CN1444852A

CN1444852A - Granulated strong action disinfectant

Info

Publication number: CN1444852A
Application number: CN 02114626
Authority: CN
Inventors: 龙膺厚
Original assignee: Individual
Current assignee: Individual
Priority date: 2002-06-17
Filing date: 2002-06-17
Publication date: 2003-10-01

Abstract

A strong disinfectant in the form of particles for dissolving in water to obtaining the aqueous solution of ClO2 is prepared from stable ClO2 solid, activating agent (active solid product of Cl) and activating assistant (solid acid) through respective granulating, coating, and proportional mixing.

Description

Granulated strong action disinfectant

Technical field the present invention relates to a kind of disinfectant: unified packing Pickering chlorine dioxide granule and production method thereof.

This product system is mixed the water-soluble aqueous solution that promptly generates chlorine dioxide by some kinds of particles in the same packing.The background technology chlorine dioxide is contemporary classic wide spectrum, efficient, quick-acting, safe disinfectant, and range of application is extremely wide, has boundless prospects.But chlorine dioxide itself is a kind of volatile damp, and walls such as plastics are had certain penetrability, thus preserve and use very not convenient.So-called stable ClO 2 solution appears in the back, adds activator by a certain percentage during use and generates aqueous solution of chlorine dioxide, and concentration is generally about 2%.But this product is stored, transportation inconvenience, the consumption of activator excessive (be stability chlorine dioxide dry matter in the solution 5-10 times), and activation process is slow, and required time is long.The non-acid activators of solid of Shanghai literary composition China sterilization research institute invention has solved the problems referred to above preferably, but non-acid activators of its solid and Pickering chlorine dioxide must deposit respectively, is the Pickering chlorine dioxide preparation for " two-component packaging ".During use, two kinds of solids add respectively in the same water body in the ratio of strictness and certain consumption and generate certain density aqueous solution of chlorine dioxide.If two kinds of solids directly contact, just might react very soon even blast; Thereby two kinds of solid materials must be stored respectively at ordinary times.In order to overcome this makes us feeling deeply inconvenience in storing, prepare, using shortcoming, many people attempt to prepare unified packaged products, but all do not succeed; Main difficulty is that the stability of product still can not expire " disinfection technology standard " middle requirement of stipulating that the Ministry of Public Health issues, and has lost necessary activity function though perhaps can satisfy stability requirement.Allowing all materials exist together among the packing, and make it to satisfy activity function and stability requirement simultaneously, is starting point of the present invention.

Summary of the invention

The invention provides a kind of product (to call " this product " in the following text) and production technology thereof, absolutely different with existing chlorine dioxide formulation products, be the Pickering chlorine dioxide granule of a kind of " unified packing ".It is characterized in that:

1. mixed by some kinds of particles, contained various uniform particles are mixed and are stored among the same packing; Getting the hybrid particles of this product, a little is water-soluble, promptly generates the aqueous solution of chlorine dioxide; The concentration of chlorine dioxide is decided by user's needs in the solution, and when dissolving, do simple the conversion and get final product by the chlorine dioxide content of this product, but free hold.

2. some kinds of contained particle systems are through microencapsulation or micropill Cotton seeds.

3. according to the kind of used raw and auxiliary material and the difference of art for coating condition, the stability of product can be controlled and be regulated, and reaches as high as to store more than 2 years and content descends and is no more than 10%.

This makes the storage, transportation of this outstanding disinfectant of chlorine dioxide, on-the-spot preparation and use become very easy, provides very advantageous conditions thereby use for its large-scale popularization.

Embodiment

This product uses Pickering chlorine dioxide, activator and activator promotor to be primary raw material.Three kinds of primary raw materials (can in advance granulate in case of necessity) are carried out microencapsulation or micropill dressing with suitable auxiliary material respectively.Then,

1. will mix by a certain percentage through stability chlorine dioxide, activator and the activator promotor of dressing;

2. or without activator promotor, and will mix by a certain percentage through the stability chlorine dioxide and the activator of dressing; Promptly get this product.

Can be according to the difference of used activator and art for coating, the stability of control products obtained therefrom kind, and thereby be used for different purposes.Fresh-keeping when storing as fruit, need to use the spacetabs type kind, and should be able to satisfy the index of defined in the disinfection technology standard that the Ministry of Public Health issues for the stability of the kind of general sterilization usefulness, promptly deposit 1-2 naturally in room temperature, its active constituent content descends and is no more than 10%, belongs to stablizing the class disinfectant; Or deposit naturally more than 2 years in room temperature, its active constituent content descends and still is no more than 10%, belongs to and stablizes the class disinfectant.

The chlorine dioxide content of this product solid particle can be controlled with the ingredient proportion of three kinds of primary raw materials on demand during fabrication.Obtainable high-load about 25%.

The assay method of this product active ingredient chlorine dioxide content is undertaken by the method for defined in the disinfection technology standard that the Ministry of Public Health issued.

Below again the production method of this product is further described and illustrates:

According to the difference of purposes, the granularity of particle can be determined with sieve method for about the 10-80 order.The particle size span of each specification should be not excessive, and specifications such as 15-25 order, 15-30 order, 60-80 order for example can be arranged.Usually be directly used in preparation thimerosal person and should use 15-25 order or 15-30 purpose specification, should use 60-80 purpose specification and be used for adding person such as disinfectant soap.

For less than 35 purpose granule materials, can use air suspension spray dryer to carry out the dressing operation.For bigger material, except that carry out the dressing operation with air suspension spray dryer, also can use coating pan general in the pharmaceuticals industry to carry out the dressing operation.A small amount of material, the method that also can stir by hand in suitable containers in the laboratory, spread out cloth, dry or dry is carried out dressing.

If material is granulated in advance, can adopt the conventional granulating process method and apparatus that uses in the pharmaceuticals industry.For example, earlier material is pulverized with cracker, sieved, the starch slurry with 8% or other binders are made softwood, granulate with granulator, and oven dry, promptly.Also can adopt other equipment such as closed full-automatic dry to press granulator to granulate automatically.A small amount of material also can add an amount of binder in the laboratory in suitable containers, the method for stir, spread out cloth by hand, dry or dry, sieving is granulated.

The employed raw and auxiliary material of this product:

1. Pickering chlorine dioxide: commercially available product, available from Shanghai literary composition China sterilization research institute.

2. activator: being the solid active chlorinated product, comprising various inorganic active chlorine and organic active chlorine, all is available raw material; For example solid clorox, calcium hypochlorite, lithium hypochlorite, postassium hypochlorite, Efficacious Disinfeitant, sym-closene and bromo-derivative thereof and salt, chlorine ammonia T, dichloro-dimethyl glycolylurea, chlorine bromine dimethyl hydantoin etc., or other available chlorine preparation.All these materials all can be buied from market.

3. activator promotor: SOLID ORGANIC acids and some inorganic acids, as various polybasic carboxylic acids and some monocarboxylic acid, substituted carboxylic acids such as halogenated acid, carboxylic acid, amino acid, other organic acids such as sulfonic acid, substituted sulfonic acid, and the acid of some solid inorganics all can be buied from market as hypophosphorous acid etc.

4. granulate and the used auxiliary material of art for coating: general binder and coating material in the available pharmaceuticals industry, as starch, carbohydrate, various water-soluble and pure soluble macromolecular materials such as dextrin, polyethylene glycol, polyvinyl alcohol, carboxymethyl cellulose, ethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methylcellulose, gelatin, sodium alginate, agar, polyacrylic resin-II type reach-the III type, and mineral grease such as dimethicone, paraffin etc. with buffer action, all can buy from market.

As the available chlorine class preparation of activator in this product, though itself also be safety and disinfectant efficiently of a class, because of Disinfection Effect not as good as chlorine dioxide and there is some bad reaction gradually superseded, just replaced by chlorine dioxide.Though also used them among the present invention, yet, the main purpose of using them is to utilize them that the mobilizing function of stability chlorine dioxide is produced free chlorine dioxide molecule soluble in water immediately at the scene, is not the antiseptic property that mainly utilizes available chlorine itself.Because chlorine dioxide is all much better than than available chlorine to the disinfecting power of all kinds of pathogenic microorganisms, thereby under the situation that reaches identical or better Disinfection Effect, the amount of contained available chlorine preparation and the available chlorine that produced thereof in this product is much smaller than the respective substance content (approximately little usually two orders of magnitude) during separately as disinfectant with the available chlorine preparation; Nature, its bad reaction is also just much smaller, thereby can be considered actual nontoxic.

Activator promotor among the present invention is an organic acid.Though the activator of the stability chlorine dioxide product of solution-type also is an organic acid, the purpose of using them among the present invention mainly is to utilize their auxiliary activation rather than main activation, thereby its consumption few (approximately little two orders of magnitude); Activating velocity depends primarily on main activator rather than these organic acids as activator promotor.

The ingredient proportion of each primary raw material can be regulated by user's needs.Typical proportion is:

1. Pickering chlorine dioxide: activator: activator promotor=1: 1-1.5: 0.1-0.2

2. Pickering chlorine dioxide: activator=1: 1-1.5

When dressing is operated, should write down the yield of primary raw material and auxiliary material.In calculating mixture during the rate of charge of various particles, should be by the actual content conversion of primary raw material.Application example: example 1. is got Pickering chlorine dioxide crystal and is pulverized, with starch slurry or sodium alginate is that binder is granulated, screening 15-20 order part, dilute alcohol solution with polyacrylic resin-II is coating material dressing in air suspension spray dryer, get white particle, screening 20-25 order part (I), standby.Getting sym-closene particle 15-20 order part, is coating material dressing in air suspension spray dryer with the aqueous solution of 1.5% carboxymethyl cellulose, white particle, screening 20-25 order part (II).Get I and II mixed in equal amounts, promptly.This product can be used as the fruit antistaling agent of spacetabs type.Example 2. is got Pickering chlorine dioxide crystal and is pulverized, and is coating material dressing in air suspension spray dryer with the dilute alcohol solution of polyacrylic resin-II, white particle, screening 60-80 order part (III); Get the crystallinity clorox and pulverize, handle with the petroleum ether solution of paraffin, fully stir, volatilization is waited to do, screening 60-80 order part (IV); Getting citric acid and pulverize, is coating material dressing in air suspension spray dryer with the aqueous solution of sodium alginate, screening 60-80 order part (V); With III, IV, V with in 2%, 1.5% and 0.1% the ratio adding soap powder, are pressed into sterilization type incense drug soap respectively.10% aqueous solution effect of this incense drug soap 5-10 minute can 100% be killed staphylococcus aureus, Escherichia coli, Candida albicans, gonococcus, microspironema pallidum, influenza virus, can destroy the antigenicity of hepatitis B surface antigen HBsAg fully.

Claims

1. unified packing Pickering chlorine dioxide granule is characterized in that:

(1). it is made up of some kinds of granule materials, and all granule materials all are present among the same inner packing simultaneously, do not have the separation of any spacer therebetween, and various particles all can freely contact closely; The water-soluble aqueous solution that promptly generates chlorine dioxide of the particle that mixes, its concentration only depend on chlorine dioxide content in the particle and the extension rate when water-soluble thereof;

(2). chlorine dioxide content can be controlled arbitrarily by the composition of regulating particle in the scope that is up to 25% (mass fraction) in the particle;

(3). its stability can be by the adjusting of the selection of activator and art for coating condition and is controlled.

2. unified packing solid chlorine dioxide granule as claimed in claim 1 is characterized in that:

(1). the granularity of said particle can have certain scope;

(2). the granularity of same specification kind can have certain span.

3. unified packing solid chlorine dioxide granule as claimed in claim 1 is characterized in that said particle comprises:

(1). Pickering chlorine dioxide particle;

(2). activator granulate;

(3). the activator promotor particle.

4. unified packing solid chlorine dioxide granule as claimed in claim 1 is characterized in that said particle comprises:

(1). Pickering chlorine dioxide particle;

(2). activator granulate.

5. make the method for the described unified packing solid chlorine dioxide granule of claim 1, it is characterized in that said particle has been carried out microencapsulation or the processing of micropill dressing processing technology.

6. make the method for the described unified packing solid chlorine dioxide granule of claim 1, it is characterized in that the primary raw material of forming some kinds of particles had been carried out the processing of granulation processing technology before the dressing processing technology is handled.

7. make the method for the described unified packing solid chlorine dioxide granule of claim 1, it is characterized in that:

(1). used activator is a solid available chlorine preparation, comprise various inorganic available chlorine and organic available chlorine, as salt solids such as the sodium of hypochlorous acid, calcium, lithium, potassium, Efficacious Disinfeitant, sym-closene and bromo-derivative thereof and salt, chlorine ammonia T, dichloro-dimethyl glycolylurea, chlorine bromine dimethyl hydantoin etc., or other available chlorine preparation.

(2). used activator promotor is the solid acid, as various polybasic carboxylic acids and some monocarboxylic acid, substituted carboxylic acids such as halogenated acid, carboxylic acid, amino acid, other organic acids such as sulfonic acid, substituted sulfonic acid, and some solid inorganic acid is as hypophosphorous acid etc.

(3). granulation and the used auxiliary material of art for coating are starch, carbohydrate, various water-soluble and pure soluble macromolecular materials such as dextrin, polyethylene glycol, polyvinyl alcohol, carboxymethyl cellulose, hydroxyethylcellulose, hydroxypropyl cellulose, hydroxypropyl methylcellulose, gelatin, sodium alginate, agar, polyacrylic resin-II type reach-the III type, and mineral grease such as dimethicone, paraffin etc. with buffer action.