CN1518441A - 具有快速释放性质的吸入式微粒 - Google Patents

具有快速释放性质的吸入式微粒 Download PDF

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Publication number
CN1518441A
CN1518441A CNA028125665A CN02812566A CN1518441A CN 1518441 A CN1518441 A CN 1518441A CN A028125665 A CNA028125665 A CN A028125665A CN 02812566 A CN02812566 A CN 02812566A CN 1518441 A CN1518441 A CN 1518441A
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China
Prior art keywords
microparticles
insulin
weight
dppc
sodium citrate
Prior art date
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Pending
Application number
CNA028125665A
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English (en)
Chinese (zh)
Inventor
ղ�ݸ���L��ʩ���ؿ�
詹妮弗·L·施米特克
P����̩
陈东浩
A���»���
理查德·P·巴泰基
��S���տ���
戴维·A·爱德华兹
杰弗里·S·赫凯奇
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Advanced Inhalation Research Inc
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Advanced Inhalation Research Inc
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Application filed by Advanced Inhalation Research Inc filed Critical Advanced Inhalation Research Inc
Publication of CN1518441A publication Critical patent/CN1518441A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
    • A61K47/544—Phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Biophysics (AREA)
  • Endocrinology (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Otolaryngology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Charge And Discharge Circuits For Batteries Or The Like (AREA)
  • Electric Propulsion And Braking For Vehicles (AREA)
CNA028125665A 2001-06-22 2002-06-24 具有快速释放性质的吸入式微粒 Pending CN1518441A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/888,126 US20020141946A1 (en) 2000-12-29 2001-06-22 Particles for inhalation having rapid release properties
US09/888,126 2001-06-22

Publications (1)

Publication Number Publication Date
CN1518441A true CN1518441A (zh) 2004-08-04

Family

ID=25392579

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA028125665A Pending CN1518441A (zh) 2001-06-22 2002-06-24 具有快速释放性质的吸入式微粒

Country Status (10)

Country Link
US (3) US20020141946A1 (https=)
EP (1) EP1404299A2 (https=)
JP (1) JP4067047B2 (https=)
CN (1) CN1518441A (https=)
CA (1) CA2449439A1 (https=)
IL (1) IL158987A0 (https=)
MX (1) MXPA03011861A (https=)
NZ (1) NZ530123A (https=)
PL (1) PL367399A1 (https=)
WO (1) WO2003000202A2 (https=)

Cited By (3)

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CN107041949A (zh) * 2008-08-15 2017-08-15 阿索尔达治疗公司 在cns神经性损伤后非‑急性期间处理的组合物及方法
CN107596518A (zh) * 2012-02-29 2018-01-19 普马特里克斯营业公司 可吸入干粉剂
CN108434126A (zh) * 2009-03-26 2018-08-24 普马特里克斯营业公司 治疗肺病的干粉配方与方法

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US20020141946A1 (en) 2002-10-03
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CA2449439A1 (en) 2003-01-03
US20100026235A1 (en) 2010-02-04
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