CN103919789A - Ultrasonic atomization steam inhalation treatment method of ephedrine composition - Google Patents
Ultrasonic atomization steam inhalation treatment method of ephedrine composition Download PDFInfo
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- CN103919789A CN103919789A CN201310010746.6A CN201310010746A CN103919789A CN 103919789 A CN103919789 A CN 103919789A CN 201310010746 A CN201310010746 A CN 201310010746A CN 103919789 A CN103919789 A CN 103919789A
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Abstract
The invention relates to a method for providing ephedrine in a gas-phase manner, wherein the ephedrine composition contains ephedrine and salicylic acid alkyl ester, preferably the salicylic acid alkyl ester is methyl salicylate, and the non-mandatory component in the composition comprises an aromatic compound such as camphor, menthol and various other essence oils. According to the method, during treatment of nasal congestion and bronchial asthma, the gas-phase manner is adopted to provide ephedrine and other treatment drugs for lesions, and the drug atomization steam inhalation treatment manner is adopted to help the drug to be rapidly absorbed into the lesion through steam so as to effectively and quickly kill viruses and bacteria, treat inflammation and congestion conditions, and improve and recover pathogenetic conditions.
Description
Technical field
The present invention relates to a kind of a kind of ultrasonic atomizatio steam Inhalation in Treating method that adopts the method, particularly ephedrine compositions of ephedrine compositions treatment nasal congestion and bronchial asthma.
Background technology
Common cold is generally accompanied by from nose and discharges fluid (rhinorrhea), sneeze, and cough, headache, and in the hyperemia of nose, bronchus and pulmonary.One or more these symptoms, are generally to take suitable medicine for example common cold tablet or cold relief capsule by whole body or part, cold external medicine, and nasal drop, nasal spray, thermohale or other medicine alleviate.People know, ephedrine alkali (being designated hereinafter simply as ephedrine) can be used for the treatment of various physiological diseases, comprises cold symptoms and other nasal mucosa and respiratory tract disease.Other purposes of ephedrine comprise: treatment angiostenosis; Strengthen the patient's who suffers from spinal column numbness blood pressure; Treatment shock; Utilize its platycoria effect and be used in test near and distance method aspect: the analeptic that is used as central nervous system (CNS); Treatment Gelineau's syndrome; By suppressing medicine, comprise that barbiturate and morphine treat CNS nosotoxicosis; And treatment myasthenia gravis.
In the treatment of these diseases, ephedrine is utilized with various forms and compositions, for example, use the sterile solution of ephedrine, and uses and administration at subcutaneous, vein and muscle.What part was used is the ephedrine solution in petroleum oil medium, and its amount is approximately 1% to 3% weight of solution.
Because ephedrine carries out rapidly metabolism in health, so it can not be used in the form of oral administration widely, for example lamellar, capsule, target agent, etc., to whole body, provide effective ingredient.This medication, is used more stable active compound conventionally.The form of ephedrine salt (ephedrine sulfate, or ephedrine sulfate) specifically, isomer isoephedrine, and closely-related aminated compounds, for example dexoxyn, norephedrine and epinephrine.Owing to being through digestive system, by absorption, enter into blood and effective ingredient is provided indirectly, therefore as all oral medication effective ingredient, the starting of therapeutical effect has been postponed.
Therefore,, in order to make nasal mucosa and upper respiratory tract have absorption maximum effect, in order to make as far as possible the surface of a great deal of directly accept effective ingredient, also, in order to reduce because body fluid flows out the loss that causes effective ingredient, preferably with gas phase, provide ephedrine.
Have been found that and will comprise ephedrine and salicylic acid C
2-C
5.The compositions of Arrcostab provides a kind of method of ephedrine with gas phase form.Said composition can be mixed with various manufactured goods, these manufactured goods can be used to treat with visitor's kind method disease and the other diseases of nasal mucosa and upper respiratory tract, or for physiological environment, in this environment, to part or the ephedrine that provides of whole body can have medical function.
Summary of the invention
The present invention includes a kind of containing by about 1% to 99%, more preferably about 2% to 25%, be preferably the ephedrine of about 5% to 10% weight, and about 1% to 99%, more preferably about 5% to 75%, be preferably the salicylic acid C of about 10% to 25%' weight
2-C
5the compositions of Arrcostab.The ephedrine that preferred compositions comprises and the weight ratio of alkyl salicylate are from about 5:1 to 1:2., more preferably about 1:1 to 1:5, and be preferably about 1:1 to l:2.5.
It is about 2% to 93% that preferred compositions also comprises, more preferably about 25% to 90%, is preferably the aromatic of about 65% to 85% weight.Preferred aromatic comprises Camphora, menthol, and their mixture.The type of aromatic and concentration can affect the speed of the ephedrine steam discharging from compositions, also have influence on organ sensation's performance of compositions.
Ephedrine mixedly or individually can be mixed with other optional materials mutually with alkyl salicylate and produce manufactured goods.Can be for the optional reduction of a fraction of the present composition, comprise other therapeutant: decongestant, isoephedrine hydrochlorate for example; Cough medicine, for example dextromethorphan; The agent of resistance amine, for example chlorphenamine; Pain relieving, acetaminophen for example; And antibacterial, for example pyrisept.These therapeutants are all added in compositions and go according to the upper safety for the treatment of and effective dosage separately.The safety of above-mentioned effective ingredient and effectively maximal dose are: 60 milligrams of isoephedrine hydrochlorates; Dextromethorphan, 20 milligrams; Chlorphenamine, 24 milligrams; And acetaminophen, 1000 millis fill.The consumption of pyrisept can be up to approximately 0.05% weight.
Compositions of the present invention can, by by ephedrine and alkyl salicylate and comprise other optional materials of aromatic, make through simple mixing.
With gaseous state, provide ephedrine, it can be used with various product form, this provides a kind of Therapeutic Method, and this Therapeutic Method past is impossible, or unpractical.The present invention helps ephedrine to provide treatment in the mode of gaseous state by having children outside the state plan the mode of medicinal atomized steam suction, be useful especially, and the mechanism of this treatment is Absorption or adsorption through skin or process mucosa.
By ultrasonic medicinal atomizing steam, suck and there is following advantage: (1) medicine steam sucks and impels local blood circulation to accelerate to make erythrocytosis, and red nucleus neutral leukocyte increases to resist infection.After medicine steam makes part warm, in tube chamber, cilium clearance rate raises, and the harmful secretions of mucosa easily excretes, and makes mucosa anti-inflammation detumescence piece, easily removes focus of infection.Improve ventilation drain, safeguard normal physiological function.(2) topical remedy's steam improves environment in pipe, improves after partial pressure of oxygen, and favourable fibre function recovers, and cilium clearance rate raises, and the harmful secretions of mucosa is easily discharged.(3) effectively Chinese and western drugs liquid atomizing steam enters bronchovesicular with air quantity and directly acts on focus.By such shortcut, killing effectively fast in focus virus and bacteria, favourable sb.'s illness took a favorable turn, rehabilitation.
The specific embodiment
Compositions of the present invention is prepared in the following method:
1, the preparation of ephedrine compositions:
Jie, suitably in the steam jacket rustless steel mixing kettle of size, add 330.8 grams of menthol crystallizations and 330.8 grams of Camphora crystallizations, reactor is loosely built, content heating be take to melting crystal simultaneously keep the temperature of fusing fluid to be about 52 ℃.When fusing, occasionally menthol and Camphora mixture are stirred, after crystallization is melted completely, 223.8 grams of methyl salicylate and 87.6 grams of ephedrines are joined in melt.Stop heating, when stirring occasionally, solution is cooled to ambient temperature.After solution is cooled to ambient temperature completely, is placed in suitable brown glass container, and is sealed.
This solution contains following component (by weight):
Ephedrine 9.0%
Methyl salicylate 23.0%
Menthol 34.0%
Camphora 34.0%
2,30Occ water purification is sprayed up through ultrasonic change water column.
3, in atomizing cup, fill the medicinal liquid making in the first step, by borrowing air quantity after medical liquid atomizing, by face shield, receive patient's mouth and nose, steam atomization medicinal liquid is sucked to nose, the pipe of breathing one's last, until alveolar.
4, according to state of an illness weight, follow the doctor's advice, regulate air quantity and mistiness degree
Seriously ill-mistiness-air quantity is large-and the large utilization rate of dose is high
Sick light-mist is light-and air quantity is little-is used as medicine on a small quantity.
Claims (10)
1. the Therapeutic Method that ephedrine compositions ultrasonic atomizatio steam sucks, is characterized in that this ephedrine compositions comprises from approximately 5% to approximately 10% ephedrine and approximately 10% to approximately 25% alkyl salicylate certainly.
2. the Therapeutic Method that ephedrine compositions ultrasonic atomizatio steam sucks, is characterized in that ephedrine that this ephedrine compositions comprises and the weight ratio of alkyl salicylate are preferably about 1:1 to l:2.5.
3. the Therapeutic Method that ephedrine compositions ultrasonic atomizatio steam sucks, is characterized in that this ephedrine compositions also wraps from approximately 65% aromatic to approximately 85% weight.
4. the method that ephedrine compositions ultrasonic atomizatio steam sucks, is characterized in that the alkyl salicylate in ephedrine compositions is selected from methyl salicylate, ethyl salicylate, amyl salicylate, and their mixture.
5. the method that ephedrine compositions ultrasonic atomizatio steam sucks, is characterized in that the aromatic in ephedrine compositions is selected from Camphora, menthol, essential oil, pinke needle oil, Eucalyptus oil, and their mixture.
6. the method that ephedrine compositions ultrasonic atomizatio steam sucks, is characterized in that, by ultrasonic medicinal atomization, by steam, sucking nasopharynx trachea until pulmonary.
7. directly act on the strong kill virus antibacterial of focus antiinflammatory rehabilitation everywhere.
8. the Therapeutic Method that ephedrine compositions ultrasonic atomizatio steam sucks, it is characterized in that the Herba Ephedrae alkali number that discharges in treatment for from 1 microgram to about l0 microgram, each nostril sucks 1 to 4 time and obtains, if need every day, sucks several times.
9. the Therapeutic Method that ephedrine compositions ultrasonic atomizatio steam sucks, is characterized in that being used for the treatment of nasal congestion and alleviates bronchial asthma.
10. simultaneously steam makes blood circulation accelerate opposing appeal to strengthen, antiinflammatory, and detumescence, drain is unobstructed, eliminates focus of infection sb.'s illness took a favorable turn rehabilitation, effective to treatment of respiratory diseases.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310010746.6A CN103919789A (en) | 2013-01-13 | 2013-01-13 | Ultrasonic atomization steam inhalation treatment method of ephedrine composition |
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| CN201310010746.6A CN103919789A (en) | 2013-01-13 | 2013-01-13 | Ultrasonic atomization steam inhalation treatment method of ephedrine composition |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108175745A (en) * | 2017-12-05 | 2018-06-19 | 河南明珍方医药科技有限公司 | A kind of ephedrine hydrochloride nasal drops agent and preparation method thereof |
| CN111358751A (en) * | 2018-12-25 | 2020-07-03 | 沈阳兴齐眼药股份有限公司 | Ophthalmic pharmaceutical composition, ophthalmic kit and medical application thereof |
-
2013
- 2013-01-13 CN CN201310010746.6A patent/CN103919789A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108175745A (en) * | 2017-12-05 | 2018-06-19 | 河南明珍方医药科技有限公司 | A kind of ephedrine hydrochloride nasal drops agent and preparation method thereof |
| CN111358751A (en) * | 2018-12-25 | 2020-07-03 | 沈阳兴齐眼药股份有限公司 | Ophthalmic pharmaceutical composition, ophthalmic kit and medical application thereof |
| CN111358751B (en) * | 2018-12-25 | 2023-04-18 | 沈阳兴齐眼药股份有限公司 | Ophthalmic pharmaceutical composition, ophthalmic kit and medical application thereof |
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Application publication date: 20140716 |