CN1436537A - Oral liquid with hyaluronic acid as effective component - Google Patents
Oral liquid with hyaluronic acid as effective component Download PDFInfo
- Publication number
- CN1436537A CN1436537A CN 02100891 CN02100891A CN1436537A CN 1436537 A CN1436537 A CN 1436537A CN 02100891 CN02100891 CN 02100891 CN 02100891 A CN02100891 A CN 02100891A CN 1436537 A CN1436537 A CN 1436537A
- Authority
- CN
- China
- Prior art keywords
- oral liquid
- hyaluronic acid
- effective component
- acid
- water
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The oral liquid with hyaluronic acid as effective component includes hyaluronic acid, citric acid, oligosaccharide or other sugar or honey and water. The present invention prepares oral liquid with hyaluronic acid through maintaining the activity of hyaluronic acid while sterilizing and preserving. The oral liquid is drunk directly and is easy to absorb. The oral liquid with hyaluorinic acid has the effects of raising immunity, delaying senility, improving the function of gastrointestinal tract, restoring luster and elasticity of skin, etc.
Description
Technical field
The present invention relates to the oral liquid made as effective component with hyaluronic acid.
Background technology
Hyaluronic acid is indispensable a kind of macromolecule mucopolysaccharide material in the humans and animals body; Main Ingredients and Appearance is a glucuronic acid; it extensively is present in intravital various tissues of humans and animals and the extracellular matrix; from connective tissue; skin; serum; all ubiquitous in the vitreum; hyaluronic acid is at first separated from buphthalmos in 1934 by American scholar Meyer and Palmer; research through the several generations scholar; real form large-scale production then be the nineties invented by Hatanaku etc. produce hyaluronic method with biological fermentation process after; existing to hyaluronic application; lay particular emphasis on ophthalmology mostly; the cardiovascular diseases; surgical wound, and the clinical treatment and the diagnosis of disease such as liver function detection.China mainly is confined to external aspects such as ophthalmology and skin protection to hyaluronic development and use.The inventor successfully is applied to hyaluronic acid in the health food through the experiment of concentrating on studies for many years, has obtained the good health care effect.
Summary of the invention
The purpose of this invention is to provide a kind of oral liquid of making as effective component with hyaluronic acid, this oral liquid has the immunologic function of adjusting and functions such as delaying human body function and skin aging.
For achieving the above object, the present invention takes following design: this with the oral liquid of hyaluronic acid as effective component, it comprises: hyaluronic acid, water, and wherein the hyaluronic acid weight percent is 0.05-2%, all the other are water.
Except that hyaluronic acid and water, also can add oligosaccharide or other table sugar, Mel etc. in this oral liquid.
This oral liquid has been made the food safety evaluation on toxicology result:
With 0.075,0.15, the oral liquid active ingredient hyaluronic acid of 0.30g/kg.bw mixed in the feedstuff feed rat 30 days.At duration of test, each treated animal growth promoter is good, and body weight, weightening finish and food utilization are compared with matched group, and there are no significant for difference (P＞0.05); All within this chamber range of normal value, gross anatomy and histopathologic examination there is no unusually for hematology, biochemical indicator and dirty body ratio.Show that this product do not see tangible subchronic toxicity effect.This oral liquid is to two kinds of sex large and small Mus per os acute toxicity tests and three genetic toxicity tests, and the result is all negative, belongs to non-poisonous material.
This oral liquid has been done the zoopery of immunoregulation effect, and its check conclusion is:
Per os gave the oral liquid of various dose after 20 days, the delayed allergy toes thicken in the method, low, in two dosage groups compare with matched group, the toes thickness difference obviously increases before and after attacking, difference has significance (P＜0.05), basic, normal, high three dosage groups are compared with matched group in the antibody-producting cell test, antibody-producting cell obviously increases, difference has significantly low (P＜0.05), all other tests there is no the immunosuppressant phenomenon, assay shows that this sample has immunoregulation effect.
This oral liquid has been done the delaying senility function zoopery:
In the drosophila survival experiment, each organizes fruit bat growth, movable good.The half death time of each concentration group fruit bat, average life and average maximum life span all are higher than matched group, wherein, the average maximum life span of the male fruit bat of 3.0% concentration group, female fruit bat average life is compared with matched group with average maximum life span, difference has significance (p＜0.05), and the female fruit bat half death time of 3.0% concentration group is compared greater than 4 days with matched group.In D-galactose modeling zoopery, after giving the oral liquid of various dose, three dosage group brain SOD activity all is higher than model control group, and difference has significance (P＜0.01), according to the health food function assessment assessment process and the method for inspection, oral liquid has function in delaying senility.
Embodiment
Add pure water 74.5kg in blending tank, add hyaluronic acid 0.5kg again, at room temperature stirred 6-12 hour, mixing speed is 40-60rpm, treat that hyaluronic acid dissolves fully after, add 25kg table sugar or Mel again, adopt the ultrafiltration apparatus degerming then.Pour in the 10ml oral liquid bottle Zha Gai sealing.Carry out outer package at last, through product inspection, dispatch from the factory.The packing system of this oral liquid enters the cleaning shop again after high temperature or ultraviolet and ozone sterilization, be used for the oral liquid packing.
Oral hyaluronic acid liquid result of use sense organ evaluating meter
| Assessment item | Significant change | Change slightly | No significant change | |
| ????1 | Whole skin is smooth, fine and smooth, high resilience, not dry and cracked, Pruritus, peeling, and the dandruff reduces | ????30 | ????6 | ????2 |
| ????2 | Facial complexion is ruddy, healthy, seem that young, wrinkle reduces, brown patch is desalinated | ????22 | ????12 | ????4 |
| ????3 | The health stretching resistance strengthens, easy catching a cold is not sick | ????20 | ????14 | ????4 |
| ????4 | Gastrointestinal function strengthens, and stomachache is alleviated, stool is logical, hemorrhoid disappear | ????32 | ????4 | ????2 |
| ????5 | Muscle power increases, from head to foot energetically, and indefatigability | ????14 | ????18 | ????6 |
The user who participates in this evaluation test is totally 38 people, and the age is 35-85 year, and everyone takes 1-2 bottle oral hyaluronic acid liquid every day, and every bottle of capacity 10ml took one month continuously.
Advantage of the present invention: the present invention adds oral liquid with hyaluronic acid as effective component, and has solved the problem of sterilization fresh in the situation that keeps activity in production technology, and is capable of direct drinking, absorbs easily. Have raising immunity, delay senility, improve gastrointestinal function, recover the several functions such as skin gloss elasticity.
Claims (2)
1,, it is characterized in that it comprises with the oral liquid of hyaluronic acid as effective component: hyaluronic acid, water, wherein the hyaluronic acid weight percent is 0.002-2%, all the other are water.
2, according to claim 1 with the oral liquid of hyaluronic acid as effective component, it is characterized in that: also contain oligosaccharide or other table sugar, Mel in the described oral liquid, the percentage by weight of each component is 0.002-2%, 5-40%, and all the other are water.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 02100891 CN1436537A (en) | 2002-02-07 | 2002-02-07 | Oral liquid with hyaluronic acid as effective component |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 02100891 CN1436537A (en) | 2002-02-07 | 2002-02-07 | Oral liquid with hyaluronic acid as effective component |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1436537A true CN1436537A (en) | 2003-08-20 |
Family
ID=27627319
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 02100891 Pending CN1436537A (en) | 2002-02-07 | 2002-02-07 | Oral liquid with hyaluronic acid as effective component |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1436537A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1302783C (en) * | 2004-12-24 | 2007-03-07 | 凌沛学 | Oral taking preparation for aesthetic health care and preparation method |
| US20140080761A1 (en) * | 2009-07-16 | 2014-03-20 | Hirosaki University | Proteoglycan-containing material |
| US9284359B2 (en) | 2011-01-19 | 2016-03-15 | Hirosaki University | Method for mass preparation of proteoglycan |
| CN114081114A (en) * | 2021-11-12 | 2022-02-25 | 华中农业大学 | Sodium hyaluronate beverage with function of regulating intestinal flora and preparation method thereof |
-
2002
- 2002-02-07 CN CN 02100891 patent/CN1436537A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1302783C (en) * | 2004-12-24 | 2007-03-07 | 凌沛学 | Oral taking preparation for aesthetic health care and preparation method |
| US20140080761A1 (en) * | 2009-07-16 | 2014-03-20 | Hirosaki University | Proteoglycan-containing material |
| US9585828B2 (en) * | 2009-07-16 | 2017-03-07 | Sunstar Inc. | Proteoglycan-containing material |
| US9284359B2 (en) | 2011-01-19 | 2016-03-15 | Hirosaki University | Method for mass preparation of proteoglycan |
| CN114081114A (en) * | 2021-11-12 | 2022-02-25 | 华中农业大学 | Sodium hyaluronate beverage with function of regulating intestinal flora and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102172269B (en) | Hidegelatin fabricated food with beautification function | |
| JP2008183011A (en) | Method for fermentation and cultivation, fermented plant extract, fermented plant extract powder and composition of fermented plant extract | |
| CN106999522A (en) | Eurycoma longifolia extract product and its for strengthen and/or stimulating immune system purposes | |
| CN103211258A (en) | Weight-losing apple vinegar health drink and preparation method thereof | |
| CN108815072A (en) | A kind of plant composition fermentation magma and its preparation method and application | |
| CN109123622A (en) | A kind of conditioning health rose fermentation ferment and preparation method thereof | |
| CN107693402A (en) | A kind of fructus hippophae moisturizing Face-protecting mask and preparation method thereof | |
| CN109662311A (en) | Ferment and its preparation method and application with function of relaxing bowel | |
| CN112425785A (en) | Composition with effects of maintaining beauty and keeping young and preparation method and application thereof | |
| JP2013063046A (en) | Fermented garlic and method of producing the same | |
| CN115554220A (en) | Microbial fermentation stock solution with skin care effect and preparation method and application thereof | |
| KR101448239B1 (en) | Cosmetic composition containing fruit vinegar | |
| KR20130026127A (en) | Head-skin nutrition supplier composition and its manufacturing method | |
| CN1436537A (en) | Oral liquid with hyaluronic acid as effective component | |
| CN101507759B (en) | Traditional Chinese medicine combination capable of preventing and treating seborrheic dermatitis and preparation and preparation method thereof | |
| CN101120750B (en) | Method for preparing ginkgo bee product | |
| CN107898806A (en) | A kind of composition and its application with strong anti-inflammatory activity | |
| CN100506085C (en) | Brown sugar health product capable of raising immunity of puerpera | |
| TW200528033A (en) | Oral skin-improving pharmaceutical preparation using cranberry abstract as active principle | |
| CN114788795A (en) | Acne-removing composition and preparation method and application thereof | |
| CN1436536A (en) | Effervescent tablet with hyaluronic acid as effective component | |
| CN101278967B (en) | Health care capsules for overall regulating immunity of organism and preparation technique | |
| CN110974935A (en) | Antibacterial nursing gel containing fullerene C60 component and preparation method thereof | |
| CN1072955C (en) | Tonic liquid of black ewe's placenta extract and its preparing method | |
| CN105999003A (en) | Folium artemisiae argyi healthcare liquor for preventing and treating dysmenorrhea and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |