CN105311081A - Application of Shanhaidan chrysanthemum indicum injection in aerosol inhalation, spray bottle aerial fog and rectal administration and method - Google Patents
Application of Shanhaidan chrysanthemum indicum injection in aerosol inhalation, spray bottle aerial fog and rectal administration and method Download PDFInfo
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- CN105311081A CN105311081A CN201410730723.7A CN201410730723A CN105311081A CN 105311081 A CN105311081 A CN 105311081A CN 201410730723 A CN201410730723 A CN 201410730723A CN 105311081 A CN105311081 A CN 105311081A
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- chrysanthemum indicum
- flos chrysanthemi
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Abstract
The invention discloses application of Shanhaidan chrysanthemum indicum injection in aerosol inhalation, spray bottle aerial fog and rectal administration and a method. The method comprises the following steps: adding an osmotic pressure regulator with mass fraction of 0.2-0.3% in chrysanthemum indicum injection; regulating a pH value to be 6.3-6.8 by using a pH regulator; preparing an obtained solution into an aerosol inhalation preparation so that the aerosol inhalation preparation is directly inhaled into a respiratory system in an atomization mode; or placing the obtained solution in a spray bottle to obtain a spray bottle aerial fog preparation which is used for covering the respiratory system in a local spraying mode; or adding a rectal absorption enhancer in the chrysanthemum indicum injection and preparing into a rectal administration preparation with a pH regulator, wherein the rectal administration preparation enters blood circulation through haemorrhoidal veins. PH values and osmotic pressures of the three preparations in the invention meet requirements of physicochemical properties of the respiratory system and an intestinal environment, a respiratory tract and an intestinal tract are not irritated, and respiratory tract infection diseases caused by viruses, bacteria and drug-resistance bacteria can be clinically treated by the chrysanthemum indicum injection.
Description
Technical field
The present invention relates to technical field of medicine, specifically SHANHAI PILL Flos Chrysanthemi indici injection is in the application of Neulized inhalation, spray bottle aerosol, rectally and method.
Background technology
Flos Chrysanthemi indici injection is by Flos Chrysanthemi Indici, sodium chloride and Polysorbate according to scientific matching, adopts the advanced technologies such as second distillation, decoction, secondary aseptic filtration to produce.Flos Chrysanthemi indici injection, heat-clearing and toxic substances removing.For fever caused by exogenous pathogenic factors, conjunctival congestion and swelling pain, have sore throat; Upper respiratory tract infection, acute tonsillitis belong to the person of attacking on pyretic toxicity.
Current clinical practice Flos Chrysanthemi indici injection is taked, with muscle injection mode administration, to be existed the Operative risks such as injection site pain, infection, broken needle, and reduces patient treatment compliance.
Summary of the invention
The object of the present invention is to provide a kind of SHANHAI PILL Flos Chrysanthemi indici injection improving safety clinical treatment and compliance in the application of Neulized inhalation, spray bottle aerosol, rectally and method, to solve the problem proposed in above-mentioned background technology.
For achieving the above object, the invention provides following technical scheme:
SHANHAI PILL Flos Chrysanthemi indici injection is in the application of Neulized inhalation, spray bottle aerosol, rectally and method, the osmotic pressure regulator that mass fraction is 0.2-0.3% is added in Flos Chrysanthemi indici injection, and by pH adjusting agent adjust ph to 6.3-6.8, gained solution ultrasound wave or compression atomization mechanism are become Neulized inhalation preparation, directly sucks respiratory system with atomised form;
Or gained solution inserted in spray bottle and make spray bottle aerosol formulations, cover respiratory system by topical spray mode;
Or in Flos Chrysanthemi indici injection, add the rectal absorption promoter that mass fraction is 0.2-0.3%, and by pH adjusting agent adjust ph to 6.3-6.8, gained solution is made rectally preparation, enters blood circulation by hemorrhoidal veins.
Adjust injection pH value in the present invention and can reduce stimulation to body to 6.3-6.8, increase the stability of injection, accelerate the absorption of medicine.The additives of conventional adjusted to ph have hydrochloric acid, citric acid, sodium hydroxide, potassium hydroxide, sodium bicarbonate, sodium hydrogen phosphate, sodium dihydrogen phosphate etc.Water balance in osmotic pressure regulator holder, keeps normal volume and form in erythrocyte, avoids haemolysis occurs.
Compared with prior art, the invention has the beneficial effects as follows: the pH value of atomization medicinal liquid prepared in the present invention and spray liquor, rectally preparation and osmotic pressure meet the physicochemical property requirement of respiratory system and intestinal environment, zest is not had to respiratory tract and intestinal, gives patient treatment by prepared medicine by corresponding medical apparatus and instruments.By above different preparation, play Flos Chrysanthemi indici injection clinical treatment by virus, antibacterial, the microbial respiratory infection diseases of drug resistance as herpangina, suppurative tonsillitis, bronchitis, viral pneumonia etc.This is route of administration and therapeutic modality that Flos Chrysanthemi indici injection is brand-new.
Detailed description of the invention
Below in conjunction with the embodiment of the present invention, be clearly and completely described the technical scheme in the embodiment of the present invention, obviously, described embodiment is only the present invention's part embodiment, instead of whole embodiments.Based on the embodiment in the present invention, those of ordinary skill in the art, not making the every other embodiment obtained under creative work prerequisite, belong to the scope of protection of the invention.
Embodiment 1
In the embodiment of the present invention, SHANHAI PILL Flos Chrysanthemi indici injection prepares Neulized inhalation preparation: add osmotic pressure regulator 0.2% in Flos Chrysanthemi indici injection, and by pH adjusting agent adjust ph to 6.3, gained solution ultrasound wave or compression atomization mechanism are become Neulized inhalation preparation, directly sucks respiratory system with atomised form.
Embodiment 2
In the embodiment of the present invention, SHANHAI PILL Flos Chrysanthemi indici injection preparation spray bottle aerosol formulations: add osmotic pressure regulator 0.3% in Flos Chrysanthemi indici injection, and by pH adjusting agent adjust ph to 6.8, gained solution is inserted in spray bottle and make spray bottle aerosol formulations, cover respiratory system by topical spray mode.
Embodiment 3
In the embodiment of the present invention, SHANHAI PILL Flos Chrysanthemi indici injection prepares rectally preparation: add rectal absorption promoter 0.25% in Flos Chrysanthemi indici injection, and by pH adjusting agent adjust ph to 6.5, gained solution is made rectally preparation, enters blood circulation by hemorrhoidal veins.
Flos Chrysanthemi indici injection relates in clinical atomization inspiration treatment respiratory infectious disease scope: herpangina, chronic pharyngitis, bronchopneumonia, viral pneumonia etc. are respiratory infection diseases up and down.Clinical research shows: effective ingredient contained by Flos Chrysanthemi indici injection is the fat-soluble small-molecule substance of volatility extracted by second distillation technique, to respiratory mucosa nonirritant, does not have bitterness, abnormal flavour, suitable Neulized inhalation and rectally treatment; Flos Chrysanthemi indici injection Neulized inhalation or upper respiratory tract topical spray effectively can play the antiviral, antibacterial of Flos Chrysanthemi Indici, sodium chloride and Polysorbate, the clinical effect such as anti-inflammatory antipyretic, relieving cough and expelling phlegm, by Neulized inhalation, this administering mode of topical spray, Flos Chrysanthemi indici injection is enable directly to enter respiratory tract and pulmonary, medicine can absorb rapidly, and local drug concentration is high, and sedimentation time is long, rapid-action, safety is high, improves the distinct clinical characters such as the compliance of patient medication.Neulized inhalation belongs to topical therapeutic, and drug dose used is little, obviously reduces medicine whole body toxic and side effects.Atomization can suck several drugs simultaneously, easy to use, does not need the cooperation of patient, no pain, treatment time short, instant effect, be particularly suitable for treating childrens respiratory tract infection.Additionally by rectally, medicine can be made directly to enter postcava by vein lower in rectum, conduct drugs to infected tissue position by blood circulation, avoid the head of liver to medicine and cross elimination effect, improve drug bioavailability, reduce the side effect to liver simultaneously.Without upper digestive tract, avoid the stimulation to gastrointestinal, gastric acid and various digestive enzyme also can be avoided the destruction of medicine; Absorb fast, rapid-action, determined curative effect.A large amount of clinical practices proves, rectally and intravenous drip no significant difference in onset and curative effect, and the bioavailability of rectally is 2 times of oral administration.Simple and quick, hurtless measure, no pain, patient gladly accepts, and improves the compliance of administration; Dosage is accurate, convenient, safety.Decrease the time of having an injection, being in hospital, save limited health resources.Clinical practice shows: no matter Flos Chrysanthemi indici injection, by these three kinds of administering modes, is all better than muscle injection mode in drug absorption, drug effect and safety.Therefore this brand-new therapeutic modality meets clinical required safe, effective, convenient, economic Therapeutic Principle, for reducing medical-risk, improving treatment compliance by social benefit positive for generation
To those skilled in the art, obviously the invention is not restricted to the details of above-mentioned one exemplary embodiment, and when not deviating from spirit of the present invention or basic feature, the present invention can be realized in other specific forms.Therefore, no matter from which point, all should embodiment be regarded as exemplary, and be nonrestrictive, scope of the present invention is limited by claims instead of above-mentioned explanation, and all changes be therefore intended in the implication of the equivalency by dropping on claim and scope are included in the present invention.
In addition, be to be understood that, although this description is described according to embodiment, but not each embodiment only comprises an independently technical scheme, this narrating mode of description is only for clarity sake, those skilled in the art should by description integrally, and the technical scheme in each embodiment also through appropriately combined, can form other embodiments that it will be appreciated by those skilled in the art that.
Claims (1)
1. SHANHAI PILL Flos Chrysanthemi indici injection is in the application of Neulized inhalation, spray bottle aerosol, rectally and method, it is characterized in that, the osmotic pressure regulator that mass fraction is 0.2-0.3% is added in Flos Chrysanthemi indici injection, and by pH adjusting agent adjust ph to 6.3-6.8, gained solution ultrasound wave or compression atomization mechanism are become Neulized inhalation preparation, directly sucks respiratory system with atomised form;
Or gained solution inserted in spray bottle and make spray bottle aerosol formulations, cover respiratory system by topical spray mode;
Or in Flos Chrysanthemi indici injection, add the rectal absorption promoter that mass fraction is 0.2-0.3%, and by pH adjusting agent adjust ph to 6.3-6.8, gained solution is made rectally preparation, enters blood circulation by hemorrhoidal veins.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410730723.7A CN105311081A (en) | 2014-12-05 | 2014-12-05 | Application of Shanhaidan chrysanthemum indicum injection in aerosol inhalation, spray bottle aerial fog and rectal administration and method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410730723.7A CN105311081A (en) | 2014-12-05 | 2014-12-05 | Application of Shanhaidan chrysanthemum indicum injection in aerosol inhalation, spray bottle aerial fog and rectal administration and method |
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| CN105311081A true CN105311081A (en) | 2016-02-10 |
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| CN201410730723.7A Pending CN105311081A (en) | 2014-12-05 | 2014-12-05 | Application of Shanhaidan chrysanthemum indicum injection in aerosol inhalation, spray bottle aerial fog and rectal administration and method |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107243024A (en) * | 2017-06-06 | 2017-10-13 | 河南太龙药业股份有限公司 | A kind of double golden pharmaceutical compositions connected, a kind of Neulized inhalation solution of double gold even and its production and use |
| CN108210541A (en) * | 2017-07-04 | 2018-06-29 | 江西天施康中药股份有限公司 | Application of the Flos Chrysanthemi indici injection in atomization inspiration treatment acute upper respiratory infection drug is prepared |
| CN109200070A (en) * | 2018-07-26 | 2019-01-15 | 广东新峰药业股份有限公司 | ZHONGJIEFENG ZHUSHEYE is in atomization and the application of rectally and preparation method thereof |
| CN109288877A (en) * | 2018-07-26 | 2019-02-01 | 广东新峰药业股份有限公司 | Earthworm injection is in atomization and the application of rectally and preparation method thereof |
| CN109288878A (en) * | 2018-07-26 | 2019-02-01 | 广东新峰药业股份有限公司 | Ilex pubescens injection is in atomization and the application of rectally and preparation method thereof |
-
2014
- 2014-12-05 CN CN201410730723.7A patent/CN105311081A/en active Pending
Non-Patent Citations (3)
| Title |
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| 严国华等: "九种中药对流行性脑脊髓膜炎带菌者973例疗效观察", 《中医杂志》 * |
| 付圆: "野菊花注射液超声雾化治疗儿童疱疹性咽峡炎的试验研究", 《当代医学》 * |
| 徐晓林等: "野菊花栓与甘草锌合用治疗慢性前列腺炎68例", 《云南中医中药杂志》 * |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107243024A (en) * | 2017-06-06 | 2017-10-13 | 河南太龙药业股份有限公司 | A kind of double golden pharmaceutical compositions connected, a kind of Neulized inhalation solution of double gold even and its production and use |
| CN107243024B (en) * | 2017-06-06 | 2018-05-29 | 河南太龙药业股份有限公司 | A kind of double golden pharmaceutical compositions connected, a kind of Neulized inhalation solution of double gold even and its preparation method and application |
| CN108210541A (en) * | 2017-07-04 | 2018-06-29 | 江西天施康中药股份有限公司 | Application of the Flos Chrysanthemi indici injection in atomization inspiration treatment acute upper respiratory infection drug is prepared |
| CN109200070A (en) * | 2018-07-26 | 2019-01-15 | 广东新峰药业股份有限公司 | ZHONGJIEFENG ZHUSHEYE is in atomization and the application of rectally and preparation method thereof |
| CN109288877A (en) * | 2018-07-26 | 2019-02-01 | 广东新峰药业股份有限公司 | Earthworm injection is in atomization and the application of rectally and preparation method thereof |
| CN109288878A (en) * | 2018-07-26 | 2019-02-01 | 广东新峰药业股份有限公司 | Ilex pubescens injection is in atomization and the application of rectally and preparation method thereof |
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Application publication date: 20160210 |
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