CN1432375A - Dog pestilence treating medicine composition - Google Patents
Dog pestilence treating medicine composition Download PDFInfo
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- CN1432375A CN1432375A CN 02100358 CN02100358A CN1432375A CN 1432375 A CN1432375 A CN 1432375A CN 02100358 CN02100358 CN 02100358 CN 02100358 A CN02100358 A CN 02100358A CN 1432375 A CN1432375 A CN 1432375A
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Abstract
The dog pestilence treating medicine composition is prepared with Chinese goldthread, angelica, rhubarb, notoginseng and sophora seed as material. It is used for treating dog's viral infection, high fever, enteritis and bloody flux and has high curative effect.
Description
The present invention relates to pharmaceutical preparation, specifically be applicable to the pharmaceutical composition of hundstaupe.
Canine distemper, canine bloody dysentery are the commonly encountered diseases of dog class, frequently-occurring disease.Usually be referred to as hundstaupe.At present hundstaupe still there is not effective Therapeutic Method.Symptomatic treatment is generally all adopted in veterinary's outpatient service, during canine distemper, often adopts dipyrone, penicillin mixings intramuscular injection as treatment, and intravenous drip glucose, normal saline etc. are in case dewater.When treatment dog class dysentery, then adopt intramuscular injection vitamin K3 and oral hydrochloride ciprofloxacin, moroxydine etc. with hemostasis, infection.The method of these symptomatic treatments, the course of treatment all long and DeGrain.
Purpose of the present invention just provides a kind of pharmaceutical composition that is used for the treatment of hundstaupe, and its effect is fast, curative effect is high.
The object of the present invention is achieved like this: selecting following Chinese medicine raw materials by weight proportion for use is Rhizoma Coptidis 20-60 part, Radix Angelicae Sinensis 10-30 part, Radix Et Rhizoma Rhei 4-8 part, Radix Notoginseng 1-10 part, and Flos Sophorae Immaturus 10-30 part is prepared into various dosage forms.
Purpose of the present invention realizes being based on hundstaupe, and many its disease is broken with tremendous force by due to the evil epidemic disease of diseases caused by exogenous pathogenic factor pestilence, sick the exterior and the interior intenseness of heat just, and intense heat in both QI and blood systems then, later stages two disease reciprocal causation, day by day critical, blood system heat is then boiled over absurd row; Then impairment of YIN dryness-transformation of qifen fever.Disease is seen unconsciousness due to high fever, and cough with asthma is more than, vomits and diarrhoea and does frequently, and asoscope is dry and cracked, the dense blood of defecating.According to Traditional Chinese medical theory, analyze, decide the side, select medicine by the program of " reason, method, side, medicine ", filter out the prescription of treatment hundstaupe unconsciousness due to high fever, enteritis red diarrhea.
The weight proportion of preferred ingredient of the present invention is: Rhizoma Coptidis 20-30 part, Radix Angelicae Sinensis 10-20 part, Radix Et Rhizoma Rhei 4-5 part, Radix Notoginseng 1-3 part, Flos Sophorae Immaturus 15-20 part.
Pharmaceutical composition of the present invention can be mixed with multiple dosage forms such as powder, oral liquid, injection, but preferably is prepared into suppository.This is that oral administration is difficulty comparatively because the tooth of dog intersects stragglyly, and need have the veterinary of certain nursing experiences to operate when injection preparation cost height and administration, thereby administration comparatively bothers.Preparation of pharmaceutical compositions of the present invention is become suppository, and the dog master can directly fill in this suppository the anus of dog simply and easily, can reach therapeutic effect.
Innovative point of the present invention is the property of medicine of each component organically is combined as a whole, and makes it both can produce significant synergism, but the bias of restriction or checking relation in five elements medicine again.
Rhizoma Coptidis in the pharmaceutical composition of the present invention all has certain killing and inhibitory action to Gram-negative, positive pathogenic bacteria and virus.Radix Angelicae Sinensis can reduce vascular permeability, suppresses the release of inflammation-causing substance in the platelet and produces antiinflammatory action, also can invigorate blood circulation simultaneously, hemopoietic, nourish blood the enhancing body resistance against diseases.Radix Et Rhizoma Rhei leads to intestinal, clearing away heat-fire, and eliminating pathogenic heat from blood to cure dysentery can be cleansed all backward, corrupt and reactionary things of gastrointestinal, and the usefulness of removing burning wood away under the boiler is arranged.Can the purify the blood heat of branch of Radix Notoginseng, the Flos Sophorae Immaturus helps Rhizoma Coptidis removing heat from blood, hemostasis, detoxifcation.All medicines are played the effect of sterilization, sterilization, antiinflammatory hemostasis with all strength altogether.Specimen is also controlled, and pathogenic factor must be disappeared, and vigour is recovered, and sick dog is healed entirely.
Each component and weight proportion are to get through repeated screening among the present invention, and its preferable range can guarantee that said composition has best mutual reinforcement between effect.
After preparation of pharmaceutical compositions of the present invention becomes fluid extract, add various pharmaceutical carriers and can be prepared into several formulations.As add starch and can be made into tablet, granule, powder; Add distilled water and can be made into mixture; The fluid extract oven dry is pulverized and be can be made into capsule; Add stearic acid and can be made into suppository.
The present invention can be used for treating viral infection, hyperpyrexia, the enteritis dysentery of dog class.
When becoming suppository, preparation of pharmaceutical compositions of the present invention can adopt following method:
Rhizoma Coptidis 2kg, Radix Et Rhizoma Rhei 0.4kg, Radix Angelicae Sinensis 1kg, Flos Sophorae Immaturus 1.5kg are decocted with water three times, and 2 hours for the first time, second and third time respectively decocted 1.5 hours, and collecting decoction filters, and filtrate is concentrated into the clear paste that relative density is 1.2～1.5 (70～80 ℃).Put coldly, adding ethanol to the alcohol amount of containing is 80%, stirs evenly, and leaves standstill 12 hours, divides and gets supernatant, reclaim ethanol after, concentrating under reduced pressure becomes the clear paste of relative density 1.35～1.38 (50～60 ℃), and cold drying (below 60 ℃), pulverizes.Get Radix Notoginseng 0.1kg and be ground into fine powder, with above clear paste powder mix homogeneously.Other gets semi-synthetic fatty acid ester 980 grams, and heat fused, temperature remain on 40 ℃ ± 2 ℃ and add above-mentioned mixed powder, stir evenly, and water and are molded as 1000, promptly.
The using method of suppository of the present invention is that rectally is filled in anus 2-3 centimetre with suppository.The each 0.1-0.15 gram of the every kg body weight of dog, four times on the one, three is a course of treatment.
Pharmaceutical composition of the present invention is not seen any toxic and side effects through animal toxicity test.
Pharmaceutical composition of the present invention shows through application, and it is brought down a fever, dysentery relieving, haemostatic effect are obvious, and sick dog rehabilitation is fast, and more the back does not have repeatedly.
It below is the animal applications data of pharmaceutical composition of the present invention.
Experimental technique:
Sick dog is adopted the random packet method, and selection medical history, the sick dog that the state of an illness is suitable are divided into two groups of experimental group and matched groups.
Experimental group uses drug suppository of the present invention, and its usage and dosage is the per anum administration, fills in rectum 2-3 centimetre, every kg body weight 0.15 gram, four times on the one.
Matched group: canine distemper is given 30% dipyrone 10ml, and intramuscular injection is mixed in ampicillin 800,000 units * 5, and secondary/day, dehydrator award 5% glucose 500ml, dexamethasone 20mg, and intravenous drip, once-a-day.Parvovirus infections gives vitamin K
31ml * 3 intramuscular injection, each 0.5 gram of ciprofloxacin, each 0.5 gram of moroxydine, secondary/day, oral.Dehydrator gives 5% glucose 500ml, normal saline 500ml, sodium bicarbonate injection 250ml, intravenous drip.
Experimental result sees Table 1, table 2.
The present invention is used for the experimental result of canine distemper disease
(table one) test number: 25
(table 2 vides infra)
Experimental result shows, drug suppository of the present invention, and its various treatment of conditions effects to hundstaupe all obviously are better than matched group, it can also be seen that from medicining condition, use medicine of the present invention more economical and practical.
Below be specific embodiments of the invention.
Embodiment 1:
With Rhizoma Coptidis 20kg, Radix Angelicae Sinensis 10kg, Radix Et Rhizoma Rhei 4kg, Flos Sophorae Immaturus 10kg, decoct with water three times, 2 hours for the first time, second and third time respectively decocted 1.5 hours, merged to decoct liquid, filtered.Filtrate is concentrated into the clear paste that relative density is 1.22 (70～80 ℃).Put coldly, add ethanol to the alcohol amount of containing and be 80% and stir evenly, left standstill 12 hours, divide and get supernatant, reclaim ethanol after, concentrating under reduced pressure becomes the clear paste of relative density 1.38 (50～60 ℃), and cold drying (below 60 ℃), pulverizes.Get Radix Notoginseng 1kg, be ground into fine powder, with above clear paste mix homogeneously.Add and get semi-synthetic fatty acid ester 8.82kg, heat fused, temperature remain on 40 ℃, add above-mentioned mixed powder and stir evenly, and water and make 9000 suppositorys.
The present invention is used for the experimental result of (dog) parvovirus infections
(table two) test number: 30
Following examples are the consumption proportion difference, and its concrete preparation method and effect are all identical with embodiment 1.
Embodiment 2-5
Claims (3)
1, a kind of pharmaceutical composition that is used for the treatment of hundstaupe is characterized in that it contains following Chinese medicine raw materials by weight proportion: Rhizoma Coptidis 20-60 part, Radix Angelicae Sinensis 10-30 part, Radix Et Rhizoma Rhei 4-8 part, Radix Notoginseng 1-10 part, Flos Sophorae Immaturus 10-30 part.
2, the pharmaceutical composition that is used for the treatment of hundstaupe according to claim 1 is characterized in that the weight proportion of raw material of Chinese medicine is:
Rhizoma Coptidis 20-30 part, Radix Angelicae Sinensis 10-20 part, Radix Et Rhizoma Rhei 4-5 part, Radix Notoginseng 1-3 part, Flos Sophorae Immaturus 15-20 part.
3, the pharmaceutical composition that is used for the treatment of hundstaupe according to claim 1, the dosage form that it is characterized in that said composition is a suppository.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB021003580A CN1182855C (en) | 2002-01-15 | 2002-01-15 | Dog pestilence treating medicine composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB021003580A CN1182855C (en) | 2002-01-15 | 2002-01-15 | Dog pestilence treating medicine composition |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1432375A true CN1432375A (en) | 2003-07-30 |
| CN1182855C CN1182855C (en) | 2005-01-05 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB021003580A Expired - Fee Related CN1182855C (en) | 2002-01-15 | 2002-01-15 | Dog pestilence treating medicine composition |
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| Country | Link |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104189458A (en) * | 2014-09-19 | 2014-12-10 | 格特生物制药（天津）有限公司 | Traditional Chinese medicine composition for treating fox canine distemper and preparation method thereof |
-
2002
- 2002-01-15 CN CNB021003580A patent/CN1182855C/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104189458A (en) * | 2014-09-19 | 2014-12-10 | 格特生物制药（天津）有限公司 | Traditional Chinese medicine composition for treating fox canine distemper and preparation method thereof |
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| Publication number | Publication date |
|---|---|
| CN1182855C (en) | 2005-01-05 |
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