CN1461341A - 肝祖先细胞克隆生长的方法 - Google Patents
肝祖先细胞克隆生长的方法 Download PDFInfo
- Publication number
- CN1461341A CN1461341A CN00820051A CN00820051A CN1461341A CN 1461341 A CN1461341 A CN 1461341A CN 00820051 A CN00820051 A CN 00820051A CN 00820051 A CN00820051 A CN 00820051A CN 1461341 A CN1461341 A CN 1461341A
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- Prior art keywords
- cell
- progenitor cells
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- hepatic progenitor
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0607—Non-embryonic pluripotent stem cells, e.g. MASC
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- C—CHEMISTRY; METALLURGY
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/067—Hepatocytes
- C12N5/0672—Stem cells; Progenitor cells; Precursor cells; Oval cells
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/05—Inorganic components
- C12N2500/10—Metals; Metal chelators
- C12N2500/20—Transition metals
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- C12N2500/00—Specific components of cell culture medium
- C12N2500/05—Inorganic components
- C12N2500/10—Metals; Metal chelators
- C12N2500/20—Transition metals
- C12N2500/24—Iron; Fe chelators; Transferrin
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2500/00—Specific components of cell culture medium
- C12N2500/05—Inorganic components
- C12N2500/10—Metals; Metal chelators
- C12N2500/20—Transition metals
- C12N2500/24—Iron; Fe chelators; Transferrin
- C12N2500/25—Insulin-transferrin; Insulin-transferrin-selenium
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/36—Lipids
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/38—Vitamins
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2500/00—Specific components of cell culture medium
- C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/11—Epidermal growth factor [EGF]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/33—Insulin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/38—Hormones with nuclear receptors
- C12N2501/39—Steroid hormones
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Developmental Biology & Embryology (AREA)
- Gastroenterology & Hepatology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2000/027428 WO2002029012A1 (en) | 2000-10-03 | 2000-10-03 | Processes for clonal growth of hepatic progenitor cells |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1461341A true CN1461341A (zh) | 2003-12-10 |
Family
ID=21741846
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN00820051A Pending CN1461341A (zh) | 2000-10-03 | 2000-10-03 | 肝祖先细胞克隆生长的方法 |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP1325111A1 (enExample) |
| JP (1) | JP2004510434A (enExample) |
| KR (1) | KR100887623B1 (enExample) |
| CN (1) | CN1461341A (enExample) |
| AU (2) | AU2000277535B2 (enExample) |
| CA (1) | CA2424779C (enExample) |
| HK (1) | HK1054570A1 (enExample) |
| IL (1) | IL155387A0 (enExample) |
| WO (1) | WO2002029012A1 (enExample) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101701219A (zh) * | 2009-11-06 | 2010-05-05 | 哈尔滨医科大学 | 编码兔肝细胞生长因子的cDNA及其表达载体和应用 |
| CN101275121B (zh) * | 2007-03-26 | 2011-05-11 | 芦银雪 | 体外培养扩增的人肝脏祖先细胞及其制备方法 |
| CN120642821A (zh) * | 2025-06-20 | 2025-09-16 | 北京医院 | 一种协同延长中性粒细胞体外存活时间的培养方法及组合物 |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL142094A0 (en) | 1998-09-29 | 2002-03-10 | Gamida Cell Ltd | Methods of controlling proliferation and differentiation of stem and progenitor cells |
| US20020187133A1 (en) | 1999-10-01 | 2002-12-12 | Hiroshi Kubota | Methods of isolating bipotent hepatic progenitor cells |
| NZ528462A (en) | 2001-03-27 | 2005-11-25 | Vertex Pharma | Compositions and methods useful for HCV infection |
| IL152904A0 (en) * | 2002-01-24 | 2003-06-24 | Gamida Cell Ltd | Utilization of retinoid and vitamin d receptor antagonists for expansion of renewable stem cell populations |
| CA2479510C (en) * | 2002-03-15 | 2019-10-29 | University Of North Carolina At Chapel Hill | Primitive and proximal hepatic stem cells |
| US20060003446A1 (en) | 2002-05-17 | 2006-01-05 | Gordon Keller | Mesoderm and definitive endoderm cell populations |
| WO2004098490A2 (en) * | 2002-05-17 | 2004-11-18 | Mount Sinai School Of Medicine Of New York University | Mesoderm and definitive endoderm cell populations |
| DE10338531A1 (de) * | 2003-08-19 | 2005-04-07 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur Reklonierung von Produktionszellen |
| US8669109B2 (en) | 2003-08-19 | 2014-03-11 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Methods of producing proteins in Chinese hamster ovary (CHO) cells |
| CA2457296A1 (en) | 2003-08-19 | 2005-02-19 | Takahiro Ochiya | Methods for inducing differentiation of pluripotent cells |
| CA2553303C (en) * | 2004-01-14 | 2014-06-10 | Novahep Ab | Human hepatic progenitor cells and methods of use thereof |
| CA2555021A1 (en) * | 2004-02-13 | 2005-08-25 | Reprocell, Inc. | Medium for preparing feeder cells for embryonic stem cells and feeder cells |
| US8874380B2 (en) | 2010-12-09 | 2014-10-28 | Rutgers, The State University Of New Jersey | Method of overcoming therapeutic limitations of nonuniform distribution of radiopharmaceuticals and chemotherapy drugs |
| EP2091335A4 (en) * | 2006-11-09 | 2012-07-04 | Gamida Cell Ltd | USE OF EX VIVO CULTIVATED HEMATOPOIETIC CELLS IN THE TREATMENT OF ACROSYNDROMES |
| US8951792B2 (en) | 2007-07-20 | 2015-02-10 | Cellartis Ab | Methods for making definitive endoderm hepatocyte (DE-hep) progenitor cells |
| JP6232638B2 (ja) * | 2013-06-24 | 2017-11-22 | 国立研究開発法人医薬基盤・健康・栄養研究所 | 肝前駆細胞増殖用培地 |
| CN104630130A (zh) * | 2014-12-05 | 2015-05-20 | 新乡医学院 | 一种大鼠肝细胞分离方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4914032A (en) * | 1985-06-06 | 1990-04-03 | Centro De Investigation Y Estudios Avanzados Del Instituto Politecnico Nacional | Process for the long-term surviving culture of hepatocytes |
| AU667680B2 (en) * | 1991-08-07 | 1996-04-04 | Albert Einstein College Of Medicine Of Yeshiva University | Proliferation of hepatocyte precursors |
| EP0729297B1 (en) * | 1993-11-19 | 2006-02-22 | ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY, a division of YESHIVA UNIVERSITY | Hepatoblasts and method of isolating same |
| CA2146735C (en) * | 1994-04-11 | 2007-02-20 | Chise Tateno | Liver parenchymal cells having clonal growth ability, method for obtaining same, method for subculturing same, and subculturing system of primary hepatocytes |
| JP3266766B2 (ja) * | 1994-08-23 | 2002-03-18 | 科学技術振興事業団 | ローン性増殖能を有する肝実質細胞とその取得方法、並びにその継代培養方法 |
| DK2048228T3 (en) * | 1999-01-19 | 2016-05-09 | Univ North Carolina | Human liver progenitors |
| CN1258589C (zh) * | 2000-10-03 | 2006-06-07 | 北卡罗来纳大学 | 分离双能肝祖细胞的方法 |
-
2000
- 2000-10-03 WO PCT/US2000/027428 patent/WO2002029012A1/en not_active Ceased
- 2000-10-03 CN CN00820051A patent/CN1461341A/zh active Pending
- 2000-10-03 IL IL15538700A patent/IL155387A0/xx unknown
- 2000-10-03 EP EP00967317A patent/EP1325111A1/en not_active Ceased
- 2000-10-03 AU AU2000277535A patent/AU2000277535B2/en not_active Ceased
- 2000-10-03 KR KR1020037004803A patent/KR100887623B1/ko not_active Expired - Fee Related
- 2000-10-03 AU AU7753500A patent/AU7753500A/xx active Pending
- 2000-10-03 HK HK03106718.5A patent/HK1054570A1/zh unknown
- 2000-10-03 CA CA2424779A patent/CA2424779C/en not_active Expired - Fee Related
- 2000-10-03 JP JP2002532583A patent/JP2004510434A/ja active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101275121B (zh) * | 2007-03-26 | 2011-05-11 | 芦银雪 | 体外培养扩增的人肝脏祖先细胞及其制备方法 |
| CN101701219A (zh) * | 2009-11-06 | 2010-05-05 | 哈尔滨医科大学 | 编码兔肝细胞生长因子的cDNA及其表达载体和应用 |
| CN120642821A (zh) * | 2025-06-20 | 2025-09-16 | 北京医院 | 一种协同延长中性粒细胞体外存活时间的培养方法及组合物 |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2004510434A (ja) | 2004-04-08 |
| EP1325111A1 (en) | 2003-07-09 |
| CA2424779C (en) | 2016-08-23 |
| CA2424779A1 (en) | 2002-04-11 |
| IL155387A0 (en) | 2003-11-23 |
| KR20040047732A (ko) | 2004-06-05 |
| AU2000277535B2 (en) | 2007-03-29 |
| WO2002029012A1 (en) | 2002-04-11 |
| KR100887623B1 (ko) | 2009-03-11 |
| AU7753500A (en) | 2002-04-15 |
| HK1054570A1 (zh) | 2003-12-05 |
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| US10093895B2 (en) | Hepatic stellate cell precursors and methods of isolating same | |
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| AU2000277535A1 (en) | Processes for clonal growth of hepatic progenitor cells | |
| CN1258589C (zh) | 分离双能肝祖细胞的方法 | |
| KR100845471B1 (ko) | 간 전구세포의 클론 증식방법 | |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C12 | Rejection of a patent application after its publication | ||
| RJ01 | Rejection of invention patent application after publication |
Open date: 20031210 |