AU2000277535B2 - Processes for clonal growth of hepatic progenitor cells - Google Patents

Processes for clonal growth of hepatic progenitor cells Download PDF

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Publication number
AU2000277535B2
AU2000277535B2 AU2000277535A AU2000277535A AU2000277535B2 AU 2000277535 B2 AU2000277535 B2 AU 2000277535B2 AU 2000277535 A AU2000277535 A AU 2000277535A AU 2000277535 A AU2000277535 A AU 2000277535A AU 2000277535 B2 AU2000277535 B2 AU 2000277535B2
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cells
hepatic
progenitors
progeny
culture medium
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Ceased
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AU2000277535A
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AU2000277535A1 (en
Inventor
Hiroshi Kubota
Lola M Reid
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University of North Carolina at Chapel Hill
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University of North Carolina at Chapel Hill
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Assigned to UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL reassignment UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL Amend patent request/document other than specification (104) Assignors: UNIVERSITY OF NORTH CAROLINA
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    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0607Non-embryonic pluripotent stem cells, e.g. MASC
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    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/067Hepatocytes
    • C12N5/0672Stem cells; Progenitor cells; Precursor cells; Oval cells
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    • C12N2500/00Specific components of cell culture medium
    • C12N2500/05Inorganic components
    • C12N2500/10Metals; Metal chelators
    • C12N2500/20Transition metals
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    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10Growth factors
    • C12N2501/11Epidermal growth factor [EGF]
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    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
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    • C12N2502/00Coculture with; Conditioned medium produced by
    • C12N2502/13Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
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  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
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  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Developmental Biology & Embryology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AU2000277535A 2000-10-03 2000-10-03 Processes for clonal growth of hepatic progenitor cells Ceased AU2000277535B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2007202994A AU2007202994A1 (en) 2000-10-03 2007-06-27 Processes for clonal growth of hepatic progenitor cells

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2000/027428 WO2002029012A1 (en) 2000-10-03 2000-10-03 Processes for clonal growth of hepatic progenitor cells

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2007202994A Division AU2007202994A1 (en) 2000-10-03 2007-06-27 Processes for clonal growth of hepatic progenitor cells

Publications (2)

Publication Number Publication Date
AU2000277535A1 AU2000277535A1 (en) 2002-06-27
AU2000277535B2 true AU2000277535B2 (en) 2007-03-29

Family

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AU2000277535A Ceased AU2000277535B2 (en) 2000-10-03 2000-10-03 Processes for clonal growth of hepatic progenitor cells
AU7753500A Pending AU7753500A (en) 2000-10-03 2000-10-03 Processes for clonal growth of hepatic progenitor cells

Family Applications After (1)

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AU7753500A Pending AU7753500A (en) 2000-10-03 2000-10-03 Processes for clonal growth of hepatic progenitor cells

Country Status (9)

Country Link
EP (1) EP1325111A1 (enExample)
JP (1) JP2004510434A (enExample)
KR (1) KR100887623B1 (enExample)
CN (1) CN1461341A (enExample)
AU (2) AU2000277535B2 (enExample)
CA (1) CA2424779C (enExample)
HK (1) HK1054570A1 (enExample)
IL (1) IL155387A0 (enExample)
WO (1) WO2002029012A1 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003233399B2 (en) * 2002-03-15 2008-03-20 University Of North Carolina At Chapel Hill Primitive and proximal hepatic stem cells
AU2003208577B2 (en) * 2002-01-24 2008-07-10 Gamida-Cell Ltd. Expansion of renewable stem cell populations
US8202724B2 (en) 1998-02-17 2012-06-19 Gamida Cell Ltd. Methods of controlling proliferation and differentiation of stem and progenitor cells

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020187133A1 (en) 1999-10-01 2002-12-12 Hiroshi Kubota Methods of isolating bipotent hepatic progenitor cells
NZ528462A (en) 2001-03-27 2005-11-25 Vertex Pharma Compositions and methods useful for HCV infection
US20060003446A1 (en) 2002-05-17 2006-01-05 Gordon Keller Mesoderm and definitive endoderm cell populations
WO2004098490A2 (en) * 2002-05-17 2004-11-18 Mount Sinai School Of Medicine Of New York University Mesoderm and definitive endoderm cell populations
DE10338531A1 (de) * 2003-08-19 2005-04-07 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Reklonierung von Produktionszellen
US8669109B2 (en) 2003-08-19 2014-03-11 Boehringer Ingelheim Pharma Gmbh & Co. Kg Methods of producing proteins in Chinese hamster ovary (CHO) cells
CA2457296A1 (en) 2003-08-19 2005-02-19 Takahiro Ochiya Methods for inducing differentiation of pluripotent cells
CA2553303C (en) * 2004-01-14 2014-06-10 Novahep Ab Human hepatic progenitor cells and methods of use thereof
CA2555021A1 (en) * 2004-02-13 2005-08-25 Reprocell, Inc. Medium for preparing feeder cells for embryonic stem cells and feeder cells
US8874380B2 (en) 2010-12-09 2014-10-28 Rutgers, The State University Of New Jersey Method of overcoming therapeutic limitations of nonuniform distribution of radiopharmaceuticals and chemotherapy drugs
EP2091335A4 (en) * 2006-11-09 2012-07-04 Gamida Cell Ltd USE OF EX VIVO CULTIVATED HEMATOPOIETIC CELLS IN THE TREATMENT OF ACROSYNDROMES
CN101275121B (zh) * 2007-03-26 2011-05-11 芦银雪 体外培养扩增的人肝脏祖先细胞及其制备方法
US8951792B2 (en) 2007-07-20 2015-02-10 Cellartis Ab Methods for making definitive endoderm hepatocyte (DE-hep) progenitor cells
CN101701219B (zh) * 2009-11-06 2013-02-20 哈尔滨医科大学 编码兔肝细胞生长因子的cDNA及其表达载体和应用
JP6232638B2 (ja) * 2013-06-24 2017-11-22 国立研究開発法人医薬基盤・健康・栄養研究所 肝前駆細胞増殖用培地
CN104630130A (zh) * 2014-12-05 2015-05-20 新乡医学院 一种大鼠肝细胞分离方法
CN120642821A (zh) * 2025-06-20 2025-09-16 北京医院 一种协同延长中性粒细胞体外存活时间的培养方法及组合物

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993003142A1 (en) * 1991-08-07 1993-02-18 Albert Einstein College Of Medicine Proliferation of hepatocyte precursors

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4914032A (en) * 1985-06-06 1990-04-03 Centro De Investigation Y Estudios Avanzados Del Instituto Politecnico Nacional Process for the long-term surviving culture of hepatocytes
EP0729297B1 (en) * 1993-11-19 2006-02-22 ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY, a division of YESHIVA UNIVERSITY Hepatoblasts and method of isolating same
CA2146735C (en) * 1994-04-11 2007-02-20 Chise Tateno Liver parenchymal cells having clonal growth ability, method for obtaining same, method for subculturing same, and subculturing system of primary hepatocytes
JP3266766B2 (ja) * 1994-08-23 2002-03-18 科学技術振興事業団 ローン性増殖能を有する肝実質細胞とその取得方法、並びにその継代培養方法
DK2048228T3 (en) * 1999-01-19 2016-05-09 Univ North Carolina Human liver progenitors
CN1258589C (zh) * 2000-10-03 2006-06-07 北卡罗来纳大学 分离双能肝祖细胞的方法

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993003142A1 (en) * 1991-08-07 1993-02-18 Albert Einstein College Of Medicine Proliferation of hepatocyte precursors

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Rogler, L.E (Feb. 1997) Am J Path, Vol. 150(2), 591-602 *

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8202724B2 (en) 1998-02-17 2012-06-19 Gamida Cell Ltd. Methods of controlling proliferation and differentiation of stem and progenitor cells
AU2003208577B2 (en) * 2002-01-24 2008-07-10 Gamida-Cell Ltd. Expansion of renewable stem cell populations
AU2003208577B9 (en) * 2002-01-24 2008-07-31 Gamida-Cell Ltd. Expansion of renewable stem cell populations
US7955852B2 (en) 2002-01-24 2011-06-07 Gamida Cell Ltd. Expansion of renewable stem cell populations
AU2003233399B2 (en) * 2002-03-15 2008-03-20 University Of North Carolina At Chapel Hill Primitive and proximal hepatic stem cells
AU2008202656B2 (en) * 2002-03-15 2011-03-17 University Of North Carolina At Chapel Hill Primitive and proximal hepatic stem cells
AU2008202656A8 (en) * 2002-03-15 2011-12-15 University Of North Carolina At Chapel Hill Primitive and proximal hepatic stem cells
AU2008202656B8 (en) * 2002-03-15 2011-12-15 University Of North Carolina At Chapel Hill Primitive and proximal hepatic stem cells

Also Published As

Publication number Publication date
JP2004510434A (ja) 2004-04-08
EP1325111A1 (en) 2003-07-09
CA2424779C (en) 2016-08-23
CA2424779A1 (en) 2002-04-11
IL155387A0 (en) 2003-11-23
CN1461341A (zh) 2003-12-10
KR20040047732A (ko) 2004-06-05
WO2002029012A1 (en) 2002-04-11
KR100887623B1 (ko) 2009-03-11
AU7753500A (en) 2002-04-15
HK1054570A1 (zh) 2003-12-05

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DA3 Amendments made section 104

Free format text: THE NATURE OF THE AMENDMENT IS: AMEND THE NAME OF THE APPLICANT/PATENTEE FROM UNIVERSITY OF NORTH CAROLINA TO UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL

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MK14 Patent ceased section 143(a) (annual fees not paid) or expired