CN1490028A - Chinese medicinal preparations for cardiac and encephalic blood vessel diseases and productions thereof - Google Patents
Chinese medicinal preparations for cardiac and encephalic blood vessel diseases and productions thereof Download PDFInfo
- Publication number
- CN1490028A CN1490028A CNA031176127A CN03117612A CN1490028A CN 1490028 A CN1490028 A CN 1490028A CN A031176127 A CNA031176127 A CN A031176127A CN 03117612 A CN03117612 A CN 03117612A CN 1490028 A CN1490028 A CN 1490028A
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- China
- Prior art keywords
- radix
- extractum
- chinese medicine
- medicine preparation
- salviae miltiorrhizae
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- 238000002360 preparation method Methods 0.000 title claims description 22
- 201000010099 disease Diseases 0.000 title description 13
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title description 13
- 210000004204 blood vessel Anatomy 0.000 title description 2
- 230000000747 cardiac effect Effects 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000003814 drug Substances 0.000 claims abstract description 30
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 19
- 208000024172 Cardiovascular disease Diseases 0.000 claims abstract description 14
- 208000026106 cerebrovascular disease Diseases 0.000 claims abstract description 14
- 230000002526 effect on cardiovascular system Effects 0.000 claims abstract description 14
- 238000002156 mixing Methods 0.000 claims abstract description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 10
- 238000001694 spray drying Methods 0.000 claims abstract description 7
- 238000000605 extraction Methods 0.000 claims description 18
- 238000010438 heat treatment Methods 0.000 claims description 18
- 244000236655 Diospyros kaki Species 0.000 claims description 13
- 235000008597 Diospyros kaki Nutrition 0.000 claims description 13
- 239000008187 granular material Substances 0.000 claims description 11
- 239000002775 capsule Substances 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 6
- 238000001035 drying Methods 0.000 claims description 5
- 239000003826 tablet Substances 0.000 claims description 5
- 239000002552 dosage form Substances 0.000 claims description 4
- 239000002671 adjuvant Substances 0.000 claims description 3
- 239000000203 mixture Substances 0.000 claims description 2
- 206010002383 Angina Pectoris Diseases 0.000 abstract description 6
- 206010065559 Cerebral arteriosclerosis Diseases 0.000 abstract description 5
- 208000029078 coronary artery disease Diseases 0.000 abstract description 5
- 201000005851 intracranial arteriosclerosis Diseases 0.000 abstract description 5
- 241000758794 Asarum Species 0.000 abstract 1
- 244000153955 Reynoutria sachalinensis Species 0.000 abstract 1
- 235000003202 Reynoutria sachalinensis Nutrition 0.000 abstract 1
- 240000007164 Salvia officinalis Species 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
- 235000005412 red sage Nutrition 0.000 abstract 1
- 239000008280 blood Substances 0.000 description 26
- 210000004369 blood Anatomy 0.000 description 26
- 230000001737 promoting effect Effects 0.000 description 23
- 230000017531 blood circulation Effects 0.000 description 12
- 208000002173 dizziness Diseases 0.000 description 10
- 208000002193 Pain Diseases 0.000 description 8
- 230000004087 circulation Effects 0.000 description 7
- 206010008479 Chest Pain Diseases 0.000 description 6
- 206010019233 Headaches Diseases 0.000 description 6
- 208000009205 Tinnitus Diseases 0.000 description 6
- 210000000038 chest Anatomy 0.000 description 6
- 231100000869 headache Toxicity 0.000 description 6
- 231100000886 tinnitus Toxicity 0.000 description 6
- 201000005577 familial hyperlipidemia Diseases 0.000 description 5
- 239000000796 flavoring agent Substances 0.000 description 4
- 235000019634 flavors Nutrition 0.000 description 4
- 210000000115 thoracic cavity Anatomy 0.000 description 4
- 230000000694 effects Effects 0.000 description 3
- 208000004880 Polyuria Diseases 0.000 description 2
- 206010037660 Pyrexia Diseases 0.000 description 2
- 235000019636 bitter flavor Nutrition 0.000 description 2
- 230000029087 digestion Effects 0.000 description 2
- 230000035619 diuresis Effects 0.000 description 2
- 201000006549 dyspepsia Diseases 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 240000008574 Capsicum frutescens Species 0.000 description 1
- 241000219780 Pueraria Species 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000000994 depressogenic effect Effects 0.000 description 1
- 230000035622 drinking Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 230000036651 mood Effects 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 231100000915 pathological change Toxicity 0.000 description 1
- 230000036285 pathological change Effects 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
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- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
A Chinese medicine in the form of particles for treating cardiovascular and cerebrovascular diseases, such as coronary heart disease, angina pectoris, cerebral arteriosclerosis, hyperlipomia, etc is prepared through extracting from asarum herb, giant knotweed rhizome and wild haw in hot water and concentrating to obtain extract, thermally extracting from acanthopanax bark and red sage root in alcohol and concentrating to obtain extract, mixing, and spray drying.
Description
The present invention relates to a kind of Chinese medicine preparation for the treatment of cardiovascular and cerebrovascular disease and preparation method thereof, belong to medicine
Technical field.
Background technology: cardiovascular and cerebrovascular disease is commonly encountered diseases, the frequently-occurring disease in a kind of modern life, because the improvement of living habit, many personnel have suffered from this class disease, symptom is reflected as: the thoracic obstruction, dizzy, uncomfortable in chest, chest pain, cardiopalmus, dizziness, headache, tinnitus and coronary heart disease, angina pectoris, cerebral arteriosclerosis and hyperlipemia, this class disease influences patient's orthobiosis, long and the not effective especially medicine of medicine present use of therapeutic process, common medicine is Radix Salviae Miltiorrhizae goods etc.; If treat with Western medicine, effectively but side effect is bigger again and medical expense is high, so generally be not patient's acceptance.
The objective of the invention is: a kind of Chinese medicine preparation for the treatment of cardiovascular and cerebrovascular disease and preparation method thereof is provided, and this medicine has blood circulation promoting and blood stasis dispelling, the removing obstruction in the collateral to relieve pain function, be used for the treatment of the thoracic obstruction that the blood stasis impatency causes, dizzy, disease is seen uncomfortable in chest, chest pain, cardiopalmus, dizziness, headache tinnitus etc., and coronary heart disease, angina pectoris, cerebral arteriosclerosis and hyperlipemia etc.; The present invention constitutes like this: the Chinese medicine preparation of treatment cardiovascular and cerebrovascular disease is to be made by Herba Erigerontis 380-420, Rhizoma Polygoni Cuspidati 360-420, Crataegi cuneatae 350-450, Radix Et Caulis Acanthopanacis Senticosi 300-350, Radix Salviae Miltiorrhizae 310-350; In order to heighten the effect of a treatment, can add Folium Kaki, Radix Puerariae, calculate according to weight proportion: it just is made by Herba Erigerontis 380-420, Rhizoma Polygoni Cuspidati 360-420, Crataegi cuneatae 350-450, Folium Kaki 360-420, Radix Et Caulis Acanthopanacis Senticosi 300-350, Radix Puerariae 300-340, Radix Salviae Miltiorrhizae 310-350; More specific prescription, ratio are Herba Erigerontis 390, Rhizoma Polygoni Cuspidati 390, Crataegi cuneatae 390, Folium Kaki 390, Radix Et Caulis Acanthopanacis Senticosi 320, Radix Puerariae 320, Radix Salviae Miltiorrhizae 320; The said Chinese medicine preparation of the present invention is a said dosage form on any pharmaceutics.Be preferably granule, tablet or capsule.The preparation method of the Chinese medicine preparation of treatment cardiovascular and cerebrovascular disease, according to given ratio, with Herba Erigerontis 380-420, Rhizoma Polygoni Cuspidati 360-420, Crataegi cuneatae 350-450 water heating extraction is condensed into extractum, with Radix Et Caulis Acanthopanacis Senticosi 300-350, Radix Salviae Miltiorrhizae 310-350 is condensed into extractum with the ethanol heating extraction, two kinds of extractum mixing spray dryinges are made 20-60 order granule, make granule, also two kinds of extractum mixing spray dryinges that obtain can be made 20-40 order granule, add adjuvant after tabletting is made tablet, can also two kinds of extractum are dry respectively, pulverize the back mix homogeneously, make capsule through capsule charge; Add behind Folium Kaki, the Radix Puerariae Herba Erigerontis 380-420, Rhizoma Polygoni Cuspidati 360-420, Crataegi cuneatae 350-450, Folium Kaki 360-420, Radix Puerariae 300-340 water
Heating extraction is condensed into extractum; Radix Et Caulis Acanthopanacis Senticosi 300-350, Radix Salviae Miltiorrhizae 310-350 are condensed into extractum with the ethanol heating extraction,, are made into the dosage form that needs according to common process then two kinds of extractum mixings, drying.
Owing to adopted technique scheme, medicine provided by the invention has blood circulation promoting and blood stasis dispelling, the removing obstruction in the collateral to relieve pain function, be used for the treatment of the thoracic obstruction that the blood stasis impatency causes, dizzy, disease is seen uncomfortable in chest, chest pain, cardiopalmus, dizziness, headache tinnitus etc., and coronary heart disease, angina pectoris, cerebral arteriosclerosis and hyperlipemia are seen above-mentioned disease person's medicine.Seedling medical knowledge opinion thinks that coronary heart disease, angina pectoris, hyperlipemia see uncomfortable in chest, chest pain, cardiopalmus, dizziness, headache tinnitus etc., its cause of disease be eating and drinking without temperance, greasy too much, mood do not relax, is subjected to severe pathogenic cold etc. outward, the damage energy and blood of human body forms.It is then depressed to feel frustrated, so that flow of QI being obstructed is smooth in the heart; Blood trouble is stasis then.The QI and blood pathological changes influences each other, so that produces the hot and cold disease of above-mentioned blood vessels.Above-mentioned uncomfortable in chest, chest pain, headache tinnitus etc. belong to heat symptom-complex, and breathe hard, dizzy etc. belongs to cold disease.According to Seedling medical knowledge opinion, belong to cold and hot complication, when also using with cold and hot medicine; Fang Xiewei of the present invention: Herba Erigerontis, slightly warm in nature, mildly bitter flavor, blood circulation promoting and blood stasis dispelling, promoting the circulation of QI to relieve pain; Radix Et Caulis Acanthopanacis Senticosi, warm in nature, acrid in the mouth, hardship, liver and kidney tonifying, blood circulation promoting and blood stasis dispelling, promoting the circulation of QI to relieve pain; Rhizoma Polygoni Cuspidati, sour in the mouth is slightly cold, and has blood circulation promoting and blood stasis dispelling, clearing away heat-damp and promoting diuresis; Crataegi cuneatae, sour in the mouth has the merit of blood circulation promoting and blood stasis dispelling, promoting digestion and removing stagnation; Radix Salviae Miltiorrhizae, acrid in the mouth, little cold, promoting blood circulation to remove blood stasis, removing heat from blood disappear bitterly, nourishing blood to tranquillize the mind; Crataegi cuneatae and Radix Salviae Miltiorrhizae be 5 merits that strengthen blood stasis dispersing and fresh blood promotings, promoting the circulation of QI to alleviate the stagnation in middle-JIAO mutually, and promptly blood stasis goes and fresh blood is given birth to, stasis of blood resistance removes and venation is logical, and each medicine is mutually 5 for playing the effect of blood circulation promoting and blood stasis dispelling, relieving dyspepsia, promoting the circulation of QI to relieve pain altogether in the side.Fang Xiewei behind adding Folium Kaki, the Radix Puerariae: Herba Erigerontis slight fever in the side, mildly bitter flavor is gone into cold warp, and function is a blood circulation promoting and blood stasis dispelling, promoting the circulation of QI to relieve pain; Folium Kaki is cold, and bitter in the mouth is sour and astringent, goes into heat warp, slow warp, and function is a dispelling wind and removing obstruction in the collateral, blood circulation promoting and blood stasis dispelling, and above-mentioned two flavors are principal agent; Rhizoma Polygoni Cuspidati is cold, bitter in the mouth, clearing away heat-damp and promoting diuresis; Bitter Pueraria lobota property is cold, bitter in the mouth suffering, the tonify deficiency of bringing down a fever; Radix Salviae Miltiorrhizae is chilly, bitter in the mouth, and blood circulation promoting and blood stasis dispelling, removing obstruction in the collateral to relieve pain, this group three flavors are all gone into hot warp; Crataegi cuneatae is hot in nature, sweet in the mouth, acid, and the circulation of qi promoting that helps digestion, dissipating blood stasis are good for the stomach; Radix Et Caulis Acanthopanacis Senticosi is hot in nature, flavor fiber crops, evil-wind expelling and dampness removing, this group two flavors are all gone into cold warp, slow warp, more than cold and hot medicine and to use be accessory drugs altogether.All medicine 5 usefulness are played blood circulation promoting and blood stasis dispelling altogether, relieving dyspepsia, the merit of promoting the circulation of QI to relieve pain.Be used for the thoracic obstruction that the blood stasis impatency causes, dizzy, disease is seen uncomfortable in chest, chest pain, and cardiopalmus, dizziness, headache tinnitus etc., and angina pectoris, cerebral arteriosclerosis and hyperlipemia are seen above-mentioned disease person.
Embodiments of the invention 1: Herba Erigerontis 380 grams, Rhizoma Polygoni Cuspidati 360 grams, Crataegi cuneatae 350 gram water heating extraction are condensed into extractum, Radix Et Caulis Acanthopanacis Senticosi 300 grams, Radix Salviae Miltiorrhizae 310 grams are condensed into extractum with the ethanol heating extraction, two kinds of extractum mixing spray dryinges are made 20-60 order granule, make granule.
Embodiments of the invention 2: Herba Erigerontis 420 grams, Rhizoma Polygoni Cuspidati 420 grams, Crataegi cuneatae 450 gram water heating extraction are condensed into extractum, Radix Et Caulis Acanthopanacis Senticosi 350 grams, Radix Salviae Miltiorrhizae 350 grams are condensed into extractum with the ethanol heating extraction, two kinds of extractum mixing spray dryinges are made 20-40 order granule, add adjuvant after tabletting is made tablet.
Embodiments of the invention 3: Herba Erigerontis 390 grams, Rhizoma Polygoni Cuspidati 390 grams, Crataegi cuneatae 390 grams, Folium Kaki 390 grams, Radix Puerariae 320 gram water heating extraction are condensed into extractum; Radix Et Caulis Acanthopanacis Senticosi 320 grams, Radix Salviae Miltiorrhizae 320 grams are condensed into extractum with the ethanol heating extraction,, are made into the capsule that needs according to common process then two kinds of extractum mixings, drying.This medicine is oral, a 4-5 grain, 3 times on the one.
Embodiments of the invention 4: Herba Erigerontis 380 grams, Rhizoma Polygoni Cuspidati 360 grams, Crataegi cuneatae 350 grams, Folium Kaki 360 grams, Radix Puerariae 300 gram water heating extraction are condensed into extractum; Radix Et Caulis Acanthopanacis Senticosi 300 grams, Radix Salviae Miltiorrhizae 310 grams are condensed into extractum with the ethanol heating extraction,, are made into pill according to common process then two kinds of extractum mixings, drying.
Embodiments of the invention 5: Herba Erigerontis 420 grams, Rhizoma Polygoni Cuspidati 420 grams, Crataegi cuneatae 450 grams, Folium Kaki 420 grams, Radix Puerariae 340 gram water heating extraction are condensed into extractum; Radix Et Caulis Acanthopanacis Senticosi 350 grams, Radix Salviae Miltiorrhizae gram 350 usefulness ethanol heating extraction are condensed into extractum,, are made into oral liquid according to common process then two kinds of extractum mixings, drying.
Claims (7)
1, a kind of Chinese medicine preparation for the treatment of cardiovascular and cerebrovascular disease is characterized in that: calculate according to weight proportion: it is to be made by Herba Erigerontis 380-420, Rhizoma Polygoni Cuspidati 360-420, Crataegi cuneatae 350-450, Radix Et Caulis Acanthopanacis Senticosi 300-350, Radix Salviae Miltiorrhizae 310-350.
2, the Chinese medicine preparation of treatment cardiovascular and cerebrovascular disease according to claim 1 is characterized in that: calculate according to weight proportion: it is made by Herba Erigerontis 380-420, Rhizoma Polygoni Cuspidati 360-420, Crataegi cuneatae 350-450, Folium Kaki 360-420, Radix Et Caulis Acanthopanacis Senticosi 300-350, Radix Puerariae 300-340, Radix Salviae Miltiorrhizae 310-350
3, according to the Chinese medicine preparation of claim 1,2 described treatment cardiovascular and cerebrovascular diseases, it is characterized in that: it is made by Herba Erigerontis 390, Rhizoma Polygoni Cuspidati 390, Crataegi cuneatae 390, Folium Kaki 390, Radix Et Caulis Acanthopanacis Senticosi 320, Radix Puerariae 320, Radix Salviae Miltiorrhizae 320.
4, according to the Chinese medicine preparation of claim 1,2 or 3 described treatment cardiovascular and cerebrovascular diseases, it is characterized in that: said Chinese medicine preparation is a said dosage form on any pharmaceutics.
5, the Chinese medicine preparation of treatment cardiovascular and cerebrovascular disease according to claim 4 is characterized in that: said Chinese medicine preparation is granule, tablet or capsule.
6, the preparation method of the Chinese medicine preparation of treatment cardiovascular and cerebrovascular disease, it is characterized in that: according to given ratio, with Herba Erigerontis 380-420, Rhizoma Polygoni Cuspidati 360-420, Crataegi cuneatae 350-450 water heating extraction is condensed into extractum, with Radix Et Caulis Acanthopanacis Senticosi 300-350, Radix Salviae Miltiorrhizae 310-350 is condensed into extractum with the ethanol heating extraction, two kinds of extractum mixing spray dryinges are made 20-60 order granule, make granule, also two kinds of extractum mixing spray dryinges that obtain can be made 20-40 order granule, add adjuvant after tabletting is made tablet, can also two kinds of extractum are dry respectively, pulverize the back mix homogeneously, make capsule through capsule charge.
7, according to the preparation method of the Chinese medicine preparation of the described treatment cardiovascular and cerebrovascular disease of claim 6, it is characterized in that:, Herba Erigerontis 380-420, Rhizoma Polygoni Cuspidati 360-420, Crataegi cuneatae 350-450, Folium Kaki 360-420, Radix Puerariae 300-340 water heating extraction are condensed into extractum according to given ratio; Radix Et Caulis Acanthopanacis Senticosi 300-350, Radix Salviae Miltiorrhizae 310-350 are condensed into extractum with the ethanol heating extraction,, are made into the dosage form that needs according to common process then two kinds of extractum mixings, drying.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03117612 CN1254259C (en) | 2003-04-01 | 2003-04-01 | Chinese medicinal preparations for cardiac and encephalic blood vessel diseases and productions thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03117612 CN1254259C (en) | 2003-04-01 | 2003-04-01 | Chinese medicinal preparations for cardiac and encephalic blood vessel diseases and productions thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1490028A true CN1490028A (en) | 2004-04-21 |
| CN1254259C CN1254259C (en) | 2006-05-03 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 03117612 Expired - Lifetime CN1254259C (en) | 2003-04-01 | 2003-04-01 | Chinese medicinal preparations for cardiac and encephalic blood vessel diseases and productions thereof |
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| Country | Link |
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| CN (1) | CN1254259C (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101002843B (en) * | 2005-12-19 | 2010-09-08 | 山东轩竹医药科技有限公司 | Medicine composition used for treating cardiovascular and cerebrovascular diseases |
| CN101966239A (en) * | 2010-09-30 | 2011-02-09 | 贵州太和制药有限公司 | Chinese medicinal composition for preventing and treating cardiac cerebral and vascular diseases and preparation method thereof |
| CN110420254A (en) * | 2019-07-26 | 2019-11-08 | 贵州太和制药有限公司 | A kind of preparation method of Chinese materia medica preparation that treating cardiovascular and cerebrovascular disease |
| CN115364149A (en) * | 2022-08-30 | 2022-11-22 | 朗致集团有限公司 | Preparation method and application of XinnaoUNIC capsule |
-
2003
- 2003-04-01 CN CN 03117612 patent/CN1254259C/en not_active Expired - Lifetime
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101002843B (en) * | 2005-12-19 | 2010-09-08 | 山东轩竹医药科技有限公司 | Medicine composition used for treating cardiovascular and cerebrovascular diseases |
| CN101966239A (en) * | 2010-09-30 | 2011-02-09 | 贵州太和制药有限公司 | Chinese medicinal composition for preventing and treating cardiac cerebral and vascular diseases and preparation method thereof |
| CN101966239B (en) * | 2010-09-30 | 2012-07-18 | 贵州太和制药有限公司 | Chinese medicinal composition for preventing and treating cardiac cerebral and vascular diseases and preparation method thereof |
| CN110420254A (en) * | 2019-07-26 | 2019-11-08 | 贵州太和制药有限公司 | A kind of preparation method of Chinese materia medica preparation that treating cardiovascular and cerebrovascular disease |
| CN115364149A (en) * | 2022-08-30 | 2022-11-22 | 朗致集团有限公司 | Preparation method and application of XinnaoUNIC capsule |
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| Publication number | Publication date |
|---|---|
| CN1254259C (en) | 2006-05-03 |
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