CN106924458A - Tibetan medicinal composition, preparation, application with preventing and treating hepatic injury function - Google Patents
Tibetan medicinal composition, preparation, application with preventing and treating hepatic injury function Download PDFInfo
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- CN106924458A CN106924458A CN201511016895.9A CN201511016895A CN106924458A CN 106924458 A CN106924458 A CN 106924458A CN 201511016895 A CN201511016895 A CN 201511016895A CN 106924458 A CN106924458 A CN 106924458A
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/26—Iron; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/38—Silver; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/285—Aucklandia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/18—Magnoliophyta (angiosperms)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
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- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Inorganic Chemistry (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a kind of Tibetan medicinal composition, and its preparation, application process.For some traditional medicines and its preparation in the prior art, with potential hepatotoxic defect, the invention provides a kind of Tibetan medicinal composition with preventing and treating hepatic injury function.This product includes 50 parts of myrobalan, 50 parts of safflower, slag tame and docile 50 parts of cream, 100 parts of myrobalan's iron filings, 50 parts of dairy gypsum rubrum, 50 parts of Herba Dracocephali Tangutici, 50 parts of the banksia rose by weight.This product is from ethno-medicine angle, it then follows monarch, minister, helps, make combination principle, the effect of complete square compatibility 5 reaches the promoting flow of qi and blood circulation, calming liver and clearing heat and relieves pain, the function with liver protection.The present invention also provides the preparation method of Tibetan medicinal composition, and its application in preventing and treating hepatic injury product is prepared.Using traditional common medicinal herbs most in use, traditionally Tibetan medicine concocting method is prepared from Tibetan medicinal composition of the present invention, and medicinal material active compound is safe and reliable with preparation method, and active compound constituent species are few, and production cost economy, preparation method are simple.
Description
Technical field
The present invention relates to a kind of Tibetan medicinal composition, more particularly to a kind of Tibetan medicinal composition with preventing and treating hepatic injury function.
Background technology
Hepatic injury is that the destruction by interior metabolism product to liver cell is drawn with toxic action, and the acute and chronic liver official disease based on liver metabolism disorder, is one of common organ disease of China.Various hepatic injuries are usually expressed as fatty liver in the early stage, and then can develop into alcoholic hepatitis, liver fibrosis, cirrhosis, or even liver failure.
Traditional medicine has been that research confirms with clinical to the therapeutic effect of hepatic injury, but the clinical practice of traditional medicine and its preparation in China in terms of liver disease in recent years is increasing, the report of adverse reaction has the gesture for increasing caused by traditional medicine and its manufactured goods, because the lethal case of neuro intoxication also has been reported that.Liver is main bioconversion place, therefore is easily damaged by medicine.It has been found that parts of traditional medicinal material has potential hepatotoxicity wind agitation.Once causing the medicinal material of the different degrees of hepatic injury of animal in toxicological experiment has tens of kinds, relate generally to some and suppress immune response, the traditional medicine of antirheumatic, treat dermopathic traditional patent medicine, traditional medicine with insecticidal action, traditional patent medicine of softening and resolving hard mass, stagnation resolvation or broken stasis of blood, the preparation containing radix bupleuri etc..
The height above sea level of Structure Dynamics In The Qinghai-tibet Region, be air-dried the bad climate environmental condition such as thin aggravate always local resident physical function operating and regulation burden.Tibetanmedicine is produced in China Qinghai-xizang Plateau Region, and a large amount of experiences are have accumulated in terms of specific aim is alleviated and preventing and treating causes burden and disease to resident's physiological function due to chronicity unfavorable factor.Tibetan medicine and pharmacology is theoretical to have long applicating history in terms of hepatic injury is prevented and treated so that Tibetan medicine acts on affirmative, and long-term taking safety in terms of hepatic injury is prevented and treated.
The content of the invention
The purpose of the present invention is providing a kind of Tibetan medicinal composition with preventing and treating hepatic injury function and its application.
To achieve the above object, technical scheme is as follows：
A kind of Tibetan medicinal composition with preventing and treating hepatic injury function, it is characterised in that：50 parts of cream, 100 parts of myrobalan's iron filings, 50 parts of dairy gypsum rubrum, 50 parts of Herba Dracocephali Tangutici, 50 parts of the banksia rose are tamed and dociled including 50 parts of myrobalan by weight, 50 parts of safflower, slag.
In above-mentioned Tibetan medicinal composition：
Myrobalan, is the dry mature fruit of combretaceae plant myrobalan (Terminalia chebula Retz.) or fine hair myrobalan (Terminalia chebula Retz.var.tomentella Kurt.).Its is bitter in taste, sour, puckery, flat；Return lung, large intestine channel.The function that traditional medicine is recorded with to cure mainly be that puckery intestines are astringed the lung, fall fire relieving sore-throat.For protracted dysentery and diarrhea, prolapse of the anus of having blood in stool, the deficiency syndrome of the lung is breathed with cough, and coughs more than long, and pharyngalgia sound is mute.The main constituents containing tannin of fruit of modern chemical composition research display myrobalan, major function is to restrain and antidiarrheal, and clinic is mainly used in treating the diseases such as lobar pneumonia, bacillary dysentery pain, diphtheriaphor.
Safflower, is Iridaceae crocus napiform root class herbaceous plant safflower (Crocus sativus L.).Traditional medicine thinks there is promoting blood circulation, stagnation resolvation, dredging collateral, removing pattogenic heat from the blood and toxic material from the body, the effect of anti-inflammatory analgetic.Modern western scientific medical thinks its pharmacological mechanism for calmness, eliminating the phlegm, spasmolysis, for having a stomachache, menstruation regulating, can control dysentery, measles, generate heat jaundice, hepatosplenomegaly, urethral infection and diabetes etc..
Slag tames and dociles cream, is that the tame and docile decocting of slag cooks into paste.It is traditional Tibetan medicine that slag is tamed and dociled, and is that the ore containing various metals such as gold, silver under certain natural conditions occurs dissolving and condenses formed mineral substance Tibetan medicine again.The tame and docile cream taste of slag is warm in nature, cold, Return liver, the spleen channel, with dredging blood vessel, blood stasis removing analgesic effect, heat symptoms caused by an exopathgen in solution stomach, liver, kidney.Modern medicine and pharmacology thinks its active ingredient for flavonoids, triterpene compound, with obvious anti-oxidant, antiinflammatory action.
Myrobalan's iron filings, commonly referred to as iron filings (myrobalan's system), standard record in《Tibet Autonomous Region's Tibetan medicine material standard》.Traditional medicine records its taste is pungent, through Liver Channel, has functions that improving eyesight, iron, removing toxic substances is mended, for diseases such as tuberculosis, edema, hepatopathy, eyes jaundice, anaemias.Modern medicine and pharmacology analyzes its main chemical compositions for triterpenoids, amino acid, phenolic acid class, carbohydrate；In recent years a large amount of domestic and international researchs confirm that triterpene acids have and reduce animal blood glucose, serum fatty acid, triglycerides, cholesterol and anti-oxidant, the effect of prevention oxidative stress.
Dairy gypsum rubrum, commonly referred to as gypsum rubrum (dairy), standard record in《Tibet Autonomous Region's Tibetan medicine material standard》.Gypsum rubrum (dairy) is diameter about 10cm, the milky cake of thickness below 3cm, and gas is micro-, lightly seasoned.With heat-clearing, nourishing, stomach invigorating, antidiarrheal, detumescence, for hot Baconic disease, physically weak weak, indigestion, all kinds of gastrointestinal diseases and ulcer, ruffian knurl, the disease such as diarrhoea.Modern pharmacological research confirms its main component for dead plaster, with bringing down a fever, strengthen body's immunity.
Herba Dracocephali Tangutici, the dry aerial parts of Labiatae dragonhead Herba Dracocephali Tangutici (Dracocephalum tanguticum Maxim.), with clearing heat and expelling damp, expelling wind to resolve the exterior, relax liver and stomach, removing heat from the liver, stomach energy, more hemostasis, sore, the function of dry yellow water, for dizziness, hepatitis, gastritis, hepatopyretic disease, stomach pyreticosis, grasserie, have blood in stool, the treatment of the disease such as arthritis, ulcerative carbuncle.Sweet-bitter flavor, cold in nature, return through stomach, liver, tool and stomach it is soothing the liver the effect of.Modern medicine and pharmacology uses wherein 11 structures of compound of physicochemical property and Modern spectroscopy technical appraisement, it is believed that its active ingredient is flavonoids, triterpene compound and amino acid, there is obvious antioxidation to mouse liver.
The banksia rose, is the feverfew banksia rose (Saussurea costus (Falc.) Li-pech).The banksia rose is acted on as traditional Chinese medicine with stomach invigorating dissipate-swelling, promoting the flow of qi and relieving stagnancy, analgesic tocolysis etc..Modern study shows that it contains some sesquiterpenoids compositions, and its main active is dehydro-α-curcumene and costunolide, and there is antitumor, antibacterial, antiulcer etc. to act on for it.Chemical analysis is carried out to it and checks following compound：Alantolactone, isoalantolactone, dehydro-α-curcumene, costunolide, stigmasterol, pregnenolone etc..Its main component dehydro-α-curcumene and costunolide have obvious antitumor activity through research.
Traditional Chinese medicine and ethno-medicine think non-alcoholic liver damage disease except heredity with infect class factor cause a disease it is outer, more by eating and drinking without temperance, addiction delicious food savoury, fat or insobriety, cause mechanism of qi retardance, damp and hot interior life, phlegm and blood stasis, block liver network caused by.Therefore, treatment should be promoting blood circulation and removing blood stasis with dispersing stagnated hepatoqi, based on dispelling phlegm and eliminating dampness.Tibetan medicinal composition of the present invention is from ethno-medicine angle, monarch, minister are followed, helped, made combination principle, it is the main ingredient in the product prescription with safflower, iron filings (myrobalan's system) Tibetan medicine, the effect of complete square compatibility 5 reaches the promoting flow of qi and blood circulation, calming liver and clearing heat and relieves pain, with protect liver, the function of liver protection.
The present invention also provides the preparation method of above-mentioned Tibetan medicinal composition simultaneously, and concrete scheme is as follows：
The preparation method of above-mentioned Tibetan medicinal composition, it is characterised in that：Each component active compound is made medicinal powder according to traditional Tibetan medicine material processing method, medicinal powder is configured in proportion according to need again, add water to cook extraction and leaching liquor is obtained, leaching liquor adds acceptable auxiliary material system in pharmacy if necessary according to the different formulation of conventional tradition patent medicine processing method system.
The formulation of specific Tibetan medicinal composition can be administered orally such as decoction, pill, powder, granule, paste, medicinal liquor, syrup, butter fat medicine.
It is effectiveness composition with Tibetan medicinal composition of the present invention or its extract, can apply to prepare preventing and treating hepatic injury product.Product is Tibetan medicinal composition of the present invention or its extract solution directly as preventing and treating AML product, or with this Tibetan medicinal composition or its extract solution be the preventing and treating hepatic injury of effectiveness composition, hepatopathy product.
Compared with prior art, the beneficial effects of the invention are as follows：(1) using common, the conventional medicinal material of tradition in Tibetan medicine and pharmacology, traditionally Tibetan medicine concocting method is prepared from this Tibetan medicinal composition, and either medicinal material active compound or preparation method are all safe and reliable；(2) this Tibetan medicinal composition active compound constituent species are few, and production cost economy, preparation method are simple.
Specific embodiment
With reference to embodiment, the preferred embodiments of the invention are further described.
Embodiment one
The pill preparation method of Tibetan medicinal composition.
Active compound component and ratio：50 parts of myrobalan, 50 parts of safflower, slag tame and docile 50 parts of cream, 100 parts of iron filings (myrobalan's system), 50 parts of gypsum rubrum (dairy), 50 parts of Herba Dracocephali Tangutici, 50 parts of the banksia rose.
Preparation method：Each component medicinal raw material is processed into fine powder according to traditional Tibetan medicine material processing method and standard after net system to scale, sieves, and mixes, and with water pill, dries, and obtains final product.
Embodiment two
The decoction preparation method of Tibetan medicinal composition.
Active compound component and ratio：50 parts of myrobalan, 50 parts of safflower, slag tame and docile 50 parts of cream, 100 parts of iron filings (myrobalan's system), 50 parts of gypsum rubrum (dairy), 50 parts of Herba Dracocephali Tangutici, 50 parts of the banksia rose.
Preparation method：Each component medicinal raw material is processed into meal according to traditional Tibetan medicine material processing method and standard after net system to scale, add 10 times of amount water of medicinal powder gross weight, immersion 1h, 98 DEG C~100 DEG C decoction 2h, filtration, collect filtrate, the dregs of a decoction add 8 times of amount water of active compound gross weight, 98 DEG C~100 DEG C decoction 1h, filtration, merge filtrate twice and obtain leaching liquor, leaching liquor is decoction.
Claims (8)
1. a kind of Tibetan medicinal composition with liver-protecting function, it is characterised in that：Including myrobalan by weight
50 parts, 50 parts of safflower, slag tame and docile 50 parts of cream, 100 parts of myrobalan's iron filings, dairy Han Shui
50 parts of stone, 50 parts of Herba Dracocephali Tangutici, 50 parts of the banksia rose.
2. application of the Tibetan medicinal composition according to claim 1 in preventing and treating hepatic injury product is prepared.
3. the preparation method of Tibetan medicinal composition according to claim 1, it is characterised in that：By each group
Point active compound is made medicinal powder according to traditional Tibetan medicine material processing method, then according to need matches somebody with somebody medicinal powder in proportion
Put, add water to cook extraction and leaching liquor is obtained, leaching liquor is according to conventional tradition patent medicine processing method system
Different formulations.
4. preparation method according to claim 3, it is characterised in that：Add and be subjected in pharmacy
Auxiliary material system.
5. preparation method according to claim 3, it is characterised in that according to following preparation method it
One implements：
It is prepared by pill：Each component medicinal raw material hides processing of crude drugs side according to tradition after net system to scale
Method is processed into fine powder, sieving, mixes, and with water pill, dries prepared pill；
It is prepared by decoction：Each component medicinal raw material is processed into meal after net system to scale, adds medicinal powder
10 times of amount water of gross weight, soak 1h, and filtrate is collected in 98 DEG C~100 DEG C decoction 2h, filtration,
The dregs of a decoction add 8 times of amount water of medicinal powder gross weight, and 98 DEG C~100 DEG C decoction 1h, filtration merges two
Secondary filtrate obtains leaching liquor, and leaching liquor is decoction.
6. damaged by the preventing and treating liver of active ingredient of the Tibetan medicinal composition described in claim 1 or its extract solution
Injured labour product.
7. product according to claim 6, it is characterised in that：It is medicine or health products.
8. product according to claim 7, it is characterised in that：It is peroral dosage form.
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| CN114470074A (en) * | 2021-12-27 | 2022-05-13 | 西藏森戈生物科技有限公司 | Tibetan medicine composition for protecting liver and tonifying spleen and preparation method thereof |
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| CN114470074A (en) * | 2021-12-27 | 2022-05-13 | 西藏森戈生物科技有限公司 | Tibetan medicine composition for protecting liver and tonifying spleen and preparation method thereof |
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Application publication date: 20170707 |