法(ADEPT)领域，更具体地，本发明涉及包含抗人精浆蛋白单链抗体/人羧肽酶A融合蛋白及前体药物甲氨喋呤－α－肽衍生物的药盒，该药盒适用于经ADEPT疗法治疗前列腺癌。本发明还涉及抗人精浆蛋白单链抗体/人羧肽酶A融合蛋白。

Description

PCT国内申请，说明书已公开。

Claims (1)

  1. PCT国内申请，权利要求书已公开。
CNB018233376A 2001-06-08 2001-06-08 包含抗人精浆蛋白单链抗体/人羧肽酶a融合蛋白及前体药物的药盒 Expired - Fee Related CN1278739C (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2001/000924 WO2002100431A1 (fr) 2001-06-08 2001-06-08 Kit pharmaceutique comprenant une proteine de fusion carboxypeptidase humaine dirigee contre un anticorps a chaine simple de proteine plasmatique seminale et promedicament

Publications (2)

Publication Number Publication Date
CN1535159A true CN1535159A (zh) 2004-10-06
CN1278739C CN1278739C (zh) 2006-10-11

Family

ID=4574810

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB018233376A Expired - Fee Related CN1278739C (zh) 2001-06-08 2001-06-08 包含抗人精浆蛋白单链抗体/人羧肽酶a融合蛋白及前体药物的药盒

Country Status (4)

Country Link
US (1) US20050053611A1 (zh)
EP (1) EP1459761A4 (zh)
CN (1) CN1278739C (zh)
WO (1) WO2002100431A1 (zh)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103156884A (zh) * 2012-04-28 2013-06-19 陕西精健新星生物医药有限公司 精浆的用途

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5206161A (en) * 1991-02-01 1993-04-27 Genentech, Inc. Human plasma carboxypeptidase B
GB9517001D0 (en) * 1995-08-18 1995-10-18 Denny William Enediyne compounds
AU6000698A (en) * 1997-02-14 1998-09-08 Zeneca Limited Proteins
GB9703201D0 (en) * 1997-02-15 1997-04-02 Zeneca Ltd Chemical compounds
CA2319468A1 (en) * 1998-02-03 1999-08-12 Inex Pharmaceuticals Corporation Sensitizing cells to compounds using lipid-mediated gene and compound delivery
US20030108544A1 (en) * 1999-09-01 2003-06-12 Genentech, Inc. Compositions and methods for the diagnosis and treatment of tumor
US6333410B1 (en) * 2000-08-18 2001-12-25 Immunogen, Inc. Process for the preparation and purification of thiol-containing maytansinoids
US20020168737A1 (en) * 2001-01-24 2002-11-14 Cornish Virginia W. Binding and catalysis screen for high throughput determination of protein function using chemical inducers of dimerization
CA2449275A1 (en) * 2001-06-05 2002-12-12 Exelixis, Inc. Dgks as modifiers of the p53 pathway and methods of use
US7153950B2 (en) * 2002-10-25 2006-12-26 Genentech, Inc. Nucleic acids encoding an immune related polypeptide

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103156884A (zh) * 2012-04-28 2013-06-19 陕西精健新星生物医药有限公司 精浆的用途
CN103156884B (zh) * 2012-04-28 2015-02-04 陕西精健新星生物医药有限公司 精浆的用途

Also Published As

Publication number Publication date
EP1459761A1 (en) 2004-09-22
WO2002100431A1 (fr) 2002-12-19
CN1278739C (zh) 2006-10-11
EP1459761A4 (en) 2005-04-13
US20050053611A1 (en) 2005-03-10

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Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
CI01 Correction of invention patent gazette

Correction item: Denomination of Invention

Correct: Kits comprising single chain antibody of anti human seminal protein / human carboxypeptidase A fusion protein and prodrugs

False: Kits comprising single chain antibody of anti human seminal protein / human A fusion protein and carboxyl titanium enzyme prodrug

Number: 40

Volume: 20

CI02 Correction of invention patent application

Correction item: Denomination of Invention

Correct: Kits comprising single chain antibody of anti human seminal protein / human carboxypeptidase A fusion protein and prodrugs

False: Kits comprising single chain antibody of anti human seminal protein / human A fusion protein and carboxyl titanium enzyme prodrug

Number: 40

Page: The title page

Volume: 20

COR Change of bibliographic data

Free format text: CORRECT: INVENTION NAME; FROM: ANTI-PROTEIN SINGLE-CHAIN ANTIBODY CONTAINING COUPLED SYSTEM/ CARBOXYL TITANIUM ENZYME A FUSION PROTEIN AND PRECURSOR KIT OF MEDICAMENT TO: ANTI-PROTEIN SINGLE-CHAIN ANTIBODY CONTAINING COUPLED SYSTEM/ CARBOXYPEPTIDASE A FUSION PROTEIN AND PRECURSOR KIT OF MEDICAMENT

ERR Gazette correction

Free format text: CORRECT: INVENTION NAME; FROM: ANTI-PROTEIN SINGLE-CHAIN ANTIBODY CONTAINING COUPLED SYSTEM/ CARBOXYL TITANIUM ENZYME A FUSION PROTEIN AND PRECURSOR KIT OF MEDICAMENT TO: ANTI-PROTEIN SINGLE-CHAIN ANTIBODY CONTAINING COUPLED SYSTEM/ CARBOXYPEPTIDASE A FUSION PROTEIN AND PRECURSOR KIT OF MEDICAMENT

C14 Grant of patent or utility model
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20061011

Termination date: 20180608