CN1520845A - Nasal administration drug for cold - Google Patents
Nasal administration drug for cold Download PDFInfo
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- CN1520845A CN1520845A CNA031040241A CN03104024A CN1520845A CN 1520845 A CN1520845 A CN 1520845A CN A031040241 A CNA031040241 A CN A031040241A CN 03104024 A CN03104024 A CN 03104024A CN 1520845 A CN1520845 A CN 1520845A
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Abstract
The present invention is one kind of nasal cavity administrated medicine composition for treating common cold. The medicine composition is one kind of Chinese medicine and Western medicine combining preparation and includes liquid an and liquid B. During treating common cold, it is sprayed to nose and nasopharynx mucous membrane directly, and has high bioavailability, fast acting, high safety and no bad reaction.
Description
Technical field the invention belongs to field of medicaments, especially a kind of Chinese and western medicinal composition by nasal-cavity administration treatment common cold.
The Chinese and western drugs of background technology treatment flu is more, and untoward reaction such as oral medication often has headache, stomachache, feels sick, vomiting suffer from the specific group of diseases such as gastrointestinal for itself, and the problem of this respect is especially outstanding.Also there is the treatment inconvenience in intravenous drip and the shortcoming of untoward reaction is arranged.Nasal-cavity administration is used for the treatment of the treatment of general disease gradually in recent years, rich blood vessel under the nasal mucosa, and medicine can directly absorb by it and enter human circulation.
Summary of the invention reduces untoward reaction in order to shorten the flu course of disease, looks after particular patients ' colony, under the preceding topic of maintenance and oral and the same curative effect of intravenous drip, reduce dosage, the reduction expense, the present invention proposes a kind of Chinese and western medicinal composition for the treatment of common cold by nasal-cavity administration.
Pharmaceutical composition of the present invention is made up of A liquid and B liquid.A liquid is Herba Houttuyniae 1-30 part, Radix Isatidis 1-20 part, the extracting solution of Herba Ephedrae 1-10 part.B liquid is ribavirin 1-10 part, the mixed liquor of vitamin C 1-10 part.A liquid is 1-10 with the ratio of B liquid for (volumetric ratio): 1
The optimum ratio of each crude drug of aforementioned pharmaceutical compositions of the present invention is Herba Houttuyniae 15-25 part, Radix Isatidis 10-20 part, Herba Ephedrae 3-6 part.Ribavirin 1-5 part, Catergen-8 part.A liquid is 1-4 with the ratio of B liquid: 1.
Preparation of drug combination method of the present invention is: choose crude drug by above-mentioned each component proportioning, preparation process is routinely produced the mixed liquor of A liquid and B liquid, with the packing of aerosol device.During use medicinal liquid directly being sprayed into nasal cavity gets final product.
Pharmaceutical composition via intranasal application of the present invention administration, employing be the bonded compound preparation of Chinese medicine and western medicine, through clinical observation, when being used for the treatment of flu, dosage is few, and expense is low, the total dosage of spray nose is the 1/10-1/30 of vein fluence, and expense is the 1/80-1/100 of intravenous drip.Effect is rapid, and spray delivery directly reaches nose, nasopharynx part mucosa, bioavailability height.Safety has no adverse reaction, and is easy to use.
The specific embodiment one. the preferred component of each crude drug of pharmaceutical composition of the present invention is 20 parts of Herba Houttuyniae, 12 parts of Radix Isatidis, 5 parts in Herba Ephedrae.2 parts of ribavirins, 3 parts of vitamin Cs.A liquid is 3: 2 with the ratio of B liquid.
Two. adopt preferred component, technology is made preparation with crude drug routinely, adopts the clinical observation material of nasal spray administration: (the temporary trade name is " refreshing spray " during clinical trial)
1. case is originated: all cases all derive from Chifeng City, Inner Mongol hospital.The object of observation is for being diagnosed as the common cold patient, totally 150 examples, and all there is cold symptoms in various degree at the age from 15-70, male 90 people, women 60 people.Wherein suffer from gastric and duodenal ulcers, liver, renal insufficiency person and amount to 31 examples.Hypertension, coronary heart disease and glycosuria amount to 9 examples, self driving person's 12 examples.
2. efficacy assessment standard: recovery from illness: body temperature descends and also is stable at more than 2d normal range, remissions such as sneeze, nasal obstruction, snivel, headache, systemic pain discomfort, local sign such as nasal mucosa hyperemia, edema, secretions, pharyngeal congestion disappears, and it is normal that the whole body situation is recovered.Take a turn for the better: body temperature is to normal range, and sneeze, nasal obstruction, snivel, headache, systemic pain discomfort are alleviated to some extent.
3. observed result: the person of throwing off a cold, the shortest 1d of treatment time, the longest 4d, wherein three days cure rates are 99.1%, improvement rate is 100%.Treat more early, and curative effect is high more.Particular patients ' such as gastrointestinal, Liver and kidney all has no adverse reaction, and is easy to use, no pain.
Claims (3)
1. pharmaceutical composition by nasal-cavity administration treatment flu, it is characterized in that: this pharmaceutical composition is made up of A liquid and B liquid, and A liquid is Herba Houttuyniae 1-30 part, Radix Isatidis 1-20 part, the extracting solution of Herba Ephedrae 1-10 part; B liquid is ribavirin 1-10 part, the mixed liquor of vitamin C 1-10 part; A liquid is 1-10 with the ratio of B liquid for (volumetric ratio): 1.
2. the pharmaceutical composition by nasal-cavity administration treatment flu according to claim 1, it is characterized in that: the optimum ratio of this each crude drug of pharmaceutical composition is Herba Houttuyniae 15-25 part, Radix Isatidis 10-20 part, Herba Ephedrae 3-6, ribavirin 1-5 part, Catergen-8 part; A liquid is 1-4 with the ratio of B liquid: 1.
3. the pharmaceutical composition by nasal-cavity administration treatment flu according to claim 1, it is characterized in that: the preferred component of this each crude drug of pharmaceutical composition is 20 parts of Herba Houttuyniae, 12 parts of Radix Isatidis, 5 parts in Herba Ephedrae, 2 parts of ribavirins, 3 parts of vitamin Cs; A liquid is 3: 2 with the ratio of B liquid.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA031040241A CN1520845A (en) | 2003-02-12 | 2003-02-12 | Nasal administration drug for cold |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA031040241A CN1520845A (en) | 2003-02-12 | 2003-02-12 | Nasal administration drug for cold |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1520845A true CN1520845A (en) | 2004-08-18 |
Family
ID=34282154
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA031040241A Pending CN1520845A (en) | 2003-02-12 | 2003-02-12 | Nasal administration drug for cold |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1520845A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1298372C (en) * | 2005-04-26 | 2007-02-07 | 上海千兆商务咨询有限公司 | Chinese traditional medicine for treating common cold |
| WO2007065314A1 (en) * | 2005-12-08 | 2007-06-14 | Pficker Pharmaceuticals, Ltd. | Compound preparation for treating virus hepatopathy |
-
2003
- 2003-02-12 CN CNA031040241A patent/CN1520845A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1298372C (en) * | 2005-04-26 | 2007-02-07 | 上海千兆商务咨询有限公司 | Chinese traditional medicine for treating common cold |
| WO2007065314A1 (en) * | 2005-12-08 | 2007-06-14 | Pficker Pharmaceuticals, Ltd. | Compound preparation for treating virus hepatopathy |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C57 | Notification of unclear or unknown address | ||
| DD01 | Delivery of document by public notice |
Addressee: Dong Gang Document name: Deemed as a notice of withdrawal (Trial) |
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| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |