CN1519001A - External lotion of Chinese traditional medicine for treating inflammation in female reproductive system - Google Patents
External lotion of Chinese traditional medicine for treating inflammation in female reproductive system Download PDFInfo
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Abstract
An externally-applied Chinese medicine in the form of lotion for treating the inflammation of female reproductive system is prepared from 10 Chinese-medicinal materials including senecio, scutellaria root, cnidium fruit, stemona root, etc.
Description
Content of the present invention belongs to the pharmaceuticals technical field, relates to a kind of compound Chinese medicinal preparation that is used for the treatment of female genital disease and preparation method thereof.
The physiological structure characteristics determined of vagina its be very easy to be subjected to the infection of pathogen antibacterial, so that a lot of women suffer from female genital disease in various degree, as vulvitis, cervicitis, bacterial vaginosis and mycotic, infusorian property and nonspecific vaginitis etc., badly influence the healthy of numerous women crowds.At present, it is existing many that this area is used to prevent and treat the medicine of female genital disease, particularly some Chinese medicine preparations have also formed rather original curative effect advantage in clinical practice, but because the sickness rate height of female genital disease and pathomechanism are comparatively complicated, more existing pharmaceutical preparatioies still can not be satisfied clinical and needs market fully, still await scientific research institution and personnel and do further exploration to develop even more ideal new Chinese medicine.
The objective of the invention is at the existing problem of state of the art, by excavate motherland's Chinese medicine resource provide a kind of prescription science, preparation and easy to use, curative effect is high and the Chinese medicine external-use lotion that is exclusively used in the treatment female genital disease that human body is had no side effect.
The preparation scheme of Chinese medicine external-use lotion of the present invention is that the designer obtains by concentrated the summary to the diagnosis and treatment based on an overall analysis of the illness and the patient's condition thought of female genital disease and in long-term clinical application and on modern pharmacy experiment and clinical practice basis according to motherland's traditional medicine.Female genital disease belongs to traditional Chinese medical science pudendal pruritus, leukorrhagia category, and disease is seen the pudendal pruritus redness, burning sensation, and pain very then, profuse leukorrhea, yellow skin is smelly dirty, yellowish fur etc.The generation of pudendal pruritus, how because of dampness-heat of the liver or stagnation of liver-QI with deficiency of the spleen, fire-transformation is given birth to wet, and damp and hot heresy is followed through making a bet, and pents up external genitals.The damp and hot pudendum that injures of making a bet, the pain so pudendum portion scratches where it itches, or experience the heresy of damp and hot evil insect poison, worm disturbs pudendum and also can send out and be pudendal pruritus.Pruritus vulvae due to damp-heat pathogen flowing down to lower-JIAO must be to be annotated in the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels by damp and hot with the profuse leukorrhea person, and damage is appointed and is with two arteries and veins, and dai channel is failed to keep an appointment, due to conception vessel is solid, or because of worm disturbs in the moon, the pudendum damage, dirty liquid is dirty to be caused.The ruling by law of syndrome of dampness-heat diffusing downward, " the damp and hot medicinal routine treatment contrary treatment of Synopsis of Treating Women's Diseases opinion leukorrhagia different " early have and expresses: " spleen is injured and have wetly, wet and give birth to heat, and heat then circulates, and goes out also from urine so sliding turbid thing infiltrates bladder.Dan Xi wets, and the person who controls with the medicine of bitter cold, though ancients Ceng Youyong Xin Wenzhi's and person more, do not know bitter cold the medicine routine treatment method also, the method for hot using warming therapy medicine contrary treatment is also.Cover damp and hot looking angry strongly fragrant in interior, Fei Xinwen contrary treatment and can open diffusing.Right damp and hot not looking angry strongly fragrant, but end leucorrhea with red and white discharge, be not ought be also as if what use the bitter cold routine treatment." the clear "Fu Qingzhu works on obstetric" of the famous Fu Shan of doctor family just of the Ming Dynasty thinks: " leucorrhea is due to the stagnation of liver-QI with deficiency of the spleen, controls and answers the liver soothing and the spleen invigorating; Leukorrhagia with greenish discharge is due to the dampness-heat of the liver, controls to let out liver-heat clearly the sharp bladder of holding concurrently; Fulminant leucorrhagia with yellowish discharge is the also damp and hot of conception vessel, and method should be mended the void of conception vessel, and the inflammation of clear kidney fire; Leucorrhea with bloody discharge is because the Liver Channel stagnated fire, walks spleen soil down, and cause damp and hot gas with blood all down due to, method of treatment must clearing away liver-fire and hold up temper." so pudendal pruritus, the leukorrhagia of treatment damp invasion of lower energizer, when being method with heat clearing and damp drying, killing parasites for relieving itching, removing heat from blood and promoting blood circulation.Comprehensive above-mentioned etiology and pathology analysis, designer of the present invention chooses some drug effects and concentrates and be easy to the raw material of Chinese medicine side of combining for absorption of human body, and make it and the solvent of certain ratio amount is mixed and made into the compound recipe lotion, the drug moiety of this lotion is by comprising Herba Senecionis Scandentis, Radix Scutellariae, Fructus Cnidii, the Radix Stemonae, Radix Sophorae Flavescentis, Flos Chrysanthemi Indici, Cortex Phellodendri, Flos Celosiae Cristatae, Radix Arnebiae (Radix Lithospermi), Borneolum Syntheticum is formed at ten interior herbal medicines and an amount of tween 80 and sorbic acid as the anticorrosive additive composition, full side has heat clearing and damp drying, killing parasites for relieving itching, the effect of reducing swelling and alleviating pain, aspect the treatment of female genital disease and prevention, all having fabulous effect, can significantly reduce or eliminate of the threat of this type of disease to vast WomanHealth.
Each the raw material of substance component and the weight percent proportioning value thereof that constitute Chinese medicine external-use lotion Chinese medicine composition of the present invention are:
Herba Senecionis Scandentis 5%～20%; Radix Scutellariae 5%～20%;
Fructus Cnidii 5%～10%; The Radix Stemonae 4%～14%;
Radix Sophorae Flavescentis 4%～14%; Flos Chrysanthemi Indici 4%～14%;
Cortex Phellodendri 4%～14%; Flos Celosiae Cristatae 6%～16%;
Radix Arnebiae (Radix Lithospermi) 4%～13%; Borneolum Syntheticum 0.2%～0.4%;
Tween 80 1%～3%; Sorbic acid 0.1%～0.5%;
The raw material of substance that constitutes solvent composition in this lotion is a water.In the actual fabrication, medicine and solvent are in 0.3～1.5: 1 ratio preparation.
The lotion of making according to above-mentioned raw materials has demonstrated fully motherland's traditional medicine about diagnosis and treatment based on an overall analysis of the illness and the patient's condition thoughts such as " treatment must aim at the pathogenesis of disease ", " treating both the principal and secondary aspects of a disease ".Herba Senecionis Scandentis bitter but sweet flavor in the side, cold in nature, merit is apt to heat-clearing and toxic substances removing, killing parasites for relieving itching, it is the key medicine of controlling various acute inflammatory diseases, bacillary dysentery, toxemia, carbuncle furuncle poison, dried exudative dermatitis skin ulcer, eczema, trichomonal vaginitis, supplement to the Herbal is called its " main pestilential pathogen ... diseases due to noxious agents produced by various parasites ... also smash and apply the skin ulcer place ", " Guizhou medical herbs " day its can " heat-clearing and toxic substances removing, expelling wind and removing dampness ", " Sichuan Chinese medicinal herbal " also calls it can " killing parasites for relieving itching be controlled scrofula and all itchy skin eruptions (washout) "; The Radix Scutellariae bitter in the mouth, cold in nature, return stomach, lung, gallbladder, large intestine channel, the function heat clearing and damp drying, eliminating fire and detoxication, removing heat from blood, " property of medicine opinion " calls it " it is unfavorable to control pyretic toxicity, hectic fever due to YIN-deficiency, alternate attack of chill and fever, the intestines and stomach, and the broken gas of stopping up is controlled five types of stranguria; it is smooth to make us a surname; go the joint unhappiness, analgesic thirsty, control dirty pain in the hot abdomen, the trusted subordinate is hard expands ", also put down in writing in " traditional herbal medicine of science " with Radix Scutellariae " the washout wound has antisepsis ".The two share Herba Senecionis Scandentis and Radix Scutellariae, and the clearing away heat-damp and expelling toxic material parasite killing clearly, wet goes heat, pudendal pruritus is ended, foul leukorrhea disappears, and the purpose of Da Zhiben, so be monarch drug altogether.Fructus Cnidii acrid in the mouth hardship, warm in nature, go into kidney, spleen channel, can dispel the wind, dampness, parasite killing, be used for the arthralgia chiefly caused by damp pathogen leukorrhagia, external treatment vulval eczema, married woman's pudendal pruritus, trichomonal vaginitis, " Japan hanako materia medica " claim its can " control cold cruelly ... help the cloudy gas of woman, mend and decrease blood stasis; waist hip pain; polyhidrosis around the external genitals exudative dermatitis, leucorrhea with bloody discharge in vain down, urine reducing "; Radix Stemonae sweet-bitter flavor, slightly warm in nature is gone into lung meridian, cures mainly function and is gentle lung qi, cough-relieving, parasite killing; The Radix Sophorae Flavescentis bitter in the mouth, cold in nature, go into liver, kidney, large intestine, small intestine meridian, but heat clearing away, dampness, parasite killing; Flos Chrysanthemi Indici acrid in the mouth hardship, cool in nature, go into lung, Liver Channel, have wind and heat dispersing, subduing swelling and detoxicating effect, " book on Chinese herbal medicine converge with speech) " calls it " removing blood stasis is soothing the liver, separate the furuncle poison that looses, stagnated blood in housewife people's abdomen, the red furuncle of the capable fire-toxin of Xie Tian is washed the skin ulcer scabies, can remove the wind parasite killing again ".More than four flavors, the Fructus Cnidii warming the kidney to activate YANG, the gentle lung qi of the Radix Stemonae, Radix Sophorae Flavescentis heat clearing and damp drying parasite killing, the Flos Chrysanthemi Indici wind and heat dispersing, four mutual reinforcements between are usefulness, the merit of its heat clearing and damp drying is more excellent, auxilliary altogether monarch drug is to strengthen the power of its removing damp-heat, detoxifcation parasite killing, so it is ministerial drug in square altogether.But Cortex Phellodendri heat clearing away, dampness, pathogenic fire purging, detoxifcation, Flos Celosiae Cristatae is apt to removing heat from blood, hemostasis, Radix Arnebiae (Radix Lithospermi) except that removing heat from blood, invigorate blood circulation, holding concurrently can heat clearing away, detoxifcation, this three herbal medicine and monarch, ministerial drug mutually 5, assistant helps its performance drug action, be altogether square in adjuvant drug.Borneolum Syntheticum leads to all keys, the stagnated fire of loosing, and removing nebula makes eye bright, and reducing swelling and alleviating pain makes as Fang Zhongzuo, and the justice of inducting the medicines into affected channel is arranged.More than all medicines associate with, cool and do not hold back, pungent drugs can disperse and bitter drugs can descend is also executed, folding is orderly, plays the merit of heat clearing and damp drying, killing parasites for relieving itching, removing heat from blood and promoting blood circulation, reducing swelling and alleviating pain altogether, examines because of opinion to control, method is upright with disease, Fang Congfa goes out, and certificate cube is arranged.
Chinese medicine external-use lotion of the present invention can obtain by following preparation process: the Herba Senecionis Scandentis in the group component, Fructus Cnidii, Flos Chrysanthemi Indici were added 10～12 times of water logging bubbles after 3 hours, and distillation extraction 3 hours is collected distillate, and the aqueous solution after distillation device is in addition collected; With the Radix Scutellariae boiled water in the group component
After 10 minutes, filter, aqueous solution device is in addition collected, Radix Scutellariae is mixed with the Radix Stemonae, Radix Sophorae Flavescentis, Cortex Phellodendri, Flos Celosiae Cristatae, Radix Arnebiae (Radix Lithospermi) in the group component, decoct with water secondary, the water logging bubble that adds 6～8 times of amounts of mixture for the first time decocted 1.5 hours after 2 hours, medicinal residues after the distillation are added mixing, and the decocting that adds 5～6 times of amounts of mixture boiled 1 hour; Aqueous solution after collecting decoction, the distillation reaches
Aqueous solution behind the Radix Scutellariae filters, and filtrate is concentrated into relative density 1.05～1.10 (40 ℃), adds ethanol, makes to contain the alcohol amount and reach 70%, leaves standstill 24～48 hours, filters, and reclaims ethanol; Add sorbic acid in the filtrate, get medicinal liquid I, place standby; The Borneolum Syntheticum of getting in the group component adds 95% dissolve with ethanol, and adds tween 80 and be uniformly dispersed, and gets distillate and adds the abundant dispersed with stirring of tween 80 and evenly add mixing in the Borneolum Syntheticum alcoholic solution in the back, get medicinal liquid II: medicinal liquid I is slowly added among the medicinal liquid II, and adding distil water filters, embedding promptly gets product.
In actual the use; get this product and be diluted to 10% (being that this product 10ml heats boiled water to the 100m1 mixing) in right amount, clean patient's pudendum, and the medicinal liquid after will diluting by irrigator is delivered to patient's vagina deep washing vagina; every day 1～2 time, seven days is a course of treatment with the medicinal liquid after the dilution.Or but demibain is used.
In development process of the present invention, according to the effect of medicament composing prescription with cure mainly, according to the principle and the method for " study of tcm new drug guide ", the designer has carried out antibiotic, antifungal, anti-trichomonal vaginitis, antiinflammatory, analgesia to this Chinese medicine external-use lotion and has cured mainly relevant pharmacodynamics test research with antipruritic etc. with function.Result of study shows that this Chinese medicine external-use lotion is external to be had than obvious suppression and deactivation common bacteria colon bacillus, staphylococcus aureus, Pseudomonas aeruginosa, staphylococcus epidermidis, proteus vulgaris, streptococcus faecalis, gonococcus, the vagina Gartner bacterium that causes vaginal infection; External also have certain inhibition and deactivation to common fungus Candida albicans, Candida parapsilosis, monilia guilliermondii, candida parakrusei, Oidium tropicale, penicillium, the Aspergillus flavus that causes colpitis mycotica; External and can kill trichomonal vaginitis effectively.In addition, press 1.84g crude drug/kg, 3.68g crude drug/kg, 7.36g crude drug/kg to the administration of mice partial smearing, can suppress the acute exudative inflammation reaction that dimethylbenzene stimulates mice ear to bring out with this Chinese medicine external-use lotion; Press 1.43g crude drug/kg, 2.946g crude drug/kg, 5.892g crude drug/kg to the administration of rat partial smearing, can suppress the rat acute inflammatory reaction that Ovum Gallus domesticus album brings out; Press 3.68g crude drug/kg, 7.36g crude drug/kg, 14.73g crude drug/kg to the mouse stomach administration, can suppress the mouse writhing reaction that acetic acid stimulates, improve the mice threshold of pain that thermostimulation causes, obviously reduce the mouse skin pruritus number of times that dextran brings out, reduce the persistent period of skin pruritus.Above result also further specifies Chinese medicine external-use lotion of the present invention and has antibiotic significantly, antifungal, a heatable brick bed trichomonal vaginitis, antiinflammatory, analgesia and itching-relieving action.When doing pharmacodynamics test, the designer is also according to the specification requirement of new Chinese medicine toxicologic study, experimental study this Chinese medicine external-use lotion to the acute toxicity of mouse stomach administration with to the long term toxicity of rat.The result shows, to after the mouse stomach administration, does not find obvious acute toxic reaction; Give the continuous vaginal mucosa topical of female rats one month with high and low two dosage of this lotion (be equivalent to respectively be grown up consumption 40 times and 20 times), the general situation of rat, hematology, blood biochemical, routine urinalysis, electrocardiogram, system's dissection, organ coefficient and histopathology all do not have obvious influence, do not find toxic reaction, convalescent period does not also have the retardance toxic reaction.In addition, the designer is also once according to the specification requirement of the local drug safety experimental study of Chinese medicine, repeatedly use this lotion to rabbit normal and damaged skin and vagina topical, and Cavia porcellus cooked the percutaneous drug delivery test, the result shows, this lotion does not have sensitization to rabbit skin and vagina nonirritant to guinea pig skin.
Claims (2)
1, a kind of Chinese medicine external-use lotion that is used for the treatment of female genital disease, it is characterized in that it by medicine and solvent in 0.3～1.5: 1 ratio is formulated, and each the raw material of substance component and the weight percent proportioning value thereof that constitute described medicine are:
Herba Senecionis Scandentis 5%～20%; Radix Scutellariae 5%～20%;
Fructus Cnidii 5%～10%; The Radix Stemonae 4%～14%;
Radix Sophorae Flavescentis 4%～14%; Flos Chrysanthemi Indici 4%～14%;
Cortex Phellodendri 4%～14%; Flos Celosiae Cristatae 6%～16%;
Radix Arnebiae (Radix Lithospermi) 4%～13%; Borneolum Syntheticum 0.2%～0.4%;
Tween 80 1%～3%: sorbic acid 0.1%～0.5%;
The raw material of substance that constitutes described solvent is a water.
2, be exclusively used in the method for preparing the described Chinese medicine external-use lotion of claim 1, it is characterized in that the Herba Senecionis Scandentis in the group component, Fructus Cnidii, Flos Chrysanthemi Indici were added 10～12 times of water logging bubbles after 3 hours, distillation extraction 3 hours is collected distillate, and the aqueous solution after distillation device is in addition collected; With the Radix Scutellariae boiled water in the group component
After 10 minutes, filter, aqueous solution device is in addition collected, Radix Scutellariae is mixed with the Radix Stemonae, Radix Sophorae Flavescentis, Cortex Phellodendri, Flos Celosiae Cristatae, Radix Arnebiae (Radix Lithospermi) in the group component, decoct with water secondary, the water logging bubble that adds 6～8 times of amounts of mixture for the first time decocted 1.5 hours after 2 hours, medicinal residues after the distillation are added mixing, and the decocting that adds 5～6 times of amounts of mixture boiled 1 hour; Aqueous solution after collecting decoction, the distillation reaches
Aqueous solution behind the Radix Scutellariae filters, and filtrate is concentrated into relative density 1.05～1.10 (40 ℃), adds ethanol, makes to contain the alcohol amount and reach 70%, leaves standstill 24～48 hours, filters, and reclaims ethanol; Add sorbic acid in the filtrate, get medicinal liquid I, place standby; The Borneolum Syntheticum of getting in the group component adds 95% dissolve with ethanol, and adds tween 80 and be uniformly dispersed, get distillate and add the abundant dispersed with stirring of tween 80 and evenly add mixing in the Borneolum Syntheticum alcoholic solution in the back, medicinal liquid II; Medicinal liquid I is slowly added among the medicinal liquid II, and adding distil water filters, and embedding promptly gets product.
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| CN1319582C (en) * | 2005-02-23 | 2007-06-06 | 黄德忠 | Chinese medicine solution agent for treating damp-heat disease and its preparing method |
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| CN102743613A (en) * | 2012-06-17 | 2012-10-24 | 李莉 | Preparation method of Chinese medicine irrigation solution for treating stomach-yin deficiency type senile vaginitis |
| CN102743612A (en) * | 2012-06-17 | 2012-10-24 | 马红 | Preparation method of Chinese medicine irrigation solution for treating bean curd broken bits type mycotic vaginitis |
| CN102743561A (en) * | 2012-06-17 | 2012-10-24 | 高业武 | Preparation method of Chinese medicine irrigation solution for treating alcoholism type mycotic vaginitis |
| CN102743649A (en) * | 2012-06-17 | 2012-10-24 | 樊桂英 | Preparation method of Chinese medicine irrigation solution for treating vagina pus type mycotic vaginitis |
| CN102743612B (en) * | 2012-06-17 | 2013-12-11 | 姚丽娟 | Preparation method of Chinese medicine irrigation solution for treating bean curd broken bits type mycotic vaginitis |
| CN102743719A (en) * | 2012-06-17 | 2012-10-24 | 马红 | Preparation method of Chinese medicine irrigation solution for treating splenogastric qi-insufficiency type senile vaginitis |
| CN104027456A (en) * | 2014-06-24 | 2014-09-10 | 贵州遵义华源医药保健品有限公司 | External-use drug for department of andrology and gynecology and preparation method of drug |
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