CN1506076A - Externally appied medicine for relieving pain and diminishing inflammation - Google Patents
Externally appied medicine for relieving pain and diminishing inflammation Download PDFInfo
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- Medicines Containing Plant Substances (AREA)
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Abstract
The externally applied medicine for relieving pain and diminishing inflammation is prepared with seven kinds of Chinese medicinal materials including wild aconite, arisaema tuber, safflower, acuteangular anisodus, gromwell, benzoin and remote lemongrass herb. It has the functions of promoting blood circulation to disperse blood clots, dredging meridian passage and stopping pain and can resist 18 kinds of bacteria, so that it has obvious curative effect on sprain, traumatic injury, pain joint, muscle and aponeurosis, etc.
Description
Technical field
The present invention relates to a kind of externally appied medicine for relieving pain and diminishing inflammation---day aromatin tincture, it is a kind of compound preparation made from the pure natural Chinese herbal medicine.
Background technology
Pain is human the most direct inherent disease.In life during the journey, pain is followed people at one's side all the time, and it is general, the most direct factor that causes spasm and forfeiture work, viability, more torments the people sometimes even than death, more makes us frightened.Along with the continuous quickening of modern life rhythm, many occupation disease are also followed, as cervical spondylosis, and psoas muscle, vertebral aponeurosis disease etc., therefore, how to remove pain for a long time is the important topic that medical circle is paid close attention to the most always.Since ancient times, people's alleviating pain has: the comparatively primary method of comforting mould, pushing, rubbing the wiping painful area, also useful Chinese herbal medicine or ointment are rubbed wiping, are sticked the method for painful area, also useful acupuncture or various therapeutic instrument carry out the analgesic method to painful area, but its curative effect and use are all unsatisfactory, therefore, be necessary to develop and develop various analgesic drug product.
Summary of the invention
The object of the present invention is to provide a kind of easy to use, safe, good analgesic effect, strong adhesion, can effectively lubricating the externally appied medicine for relieving pain and diminishing inflammation of skin.
Medicine provided by the invention is made by the raw material of following weight portion:
Radix Aconiti Kusnezoffii 100-160 part Rhizoma Arisaematis 40-90 part
Flos Carthami 40-80 part Radix Anisodi Acutanguli 30-70 part
10 50 parts of Radix Arnebiae (Radix Lithospermi) 20-50 part Benzoinumes
Herba Cymbopogonis 10-20 part.
Radix Aconiti Kusnezoffii is the dried root of cohosh Aconitum kusnezoffii Reichb (Aconitum Kusnezoffli Reichb) in the side, and is hot, bitter, hot, very toxic, GUIXIN, liver,kidney,spleen warp, expelling wind and removing dampness, antalgic is used for anemofrigid-damp arthralgia, arthralgia has the narcotic analgesic effect, so be monarch drug.Radix Anisodi Acutanguli is the dry root of plant of Solanaceae Radix Anisodi Acutanguli (Anisodusa acntangulus CYWuetc Chen), and is poisonous, hot, bitter, warm in nature, and the merit of relieving spasm to stop pain is arranged, and can be used for rheumatalgia, with the merit of principal drug assistance, is ministerial drug.Rhizoma Arisaematis is that (bitter, suffering, warm, poisonous is returned lung, liver, spleen channel to the aroid Rhizoma Arisaematis, is drying dampness to eliminate phlegm for Arisacmacrubescens (Wall), dry tuber Schott), expellings wind and relieving convulsion, and the product of mass dissipating and swelling eliminating can be used for outer grieved swollen; Flos Carthami is the dried floral of feverfew Flos Carthami (Carthamus tinctoriusL), Xin Wen, and GUIXIN, Liver Channel have promoting blood circulation to restore menstrual flow, and the merit of eliminating stasis to stop pain can be used for skin infection and swells and ache, the adjuvant drug in both sides of being all.Radix Arnebiae (Radix Lithospermi) is the dry root of comfrey (Arnebiaeuchroma (Royle) Johnest), sweet, salty, cold, GUIXIN, Liver Channel, removing heat from blood is arranged, invigorate blood circulation, the merit of detoxifcation rash, being used for the heat in blood poison contains, skin infection, warm rash, burn due to hot liquid or fire: Benzoinum is the dry resin of Styracaceae plant styrax tonkinensis Craib ex Hart (StyraxtonKinensis (Pierre) CraibexHart), hot, bitter, flat, GUIXIN, spleen channel, can have one's ideas straightened out, clear refreshing, circulation of qi promoting, invigorate blood circulation, pain relieving, and can be in harmonious proportion medicine fragrance, Herba Cymbopogonis is the herb of grass Herba Cymbopogonis (Cymboppgpndistans (Nees) A.Camus), merit with expelling pathogen from the exterior and eliminating dampness by diuresis, but dispelling the wind and dampness pathogens muscles and bones ache, they are messenger drug altogether.
The present invention has following advantage and effect: all medicines in full side share, play the merit of blood circulation promoting and blood stasis dispelling, collateral dredging, analgesia altogether, the part is sprained, and all positions pain such as traumatic injury and joint, muscle, fascia have significant curative effect, local topical, the efficacy of a drug is through, the present invention all has certain antibacterial action to 18 kinds of antibacterials such as streptococcus, streptococcus pneumoniae, staphylococcus aureuses, also has skin moistening, saturating skin simultaneously, absorbs fast, effects such as treating both the principal and secondary aspects of a disease also have curative effect preferably to skin diseases simultaneously.
The following pharmacodynamics test of the present invention's process:
The experiment material
1, medicine and reagent
Tincture of vanilla spray provided by the invention: 3.8g crude drug/ml, containing the alcohol amount is 40%.
The YUNNAN BAIYAO spray: Yunnan Paiyao Group Corp., Ltd produces, lot number 990703.Positive control drug.
Carrageenin: U.S. SIGMA company produces, lot number: 127H1227.
Dimethylbenzene: lot number 880610.Glacial acetic acid, analytical pure, lot number 950303-1.
2, animal: the Wistar rat, 1 grade, male, body weight 150-200 gram.Kunming mouse, 1 grade.
3, instrument: electronic balance, Mus foot volume determination device, pharmacology, Physiological Experiment are used instrument more, thermostatic electric heater, card punch, electronic stopclock, thermometer etc.
Method and result
1, the inhibitory action of on Carrageenan pedal swelling
Get 40 of qualified male Wistar rats, be divided into 4 groups at random, be matched group (40% ethanol), YUNNAN BAIYAO spray group, the present invention's tincture of vanilla spray height, low two dosage groups, normal breeding observing 1 day, carried out preventive administration 2 days by wiping outside group is below the right back ankle of rat joint, YUNNAN BAIYAO spray group and tincture of vanilla spray low dose group are all to former dosage form, tincture of vanilla spray high dose group gives with concentrating 3 times in the former dosage form water-bath, the administration volume only is 0.2ml/, cause scorching preceding elder generation and measure the right back sufficient sole of the foot normal volume of each Mus with Mus foot volume determination device, outer again wiping of experiment each group on the same day is administered once, cause inflammation (0.1ml/ only) with 1% carrageenin in the right back sufficient plantar subcutaneous injection of each Mus after 1 hour, cause the outer again wiping administration of each treated animal of scorching back 1 time, measure the right back sufficient sole of the foot volume of 6 time periods with Mus foot volume determination device respectively, causing scorching front and back volume difference is the swelling degree, and calculates swelling rate and suppression ratio.It the results are shown in Table 1.Result of the test shows that tincture of vanilla spray high and low dose group all has the obvious suppression effect to the rat carrageenan pedal swelling in 5 time periods of 1-5h, and the suppression ratio of two dosage groups is close.
2, the influence of xylol induced mice auricle edema
Get 40 of qualified male mouse of kunming, body weight 28-32 gram, normal breeding observing 1 day, be divided into 4 groups at random, every group 10, be matched group (40% ethanol), YUNNAN BAIYAO spray group, the present invention's tincture of vanilla spray high dose (114%) group, low dosage (38%) group delivers medicine to mouse right ear two sides (0.1ml/ only) with evenly outer wiping of disinfecting cotton swab respectively by group, use clear water flush away medicine after 1 hour, clean with dry cotton ball, fully contact with each Mus auris dextra two sides of the outer wiping of 100% dimethylbenzene (0.05ml/ only) and cause inflammation, take off cervical vertebra after 15 minutes and put to death animal, two ears about taking off, with diameter 8mm card punch each Mus two ear is downcut with the position homalographic, use scales/electronic balance weighing, heavily deducting left ear method of double differences value with auris dextra is the swelling value, calculating causes scorching auricle weightening finish percentage rate M and suppression ratio I, the results are shown in Table 2.Result of the test shows that two dosage groups of tincture of vanilla external xylol induced mice auricle edema all has obvious inhibitory action, and less than 0.01, difference all has highly significant through statistical procedures P.
3, analgesic test (hot plate method)
Get the Healthy female Kunming mouse, normal breeding observing 3 days is regulated 0.5 ℃ of thermostatic electric heater to 55, measures each Mus pain threshold (licking the sufficient time), and is all less than 5 seconds or all give it up greater than 30 seconds persons.Screen 40 of qualified Mus, be divided into 4 groups at random, be i.e. matched group (40% ethanol), YUNNAN BAIYAO spray group, high and low two the dosage groups of the present invention's tincture of vanilla spray.Each is organized mice and measure twice of pain threshold respectively before medication, each 1 hour at interval, to twice pain threshold average is the preceding threshold of pain of administration (S), wipe the mice four-footed outward with the preparation of YUNNAN BAIYAO spray group and high and low two concentration of tincture of vanilla spray respectively by group after 1 hour, every sufficient 0.1ml, outer 40% ethanol of wiping of matched group, flush away medicinal liquid after 15 minutes, measure the pain threshold of 15 minutes, 30 minutes, 60 minute 3 time periods after the administration respectively, on the same group behind the medicine prodrug pain threshold do t check and compare, the results are shown in Table 3.Result of the test shows, after the YUNNAN BAIYAO spray is wiped administration outward, pain threshold before the pain threshold of 15 minutes, 30 minutes, 60 minute each time period is obviously greater than medicine, than t check P less than 0.01, significant difference is all arranged, illustrate that the outer wiping of two medicines all has significant analgesia role.
4, analgesic test (writhing method)
Get 40 of qualified Kunming mouses, male and female half and half, body weight 18-22 gram, normal breeding observing 1 day, be divided into 4 groups at random, be matched group (40% ethanol), YUNNAN BAIYAO spray group (former dosage form), the present invention's tincture of vanilla spray high dose (114%) group, low dosage (38%) group, with the animal abdominal part with the hand shears unhairing after, by the preventative respectively outer administration (0.2ml/ is only) 3 days of wiping of above-mentioned group, administration 1 time again in the 4th day, the glacial acetic acid of each Mus lumbar injection 05% after 30 minutes (0.2ml/ only), immediately in the observed and recorded 30 minutes each Mus turn round the body number of times, the results are shown in Table 4.Result of the test shows that high and low two the dosage groups of tincture of vanilla spray because of the writhing response that glacial acetic acid causes all has obvious inhibitory action, illustrate that the present invention has significant analgesia role to mice.
The following clinical trial of the present invention's process:
1, physical data
Case 326 examples, wherein male 181 examples, women 145 examples, the oldest person 78 years old, reckling 13 years old, 40-65 year accounts for 73.2%, and average 46 years old, the course of disease was the shortest 3 days, and is the longest 2 years, and a 6-24 month person accounts for 69.53%, average 12 months.
2, diagnostic criteria
The main foundation of diagnostic criteria and classification, medical history, clinical sign.Imaging examination results such as CT, the diagnosis typing standard of cervical spondylosis is by the cervical spondylosis diagnostic criteria typing of State Administration of Traditional Chinese Medicine's issue in 1994.
3, Therapeutic Method
The one, the tincture of vanilla external application for curing, all the patient is coated with soaking the medicine wet tissue after adopting tincture of vanilla to embrocate, and changes dressings every day once, and 7 days is a course of treatment.
The 2nd, manipulation, the patient accepts massage treatment before coated tincture of vanilla, play the composite treatment that medicine, acupuncture point and meridians effect combine.
4, therapeutic outcome
Criterion of therapeutical effect is according to " the disease of tcm diagnosis criterion of therapeutical effect " of State Administration of Traditional Chinese Medicine's issue in 1994.
Cure: original various disease disappears, and muscular strength is normal, neck, limb functional recover are normal, can participate in and normally work and work.。
Take a turn for the better: original various sx, neck, shoulder, back pain alleviate, and the neck limb function improves.
Do not heal: symptom does not have improvement.
The result: this group treatment time is the shortest 7 days, the longest 69 days.Cure 298 examples, 28 examples that take a turn for the better see table 5 for details.
Discuss: the drug penetration of tincture of vanilla is strong, produces the heat effect effect during drug osmotic gradually, through the fur acupuncture points on the human body, from outward appearance to inner essence be penetrated into muscle, ligament, skeleton be with the mediation space between skin and muscles, open hair key and reach to vent one's spleen and invigorate blood circulation, relaxing muscles and tendons and activating QI and blood in the collateral, dispelling cold by warming the meridian, microcirculation improvement and local nutritional status.And medicine has the heat effect that heat-clearing and toxic substances removing and medicine produce, and microorganism has the inhibition deactivation to source of disease, energy antiinflammatory, analgesia can be " the acupuncture point effect of thing medicine ", and have dosage little, characteristics such as curative effect is rapid, remarkable are a kind of effective external used medicines for the treatment of acute and chronic disease.
The specific embodiment
Embodiment 1
Get raw material by following proportioning, and make acceptable external application preparation with processing method of the prior art:
Radix Aconiti Kusnezoffii 100 gram Rhizoma Arisaematiss 40 grams
Flos Carthami 40 gram Radix Anisodi Acutangulis 50 grams
Radix Arnebiae (Radix Lithospermi) 50 gram Benzoinumes 10 grams
Herba Cymbopogonis 10 grams.
Embodiment 2
Get raw material by following proportioning, and make acceptable external application preparation with processing method of the prior art:
Radix Aconiti Kusnezoffii 160 gram Rhizoma Arisaematiss 90 grams
Flos Carthami 80 gram Radix Anisodi Acutangulis 70 grams
Radix Arnebiae (Radix Lithospermi) 20 gram Benzoinumes 50 grams
Herba Cymbopogonis 20 grams.
Embodiment 3
Get raw material by following proportioning, and make acceptable external application preparation with processing method of the prior art:
Radix Aconiti Kusnezoffii 130 gram Rhizoma Arisaematiss 70 grams
Flos Carthami 60 gram Radix Anisodi Acutangulis 60 grams
Radix Arnebiae (Radix Lithospermi) 30 gram Benzoinumes 40 grams
Herba Cymbopogonis 20 grams.
Table 1 " tincture of vanilla " spray is to the influence of rat carrageenan pedal swelling
Cause scorching back different time swelling rate (%) (1%)
Group animal dosage
(only) be 1h 2h 3h 4h 5h 6h (%)
Matched group 10 40% ethanol 41.8 ± 6.7 76.5 ± 5.6 78.2 ± 4.6 77.5 ± 4.2 72.7 ± 53 57.6 ± 8.2
Yunnan white 10/34.5 ± 7.9 63.2 ± 9.2 68.7 ± 6.8 69.8 ± 5.4 62.2 ± 5.8 50.9 ± 8.7
Medicine aerosol (17.5) (17.4) (12.1) (9.9) (8.9) (11.6)
Tincture of vanilla low 10 38% 30.7 ± 7.0 66.0 ± 3.7 67.9 ± 4.6 67.8 ± 3.6 62.9 ± 4.8 57.2 ± 4.2
(26.6)??????(13.7)??????(13.2)??????(12.5)?????(13.5)?????(0.6)
Tincture of vanilla high 10 114% 33.8 ± 7.2 65.6 ± 3.5 68.5 ± 3.4 68.3 ± 3.9 60.2 ± 5.4 55.9 ± 4.2
(19.1)??????(14.2)??????(12.4)??????(11.9)?????(17.2)?????(3.0)
Annotate: compare with matched group
*P＜0.05,
*P＜0.01.
Table 2 " tincture of vanilla " spray xylol causes the influence of mice auricle swelling
Group animal dosage inflammation rate of body weight gain suppression ratio
(only) be (M ± s) (I) (%)
Matched group 10 40% ethanol 86.3 ± 24.9/
YUNNAN BAIYAO spray 10/41.3 ± 10.9
*52.1
Tincture of vanilla low 10 38% 44.4 ± 11.5
*48.6
Tincture of vanilla high 10 114% 42.9 ± 9.2
*50.3
Annotate: compare with matched group
*P＜0.01
Table 3 tincture of vanilla spray is to the analgesic activity (hot plate method) of mice
The threshold of pain after the preceding threshold of pain administration of group animal dosed administration
(only) be (S ± SD) 15 minutes 30 minutes 60 minutes (%)
Matched group 10 40% ethanol 12.9 ± 4.0 11.2 ± 3.4 11.7 ± 3.3 12.0 ± 4.4
YUNNAN BAIYAO spray 10/12.1 ± 3.4 19.2 ± 6.3 24.0 ± 10.8 36.7 ± 15.0
Tincture of vanilla low dosage 10 38% 12.7 ± 3.2 25.0 ± 1.8 25.4 ± 12.4 26.4 ± 12.4
Tincture of vanilla high dose 10 114% 12.2 ± 1.3 27.1 ± 10.7 27.5 ± 9.9 29 ± 8.1
Annotate: with contrast before the administration
*P＜0.01
Table 4 " tincture of vanilla " spray is to the analgesic activity (writhing method) of mice
Group animal dosage is turned round the body number of times
(only) be (X ± s) (%)
Matched group 10 40% ethanol 52.1 ± 6.9
Yunnan Baiyao aerosol 10/46.6 ± 3.8
*
Tincture of vanilla low 10 38% 45.1 ± 4.1
*
Tincture of vanilla high 10 114% 43.8 ± 5.0
*
Annotate: compare with matched group
*P＜0.05,
*P＜0.01
Table 5 (tincture of vanilla) is used for 326 routine patients' therapeutic outcome
| The sick typing of planting | Case load | Cure | Take a turn for the better | Do not heal | Cure rate+improvement rate |
| Acute soft tissue injury | ????19 | ??18 | ??1 | ??0 | |
| Stiff neck (cervical region is sprained) | ????28 | ??28 | ??0 | ||
| Neck thoracic dorsal buttocks myofascitis | ????23 | ??21 | ??2 | ??0 | |
| Chronic lumbar muscle strain | ????39 | ??36 | ??3 | ??0 | |
| Acute lumbar muscle sprain | ????15 | ??15 | ??0 | ||
| Scapulohumeral periarthritis | ????21 | ??18 | ??3 | ??0 | |
| Cervical spondylosis (neck type, N root type, vertebra A type, sympathetic N type, mixed type) | ????109 | ??97 | ??12 | ??0 | |
| Tennis elbow (external humeral epicondylitis) | ????11 | ??11 | ??0 | ||
| Prolapse of lumbar intervertebral disc, ischium N pain | ????54 | ??47 | ??7 | ??0 | |
| The closure bone splits | ????3 | ??3 | ??0 | ||
| Dermatosis, herpes of mouth, dermatitis | ????4 | ??4 | ??0 |
Claims (1)
1, a kind of externally appied medicine for relieving pain and diminishing inflammation is characterized in that being made by the raw material of following weight portion:
Radix Aconiti Kusnezoffii 100-160 part Rhizoma Arisaematis 40-90 part
Flos Carthami 40-80 part Radix Anisodi Acutanguli 30-70 part
Radix Arnebiae (Radix Lithospermi) 20-50 part Benzoinum 10-50 part
Herba Cymbopogonis 10-20 part.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 02127972 CN1228064C (en) | 2002-12-07 | 2002-12-07 | Externally appied medicine for relieving pain and diminishing inflammation |
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| Application Number | Priority Date | Filing Date | Title |
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| CN 02127972 CN1228064C (en) | 2002-12-07 | 2002-12-07 | Externally appied medicine for relieving pain and diminishing inflammation |
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| Publication Number | Publication Date |
|---|---|
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| CN1228064C CN1228064C (en) | 2005-11-23 |
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|---|---|---|---|
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| Country | Link |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101152378B (en) * | 2007-09-26 | 2010-04-21 | 徐雪梅 | Externally used traditional Chinese medicine preparation for diminishing the inflammation and reducing the pain |
| CN101972428A (en) * | 2010-11-02 | 2011-02-16 | 史志辉 | Preparation method of traditional Chinese medicine composition |
| CN102406858A (en) * | 2011-12-01 | 2012-04-11 | 向飞丹州 | Disinfection antibacterial agent |
-
2002
- 2002-12-07 CN CN 02127972 patent/CN1228064C/en not_active Expired - Lifetime
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101152378B (en) * | 2007-09-26 | 2010-04-21 | 徐雪梅 | Externally used traditional Chinese medicine preparation for diminishing the inflammation and reducing the pain |
| CN101972428A (en) * | 2010-11-02 | 2011-02-16 | 史志辉 | Preparation method of traditional Chinese medicine composition |
| CN102406858A (en) * | 2011-12-01 | 2012-04-11 | 向飞丹州 | Disinfection antibacterial agent |
| CN102406858B (en) * | 2011-12-01 | 2013-07-10 | 向飞丹州 | Disinfection antibacterial agent |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1228064C (en) | 2005-11-23 |
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