CN107334754B - Qingkailing solution preparation for aerosol inhalation and preparation method thereof - Google Patents
Qingkailing solution preparation for aerosol inhalation and preparation method thereof Download PDFInfo
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Abstract
The invention relates to a qingkailing solution preparation for aerosol inhalation, belonging to the field of pharmaceutics. A solution preparation for aerosol inhalation of qingkailing comprises (1) qingkailing effective component; (2) isotonic agent and solvent, and buffer solution. The solution preparation prepared by the invention makes up the blank of the current domestic market, is specially designed for patients for atomization and inhalation, is matched with an atomizer for use, is convenient to use, has different administration routes compared with qingkailing injection, reduces the dosage and improves the safety.
Description
Technical Field
The invention relates to a qingkailing solution preparation for aerosol inhalation and a preparation method thereof, belonging to the field of pharmaceutics.
Background
The qingkailing injection is developed on the basis of an ancient prescription of Angong Niuhuang pills, has the main components of buffalo horn, nacre, isatis root and the like, and has the effects of clearing away heat and toxic materials, tranquilizing and allaying excitement. Mainly treats patients with symptoms of high fever, dysphoria, sore throat, crimson tongue, yellow fur and rapid pulse caused by exogenous wind-heat seasonal toxin and internal exuberance of fire toxin; the symptoms of upper respiratory tract infection, viral cold, acute suppurative tonsillitis, acute pharyngitis, acute tracheitis, high fever and the like belong to the patients with the symptoms.
In recent years, with the increase of clinical medication population, the adverse reactions are reported more and more, and the adverse reactions are mainly shown in severe adverse reactions such as anaphylactic shock, allergic asthma and the like. Therefore, the development of a safer dosage form is urgently needed, adverse reactions are reduced, and the clinical medication safety is improved.
Disclosure of Invention
The invention mainly solves the technical problem of providing a safe, effective and excellent-quality qingkailing solution preparation for atomization and inhalation; the invention also provides a preparation method of the preparation.
The invention is realized by the following technical scheme:
a solution formulation for the aerosol inhalation of qingkailing comprising:
(1) effective components of QINGKAILING;
(2) isotonic agents and solvents;
buffers may also be added.
Wherein the mass ratio of the effective components to the isotonic agent is 1: 1-1: 5.
The active ingredients are prepared by the following steps:
10-20 parts of cholic acid, 50-300 parts of mother-of-pearl, 10-25 parts of hyodeoxycholic acid, 50-500 parts of cape jasmine fruit, 50-500 parts of buffalo horn, 500-2000 parts of radix isatidis, 5-50 parts of baicalin and 50-4000 parts of honeysuckle flower
Weighing eight medicines according to the weight parts, decocting the isatis root with water twice, each time for 1 hour, mixing decoctions, filtering, concentrating the filtrate to a proper amount, adding ethanol to enable the alcohol content to reach 60%, refrigerating, filtering, recovering ethanol from the filtrate, adding water, and refrigerating for later use; decocting fructus Gardeniae in water twice for 1 hr and 0.5 hr, mixing decoctions, filtering, concentrating the filtrate to appropriate amount, adding ethanol to make ethanol content reach 60%, refrigerating, filtering, recovering ethanol from the filtrate, adding water, and refrigerating; decocting flos Lonicerae with water twice, each for 0.5 hr, mixing decoctions, filtering, concentrating the filtrate to appropriate amount, adding ethanol to make ethanol content reach 75%, filtering, adjusting pH of the filtrate to 8.0, refrigerating, recovering ethanol, adding ethanol to make ethanol content reach 85%, refrigerating, filtering, recovering ethanol from the filtrate, adding water, and refrigerating for use; hydrolyzing cornu Bubali powder with barium hydroxide solution and Concha Margaritifera powder with sulfuric acid for 7-9 hr, filtering, mixing filtrates, adjusting pH to 3.5-4.0, filtering, adding ethanol to ethanol content of 60%, refrigerating, filtering, recovering ethanol from filtrate, adding water, and refrigerating; mixing fructus Gardeniae solution, radix Isatidis solution, cornu Bubali and Concha Margarit hydrolyzed mixture, adding into 75% ethanol solution of cholic acid and hyodeoxycholic acid, mixing, adding ethanol until ethanol content reaches 75%, adjusting pH to 7.0, refrigerating, filtering, recovering ethanol from filtrate, adding water, and refrigerating; dissolving baicalin in water for injection, adjusting the pH value to 7.5, adding honeysuckle extract, mixing uniformly, combining with the above standby solutions, mixing uniformly, and concentrating to a proper amount to obtain the active ingredient of the invention.
The isotonic agent is one of sodium chloride, potassium chloride, magnesium chloride, calcium chloride, glucose, xylitol, and sorbitol.
The buffer solution is one of citric acid-sodium citrate, citric acid-disodium hydrogen phosphate, potassium dihydrogen phosphate-disodium hydrogen phosphate, citric acid-sodium hydroxide, and citric acid-disodium hydrogen phosphate.
The pH of the aerosolized inhalation solution is from 3.0 to 8.5; preferably the pH is 4.0-7.0.
The dosage of the atomized inhalation solution is 0.1-0.8 times of the dosage of the qingkailing injection; the preferable dosage is 0.3-0.6 times of the dosage of QINGKAILING injection.
The qingkailing solution preparation for aerosol inhalation can be used for treating upper respiratory tract infection, viral cold, acute suppurative tonsillitis, acute pharyngitis, acute tracheitis and the like.
The invention has the advantages that the invention provides a new preparation form which is superior to qingkailing injection, the preparation is directly inhaled from the respiratory tract, is locally aggregated into higher concentration, directly acts on a receptor or a target receptor on the surface of the airway to play a role, can be directly absorbed from the mucous membrane of the airway and the lung, can directly deliver the effective components to the focus of infection by the administration mode, is safe and effective, has high bioavailability, can realize low dose and quick and effective treatment, and has obvious advantages.
The solution preparation prepared by the invention makes up the blank in the current domestic market, can avoid the potential safety hazard caused by the lack of special preparation medicines for inhalation therapy and the use of qingkailing injection for replacing the inhalation therapy. The solution preparation prepared by the invention is specially designed for patients for atomization and inhalation, is matched with an atomizer for use, is convenient and fast in use process, has different administration routes compared with qingkailing injection, reduces the dosage and improves the safety.
The beneficial effects of the present invention are further illustrated by the following test examples:
preparing 60 rat models of upper respiratory tract infection, randomly dividing the rat models into a normal control group, a positive control group, a drug group I, a drug group II, a drug group III and a drug group IV, wherein each group comprises 10 rats, and the normal control group is administered with the same amount of normal saline for intravenous injection; the positive control group is given intravenous injection of qingkailing injection; the first, second, third and fourth drug groups are respectively administered with QINGKAILING aerosol inhalation solution (the dosage is 0.1 times, 0.3 times, 0.6 times and 0.8 times of QINGKAILING injection respectively), and continuously administered for 3 days, and the cure rate, adverse reaction incidence rate and drug peak concentration in lung tissue and blood after the last administration of the drug are observed. In particular, see the following table:
table conditions after treatment of each group
Therefore, each drug group has better treatment effect on the upper respiratory tract infected rats, wherein the treatment effect of the drug groups II, III and IV is obviously better than that of the positive control group, and no adverse reaction occurs.
In conclusion, the medicine group has small dosage and less adverse reaction, the medicine is mainly gathered in the lung to form higher concentration, the medicine effect components can directly act on the focus, the bioavailability is high, and the low-dosage quick and effective treatment is realized, so the medicine has obvious advantages.
Similarly, the effect of the medicine group on treating viral cold, acute suppurative tonsillitis, acute pharyngitis, acute tracheitis and the like is also obviously better than that of qingkailing injection.
The therapeutic effect of the qingkailing aerosol inhalation solution is obviously better than that of qingkailing injection, the present invention fills the blank of qingkailing special aerosol inhalation solution in domestic market, compared with qingkailing injection, the dosage is greatly reduced, which is 0.1-0.8 times, preferably 0.3-0.6 times of that of qingkailing injection, and simultaneously the administration route is changed, and the occurrence of adverse reaction is reduced, therefore, the qingkailing aerosol inhalation solution has creative and prominent substantive characteristics and remarkable progress.
Detailed Description
The preparation process and the materials used in the preparation or the dosage of the materials used in the preparation in the following pharmaceutical preparation examples are not limited to the words, and all the preparation methods containing the pharmaceutical composition provided by the present invention are within the protection scope of the present invention.
Example 1
(1) Preparation of active ingredients:
10-20 parts of cholic acid, 50-300 parts of mother-of-pearl, 10-25 parts of hyodeoxycholic acid, 50-500 parts of cape jasmine fruit, 50-500 parts of buffalo horn, 500-2000 parts of radix isatidis, 5-50 parts of baicalin and 50-4000 parts of honeysuckle flower
Weighing eight medicines according to the weight parts, decocting the isatis root with water twice, each time for 1 hour, mixing decoctions, filtering, concentrating the filtrate to a proper amount, adding ethanol to enable the alcohol content to reach 60%, refrigerating, filtering, recovering ethanol from the filtrate, adding water, and refrigerating for later use; decocting fructus Gardeniae in water twice for 1 hr and 0.5 hr, mixing decoctions, filtering, concentrating the filtrate to appropriate amount, adding ethanol to make ethanol content reach 60%, refrigerating, filtering, recovering ethanol from the filtrate, adding water, and refrigerating; decocting flos Lonicerae with water twice, each for 0.5 hr, mixing decoctions, filtering, concentrating the filtrate to appropriate amount, adding ethanol to make ethanol content reach 75%, filtering, adjusting pH of the filtrate to 8.0, refrigerating, recovering ethanol, adding ethanol to make ethanol content reach 85%, refrigerating, filtering, recovering ethanol from the filtrate, adding water, and refrigerating for use; hydrolyzing cornu Bubali powder with barium hydroxide solution and Concha Margaritifera powder with sulfuric acid for 7-9 hr, filtering, mixing filtrates, adjusting pH to 3.5-4.0, filtering, adding ethanol to ethanol content of 60%, refrigerating, filtering, recovering ethanol from filtrate, adding water, and refrigerating; mixing fructus Gardeniae solution, radix Isatidis solution, cornu Bubali and Concha Margarit hydrolyzed mixture, adding into 75% ethanol solution of cholic acid and hyodeoxycholic acid, mixing, adding ethanol until ethanol content reaches 75%, adjusting pH to 7.0, refrigerating, filtering, recovering ethanol from filtrate, adding water, and refrigerating; dissolving baicalin in water for injection, adjusting the pH value to 7.5, adding honeysuckle extract, mixing uniformly, combining with the above standby solutions, mixing uniformly, and concentrating to a proper amount to obtain the active ingredient of the invention.
(2) Preparation of qingkailing solution for aerosol inhalation:
weighing the effective components according to the prescription amount, adding a proper amount of water for injection, and uniformly stirring to obtain a solution 1; adding appropriate amount of water for injection into sodium chloride and citric acid, and stirring to dissolve to obtain solution 2; mixing the solution 1 and the solution 2, and uniformly stirring to obtain a solution 3; and preparing a solution of 0.4mol/L by adding a proper amount of disodium hydrogen phosphate and a proper amount of water for injection, slowly adding the solution into the solution 3 while stirring, adjusting the pH value to 5.0-7.0, adding 1000ml of water for injection, filling and sealing to obtain the compound disodium hydrogen phosphate injection.
Example 2
(1) Preparation of active ingredients: the same as in example 1.
(2) Preparation of qingkailing solution for aerosol inhalation:
weighing the effective components according to the prescription amount, adding a proper amount of water for injection, and uniformly stirring to obtain a solution 1; taking sodium chloride, adding a proper amount of water for injection, and stirring to dissolve to obtain a solution 2; mixing the solution 1 and the solution 2, and uniformly stirring to obtain a solution 3; and preparing a solution of 0.4mol/L by adding a proper amount of disodium hydrogen phosphate and a proper amount of water for injection, slowly adding the solution into the solution 3 while stirring, adjusting the pH value to 4.0-7.0, adding 1000ml of water for injection, filling and sealing to obtain the compound disodium hydrogen phosphate injection.
Example 3
(1) Preparation of active ingredients: the same as in example 1.
(2) Preparation of qingkailing solution for aerosol inhalation:
weighing the effective components according to the prescription amount, adding a proper amount of water for injection, and uniformly stirring to obtain a solution 1; adding a proper amount of water for injection into magnesium chloride and citric acid, and stirring to dissolve to obtain a solution 2; mixing the solution 1 and the solution 2, and uniformly stirring to obtain a solution 3; and preparing a solution of 0.2mol/L by adding a proper amount of disodium hydrogen phosphate and a proper amount of water for injection, slowly adding the solution into the solution 3 while stirring, adjusting the pH value to 5.0-6.0, adding 1000ml of water for injection, filling and sealing to obtain the compound disodium hydrogen phosphate injection.
Example 4
(1) Preparation of active ingredients: the same as in example 1.
(2) Preparation of qingkailing solution for aerosol inhalation:
weighing the effective components according to the prescription amount, adding a proper amount of water for injection, and uniformly stirring to obtain a solution 1; adding appropriate amount of water for injection into calcium chloride and citric acid, and stirring to dissolve to obtain solution 2; mixing the solution 1 and the solution 2, and uniformly stirring to obtain a solution 3; and preparing a solution of 0.4mo1/L by adding a proper amount of disodium hydrogen phosphate and a proper amount of water for injection, slowly adding the solution into the solution 3 while stirring, adjusting the pH value to 5.0-6.5, adding 1000ml of water for injection, filling and sealing to obtain the compound disodium hydrogen phosphate injection.
Example 5
(1) Preparation of active ingredients: the same as in example 1.
(2) Preparation of qingkailing solution for aerosol inhalation:
weighing the effective components according to the prescription amount, adding a proper amount of water for injection, and uniformly stirring to obtain a solution 1; adding appropriate amount of water for injection into sodium chloride and citric acid, and stirring to dissolve to obtain solution 2; mixing the solution 1 and the solution 2, and uniformly stirring to obtain a solution 3; and preparing a solution of 0.4mol/L by adding an appropriate amount of water for injection into an appropriate amount of sodium citrate, slowly adding the solution into the solution 3 while stirring, adjusting the pH value to 6.0-7.0, adding 1000ml of water for injection, filling and sealing to obtain the sodium citrate injection.
Example 6
(1) Preparation of active ingredients: the same as in example 1.
(2) Preparation of qingkailing solution for aerosol inhalation:
weighing the effective components according to the prescription amount, adding a proper amount of water for injection, and uniformly stirring to obtain a solution 1; adding appropriate amount of water for injection into glucose and citric acid, and stirring to dissolve to obtain solution 2; mixing the solution 1 and the solution 2, and uniformly stirring to obtain a solution 3; and preparing a solution of 0.4mol/L by adding a proper amount of disodium hydrogen phosphate and a proper amount of water for injection, slowly adding the solution into the solution 3 while stirring, adjusting the pH value to 4.5-5.5, adding 1000ml of water for injection, filling and sealing to obtain the compound disodium hydrogen phosphate injection.
Example 7
(1) Preparation of active ingredients: the same as in example 1.
(2) Preparation of qingkailing solution for aerosol inhalation:
weighing the effective components according to the prescription amount, adding a proper amount of water for injection, and uniformly stirring to obtain a solution 1; adding appropriate amount of water for injection into xylitol and citric acid, and stirring to dissolve to obtain solution 2; mixing the solution 1 and the solution 2, and uniformly stirring to obtain a solution 3; and adding an appropriate amount of sodium hydroxide and an appropriate amount of water for injection to prepare a solution of 0.1mol/L, slowly adding into the solution 3 while stirring, adjusting the pH value to 3.0-5.0, adding 1000ml of water for injection, filling and sealing to obtain the product.
Example 8
(1) Preparation of active ingredients: the preparation method is the same as example 1.
(2) Preparation of qingkailing solution for aerosol inhalation:
weighing the effective components according to the prescription amount, adding a proper amount of water for injection, and uniformly stirring to obtain a solution 1; taking sodium chloride and potassium dihydrogen phosphate, adding a proper amount of water for injection, and stirring to dissolve to obtain a solution 2; mixing the solution 1 and the solution 2, and uniformly stirring to obtain a solution 3; and preparing a solution of 0.4mol/L by adding a proper amount of disodium hydrogen phosphate and a proper amount of water for injection, slowly adding the solution into the solution 3 while stirring, adjusting the pH value to 7.5-8.5, adding 1000ml of water for injection, filling and sealing to obtain the compound disodium hydrogen phosphate injection.
Example 9
(1) Preparation of active ingredients: the preparation method is the same as example 1.
(2) Preparation of qingkailing solution for aerosol inhalation:
weighing the effective components according to the prescription amount, adding a proper amount of water for injection, and uniformly stirring to obtain a solution 1; adding appropriate amount of water for injection into sorbitol and citric acid, and stirring to dissolve to obtain solution 2; mixing the solution 1 and the solution 2, and uniformly stirring to obtain a solution 3; and preparing a solution of 0.2mo1/L by adding a proper amount of disodium hydrogen phosphate and a proper amount of water for injection, slowly adding the solution into the solution 3 while stirring, adjusting the pH value to 5.0-6.0, adding 1000ml of water for injection, filling and sealing to obtain the compound disodium hydrogen phosphate injection.
Example 10
(1) Preparation of active ingredients: the preparation method is the same as example 1.
(2) Preparation of qingkailing solution for aerosol inhalation:
weighing the effective components according to the prescription amount, adding a proper amount of water for injection, and uniformly stirring to obtain a solution 1; adding appropriate amount of water for injection into sodium chloride and citric acid, and stirring to dissolve to obtain solution 2; mixing the solution 1 and the solution 2, and uniformly stirring to obtain a solution 3; and preparing a solution of 0.2mol/L by adding a proper amount of disodium hydrogen phosphate and a proper amount of water for injection, slowly adding the solution into the solution 3 while stirring, adjusting the pH value to 5.0-6.5, adding 1000ml of water for injection, filling and sealing to obtain the compound disodium hydrogen phosphate injection.
Example 11
(1) Preparation of active ingredients: the preparation method is the same as example 1.
(2) Preparation of qingkailing solution for aerosol inhalation:
weighing the effective components according to the prescription amount, adding a proper amount of water for injection, and uniformly stirring to obtain a solution 1; adding a proper amount of water for injection into magnesium chloride, and stirring to dissolve the magnesium chloride to obtain a solution 2; mixing the solution 1 and the solution 2, and uniformly stirring to obtain a solution 3; and preparing a solution of 0.4mol/L by adding a proper amount of disodium hydrogen phosphate and a proper amount of water for injection, slowly adding the solution into the solution 3 while stirring, adjusting the pH value to 6.5-8.5, adding 1000ml of water for injection, filling and sealing to obtain the compound disodium hydrogen phosphate injection.
Claims (2)
1. A solution formulation for the aerosol inhalation of qingkailing, wherein the formulation comprises:
the preparation method comprises the following steps: weighing the effective components according to the prescription amount, adding a proper amount of water for injection, and uniformly stirring to obtain a solution 1; adding appropriate amount of water for injection into sodium chloride and citric acid, and stirring to dissolve to obtain solution 2; mixing the solution 1 and the solution 2, and uniformly stirring to obtain a solution 3; adding appropriate amount of sodium citrate and appropriate amount of water for injection to obtain 0.4mol/L solution, stirring and slowly adding into solution 3, adjusting pH to 6.0-7.0, adding 1000ml of water for injection, bottling, and sealing to obtain the final product;
wherein, the preparation of the effective components: 10-20 parts of cholic acid, 50-300 parts of mother-of-pearl, 10-25 parts of hyodeoxycholic acid, 50-500 parts of cape jasmine, 50-500 parts of buffalo horn, 500-2000 parts of radix isatidis, 5-50 parts of baicalin and 50-4000 parts of honeysuckle; weighing eight medicines according to the weight parts, decocting the isatis root with water twice, each time for 1 hour, mixing decoctions, filtering, concentrating the filtrate to a proper amount, adding ethanol to enable the alcohol content to reach 60%, refrigerating, filtering, recovering ethanol from the filtrate, adding water, and refrigerating for later use; decocting fructus Gardeniae in water twice for 1 hr and 0.5 hr, mixing decoctions, filtering, concentrating the filtrate to appropriate amount, adding ethanol to make ethanol content reach 60%, refrigerating, filtering, recovering ethanol from the filtrate, adding water, and refrigerating; decocting flos Lonicerae with water twice, each for 0.5 hr, mixing decoctions, filtering, concentrating the filtrate to appropriate amount, adding ethanol to make ethanol content reach 75%, filtering, adjusting pH of the filtrate to 8.0, refrigerating, recovering ethanol, adding ethanol to make ethanol content reach 85%, refrigerating, filtering, recovering ethanol from the filtrate, adding water, and refrigerating for use; hydrolyzing cornu Bubali powder with barium hydroxide solution and Concha Margaritifera powder with sulfuric acid for 7-9 hr, filtering, mixing filtrates, adjusting pH to 3.5-4.0, filtering, adding ethanol to ethanol content of 60%, refrigerating, filtering, recovering ethanol from filtrate, adding water, and refrigerating; mixing fructus Gardeniae solution, radix Isatidis solution, cornu Bubali and Concha Margarit hydrolyzed mixture, adding into 75% ethanol solution of cholic acid and hyodeoxycholic acid, mixing, adding ethanol until ethanol content reaches 75%, adjusting pH to 7.0, refrigerating, filtering, recovering ethanol from filtrate, adding water, and refrigerating; dissolving baicalin in water for injection, adjusting pH to 7.5, adding flos Lonicerae extract, mixing with above solutions, mixing, and concentrating to appropriate amount to obtain effective components.
2. A solution formulation for the aerosol inhalation of qingkailing, wherein the formulation comprises:
weighing the effective components according to the prescription amount, adding a proper amount of water for injection, and uniformly stirring to obtain a solution 1; adding appropriate amount of water for injection into sodium chloride and citric acid, and stirring to dissolve to obtain solution 2; mixing the solution 1 and the solution 2, and uniformly stirring to obtain a solution 3; adding appropriate amount of disodium hydrogen phosphate into appropriate amount of water for injection to obtain 0.2mol/L solution, stirring, slowly adding into solution 3, adjusting pH to 5.0-6.5, adding 1000ml of water for injection, bottling, and sealing;
wherein, the preparation of the effective components: 10-20 parts of cholic acid, 50-300 parts of mother-of-pearl, 10-25 parts of hyodeoxycholic acid, 50-500 parts of cape jasmine fruit, 50-500 parts of buffalo horn, 500-2000 parts of radix isatidis, 5-50 parts of baicalin and 50-4000 parts of honeysuckle flower, wherein eight medicines are weighed according to the weight parts, the radix isatidis is decocted twice by adding water, each time lasts for 1 hour, decoction liquid is combined, filtered, the filtrate is concentrated to a proper amount, ethanol is added to ensure that the ethanol content reaches 60%, the mixture is refrigerated and filtered, the ethanol is recovered from the filtrate, and the water is added and refrigerated for later use; decocting fructus Gardeniae in water twice for 1 hr and 0.5 hr, mixing decoctions, filtering, concentrating the filtrate to appropriate amount, adding ethanol to make ethanol content reach 60%, refrigerating, filtering, recovering ethanol from the filtrate, adding water, and refrigerating; decocting flos Lonicerae with water twice, each for 0.5 hr, mixing decoctions, filtering, concentrating the filtrate to appropriate amount, adding ethanol to make ethanol content reach 75%, filtering, adjusting pH of the filtrate to 8.0, refrigerating, recovering ethanol, adding ethanol to make ethanol content reach 85%, refrigerating, filtering, recovering ethanol from the filtrate, adding water, and refrigerating for use; hydrolyzing cornu Bubali powder with barium hydroxide solution and Concha Margaritifera powder with sulfuric acid for 7-9 hr, filtering, mixing filtrates, adjusting pH to 3.5-4.0, filtering, adding ethanol to ethanol content of 60%, refrigerating, filtering, recovering ethanol from filtrate, adding water, and refrigerating; mixing fructus Gardeniae solution, radix Isatidis solution, cornu Bubali and Concha Margarit hydrolyzed mixture, adding into 75% ethanol solution of cholic acid and hyodeoxycholic acid, mixing, adding ethanol until ethanol content reaches 75%, adjusting pH to 7.0, refrigerating, filtering, recovering ethanol from filtrate, adding water, and refrigerating; dissolving baicalin in water for injection, adjusting pH to 7.5, adding flos Lonicerae extract, mixing with above solutions, mixing, and concentrating to appropriate amount to obtain effective components.
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| CN1631401A (en) * | 2003-12-23 | 2005-06-29 | 吴开敏 | Medicine for preventing and treating SARS |
| CN1781520A (en) * | 2005-08-29 | 2006-06-07 | 贵州益佰制药股份有限公司 | Method for preparing Qingkailing preparation |
| CN1830470A (en) * | 2005-03-11 | 2006-09-13 | 贵州益佰制药股份有限公司 | Aerosol and its preparation method |
| CN101327262A (en) * | 2007-12-07 | 2008-12-24 | 广州市医药工业研究所 | Qingkailing suppositorium |
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| CN1631401A (en) * | 2003-12-23 | 2005-06-29 | 吴开敏 | Medicine for preventing and treating SARS |
| CN1830470A (en) * | 2005-03-11 | 2006-09-13 | 贵州益佰制药股份有限公司 | Aerosol and its preparation method |
| CN1781520A (en) * | 2005-08-29 | 2006-06-07 | 贵州益佰制药股份有限公司 | Method for preparing Qingkailing preparation |
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