CN1448162A

CN1448162A - Female external sterilization film

Info

Publication number: CN1448162A
Application number: CN 02115684
Authority: CN
Inventors: 孙润民; 谈航飞
Original assignee: Individual
Current assignee: Individual
Priority date: 2002-04-02
Filing date: 2002-04-02
Publication date: 2003-10-15

Abstract

The women's externally applied sterilizing film is prepared with Chinese medicinal materials including bletilla tuber containing colloidal matter for filming, flavescent sophora root, cnidium fruit, anemarrhena rhizome, mustard seed, etc. It is suitable for the auxiliary treatment of women's vaginitis, vulvitis, genital pruritus, crab louse, etc.

Description

Female external sterilization film

Technical field

The invention belongs to the medicinal preparation technical field, a kind of female external sterilization film that is particularly related to the auxiliary treatment of gynaecopathias such as being applicable to female vagina or vulvitis.

Background technology

Gynecological inflammation is women sexual organ's commonly encountered diseases and a frequently-occurring disease, and the Chinese herbal medicine that is used for the treatment of gynecological inflammation is a lot, as Radix Sophorae Flavescentis, Fructus Cnidii, Atractylodes lancea (Thunb.) DC., Herba Portulacae, the Radix Stemonae, Cortex Pseudolaricis, Herba Agrimoniae, dried Alumen or the like.Traditional using method by these herbal prescriptions is decocting washout or stifling the earliest, the water preparation made from extracting solution was arranged afterwards,, be used for washout or lavation as " JIEERYIN ", " Yu Tai is clean " etc., suppository was arranged in recent years as " controlling Mi Lingshuan " etc., and dosage form such as effervescent tablet occurs.All there is certain deficiency in these dosage forms: water preparation is no matter be washout, lavation or stifling, all cumbersome, and carries should not go out the time; The suppository time spent needs the phase of reposing, the active receiving influence during use; Effervescent tablet then exists medicine and dissolves slowlyer, acts on problems such as inhomogeneous.

Summary of the invention

Female external sterilization film (hereinafter to be referred as " sterilization film ") is made by Chinese herbal medicine extract, and composition and content ratio see the following form:

Composition	Radix Sophorae Flavescentis	Fructus Cnidii	Cortex Phellodendri	Herba Portulacae	The Radix Stemonae	The Fructus Kochiae	The Rhizoma Anemarrhenae
Composition	Radix Sophorae Flavescentis	Fructus Cnidii	Cortex Phellodendri	Herba Portulacae	The Radix Stemonae	The Fructus Kochiae	The Rhizoma Anemarrhenae	Content (%)	15-20	10-15	5-10	5-10	5-10	3-8	3-8
Composition	Atractylodes lancea (Thunb.) DC.	Semen Sinapis Albae	Cortex Pseudolaricis	Herba Agrimoniae	Dried Alumen	The Pseudobulbus Bletillae (Rhizoma Bletillae)		Content (%)	15-20	10-15	5-10	5-10	5-10	3-8	3-8
Composition	Atractylodes lancea (Thunb.) DC.	Semen Sinapis Albae	Cortex Pseudolaricis	Herba Agrimoniae	Dried Alumen	The Pseudobulbus Bletillae (Rhizoma Bletillae)		Content (%)	3-8	2-8	2-4	2-4	2-5	15-25

The sterilization film utilizes the good filming of the contained colloidal substance of the Pseudobulbus Bletillae (Rhizoma Bletillae), join with polyvinyl alcohol, Polyethylene Glycol, Borneolum Syntheticum and glycerol as carrier, the extract through other compositions of assembly rationally in the absorbed component is made the sterilization film.The contained main effective ingredient of sterilization film is cnidimine (Cnidimine), ammidin (Alloimperatorineine), d-matrine (d-Matrine), oxymatrine (d-Oxy-matrine), zhimusaponin (Timosaponin), potassium myronate (Sinigrin) and berberine (Berberine) etc.The sterilization film has the bactericidal antiphlogistic effect, experimental verification, and the sterilization film can effectively be killed various bacteria brood bodies such as comprising escherichia coli, staphylococcus aureus, gonococcus, bacillus pyocyaneus, Candida albicans and mycete; Can kill infusorian and pubic louse and oophyte; The propagation that prevents sexually transmitted disease (STD) and other pudendum diseases also there is certain effect.

The sterilization film is applicable to women vaginitis and the vulvitis that causes because of multiple reason, the auxiliary treatment that reaches diseases such as pudendal pruritus, leucorrhea with red and white discharge, sombre disease, pubic louse, cervix uteri wall wart and condyloma acuminatum.The sterilization film is effective, and volume is little, is easy to carry, and uses also very convenient.

Sterilization film diaphragm is faint yellow transparent or semitransparent shape, and softness is flexible, can all be dissolved in water in 7 minutes in the time of 37 ℃.Long 70 ± the 2mm of diaphragm, wide 50 ± 0.2mm, thick 0.13 ± 0.02mm, every heavy 0.5 ± 0.1g.

Each a slice when the sterilization film uses is directly put into intravaginal after agglomerating, not water flushing in 30 minutes after the medication, once a day, and each a slice, six days is a course of treatment.Except anemia of pregnant woman's forbidding and the careful usefulness of allergic constitution, the sterilization film does not have other contraindications.

The present invention's (name of product is " Ai Liwei sterilize film ") carries out acute, chronic pharmacological toxicology through Henan Province health and epidemic prevention station and checks, and assay is as follows:

Acute oral test (white mice): sterilization film LD＞20000mg/kg, the nontoxic level in true border.

Bactericidal assay: 1, the sterilization membrane interaction is 20 minutes, can reach 99.93% to the staphylococcus aureus killing rate, acts on 80 minutes and can reach 100%.

2, the sterilization membrane interaction is 20 minutes, can reach 99.95% to the escherichia coli killing rate, acts on effect in 80 minutes and can reach 100%.

Eye stimulation test (rat) average integral index is zero, true border nonirritant.

Stability test: the sterilization film is deposited 14 days in 54 ℃ of calorstats after, to the basic no change of staphylococcus aureus killing rate.

Description of drawings

Fig. 1 is a process chart of the present invention.

The specific embodiment

Embodiment: (in 10 square metres of sterilization films

One, prescription

Radix Sophorae Flavescentis 200g Fructus Cnidii 100g Cortex Phellodendri 100g Herba Portulacae 50g Radix Stemonae 50g

Fructus Kochiae 50g Rhizoma Anemarrhenae 50g Atractylodes lancea (Thunb.) DC. 50g Semen Sinapis Albae 40g Cortex Pseudolaricis 40g

Herba Agrimoniae 40g dried Alumen 30g Borneolum Syntheticum 5g Pseudobulbus Bletillae (Rhizoma Bletillae) 200g soil temperature 80 40

Glycerol 10ml polyvinyl alcohol 17-88 300g polyethylene glycol 6000 50g

Two, method

(1), A liquid preparation:

1, Fructus Cnidii and Atractylodes lancea (Thunb.) DC. are ground into coarse powder, added the 1000ml alcohol dipping 24 hours, added the 800ml alcohol dipping again 24 hours, filter and the squeezing medicinal residues, merge filtrate and pressed liquor, add 0.3%H ₂SO ₄(V/V) get reserve liquid 1.

2, Radix Sophorae Flavescentis powder is broken into coarse powder, flooded 24 hours, use up, collect percolate and get reserve liquid 2 with speed percolation to the reserve liquid 1 of per minute 3ml with reserve liquid 1.

3, Herba Portulacae, the Radix Stemonae, Cortex Pseudolaricis and Herba Agrimoniae are ground into coarse powder,, use up with speed percolation to the reserve liquid 2 of per minute 5ml with reserve liquid 2 dipping 24 hours, collect A liquid.

(2) B liquid preparation:

The Fructus Kochiae, the Rhizoma Anemarrhenae, Semen Sinapis Albae and alumen powder are broken into coarse powder,, add water 1360ml for the first time, add water 850ml for the second time, merge twice leachate and medicinal residues pressed liquor with deionized water room temperature merceration twice, B liquid.

(3) C crystallization preparation:

Slaked lime 10g put add altogether 20ml of deionized water in the mortar at twice, grind to form uniform lime cream, continue to add water to 600ml, the Cortex Phellodendri that will be ground into coarse powder after stirring slowly adds, constantly stir, place 6 hours (constantly stir) back barrelling, add the water percolation after emitting existing soak as early as possible, collect percolate 1200ml.In this percolate, slowly add an amount of NaCL again, left standstill after the stirring 24 hours, crystallization is all separated out, get the C crystallization with suction funnel leaching crystallization.

(4) D liquid preparation;

A liquid and B liquid are merged, and room temperature is placed and was made it abundant precipitation in 24 hours, and double-deck filter paper filtering is collected filtrate, is evaporated to 2000ml, with saturated NH ₄It is 4.7 that the OH aqueous solution is adjusted pH, filter, sterilize D liquid.

(5) system film:

Pseudobulbus Bletillae (Rhizoma Bletillae) powder is broken into coarse powder, adds 600ml deionized water dipping 24 hours, add D liquid again, room temperature dipping two days with 0.5 filter press filter pressing, gets the about 1500ml of filtrate; The polyvinyl alcohol, Polyethylene Glycol, Borneolum Syntheticum, glycerol and the C crystallization that are ground into fine powder are joined in this liquid, and 80 ℃ of slow fire heating heat while stirring, and make it dissolving evenly, add water and adjust the medicine slurry that total amount is 2kg.The medicine slurry is paved into 10m ²The medicine film, the thick about 0.12mm of dry product cuts into the diaphragm of 5 * 7cm, packing finished product.

Claims

1, a kind of female external sterilization film, it is characterized in that utilizing the rhagiocrin good filming characteristic of Chinese medicine Pseudobulbus Bletillae (Rhizoma Bletillae) institute as carrier, the effective extract in absorption Radix Sophorae Flavescentis, Fructus Cnidii, the Rhizoma Anemarrhenae, Semen Sinapis, Cortex Phellodendri, Herba Agrimoniae, Atractylodes lancea (Thunb.) DC., the Radix Stemonae, the Fructus Kochiae, Cortex Pseudolaricis and the dried Alumen is fixed into membranaceous.

2, the female external sterilization film of claim 1, the percentage ratio that it is characterized in that contained each composition are Radix Sophorae Flavescentis 15-20%, Fructus Cnidii 10-15%, Cortex Phellodendri 7-15%, Herba Portulacae 6-12%, Radix Stemonae 8-13%, Fructus Kochiae 3-8%, Rhizoma Anemarrhenae 3-8%, Atractylodes lancea (Thunb.) DC. 3-8%, Semen Sinapis Albae 2-8%, Cortex Pseudolaricis 2-4%, Herba Agrimoniae 2-4%, dried Alumen 2-5%, Pseudobulbus Bletillae (Rhizoma Bletillae) 15-22%.