CN109200070A - ZHONGJIEFENG ZHUSHEYE is in atomization and the application of rectally and preparation method thereof - Google Patents
ZHONGJIEFENG ZHUSHEYE is in atomization and the application of rectally and preparation method thereof Download PDFInfo
- Publication number
- CN109200070A CN109200070A CN201810835642.1A CN201810835642A CN109200070A CN 109200070 A CN109200070 A CN 109200070A CN 201810835642 A CN201810835642 A CN 201810835642A CN 109200070 A CN109200070 A CN 109200070A
- Authority
- CN
- China
- Prior art keywords
- preparation
- rectally
- atomization
- zhongjiefeng
- zhongjiefeng zhusheye
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0031—Rectum, anus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/04—Drugs for disorders of the respiratory system for throat disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Virology (AREA)
- Otolaryngology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Dispersion Chemistry (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses ZHONGJIEFENG ZHUSHEYEs in atomization and the application of rectally and preparation method thereof, the osmotic pressure regulator that mass fraction is 0.2%~0.3% is added into ZHONGJIEFENG ZHUSHEYE, and pH value is adjusted to 6.3~6.8 with pH adjusting agent, by acquired solution ultrasonic wave or compression atomization mechanism at Neulized inhalation preparation, respiratory system is directly sucked in by atomised form or by topical spray in a manner of cover respiratory system；The rectal absorption promotor that mass fraction is 0.2%~0.3% is added into ZHONGJIEFENG ZHUSHEYE, and pH value is adjusted to 6.3-6.8 with pH adjusting agent, acquired solution is made rectally preparation or acquired solution is placed in dropper, rectum trickle irrigation preparation is made, enters blood circulation by hemorrhoidal veins.The present invention meets the physicochemical property requirement of respiratory system and intestinal environment, does not have irritation to respiratory tract and enteron aisle, gives prepared drug to patient's treatment by corresponding medical apparatus and instruments；By the above different preparations, a variety of diseases of ZHONGJIEFENG ZHUSHEYE clinical treatment are played.
Description
Technical field
The present invention relates to technical field of medicine more particularly to ZHONGJIEFENG ZHUSHEYE in atomization and the application of rectally
And preparation method thereof.
Background technique
ZHONGJIEFENG ZHUSHEYE is using second distillation, to be decocted by Glabrous Sarcandra Herb, sodium chloride and polysorbate according to scientific matching
It boils, the advanced technologies such as second level aseptic filtration produce.ZHONGJIEFENG ZHUSHEYE, clearing heat and detoxicating, dispersing swelling and dissipating binds are used for heat toxin
Stop up pneumonia, ecphyaditis, cellulitis, bacillary dysentery, abscess caused by containing, combines with ZHONGJIEFENG PIAN for digestive system cancer, cancer of pancreas, liver
The tumours such as cancer.Clinical application ZHONGJIEFENG ZHUSHEYE is taken at present is administered with muscle injection mode, and there are injection site pains, sense
The Operative risks such as dye, broken needle, and reduce patient and treat compliance.
Summary of the invention
The purpose of the present invention is to solve disadvantages existing in the prior art, and the ZHONGJIEFENG ZHUSHEYE proposed is being atomized
And application of rectally and preparation method thereof.
To achieve the goals above, present invention employs following technical solutions:
Matter is added into ZHONGJIEFENG ZHUSHEYE in atomization and the application of rectally and preparation method thereof for ZHONGJIEFENG ZHUSHEYE
The osmotic pressure regulator that score is 0.2%~0.3% is measured, and adjusts pH value to 6.3~6.8, by acquired solution with pH adjusting agent
With ultrasonic wave or compression atomization mechanism at Neulized inhalation preparation, respiratory system is directly sucked in atomised form or by part spray
Mist mode covers respiratory system；
Mass fraction is added into ZHONGJIEFENG ZHUSHEYE and is 0.2%~0.3% rectal absorption promotor, and is adjusted with pH
Agent adjusts pH value to 6.3-6.8, and rectally preparation is made in acquired solution or rectum will be made in acquired solution merging dropper
Trickle irrigation preparation enters blood circulation by hemorrhoidal veins.
Preferably, the osmotic pressure regulator is one of sodium chloride, boric acid, glucose, borax.
Preferably, the rectal absorption promotor be salicylate, 5- methoxysalicylic acid, surfactant, enamine and
One of its derivative, fatty acid.
Preferably, the pH adjusting agent is hydrochloric acid and sodium hydroxide.
Compared with prior art, the beneficial effects of the present invention are:
Prepared atomization medical fluid and spray liquor, the pH value of rectally preparation and osmotic pressure meet breathing in the present invention
System and the requirement of the physicochemical property of intestinal environment, do not have irritation to respiratory tract and enteron aisle, prepared drug are passed through phase
Medical apparatus and instruments are answered to give patient's treatment；By the above different preparations, ZHONGJIEFENG ZHUSHEYE clinical treatment is played by viral, thin
Respiratory infection diseases caused by bacterium, drug-fast bacteria such as herpangina, suppurative tonsillitis, bronchitis, viral lung
Inflammation, lung cancer etc..
Specific embodiment
The technical scheme in the embodiments of the invention will be clearly and completely described below, it is clear that described implementation
Example is only a part of the embodiment of the present invention, instead of all the embodiments.
Embodiment 1:
The osmotic pressure regulator that mass fraction is 0.2% is added into ZHONGJIEFENG ZHUSHEYE, and adjusts pH with pH adjusting agent
Value, by acquired solution ultrasonic wave or compression atomization mechanism at Neulized inhalation preparation, is directly sucked in atomised form and is exhaled to 6.3
Desorption system covers respiratory system by topical spray mode；
Wherein, osmotic pressure regulator is one of sodium chloride, boric acid, glucose, borax.
Wherein, pH adjusting agent is hydrochloric acid and sodium hydroxide.
Embodiment 2:
Mass fraction is added into ZHONGJIEFENG ZHUSHEYE and is 0.25% rectal absorption promotor, and is adjusted with pH adjusting agent
Acquired solution is made rectally preparation or rectum trickle irrigation preparation will be made in acquired solution merging dropper, led to by pH value to 6.5
It crosses hemorrhoidal veins and enters blood circulation.
Wherein, pH adjusting agent is hydrochloric acid and sodium hydroxide.
Wherein, rectal absorption promotor is salicylate, 5- methoxysalicylic acid, surfactant, enamine and its derivative
One of object, fatty acid.
Embodiment 3:
The osmotic pressure regulator that mass fraction is 0.3% is added into ZHONGJIEFENG ZHUSHEYE, and adjusts pH with pH adjusting agent
Acquired solution is placed in dropper and rectum trickle irrigation preparation is made, enter blood circulation by hemorrhoidal veins by value to 6.8.
Wherein, osmotic pressure regulator is one of sodium chloride, boric acid, glucose, borax.
Wherein, pH adjusting agent is hydrochloric acid and sodium hydroxide.
Prepared atomization medical fluid and spray liquor, the pH value of rectally preparation and osmotic pressure meet breathing in the present invention
System and the requirement of the physicochemical property of intestinal environment, do not have irritation to respiratory tract and enteron aisle, prepared drug are passed through phase
Medical apparatus and instruments are answered to give patient's treatment；By the above different preparations, ZHONGJIEFENG ZHUSHEYE clinical treatment is played by viral, thin
Respiratory infection diseases caused by bacterium, drug-fast bacteria such as herpangina, suppurative tonsillitis, bronchitis, viral lung
Inflammation, lung cancer etc..
Claims (4)
1. ZHONGJIEFENG ZHUSHEYE is in atomization and the application of rectally and preparation method thereof, which is characterized in that injected to Glabrous Sarcandra Herb
It is added the osmotic pressure regulator that mass fraction is 0.2%~0.3% in liquid, and adjusts pH value to 6.3~6.8 with pH adjusting agent,
By acquired solution ultrasonic wave or compression atomization mechanism at Neulized inhalation preparation, with atomised form be directly sucked in respiratory system or
Respiratory system is covered by topical spray mode；
The rectal absorption promotor that mass fraction is 0.2%~0.3% is added into ZHONGJIEFENG ZHUSHEYE, and with pH adjusting agent tune
PH value is saved to 6.3-6.8, rectally preparation is made in acquired solution or rectum trickle irrigation will be made in acquired solution merging dropper
Preparation enters blood circulation by hemorrhoidal veins.
2. ZHONGJIEFENG ZHUSHEYE according to claim 1 is in atomization and the application of rectally and preparation method thereof, spy
Sign is that the osmotic pressure regulator is one of sodium chloride, boric acid, glucose, borax.
3. ZHONGJIEFENG ZHUSHEYE according to claim 1 is in atomization and the application of rectally and preparation method thereof, spy
Sign is, the rectal absorption promotor be salicylate, 5- methoxysalicylic acid, surfactant, enamine and its derivative,
One of fatty acid.
4. ZHONGJIEFENG ZHUSHEYE according to claim 1 is in atomization and the application of rectally and preparation method thereof, spy
Sign is that the pH adjusting agent is hydrochloric acid and sodium hydroxide.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810835642.1A CN109200070A (en) | 2018-07-26 | 2018-07-26 | ZHONGJIEFENG ZHUSHEYE is in atomization and the application of rectally and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810835642.1A CN109200070A (en) | 2018-07-26 | 2018-07-26 | ZHONGJIEFENG ZHUSHEYE is in atomization and the application of rectally and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109200070A true CN109200070A (en) | 2019-01-15 |
Family
ID=64990237
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810835642.1A Pending CN109200070A (en) | 2018-07-26 | 2018-07-26 | ZHONGJIEFENG ZHUSHEYE is in atomization and the application of rectally and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109200070A (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105287846A (en) * | 2014-12-05 | 2016-02-03 | 陕西医药控股集团山海丹药业有限责任公司 | Application of Shanhaidan Yujin injection in atomizing inhalation, spray bottle aerosol and rectal administration and method |
| CN105287854A (en) * | 2014-12-04 | 2016-02-03 | 耿福能 | Preparation method of and application of compound Haqing injection in preparing preparation for atomizing and rectal administration |
| CN105311081A (en) * | 2014-12-05 | 2016-02-10 | 陕西医药控股集团山海丹药业有限责任公司 | Application of Shanhaidan chrysanthemum indicum injection in aerosol inhalation, spray bottle aerial fog and rectal administration and method |
-
2018
- 2018-07-26 CN CN201810835642.1A patent/CN109200070A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105287854A (en) * | 2014-12-04 | 2016-02-03 | 耿福能 | Preparation method of and application of compound Haqing injection in preparing preparation for atomizing and rectal administration |
| CN105287846A (en) * | 2014-12-05 | 2016-02-03 | 陕西医药控股集团山海丹药业有限责任公司 | Application of Shanhaidan Yujin injection in atomizing inhalation, spray bottle aerosol and rectal administration and method |
| CN105311081A (en) * | 2014-12-05 | 2016-02-10 | 陕西医药控股集团山海丹药业有限责任公司 | Application of Shanhaidan chrysanthemum indicum injection in aerosol inhalation, spray bottle aerial fog and rectal administration and method |
Non-Patent Citations (1)
| Title |
|---|
| 吴嘉瑞等主编: "《中药注射剂不良反应与安全应用》", 31 May 2012, 中国中医药出版社 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN107789340B (en) | Solution preparation for andrographis paniculata aerosol inhalation and preparation method thereof | |
| CN105311081A (en) | Application of Shanhaidan chrysanthemum indicum injection in aerosol inhalation, spray bottle aerial fog and rectal administration and method | |
| US20210008239A1 (en) | Medical Ozone Sterile Isotonic Saline Solution And Preparation Method And Application Thereof | |
| CN105287846A (en) | Application of Shanhaidan Yujin injection in atomizing inhalation, spray bottle aerosol and rectal administration and method | |
| CN104721241B (en) | A kind of Chinese Hibiscu petal extract and its application | |
| CN109200070A (en) | ZHONGJIEFENG ZHUSHEYE is in atomization and the application of rectally and preparation method thereof | |
| CN1939421A (en) | Antibacterial and antiviral Chinese medicinal composition | |
| CN109288877A (en) | Earthworm injection is in atomization and the application of rectally and preparation method thereof | |
| CN111000901A (en) | Novel method for treating bronchitis by gasifying and inhaling eucalyptus oil | |
| CN114177231B (en) | Antipyretic pharmaceutical composition, antipyretic gel and preparation method | |
| CN109288878A (en) | Ilex pubescens injection is in atomization and the application of rectally and preparation method thereof | |
| CN103040883A (en) | Compound radix isatidis spray and preparation method thereof | |
| CN109745460A (en) | A kind of fresh bamboo sap Neulized inhalation pharmaceutical solutions and preparation method thereof | |
| CN113209056A (en) | Trollius chinensis solution preparation for aerosol inhalation and preparation method thereof | |
| CN107773581A (en) | A kind of silver yellow Neulized inhalation pharmaceutical solutions and preparation method thereof | |
| CN107913332A (en) | A kind of clinical laboratory combination of Chinese tradiational and Western medicine disinfectant and preparation method | |
| CN107669890B (en) | A kind of Chinese medicine composition and preparation method thereof with clearing preventing phlegm from forming and stopping coughing effect | |
| CN105998504A (en) | Traditional Chinese medicinal narcotic preparation | |
| CN108904603A (en) | It is a kind of to treat acute-chronic purulent tympanitis pharmaceutical preparation | |
| CN111467218A (en) | Acupoint holographic injection method | |
| RU2140273C1 (en) | Method of treatment of patients with catarrhal illnesses | |
| CN100469373C (en) | Medicine for treating piles and its preparing process | |
| CN117298188A (en) | Traditional Chinese medicine for treating rhinitis and preparation method thereof | |
| CN108478771A (en) | A kind of Chinese medicine composition for treating the accumulation of capillary rupture clot | |
| CN109125406A (en) | A kind of drug for treating hemoptysis |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20190115 |
|
| RJ01 | Rejection of invention patent application after publication |