CN1500497A - Preparation method of compound soft capsule of traditional Chinese medicine and use - Google Patents
Preparation method of compound soft capsule of traditional Chinese medicine and use Download PDFInfo
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- CN1500497A CN1500497A CNA021340501A CN02134050A CN1500497A CN 1500497 A CN1500497 A CN 1500497A CN A021340501 A CNA021340501 A CN A021340501A CN 02134050 A CN02134050 A CN 02134050A CN 1500497 A CN1500497 A CN 1500497A
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- soft capsule
- volatile oil
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Abstract
The present invention relates to pharmaceutical technology and aims at solving the problem of Chinese medicine for treating stomachache with excessively great dosage and inconvenience in taking. Clove and cassia as main ingredients in recipe for treating stomachache are extracted and refined to obtain volatile oil with total content over 50 % of eugenol and cinnamaldehyde as the effective components. The pungent volatile oil is capsulized to prepare the compound Chinese medicine soft capsule. The capsule preparation has high stability and high bioavailability and is used mainly in treating diseases with stomachache as main symptom.
Description
The technical field pharmaceutical technology
Background technology Flos Caryophylli, Cortex Cinnamomi are the Chinese medicine materials, and by prescription or be used for the treatment of stomachache separately and be the various gastropathy of cardinal symptom.Soft capsule is a kind of common formulations, is used for fat-soluble medicine more.
The active ingredient of Flos Caryophylli, cinnamomic treatment stomachache is a volatile oil, the tradition usage is to add in decoction or the powder to use, but the volatile oil content that decoction keeps is low, though and powder can keep whole volatile oil, but the dosage form backwardness is taken inconvenience and dosage is big, by suitable technology extraction effective ingredient volatile oil wherein, and make efficiently, dosage form easily, the treatment that is used to have a stomachache is the problem that the present invention solves.
Summary of the invention is the prescription that main composition function cures mainly stomachache with Flos Caryophylli, Cortex Cinnamomi, by pharmacodynamics screening (is index with the analgesia), determines that Flos Caryophylli, cinnamomic effective site are volatile oil.Through extracting, making with extra care, obtain effective site (fourth osmanthus volatile oil), and make wherein effective ingredient eugenol, cinnamic aldehyde content sum surpass 50% (eugenol of test agent, cinnamic aldehyde content sum reach about 83% in three batches).Because fourth osmanthus volatile oil has acid, effumability, to characteristics such as photaesthesia, therefore select for use soft capsule that volatile oil is wrapped in the soft capsule, volatile oil is hedged off from the outer world, covered the discomfort of medicine and smelt flavor, improve stability of formulation, the soft capsule that makes is exquisite appearance not only, taking convenience, steady quality, and medicament contg is accurate, the precision height, it is fast to prove effective, the bioavailability height.Prove through pharmacodynamics test: the fourth cassia oil has anti-peptic ulcer, analgesia, antiinflammatory and regulates the effect of gastrointestinal motility.As seen fourth cassia oil soft capsule has the active constituent content height, and pharmacological action is obvious, and is rapid-action, and characteristics such as bioavailability height can satisfy the requirement of clinical application.
The specific embodiment cures mainly (warming stomach for dispelling cold, promoting the circulation of QI to relieve pain according to the prescription function.Be used for gastric abscess), by pharmacodynamics screening (is index with the analgesia), determine that Flos Caryophylli, cinnamomic effective site are volatile oil.Through extracting, making with extra care, obtain effective site (fourth osmanthus volatile oil), and make wherein effective ingredient eugenol, cinnamic aldehyde content sum surpass 50% (eugenol of test agent, cinnamic aldehyde content sum reach about 83% in three batches).Because fourth osmanthus volatile oil has acid, effumability, to characteristics such as photaesthesia, therefore select for use soft capsule that volatile oil is wrapped in the soft capsule, volatile oil is hedged off from the outer world, covered the discomfort of medicine and smelt flavor, improve stability of formulation, the soft capsule that makes is exquisite appearance not only, taking convenience, steady quality, and medicament contg is accurate, the precision height, it is fast to prove effective, the bioavailability height.Prove through pharmacodynamics test: the fourth cassia oil has anti-peptic ulcer, analgesia, antiinflammatory and regulates the effect of gastrointestinal motility.As seen fourth cassia oil soft capsule has the active constituent content height, and pharmacological action is obvious, and is rapid-action, and characteristics such as bioavailability height can satisfy the requirement of clinical application.
Requirement according to compound recipe two class new Chinese medicines, cure mainly and the pharmacodynamics results of screening according to the prescription function, with the content of carrying oil mass and main effective ingredient eugenol, cinnamic aldehyde is evaluation index, filtering out optimum extraction process is: add 8 times of water gagings, water proof distillation 8 hours is collected volatile oil, cold preservation 24 hours, remove moisture, get effective site: fourth osmanthus volatile oil.
Fourth cassia oil and soybean oil mixing, standby.Get gelatin, glycerol, simple syrup and add the deionized water mixing, heat tracing adds methyl parahydroxybenzoate, ethylparaben, stir, and evacuation, the capsule material is made in 70 ℃ of insulations 20 minutes.Get the mixture of fourth cassia oil and soybean oil, adopt pressing to make soft capsule with the capsule material.
Claims (2)
- Ask for protection be a kind of be used for the treatment of the treatment gastralgia be the Chinese medicine compound preparation of soft capsule method and the purposes of primary symptom disease.With the total technical characterictic of prior art be that two kinds of former plants of this preparation all are medical materials, also be used to treat this disease.Its technical characterictic is the volatile oil that extracts based in Flos Caryophylli, the Cortex Cinnamomi, and effective ingredient eugenol wherein, cinnamic aldehyde content sum surpass 50%.Fourth cassia oil and soybean oil mixing, standby.Get gelatin, glycerol, simple syrup and add the deionized water mixing, heat tracing adds methyl parahydroxybenzoate, ethylparaben, stir, and evacuation, the capsule material is made in 70 ℃ of insulations 20 minutes.Get the mixture of fourth cassia oil and soybean oil, adopt pressing to make soft capsule, be used for the treatment of the disease that gastralgia is a primary symptom with the capsule material.Claim1, extract volatile oil (effective ingredient eugenol wherein, cinnamic aldehyde content sum are between 50-98%) from Flos Caryophylli, Cortex Cinnamomi, as main composition, add adjuvant, mixing is made soft capsule.
- 2, above-mentioned preparation is used for the treatment of the disease that gastralgia is a primary symptom.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CNA021340501A CN1500497A (en) | 2002-11-14 | 2002-11-14 | Preparation method of compound soft capsule of traditional Chinese medicine and use |
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CNA021340501A CN1500497A (en) | 2002-11-14 | 2002-11-14 | Preparation method of compound soft capsule of traditional Chinese medicine and use |
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CN1500497A true CN1500497A (en) | 2004-06-02 |
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CNA021340501A Pending CN1500497A (en) | 2002-11-14 | 2002-11-14 | Preparation method of compound soft capsule of traditional Chinese medicine and use |
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103908494A (en) * | 2014-03-24 | 2014-07-09 | 江西德上制药有限公司 | Method for producing clove-cinnamon stomach-warming capsule by combination of micro-grinding with bio-enzyme |
CN105944104A (en) * | 2016-06-17 | 2016-09-21 | 上海凯宝药业股份有限公司 | Pharmaceutical composition for treating digestive tract ulcer |
CN107510716A (en) * | 2016-06-17 | 2017-12-26 | 上海凯宝药业股份有限公司 | A kind of pharmaceutical composition for treating intestinal irritable syndrome and its production and use |
-
2002
- 2002-11-14 CN CNA021340501A patent/CN1500497A/en active Pending
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103908494A (en) * | 2014-03-24 | 2014-07-09 | 江西德上制药有限公司 | Method for producing clove-cinnamon stomach-warming capsule by combination of micro-grinding with bio-enzyme |
CN105944104A (en) * | 2016-06-17 | 2016-09-21 | 上海凯宝药业股份有限公司 | Pharmaceutical composition for treating digestive tract ulcer |
CN107510716A (en) * | 2016-06-17 | 2017-12-26 | 上海凯宝药业股份有限公司 | A kind of pharmaceutical composition for treating intestinal irritable syndrome and its production and use |
CN107510716B (en) * | 2016-06-17 | 2020-06-30 | 上海凯宝药业股份有限公司 | Pharmaceutical composition for treating irritable bowel syndrome and preparation method and application thereof |
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