CN1430998A - Drip pills for curing aphtha and its preparing method - Google Patents
Drip pills for curing aphtha and its preparing method Download PDFInfo
- Publication number
- CN1430998A CN1430998A CN03112765A CN03112765A CN1430998A CN 1430998 A CN1430998 A CN 1430998A CN 03112765 A CN03112765 A CN 03112765A CN 03112765 A CN03112765 A CN 03112765A CN 1430998 A CN1430998 A CN 1430998A
- Authority
- CN
- China
- Prior art keywords
- parts
- drop pill
- add
- aphtha
- fructus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000006187 pill Substances 0.000 title claims abstract description 28
- 208000002399 aphthous stomatitis Diseases 0.000 title claims abstract description 23
- 238000000034 method Methods 0.000 title description 5
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims abstract description 12
- 238000002156 mixing Methods 0.000 claims abstract description 11
- 235000000177 Indigofera tinctoria Nutrition 0.000 claims abstract description 5
- 241000207929 Scutellaria Species 0.000 claims abstract description 5
- 229940097275 indigo Drugs 0.000 claims abstract description 5
- COHYTHOBJLSHDF-UHFFFAOYSA-N indigo powder Natural products N1C2=CC=CC=C2C(=O)C1=C1C(=O)C2=CC=CC=C2N1 COHYTHOBJLSHDF-UHFFFAOYSA-N 0.000 claims abstract description 5
- 239000000843 powder Substances 0.000 claims description 29
- 239000003814 drug Substances 0.000 claims description 15
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims description 11
- 244000293323 Cosmos caudatus Species 0.000 claims description 11
- 235000005956 Cosmos caudatus Nutrition 0.000 claims description 11
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 claims description 11
- 238000002481 ethanol extraction Methods 0.000 claims description 11
- 229920002584 Polyethylene Glycol 6000 Polymers 0.000 claims description 10
- 229940057995 liquid paraffin Drugs 0.000 claims description 10
- 229940093429 polyethylene glycol 6000 Drugs 0.000 claims description 10
- 238000002360 preparation method Methods 0.000 claims description 10
- 229940079593 drug Drugs 0.000 claims description 8
- QQILFGKZUJYXGS-UHFFFAOYSA-N Indigo dye Chemical compound C1=CC=C2C(=O)C(C3=C(C4=CC=CC=C4N3)O)=NC2=C1 QQILFGKZUJYXGS-UHFFFAOYSA-N 0.000 claims description 7
- 239000006071 cream Substances 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 6
- 230000006837 decompression Effects 0.000 claims description 5
- 238000001704 evaporation Methods 0.000 claims description 5
- 230000008020 evaporation Effects 0.000 claims description 5
- 239000000706 filtrate Substances 0.000 claims description 5
- 230000004927 fusion Effects 0.000 claims description 5
- 239000007788 liquid Substances 0.000 claims description 5
- 239000012567 medical material Substances 0.000 claims description 5
- 241000555712 Forsythia Species 0.000 claims description 4
- 240000001972 Gardenia jasminoides Species 0.000 claims description 4
- 238000001291 vacuum drying Methods 0.000 claims description 4
- 230000000694 effects Effects 0.000 abstract description 6
- 235000013399 edible fruits Nutrition 0.000 abstract 2
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 241000555682 Forsythia x intermedia Species 0.000 abstract 1
- 244000111489 Gardenia augusta Species 0.000 abstract 1
- 235000018958 Gardenia augusta Nutrition 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 229940041616 menthol Drugs 0.000 abstract 1
- 241000699670 Mus sp. Species 0.000 description 5
- 208000025865 Ulcer Diseases 0.000 description 5
- 231100000397 ulcer Toxicity 0.000 description 5
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 210000000214 mouth Anatomy 0.000 description 3
- MFYSYFVPBJMHGN-ZPOLXVRWSA-N Cortisone Chemical compound O=C1CC[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 MFYSYFVPBJMHGN-ZPOLXVRWSA-N 0.000 description 2
- -1 Dichlorodiphenyl Acetate Chemical compound 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 2
- 241000699666 Mus <mouse, genus> Species 0.000 description 2
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 2
- 230000003115 biocidal effect Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 230000035876 healing Effects 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 230000001629 suppression Effects 0.000 description 2
- 230000008961 swelling Effects 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 241000700199 Cavia porcellus Species 0.000 description 1
- 206010014025 Ear swelling Diseases 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 208000007117 Oral Ulcer Diseases 0.000 description 1
- 208000025157 Oral disease Diseases 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 208000036142 Viral infection Diseases 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 229940113118 carrageenan Drugs 0.000 description 1
- 235000010418 carrageenan Nutrition 0.000 description 1
- 229920001525 carrageenan Polymers 0.000 description 1
- 239000000679 carrageenan Substances 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 206010023683 lagophthalmos Diseases 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000002483 medication Methods 0.000 description 1
- 208000030194 mouth disease Diseases 0.000 description 1
- VIKNJXKGJWUCNN-XGXHKTLJSA-N norethisterone Chemical compound O=C1CC[C@@H]2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 VIKNJXKGJWUCNN-XGXHKTLJSA-N 0.000 description 1
- 235000021590 normal diet Nutrition 0.000 description 1
- 230000000242 pagocytic effect Effects 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 238000002636 symptomatic treatment Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 231100000041 toxicology testing Toxicity 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
- 239000008096 xylene Substances 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
A dropping pill for treating aphtha is prepared from menthol, polyethanediol-6000 and 9 Chinese-medicinal materials including forsythia fruit, scutellaria root, capejasmine fruit, natural indigo, etc. through extracting with alcohol for part of them, grinding others, mixing and dropping in atoleine. Its advantages are high curative effect, and quickly taking its effect.
Description
Technical field
The present invention relates to a kind of drop pill for the treatment of aphtha and preparation method thereof.
Background technology
The method of existing treatment aphtha, western medical treatment is many to be the inflammation symptomatic treatment that the directed toward bacteria sexuality is dyed based on antibiotic and 17-hydroxy-11-dehydrocorticosterone, however aphtha often be again due to the viral infection, often at a loss what to do to this antibiotic and 17-hydroxy-11-dehydrocorticosterone.
The Chinese traditional treatment aphtha adopts clearing away heat-fire, reducing swelling and alleviating pain, and putrefaction-removing granulation-promoting, wholistic therapy, effect is better, but uses the powder external application more, and medicine is molten the loosing in the oral cavity easily, and action time is short, efficacy of a drug deficiency, and use inconvenient.And aphtha is a kind of commonly encountered diseases, frequently-occurring disease, and pain during morbidity meets irritable food, and the pain increased, influences normal diet and communication.
Summary of the invention
The objective of the invention is to: use modern preparation technique, the strong point of performance Chinese medicine aphtha disease is developed good effect, new Chinese traditional patent formulation preparation safe and convenient to use.
Technical scheme of the present invention is achieved in that a kind of drop pill for the treatment of aphtha; it selects for use the share of medical material to be (consumption is a weight portion): A group: Fructus Forsythiae 1-6 part, Radix Scutellariae 1-5 part, Fructus Gardeniae 1-5 part, Radix Glycyrrhizae 1-5 part; the 50-90% ethanol extraction that more than adds 24-126 part gets dry extract; B group: A organize dried cream all, Indigo Naturalis 1-5 part, Gypsum Fibrosum Preparatum 0.1-2 part, Margarita layer powder 0.1-2 part, artificial Calculus Bovis 0.1-1 part; more than get fine powder; it is an amount of to add Polyethylene Glycol-6000, Mentholum 0.005-0.1 part, Borneolum Syntheticum 0.1-2 part.
A kind of treatment aphtha method for preparing drop pills, its concrete steps are as follows: get Fructus Forsythiae 1-6 part, Radix Scutellariae 1-5 part, Fructus Gardeniae 1-5 part, Radix Glycyrrhizae 1-5 part, twice of the 50-90% ethanol extraction that more than adds 24-126 part, each 1.5 hours, merge extracted twice liquid, cool, filter, filtrate decompression is recycled to (60 ℃) relative density 1.20-1.25, goes to the water-bath evaporation and concentration, 70 ℃ of vacuum dryings, get dry extract, add Indigo Naturalis 1-5 part, Gypsum Fibrosum Preparatum 0.1-2 part, Margarita layer powder 0.1-2 part, artificial Calculus Bovis 0.1-1 part, mix and pulverize, cross 80 mesh sieves, get fine powder; Taking polyethylene glycol-6000 is an amount of in addition, 95 ℃ of water-bath fusions, add above-mentioned whole fine powder, fully mixing is incubated 0.5 hour, add Mentholum 0.005-0.1 part, Borneolum Syntheticum 0.1-2 part, mixing drips with dropper and to be 5-10 ℃ liquid paraffin to temperature, takes out drop pill, dry liquid paraffin, promptly get drop pill.
Drop pill is the comparatively ideal dosage form of treatment oral disease.It is simple to have process equipment, convenient for production, with low cost, is easy to control of quality, helps sanitation and hygiene and environmental conservation; Medicine to some indissoluble can improve its bioavailability by making drop pill; Be applicable to the local application in oral cavity, safe and convenient to use concerning the patient, gram eye the defective of easily being broken up, diluting during medications such as traditional drop, powder, can bring into play efficient, quick-acting effects.
The present invention treats the main pharmacodynamics result of study of the drop pill of aphtha: mucosal ulcer has the obvious treatment effect to the experimental animal models aphtha: the rat oral cavity causes mucosal ulcer because of carbolic acid, apply these medicine 178 mg/kg, 356 mg/kg, 712 milli mg/kg gram/kilograms, 2 times/day, for three days on end, can reduce the ulcer area, the reaction that reduces inflammation, quicken ulcer healing; Dichlorodiphenyl Acetate causes the rabbit oral ulcer, applies 41 mg/kg, 82 mg/kg, 164 mg/kg, divides 3 times/day, totally 3 days, sees promptly that the ulcer area dwindled in 24 hours, decrustation healing successively after 3 days.The mice foot applies this medicine, obviously suppresses carrageenan and causes the mice foot swelling, improves inhibitory rate of intumesce.Oral administration 1.2 gram/kilograms can obviously improve the suppression ratio of mice caused by dimethylbenzene xylene ear swelling.Above action intensity is similar to BINGPENG SAN.This medicine oral administration 0.1-0.6 gram/kilogram, the mouse writhing that can obviously suppress to be caused by acetic acid reacts, and its suppression ratio is apparently higher than BINGPENG SAN (P＜0.05), and local application can obviously reduce the integrated value because of formaldehyde-caused pain mice.This medicine improves the phagocytic activity of mice to carbon powder significantly, shows that this medical instrument has certain immunological enhancement.
Toxicological study: mouse gavaging LD50 is 25.8/ kilogram (suitable 60.4 gram crude drug/kilograms), and 95% confidence limit is the 21.6-30.0/ kilogram, and the LD50 that surveys is equivalent to the clinical plan of people with dosage 7818 times by every kg body weight calculating.Local application's test shows this medicine nonirritant in family's lagophthalmos conjunctival sac, and the guinea pig skin hypersensitive test was not met quick reaction.
The specific embodiment
Below in conjunction with embodiment the present invention is further described.
Embodiment 1:
The present invention treats the dripping pill selected of aphtha and organizes for (consumption is a weight portion): A with the share of medical material: Fructus Forsythiae 1-6 part, Radix Scutellariae 1-5 part, Fructus Gardeniae 1-5 part, Radix Glycyrrhizae 1-5 part; the 50-90% ethanol extraction that more than adds 24-126 part; get dry extract; B group: A organize dried cream all, Indigo Naturalis 1-5 part, Gypsum Fibrosum Preparatum 0.1-2 part, Margarita layer powder 0.1-2 part, artificial Calculus Bovis 0.1-1 part; more than get fine powder; it is an amount of to add Polyethylene Glycol-6000, Borneolum Syntheticum 0.1-2 part, Mentholum 0.005-0.1 part.
Embodiment 2:
The share of further selected medical material of the present invention is (consumption is a weight portion): A group: Fructus Forsythiae 3-6 part, Radix Scutellariae 2-4 part, Fructus Gardeniae 2-4 part, Radix Glycyrrhizae 2-4 part; the 60-80% ethanol extraction that more than adds 64-168 part; get dry extract; B group: A organize dried cream all, Indigo Naturalis 2-4 part, Gypsum Fibrosum Preparatum 1-2 part, Margarita layer powder 0.1-1 part, artificial Calculus Bovis 0.1-1 part; more than get fine powder; it is an amount of to add Polyethylene Glycol-6000, Borneolum Syntheticum 0.5-1 part, Mentholum 0.005-0.05 part.
Embodiment 3:
The share of the best preferred medical material of the present invention is (consumption is a weight portion): A group: 4.5 parts of Fructus Forsythiaes, 3 parts of Radix Scutellariaes, 3 parts of Fructus Gardeniaes, 3 parts in Radix Glycyrrhizae; more than add 81 parts 70% ethanol extraction; get dry extract; B group: A organize dried cream all, 2.5 parts of Indigo Naturaliss, 1.5 parts of Gypsum Fibrosum Preparatum, 0.3 part of Margarita layer powder, 0.15 part of artificial Calculus Bovis; more than get fine powder; it is an amount of to add Polyethylene Glycol-6000,0.6 part of Borneolum Syntheticum, 0.01 part of Mentholum.
The present invention treats the preparation method of aphtha drop pill, and its concrete steps are as follows:
Get Fructus Forsythiae 1-6 part, Radix Scutellariae 1-5 part, Fructus Gardeniae 1-5 part, Radix Glycyrrhizae 1-5 part, more than add the 50-90% ethanol extraction twice of 24-126 part, each 1.5 hours, merge extracted twice liquid, cool, filter, filtrate decompression is recycled to (60 ℃) relative density 1.20-1.25, go to the water-bath evaporation and concentration, 70 ℃ of vacuum dryings get dry extract, add Indigo Naturalis 1-5 part, Gypsum Fibrosum Preparatum 0.1-2 part, Margarita layer powder 0.1-2 part, artificial Calculus Bovis 0.1-1 part, mix and pulverize, cross 80 mesh sieves, get fine powder; Taking polyethylene glycol-6000 is an amount of in addition, 95 ℃ of water-bath fusions, add above-mentioned whole fine powder, fully mixing is incubated 0.5 hour, add Mentholum 0.005-0.1 part, Borneolum Syntheticum 0.1-2 part, mixing drips with the dropper of 1.9 millimeters of internal diameters and to be 5-10 ℃ liquid paraffin to temperature, takes out drop pill, dry liquid paraffin, promptly.
It is as follows that the present invention treats the preparation method further step of aphtha drop pill:
Get 4.5 parts of Fructus Forsythiaes, 3 parts of Radix Scutellariaes, 3 parts of Fructus Gardeniaes, 3 parts in Radix Glycyrrhizae, more than add 81 parts 70% ethanol extraction twice, each 1.5 hours, merge extracted twice liquid, cool, filter, filtrate decompression is recycled to (60 ℃) relative density 1.20-1.25, go to the water-bath evaporation and concentration, 70 ℃ of vacuum dryings get dry extract, add 2.5 parts of Indigo Naturaliss, 1.5 parts of Gypsum Fibrosum Preparatum, 0.3 part of Margarita layer powder, 0.15 part of artificial Calculus Bovis, mix and pulverize, cross 80 mesh sieves, get fine powder; Taking polyethylene glycol-6000 is an amount of in addition, 95 ℃ of water-bath fusions, add above-mentioned whole fine powder, fully mixing is incubated 0.5 hour, add 0.01 part of Mentholum, 0.6 part of Borneolum Syntheticum, mixing drips with the dropper of 1.9 millimeters of internal diameters and to be 5-10 ℃ liquid paraffin to temperature, takes out drop pill, dry liquid paraffin, promptly.Every ball weighs 35 milligrams, is equivalent to 16 milligrams of crude drugs.
Claims (6)
1, a kind of drop pill for the treatment of aphtha; it is characterized in that: select for use the share of medical material to be (consumption is a weight portion): A group in the described drops: Fructus Forsythiae 1-6 part, Radix Scutellariae 1-5 part, Fructus Gardeniae 1-5 part, Radix Glycyrrhizae 1-5 part; the 50-90% ethanol extraction that more than adds 24-126 part; get dry extract; B group: A organize dried cream all, Indigo Naturalis 1-5 part, Gypsum Fibrosum Preparatum 0.1-2 part, Margarita layer powder 0.1-2 part, artificial Calculus Bovis 0.1-1 part; more than get fine powder; it is an amount of to add Polyethylene Glycol-6000, and Borneolum Syntheticum 0.1-2 part, Mentholum 0.005-0.1 part are made pill.
2, according to the drop pill of the described treatment aphtha of claim 1; it is characterized in that: the share in drug of choice village is (consumption is a weight portion): A group in the drops: 4.5 parts of Fructus Forsythiaes, 3 parts of Radix Scutellariaes, 3 parts of Fructus Gardeniaes, 3 parts in Radix Glycyrrhizae; more than add 81 parts 70% ethanol extraction; get dry extract; B group: A organize dried cream all, 2.5 parts of Indigo Naturaliss, 1.5 parts of Gypsum Fibrosum Preparatum, 0.3 part of Margarita layer powder, 0.15 part of artificial Calculus Bovis; more than get fine powder; it is an amount of to add Polyethylene Glycol-6000, and 0.6 part of Borneolum Syntheticum, Mentholum are made pill for 0.01 part.
3, a kind of preparation method for the treatment of the aphtha drop pill, its concrete steps are as follows: Fructus Forsythiae 1-6 part, Radix Scutellariae 1-5 part, Fructus Gardeniae 1-5 part, Radix Glycyrrhizae 1-5 part, twice of the 50-90% ethanol extraction that adds 24-126 part, each 1.5 hours, merge extracted twice liquid, cool, filter, filtrate decompression is recycled to (60 ℃) relative density 1.20-1.25, go to the water-bath evaporation and concentration, get stiff paste, 70 ℃ of vacuum dryings get dry extract, add Indigo Naturalis 1-5 part, Gypsum Fibrosum Preparatum 0.1-2 part, Margarita layer powder 0.1-2 part, artificial Calculus Bovis 0.1-1 part, mix and pulverize, cross 80 mesh sieves, get fine powder; Taking polyethylene glycol-6000 is an amount of in addition, 95 ℃ of water-bath fusions, add above-mentioned whole fine powder, fully mixing is incubated 0.5 hour, Mentholum 0.005-0.1 part, Borneolum Syntheticum 0.1-2 part of adding recipe quantity, mixing drips with dropper and to be 5-10 ℃ liquid paraffin to temperature, takes out drop pill, dry liquid paraffin, promptly get drop pill.
4, according to the preparation method of the described treatment aphtha of claim 3 drop pill, its further step is as follows: get 4.5 parts of Fructus Forsythiaes, 3 parts of Radix Scutellariaes, 3 parts of Fructus Gardeniaes, 3 parts in Radix Glycyrrhizae, more than add 81 parts twice of 70% ethanol extraction, each 1.5 hours, merge extracted twice liquid, cool, filter, filtrate decompression is recycled to (60 ℃) relative density 1.20-1.25, goes to the water-bath evaporation and concentration, 70 ℃ of dried making an uproar of vacuum, get dry extract, add 2.5 parts of Indigo Naturaliss, 1.5 parts of Gypsum Fibrosum Preparatum, 0.3 part of Margarita layer powder, 0.15 part of artificial Calculus Bovis, mix and pulverize, cross 80 mesh sieves, get fine powder; Taking polyethylene glycol-6000 is an amount of in addition, 95 ℃ of water-bath fusions, add above-mentioned whole fine powder, fully mixing is incubated 0.5 hour, add 0.01 part of Mentholum, 0.6 part of Borneolum Syntheticum, mixing drips with the dropper of 1.9 millimeters of internal diameters and to be 5-10 ℃ liquid paraffin to temperature, takes out drop pill, dry liquid paraffin, promptly.Every ball weighs 35 milligrams, is equivalent to 16 milligrams of crude drugs.
5, according to the preparation method of the described treatment aphtha of claim 3 drop pill, it is characterized in that: the internal diameter of described dropper is 1.9 millimeters.
6, according to the preparation method of the described treatment aphtha of claim 4 drop pill, it is characterized in that: drop pill weighs 35 milligrams, is equivalent to 16 milligrams of crude drugs.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB031127657A CN1214809C (en) | 2003-01-27 | 2003-01-27 | Drip pills for curing aphtha and its preparing method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB031127657A CN1214809C (en) | 2003-01-27 | 2003-01-27 | Drip pills for curing aphtha and its preparing method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1430998A true CN1430998A (en) | 2003-07-23 |
| CN1214809C CN1214809C (en) | 2005-08-17 |
Family
ID=4790289
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB031127657A Expired - Lifetime CN1214809C (en) | 2003-01-27 | 2003-01-27 | Drip pills for curing aphtha and its preparing method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1214809C (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111437315A (en) * | 2020-04-18 | 2020-07-24 | 南京英颜生物科技有限公司 | A nanometer eye vision nutrient spray extracted from plant |
| CN114288232A (en) * | 2022-01-14 | 2022-04-08 | 江苏罗来雅实业股份有限公司 | Paste for effectively eliminating halitosis and preparation method thereof |
| CN115025125A (en) * | 2022-06-24 | 2022-09-09 | 四川大学 | A pharmaceutical composition for treating oral ulcer and preparation method thereof |
-
2003
- 2003-01-27 CN CNB031127657A patent/CN1214809C/en not_active Expired - Lifetime
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111437315A (en) * | 2020-04-18 | 2020-07-24 | 南京英颜生物科技有限公司 | A nanometer eye vision nutrient spray extracted from plant |
| CN114288232A (en) * | 2022-01-14 | 2022-04-08 | 江苏罗来雅实业股份有限公司 | Paste for effectively eliminating halitosis and preparation method thereof |
| CN115025125A (en) * | 2022-06-24 | 2022-09-09 | 四川大学 | A pharmaceutical composition for treating oral ulcer and preparation method thereof |
| CN115025125B (en) * | 2022-06-24 | 2023-09-29 | 四川大学 | Pharmaceutical composition for treating dental ulcer and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1214809C (en) | 2005-08-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR20040029072A (en) | Composition comprising wenguanguo extracts, methods for preparing same and uses thereof | |
| CN101708229A (en) | Oral tablet and preparation method thereof | |
| CN100453106C (en) | Chinese medicine compound preparation for treating laryngopharyngitis and tonsillitis and its preparing method | |
| CN101040950B (en) | Method of preparing compound Houttuynia cordata dropping pills | |
| KR20090081810A (en) | Cosmetic composition containing herb extracts | |
| CN102114113B (en) | Preparation method of Chinese pulsatilla root decoction granules | |
| CH699749B1 (en) | Prepared mixture of spagyric and plants in propolis tincture for dry cough in children. | |
| CN102743663B (en) | Chinese medicinal preparation for treating urinary infection and preparation method thereof | |
| CN1214809C (en) | Drip pills for curing aphtha and its preparing method | |
| KR101600751B1 (en) | Method of preparing oriental medicine composition containing extract of deer antlers for treating infertility in women | |
| CN101744973A (en) | Chinese medicinal extractum and extraction process thereof | |
| CN102727705B (en) | Traditional Chinese medicine composition for preventing or treating cervical erosion | |
| Shameem et al. | A review on potential properties and therapeutic application of Asparagus racemosus wild | |
| CN113116960A (en) | A Chinese medicinal composition for treating alopecia, and its preparation method | |
| CN102755519B (en) | Kudzuvine root-kudzuvine flower anti-canker sore particle and preparation method thereof | |
| CN105343847A (en) | Traditional Chinese medicine composition for treating eczema containing folium artemisiae argyi and preparing method thereof | |
| CN110772598A (en) | Composition for treating aphtha, application and taking method thereof | |
| CN108992538A (en) | A kind of Chinese medicine preparation and preparation method of hair growth | |
| CN104027652A (en) | Traditional Chinese medicine preparation for decreasing blood sugar and preparation method of traditional Chinese medicine preparation | |
| CN114533835B (en) | A Chinese medicinal composition with effects of removing pathogenic wind and dampness, and its preparation method | |
| CN114601807B (en) | Preparation method of fritillaria lung-clearing concentrated pills | |
| CN106983822A (en) | It is a kind of to treat Chinese medicine composition of vaginitis and its preparation method and application | |
| CN111419890B (en) | Sea-buckthorn seed oil extract and application thereof | |
| CN105169342A (en) | Traditional Chinese medicine composition for treating eczema and preparation method thereof | |
| CN107334988B (en) | Traditional Chinese medicine composition for treating pulmonary abscess |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| ASS | Succession or assignment of patent right |
Owner name: SUZHOU CHENGZHENG-XINKAI PHARMACEUTICAL CO., LTD. Free format text: FORMER OWNER: CHANGZHENG PHARMACEUTICAL FACTORY, SUZHOU IN WUZHONG INDUSTRY CO LTD, JIANGSU Effective date: 20060915 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20060915 Address after: 215128 No. 2, Soochow South Road, Jiangsu, Suzhou Patentee after: SUZHOU CHANGZHENG-XINKAI PHARMACEUTICAL CO.,LTD. Address before: Soochow road Wuzhong Economic Development Zone in Suzhou City, Jiangsu Province, No. 2 215128 Patentee before: Changzheng Pharmaceutical Factory Suzhou in Wuzhong Industry Co.,Ltd. Jiangsu |
|
| ASS | Succession or assignment of patent right |
Owner name: JIANGSU WUZHONG PHARMACEUTICAL GROUP CO., LTD. Free format text: FORMER OWNER: CHANGZHENG-XINKAI PHARMACEUTIC CO., LTD., SUZHOU Effective date: 20130814 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20130814 Address after: Soochow road Wuzhong Economic Development Zone in Suzhou City, Jiangsu Province, No. 2, building 8, 215128 Patentee after: JIANGSU WUZHONG PHARMACEUTICAL Group Corp. Address before: 215128 No. 2, Soochow South Road, Jiangsu, Suzhou Patentee before: SUZHOU CHANGZHENG-XINKAI PHARMACEUTICAL CO.,LTD. |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20161026 Address after: Soochow road Wuzhong Economic Development Zone in Suzhou City, Jiangsu Province, No. 2, building 8, 215128 Patentee after: JIANGSU WUZHONG PHARMACEUTICAL Group Corp. Patentee after: SUZHOU PHARMACEUTICAL FACTORY, JIANGSU WUZHONG PHARMACEUTICAL Group Corp. Address before: Soochow road Wuzhong Economic Development Zone in Suzhou City, Jiangsu Province, No. 2, building 8, 215128 Patentee before: JIANGSU WUZHONG PHARMACEUTICAL Group Corp. |
|
| CX01 | Expiry of patent term | ||
| CX01 | Expiry of patent term |
Granted publication date: 20050817 |