CN1528360A - Use of plant spearmint for peparing medicine for treating oral, Pharyngeal,esophagus inflammation and hemorrhagic diseases - Google Patents
Use of plant spearmint for peparing medicine for treating oral, Pharyngeal,esophagus inflammation and hemorrhagic diseases Download PDFInfo
- Publication number
- CN1528360A CN1528360A CNA031340865A CN03134086A CN1528360A CN 1528360 A CN1528360 A CN 1528360A CN A031340865 A CNA031340865 A CN A031340865A CN 03134086 A CN03134086 A CN 03134086A CN 1528360 A CN1528360 A CN 1528360A
- Authority
- CN
- China
- Prior art keywords
- herba menthae
- preparation
- menthae rotundifoliae
- pharyngeal
- plant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention relates to application of plant Mentha spicate L. in preparation of medicine for curing the diseases of stomatitis, pharyngitis, esophagitis and hemorrhagic disease. Said invented medicine is made up by using extract of dried stem and leaf of said plant Mentha spicate L. and other auxiliary medicinal materials, and the weight ratio of extract of the plant Mentha spicate L. and said invented preparation is 0.5-100:1. Said invented medicine has the functions of relieving inflammation, arresting bleeding, stopping pain, eliminating watery distension and ulcer, has no any toxic side effects, and can be made into the soluble granules, powder preparation, capsule preparation, oral preparation and injection preparation.
Description
Technical field: the present invention relates to the new drug purposes of a kind of plant Herba Menthae Rotundifoliae, particularly is the application of feedstock production treatment oral cavity, pharyngeal, esophagus inflammation and hemorrhagic disease medicine aspect with the Herba Menthae Rotundifoliae.
Background technology: Herba Menthae Rotundifoliae (Mentha spicata L.) is the Labiatae mint, and nature and flavor suffering, sweet, tepor have expelling wind and cold, regulate the flow of vital energy, the function of pain relieving, cough-relieving, detumescence, detoxifcation.The successive dynasties book on Chinese herbal medicine is to the rare record of Herba Menthae Rotundifoliae, and idol is mentioned, as saying in " the herbal property of medicine is equipped with medicine ": " controlling children's's breast coughs ", " south of the Five Ridges gather medicinal herbs record " middle saying " married woman's abdominal pain in menstruation is controlled in the regulating menstruation of commentaries on classics dispersing wind and cold ".Generally cure mainly diseases such as being used for flu, fever, cough, flatulence, traumatic injury stasis of blood pain, conjunctival congestion and swelling pain, epistaxis, black furuncle.At present, Herba Menthae Rotundifoliae is not written into pharmacopeia as yet both at home and abroad, more not it as the clinical treatment drug use.
Summary of the invention: main purpose of the present invention provides the use of Herba Menthae Rotundifoliae (Mentha spicata L.) as preparation treatment oral cavity, pharyngeal, esophagus inflammation and hemorrhagic disease medicine.So far, still lack in treatment oral cavity, pharyngeal, esophagus inflammation and hemorrhagic disease both at home and abroad and use single natural plant and obtain good drug effect, and the medicine that has no side effect.The single natural plants of application Herba Menthae Rotundifoliae is treated this disease and is still belonged to the first time.
The objective of the invention is to be achieved through the following technical solutions: used Herba Menthae Rotundifoliae (Menthaspicata L.) is the Labiatae mint.Adopt Herba Menthae Rotundifoliae stem leaves of plants dry product, process through extraction, the weight ratio of Herba Menthae Rotundifoliae plant and preparation is 0.5-100: 1.Its medicine can be made into following dosage form:
1. prepare dissolved granule, capsule, oral liquid, buccal tablet;
2. preparation has the preparation of controlled-release technology and microgranule capsule technique;
3. be prepared into injection-type preparation (muscle or vein);
The invention of Herba Menthae Rotundifoliae treatment oral cavity, pharyngeal, esophagus inflammation and hemorrhagic disease, be to carry out a large amount of scientific experimentations through Shenyang Pharmaceutical University and new Chinese medicine development center, Liaoning Province, and the Natural Medicine Chemistry composition that contains in its plant is analyzed its result show: the Herba Menthae Rotundifoliae efficacy component does not exist only in its fragrant volatile oil, main being present in its non-volatile position.
Prove through number of research projects, and found at home and abroad first that the Herba Menthae Rotundifoliae plant contains five kinds in the world from undiscovered noval chemical compound, as: 10,13,14-trihydroxy-11-(Z)-octadecenoic acid (S8), Herba Menthae Rotundifoliae glycosides A, Herba Menthae Rotundifoliae glycosides B.Lot of experiments proves that the contained active ingredient of Herba Menthae Rotundifoliae has the obvious suppression effect to Pseudomonas such as the staphylococcus aureus in the antibacterial activity screening system of being set up, staphylococcus epidermidis, escherichia coli, Bacillus cereus, pneumobacillus, Resina garciniae sarcina, bacillus pyocyaneus.Irritated stomach Herba Menthae Rotundifoliae dissolved granule 2g/kg in continuous three days for rat, can obviously suppress carrageenin and cause rat paw edema., can obviously suppress the rat chronic granuloma and form rat oral gavage with continuous six days of Herba Menthae Rotundifoliae dissolved granule 6g/kg, its suppression ratio is up to 30.2%.With Herba Menthae Rotundifoliae 5g/kg, 10g/kg continuous irrigation stomach three days, can obviously prolong the threshold of pain time of mice to hot plate pain, its threshold of pain rate elongation is up to 50.1%, 58%.Irritate stomach Herba Menthae Rotundifoliae dissolved granule 2.5g/kg, 5g/kg, 10g/kg in continuous 5 days for mice, can obviously increase platelet counts in the mouse blood.Show that from the above-mentioned test of pesticide effectiveness result Herba Menthae Rotundifoliae except that active chronic inflammation being had the stronger inhibitory action, also has pain relieving and anastalsis.The Herba Menthae Rotundifoliae electuary carries out acute toxicity test to the mice administration and shows: the maximum tolerated dose in the mouse stomach Herba Menthae Rotundifoliae electuary 1 day is 168g (crude drug)/kg, is equivalent to 224 times of 60kg body weight people consumption.
These medicine material wide material sources, preparation technology advanced person, functions such as its antiinflammatory, hemostasis, pain relieving, elimination inflammatory edema and ulcer are outstanding.Be characterized in short treating period, instant effect, do not influence patient work and have a rest, and medicine belongs to the pure natural product, have no side effect, cost is low, is suitable for and applies.This medicine can be made dissolved granule, powder, capsule preparations, oral agents and ejection preparation according to the clinical practice needs.
The specific embodiment:
The present invention will be further described below in conjunction with embodiment.
Embodiment one
The preparation dissolved granule
At first clean dry product Herba Menthae Rotundifoliae 2000g, the water saturates that adds 10 times of amounts, extract volatile oil with hydrodistillation, extracted 4 hours, collect volatile oil, water liquid device is in addition collected, and filters, filtrate is concentrated into the extractum that relative density is 1.25-1.30 under 50 ℃ of temperature, medicinal residues each 1 hour, merge extracted twice liquid with 60% alcohol reflux secondary, filter, filtrate recycling ethanol also is concentrated into the extractum that relative density is 1.25-1.30 under 50 ℃ of temperature, merge extractum twice, then decompression, dry, pulverize, use alcohol granulation, dry again, granulate, the packing dissolved granule 1000g that gets product.
Embodiment two
Preparation sustained-release microparticle capsule
Prescription: Herba Menthae Rotundifoliae dry product 2000g, starch 1000g, ethanol is an amount of.
Method for making: make dry extract as preparation method in the granule, add starch 1000g mix homogeneously, stir with an amount of ethanol and granulate, drying with enteric solubility acrylic resin coating, incapsulates, and makes 5000 of capsules altogether.
Embodiment three
Preparation injection (muscle)
Prescription: Herba Menthae Rotundifoliae dry product 1000g, NaCl8g, benzyl alcohol 10ml adds the injection water to 1000ml.
Method for making: get dry product Herba Menthae Rotundifoliae 1000g, add 10 times of amount distilled water and soak into, extract volatile oil with hydrodistillation, collect volatile oil, water liquid device is in addition collected, and filters, filtrate concentrates the back and adds the ethanol stirring, and precipitation filters, filtrate recycling ethanol, merge with above-mentioned concentrated solution, filter, add benzyl alcohol 10ml, add NaCl8g, stirring and dissolving adds the injection water to 1000ml, G
3Sintered glass funnel filters, embedding, 100 ℃ of sterilization 30min.
Claims (7)
1, the plant Herba Menthae Rotundifoliae is as the application of preparation treatment oral cavity, pharyngeal, esophagus inflammation and hemorrhagic disease medicine, and it is characterized in that: adopt Herba Menthae Rotundifoliae stem leaves of plants dry product, process through extraction, the weight ratio of Herba Menthae Rotundifoliae plant and preparation is 0.5-100: 1.
2, plant Herba Menthae Rotundifoliae according to claim 1 is characterized in that: can prepare dissolved granule, capsule, oral liquid or buccal tablet as the application of preparation treatment oral cavity, pharyngeal, esophagus inflammation and hemorrhagic disease medicine.
3, plant Herba Menthae Rotundifoliae according to claim 1 is characterized in that: can prepare the preparation with controlled-release technology and microgranule capsule technique as the application of preparation treatment oral cavity, pharyngeal, esophagus inflammation and hemorrhagic disease medicine.
4, plant Herba Menthae Rotundifoliae according to claim 1 is characterized in that: can be prepared into the injection-type preparation as the application of preparation treatment oral cavity, pharyngeal, esophagus inflammation and hemorrhagic disease medicine.
5, plant Herba Menthae Rotundifoliae according to claim 2 is as preparation treatment oral cavity, pharyngeal, the application of esophagus inflammation and hemorrhagic disease medicine, it is characterized in that: the preparation dissolved granule, at first clean dry product Herba Menthae Rotundifoliae 2000g, the water saturates that adds 10 times of amounts, extract volatile oil with hydrodistillation, extracted 4 hours, collect volatile oil, water liquid device is in addition collected, and filters, filtrate is concentrated into the extractum that relative density is 1.25-1.30 under 50 ℃ of temperature, medicinal residues each 1 hour, merge extracted twice liquid with 60% alcohol reflux secondary, filter, filtrate recycling ethanol also is concentrated into the extractum that relative density is 1.25-1.30 under 50 ℃ of temperature, merge extractum twice, then decompression, dry, pulverize, use alcohol granulation, dry again, granulate, the packing dissolved granule 1000g that gets product.
6, plant Herba Menthae Rotundifoliae according to claim 3 is characterized in that as the application of preparation treatment oral cavity, pharyngeal, esophagus inflammation and hemorrhagic disease medicine: preparation sustained-release microparticle capsule, and prescription: Herba Menthae Rotundifoliae dry product 2000g, starch 1000g, ethanol is an amount of; Method for making: make dry extract as preparation method in the granule, add starch 1000g mix homogeneously, stir with an amount of ethanol and granulate, drying with enteric solubility acrylic resin coating, incapsulates, and makes 5000 of capsules altogether.
7, plant Herba Menthae Rotundifoliae according to claim 4 is as the application of preparation treatment oral cavity, pharyngeal, esophagus inflammation and hemorrhagic disease medicine, it is characterized in that: preparation injection, prescription: Herba Menthae Rotundifoliae dry product 1000g, NaCl8g, benzyl alcohol 10ml adds the injection water to 1000ml; Method for making: get dry product Herba Menthae Rotundifoliae 1000g, add 10 times of amount distilled water and soak into, extract volatile oil with hydrodistillation, collect volatile oil, water liquid device is in addition collected, and filters, filtrate concentrates the back and adds the ethanol stirring, and precipitation filters, filtrate recycling ethanol, merge with above-mentioned concentrated solution, filter, add benzyl alcohol 10ml, add NaCl8g, stirring and dissolving adds the injection water to 1000ml, G
3Sintered glass funnel filters, embedding, 100 ℃ of sterilization 30min.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA031340865A CN1528360A (en) | 2003-09-28 | 2003-09-28 | Use of plant spearmint for peparing medicine for treating oral, Pharyngeal,esophagus inflammation and hemorrhagic diseases |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA031340865A CN1528360A (en) | 2003-09-28 | 2003-09-28 | Use of plant spearmint for peparing medicine for treating oral, Pharyngeal,esophagus inflammation and hemorrhagic diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1528360A true CN1528360A (en) | 2004-09-15 |
Family
ID=34286130
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA031340865A Pending CN1528360A (en) | 2003-09-28 | 2003-09-28 | Use of plant spearmint for peparing medicine for treating oral, Pharyngeal,esophagus inflammation and hemorrhagic diseases |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1528360A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100516186C (en) * | 2006-05-12 | 2009-07-22 | 魏平飞 | Aromatic composition extracted from Cymbidium goeringii Rchb. f. and extracting method thereof |
-
2003
- 2003-09-28 CN CNA031340865A patent/CN1528360A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100516186C (en) * | 2006-05-12 | 2009-07-22 | 魏平飞 | Aromatic composition extracted from Cymbidium goeringii Rchb. f. and extracting method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1079152A (en) | Preparation method of quick-acting bone injury medicine | |
| CN102228485A (en) | Composition for burn rehabilitation and preparation method thereof | |
| CN102813751A (en) | Wound treatment agent | |
| CN103990028A (en) | Traditional Chinese medicine prickly heat powder | |
| CN1589852A (en) | External use nose drop agent for treating common cold and its preparation method | |
| CN1528360A (en) | Use of plant spearmint for peparing medicine for treating oral, Pharyngeal,esophagus inflammation and hemorrhagic diseases | |
| CN103446564B (en) | Chinese medicine composition of a kind of anti-inflammation and preparation method thereof | |
| CN100411666C (en) | Broad-specturm medicine for treating snake venom poisoning | |
| CN1528358A (en) | Use of plant spearmint for preparing medicine for treating urinary system inflammation and hemorrhagic diseases | |
| CN1528357A (en) | Use of plant spearmint for preparing medicine for treating esophagus cancer | |
| CN1528356A (en) | Use of plant spearmint for preparing medicines for treating women's inflammation and hemorrhagic diseases | |
| CN1528361A (en) | use of plant spearmint for preparing medicine for treating upper respiratory tract system inflammation and hemorrhagic diseases | |
| CN1528359A (en) | Use of plant spearmint for preparing medicine for treating chronic gastritis, stomach and duodenal ulcer and hemorrhagic diseases | |
| CN1159042C (en) | Medicine prepared from spearmint for treating chronic and ulcerative colitis and its preparing process | |
| CN112022947A (en) | Bacteriostatic agent based on traditional Chinese herbal medicines and small molecular compounds, and preparation method and application thereof | |
| CN106728069B (en) | Slough-removing and tissue regeneration-promoting paste for treating scalds and burns | |
| CN101214280B (en) | Chinese medicine for treating burn, scald and sores and preparation thereof | |
| CN101703570A (en) | Medicament prepared by using spearmint plant for treating atrophic gastritis | |
| CN1278727C (en) | Colonitis enteroclysm | |
| CN1167453C (en) | A powder for the treatment of hemorrhoid | |
| CN1058634C (en) | Use of plant mentha spicata for preparing pile-treating medicine | |
| CN1238012C (en) | Chinese medicine in the form of spray for treating infection of tonsil | |
| CN1097316A (en) | The prescription and the production technology of one group of burn Chinese medicine | |
| CN1103791A (en) | Sprinkling agent for burns and the process for prepn. of same | |
| CN1229651A (en) | Haemorrhoids powder |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C12 | Rejection of a patent application after its publication | ||
| RJ01 | Rejection of invention patent application after publication |