CN107334988B - Traditional Chinese medicine composition for treating pulmonary abscess - Google Patents
Traditional Chinese medicine composition for treating pulmonary abscess Download PDFInfo
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Abstract
The invention belongs to the field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating pulmonary abscess. The traditional Chinese medicine composition is prepared from the following raw material components: honeysuckle stem, pomegranate flower, achyranthes aspera, radix stemonae, rhizoma bletillae, rock candy and beautiful millettia root. The traditional Chinese medicine composition disclosed by the invention is added with beautiful millettia root on the basis of the folk prescription for treating pulmonary abscess, so that the treatment effect is greatly enhanced, the recurrence rate is reduced, the recurrence time is prolonged, and the toxic and side effects are reduced.
Description
[ technical field ] A method for producing a semiconductor device
The invention relates to the field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine composition for treating pulmonary abscess.
[ background of the invention ]
Pulmonary abscess is a disease of lung abscess and coughing up of saliva and pus blood, and is mostly caused by stagnation of wind-heat pathogen in lung, such as lung abscess and lung gangrene; or the disease changes are generally divided into three stages, the exterior syndrome stage: it is mainly manifested as aversion to cold, fever, sweating, cough, chest pain, and floating and rapid pulse; and (3) in the suppurative stage: it is mainly manifested as cough, dyspnea, chest fullness, chest pain, frequent cold, and slippery and rapid pulse; in the festering stage: it is mainly manifested as a stinky cough with purulent blood. Can also be used for other diseases. The existing medicine for treating pulmonary abscess mainly comprises western medicines and antibiotics, and is easy to generate drug resistance and toxic and side effects after long-term use; in clinical practice, the traditional Chinese medicine mostly has the effects of clearing heat and removing toxicity and treating based on syndrome differentiation, can relieve partial symptoms, but has slow effect and high recurrence rate.
For treating pulmonary abscess, the folk proved recipe is as follows: pomegranate flower, achyranthes aspera, honeysuckle stem, stemona root, bletilla and crystal sugar, and the two components are decocted to water for oral administration. Although the formula has a certain effect on treating pulmonary abscess, the formula also has two problems, namely low treatment effective rate, high recurrence rate and short recurrence time; secondly, the prescription contains the achyranthes aspera which has nephrotoxicity, thus limiting the clinical application of the prescription.
[ summary of the invention ]
The invention aims to: aiming at the defects of the prior art, the traditional Chinese medicine composition for treating pulmonary abscess is provided, and the beautiful millettia root is added to the composition on the basis of folk prescription, so that the treatment effect is greatly enhanced, the recurrence rate is reduced, the recurrence time is prolonged, and the toxic and side effects are reduced.
In order to achieve the purpose, the technical scheme adopted by the invention is as follows:
a traditional Chinese medicine composition for treating pulmonary abscess is prepared from the following raw material components: honeysuckle stem, pomegranate flower, achyranthes aspera, radix stemonae, rhizoma bletillae, rock candy and beautiful millettia root.
Preferably, the traditional Chinese medicine composition is prepared from the following raw material components: 45-60 parts of honeysuckle stem, 10-20 parts of pomegranate flower, 10-20 parts of achyranthes aspera, 5-15 parts of radix stemonae, 5-15 parts of rhizoma bletillae, 3-10 parts of rock sugar and 5-15 parts of beautiful millettia root.
More preferably, the traditional Chinese medicine composition is prepared from the following raw material components: 50-60 parts of honeysuckle stem, 15-20 parts of pomegranate flower, 15-20 parts of achyranthes aspera, 10-15 parts of radix stemonae, 10-15 parts of rhizoma bletillae, 6-10 parts of rock sugar and 10-15 parts of beautiful millettia root.
More preferably, the traditional Chinese medicine composition is prepared from the following raw material components: 50 parts of honeysuckle stem, 15 parts of pomegranate flower, 15 parts of achyranthes root, 10 parts of radix stemonae, 10 parts of rhizoma bletillae, 6 parts of rock candy and 10 parts of beautiful millettia root.
The invention also provides a preparation method of the traditional Chinese medicine composition, which comprises the following steps: weighing the raw material components according to the proportion, drying, crushing into fine powder, sieving and mixing uniformly to obtain the composition.
The invention also provides another preparation method of the traditional Chinese medicine composition, which comprises the following steps: weighing the raw material components according to the proportion, and then decocting with 6-12 times of water for 1-3 times, 1-3 hours each time; mixing the medicinal liquids, and filtering; centrifuging the filtrate, and collecting the supernatant; concentrating the supernatant into extract; or further concentrating the supernatant, drying, and pulverizing into dry extract powder.
In the preparation method of the traditional Chinese medicine composition, preferably, the raw material components of the composition are firstly crushed into medicinal material coarse powder, water is added to the medicinal material coarse powder and mixed uniformly to obtain a suspension, and the suspension is soaked and then decocted.
Specifically, the raw material components of the composition are crushed into medicinal material coarse powder; adding 6-12 times of water into the crude powder, uniformly mixing to obtain a suspension, soaking for 10min, decocting for 2 times, each time for 1h, combining liquid medicines, filtering, centrifuging the filtrate, and collecting a supernatant; concentrating the supernatant in water bath, spray drying at 70 ℃, and sieving with a 120-mesh sieve to obtain dry extract powder.
The invention also provides a traditional Chinese medicine preparation for treating pulmonary abscess, which is prepared from the traditional Chinese medicine composition independently or comprises the traditional Chinese medicine composition and a pharmaceutically acceptable carrier.
The traditional Chinese medicine composition can be mixed with a proper pharmaceutically acceptable carrier (auxiliary materials or auxiliary components), and then prepared into a product for treating pulmonary abscess according to a conventional product preparation method.
For example: 1. in the field of medicine: mixing with acceptable common auxiliary additives such as disintegrant, excipient, lubricant, binder, filler, etc. in oral preparation, and making into tablet, pill, capsule, granule or various corresponding solid oral preparations such as sustained release agent and controlled release agent by conventional operation method and process; mixing with conventional auxiliary additives such as matrix, surfactant, penetration enhancer, etc., and making into semi-solid preparation such as topical unguent, suppository, and gel by conventional method and process. Mixing with conventional solubilizing agent, emulsifier, lubricant, foaming or defoaming agent, diluent, antiseptic, stabilizer, correctant, and thickener, and making into oral preparation in the form of liquid preparation such as aqua, syrup, and oral liquid; mixing with conventional suspending agent, stabilizer, dispersant or solution osmotic pressure regulating agent, and making into injection such as injection solution and powder for injection by corresponding conventional method.
2. In the field of functional foods: the common auxiliary additive components are mixed and then can be prepared into functional foods in the forms of bread, functional beverages, health-care tea, chewing gum and the like according to the conventional operation method and process.
The invention also provides application of the traditional Chinese medicine composition or the preparation in preparing a medicine for treating pulmonary abscess.
The raw materials used in the invention are as follows:
honeysuckle stem is dried flower bud or flower with initial blossom of honeysuckle family L% onica thunb, lonicera macranthoides L% onicamacronanthoides hand-Mazz, lonicera hypoglauca Miq L% onica hyogluca Miq, lonicera huannanensis L% onica DC, or lonicera fulvotomosa L% onica Hsu et S.C.Cheng.
Pomegranate flower is flower of Punica Granati Punica grandirum L inn.
The radix Achyranthis bidentatae is dried root and rhizome of wild radix Achyranthis bidentatae didentata Blume, radix Achyranthis bidentatae Longifolia (Makino) Makino, radix Achyranthis bidentatae aspera L, radix Achyranthis bidentatae Achranthes aspera L, var. indica L.
Stemona is dried root tuber of Stemona sessilifolia (Miq.) Miq., Stemona tuberosa (Bl.) Miq or Stemona tuberosa (Bl.) L our.
And (3) common bletilla pseudobulb: is a dried tuber of the plant Bletilla striata (Thunb.) reichb.f. of the family Orchidaceae.
Beautiful millettia root: is dried root of Millettia speciosa champ. of Millettia of Leguminosae.
In summary, due to the adoption of the technical scheme, the invention has the beneficial effects that:
according to the invention, the beautiful millettia root is added on the basis of folk prescription, the beautiful millettia root has the effects of tonifying deficiency, moistening lung and strengthening tendons and activating collaterals, the symptoms of tonifying deficiency, moistening lung can be treated, and the lung meridian dredging is just suitable for the cause of qi and blood stagnation and lung meridian stasis of pulmonary abscess, so that the root cause can be treated, the treatment effect is greatly enhanced by treating both principal and secondary aspects of diseases, the recurrence rate is reduced, and the recurrence time is prolonged; on the other hand, after the beautiful millettia root and the achyranthes root are added for compatibility, the toxic and side effects of the prescription are reduced, and the test result shows that the kidney toxicity of the prescription is greatly reduced after the combination of the beautiful millettia root and the achyranthes root.
[ detailed description ] embodiments
Example 1
Prescription: 50g of honeysuckle stem, 15g of pomegranate flower, 15g of achyranthes root, 10g of radix stemonae, 10g of rhizoma bletillae, 6g of rock sugar and 10g of beautiful millettia root.
The preparation method comprises the following steps: the seven ingredients are crushed into medicinal material coarse powder; adding 10 times of distilled water, mixing to obtain suspension, soaking for 10min, decocting for 2 times (each time for 1 hr), mixing decoctions, filtering, centrifuging the filtrate, and collecting supernatant; concentrating the supernatant in water bath, spray drying at about 70 deg.C, sieving the obtained fine powder with 120 mesh sieve, and making into dry extract powder.
Example 2
Prescription: 50g of honeysuckle stem, 15g of pomegranate flower, 15g of achyranthes root, 10g of radix stemonae, 10g of rhizoma bletillae, 6g of rock sugar and 10g of beautiful millettia root.
The preparation method comprises the following steps: crushing the seven raw materials into medicinal coarse powder (sieving by a 20-mesh sieve); adding water 12 times the weight of the crude powder into the crude powder, mixing uniformly to obtain a suspension, soaking for 5min, decocting for 1 time for 3h, filtering the liquid medicine, centrifuging the filtrate, collecting the supernatant, and concentrating to obtain an extract with the relative density of 1.10.
Example 3
Prescription: 45g of honeysuckle stem, 10g of pomegranate flower, 10g of achyranthes aspera, 5g of radix stemonae, 5g of rhizoma bletillae, 3g of rock candy and 5g of beautiful millettia root.
The preparation method comprises the following steps: the seven ingredients are firstly prepared into extract according to the preparation method of the embodiment 2, and then the auxiliary materials are added to prepare the granules. Is orally administered to patients, one prescription dose each time, 3 times a day, and 20 days as a course of treatment.
Example 4
Prescription: 55g of honeysuckle stem, 18g of pomegranate flower, 16g of achyranthes root, 12g of radix stemonae, 8g of rhizoma bletillae, 6g of rock sugar and 11g of beautiful millettia root.
The preparation method comprises the following steps: the seven ingredients are prepared into capsules by firstly obtaining dry extract powder according to the preparation method of the embodiment 1 and then adding auxiliary materials. Is orally administered to patients, one prescription dose each time, 3 times a day, and 20 days as a course of treatment.
Example 5
Prescription: 60g of honeysuckle stem, 20g of pomegranate flower, 20g of achyranthes aspera, 15g of radix stemonae, 15g of rhizoma bletillae, 10g of rock candy and 15g of beautiful millettia root.
The preparation method comprises the following steps: (1) the seven ingredients are firstly prepared into extractum according to the preparation method of the embodiment 2;
(2) melting glycerogelatin in water bath, adding the extract obtained in step 1, mixing, pouring into a suppository mold coated with release agent, cooling, taking out, and filling into anus for 1 prescription dose each time, 3 times a day, and 20 days as a treatment course.
Comparative example 1
Prescription: 50g of honeysuckle stem, 15g of pomegranate flower, 15g of achyranthes root, 10g of radix stemonae, 10g of rhizoma bletillae and 6g of rock sugar.
The preparation method is the same as in example 1.
Comparative example 2
Prescription: 45g of honeysuckle stem, 10g of pomegranate flower, 10g of achyranthes aspera, 5g of radix stemonae, 5g of rhizoma bletillae and 3g of rock candy.
The preparation method comprises the following steps: the six ingredients are firstly prepared into extract according to the preparation method of the embodiment 2, and then the auxiliary materials are added to prepare the granules. Is orally administered to patients, one prescription dose each time, 3 times a day, and 20 days as a course of treatment.
Experimental example 1 curative effect of the traditional Chinese medicine composition for treating pulmonary abscess
In clinical experiments, 400 patients with pulmonary abscess, 18-55 years old, 29 years old and 7-25 days of course, were selected and randomly grouped into 3 groups (examples 3-5), 100 patients in each group and 100 patients in a control group (comparative example 2).
The diagnosis basis is the Chinese medicine industry standard of the people's republic of China, the diagnosis curative effect standard of internal medicine diseases of traditional Chinese medicine (ZY/T001.1-94): (1) the onset of disease is acute, and the disease is often suddenly attacked by chills and fever, cough and chest pain, and thick breath. (2) A large amount of yellowish green purulent or bloody purulent sputum is vomited into water, and the deep part is abscess and purulent while the superficial part is phlegm, which is stinky in smell. (3) The local percussion is voiced, the respiratory sound is weakened or strengthened, the tremble sound is strengthened, and the respiratory sound or the moist rale sound of the bronchus can be heard. (4) The total number of white blood cells and neutrophils is increased. (5) Pathogenic bacteria are cultured in the sputum. When X-ray radiography is carried out on the chest, large dense inflammatory shadows or a bright area and a liquid plane can be seen in the lung.
The treatment method comprises the following steps: the treatment group uses the traditional Chinese medicine preparation prepared in the embodiment 3-5 of the invention, and is orally taken by patients, wherein the dosage is one prescription every time, 3 times a day and 20 days are one treatment course.
The control group used the Chinese medicinal preparation of comparative example 2 for oral administration to patients, one prescription dose each time, 3 times a day, 20 days as a treatment course.
And (3) evaluating the curative effect: (1) and (3) curing: the symptoms and signs disappear, and the laboratory examination returns to normal. (2) The method has the following advantages: the symptoms and physical signs are obviously relieved, and the focus of the lung is partially absorbed or the range of the pus cavity is reduced. (3) And (4) invalidation: the symptoms and signs are not improved.
After 1 treatment period, the treatment results are shown in table 1:
table 1 comparison of the curative effects, recurrence rates and recurrence times of pulmonary abscess in examples 3 to 5 and comparative example 2
And (3) comparing the curative effects: the total effective rate and cure rate of the treatment group are obviously higher than those of the control group, and the differences are very significant (P is less than 0.01) after statistical treatment.
And (4) conclusion: compared with a comparative example, the external traditional Chinese medicine composition has the advantages of higher curative effect, lower recurrence rate and longer recurrence time by adding the beautiful millettia root for treatment.
Experimental example 2 research on radix millettiae speciosae for preventing and treating acute nephrotoxicity of radix achyranthis bidentatae
1. Experimental animals: healthy Wistar rats weighing 180-200 g, female, provided by animal laboratories of Guangxi medical university, were fed normally, free diet.
2. Preparation of the medicine: example 1, comparative example 1
3. The animal administration method comprises the following steps: the experimental animals were randomly divided into a blank control group, a comparative example 1 group and an example 1 group, and were divided into 3 groups of 10 animals, and the dry extract powder was added with water to prepare 2.5ml/100g (equivalent to 30 g. kg. in the administration group)-1·d-1) The animals were gavaged daily 2 times a day (9: 00 am, 16:00 pm) and the control group was given the sameThe stomach is irrigated with tap water for 2 times, the experiment is carried out for 7 days, urine protein, urine sugar and urine occult blood are measured after the experiment is finished, urine is left after the experiment is finished, the rat is killed, blood and kidney tissues are taken, the kidney tissues are fixed by 10% formaldehyde, and hematoxylin-eosin (HE) staining is carried out after dehydration, transparency and paraffin embedding and slicing.
4. The observation indexes comprise ① observing animal general conditions with naked eyes, weighing body weight, ② detecting rat Urine Protein (UPR), urea nitrogen (BUN), blood creatinine (Scr), urine sugar (G L U), blood urine β 2-MG and urine NAG enzyme, detecting biochemical indexes with a semi-automatic biochemical analyzer and an enzyme-linked immunosorbent assay, and observing the injury conditions of renal tubules and glomeruli of rats in different dose groups under ③ kidney histopathological section HE staining light mirror.
5. Results
5.1 change in behavior and body weight of rats, see Table 2.
TABLE 2 behavior and weight changes in the rats of each group
From Table 2, it was observed that the rats in the group of comparative example 1 were generally in a worse condition than those in the group of example 1, resulting in depilation, bradykinesia and death, and had a more significant weight loss (P <0.05), and the death phenomenon was observed, demonstrating that the group of comparative example 1 had a high nephrotoxicity and the group of example 1 had a reduced nephrotoxicity.
5.2 routine comparison of urine for various groups of rats, see Table 3.
TABLE 3 routine comparison of urine for various groups of rats
5.3 comparison of renal function in rats of each group: see table 4.
TABLE 4 comparison of renal function in rats of each group
5.4 rat kidney histomorphometric changes: the kidney morphology examination finds that the kidney of the rats in the blank control group is basically normal, the renal interstitium in the group of the comparative example 1 is moderate in edema, a large amount of lymphocyte infiltration is caused, the renal tubular epithelial cell vacuole degeneration is caused, the cytoplasm is shed, a few lesions are occasionally seen, the glomerulus and the renal small blood vessel are not obviously changed, and the renal interstitium in the group of the example 1 is free from edema, is free from lymphocyte infiltration, is free from vacuole degeneration and is basically similar to the blank control group.
And (4) conclusion: the pathological changes of the compound radix millettiae speciosae and the radix achyranthis bidentatae in the group of the embodiment 1 are light, which shows that the radix millettiae speciosae has different degrees of reduction on acute nephrotoxicity of the radix achyranthis bidentatae, and the radix millettiae speciosae has the detoxifying effect on the radix achyranthis bidentatae and has obvious detoxifying effect.
The above description is intended to describe in detail the preferred embodiments of the present invention, but the embodiments are not intended to limit the scope of the claims of the present invention, and all equivalent changes and modifications made within the technical spirit of the present invention should fall within the scope of the claims of the present invention.
Claims (9)
1. A traditional Chinese medicine composition for treating pulmonary abscess is characterized by being prepared from the following raw material components: 45-60 parts of honeysuckle stem, 10-20 parts of pomegranate flower, 10-20 parts of achyranthes aspera, 5-15 parts of radix stemonae, 5-15 parts of rhizoma bletillae, 3-10 parts of rock sugar and 5-15 parts of beautiful millettia root.
2. The traditional Chinese medicine composition according to claim 1, which is characterized by being prepared from the following raw material components: 50-60 parts of honeysuckle stem, 15-20 parts of pomegranate flower, 15-20 parts of achyranthes aspera, 10-15 parts of radix stemonae, 10-15 parts of rhizoma bletillae, 6-10 parts of rock sugar and 10-15 parts of beautiful millettia root.
3. The traditional Chinese medicine composition according to claim 1 or 2, which is characterized by being prepared from the following raw material components: 50 parts of honeysuckle stem, 15 parts of pomegranate flower, 15 parts of achyranthes root, 10 parts of radix stemonae, 10 parts of rhizoma bletillae, 6 parts of rock candy and 10 parts of beautiful millettia root.
4. A method for preparing the traditional Chinese medicine composition of any one of claims 1 to 3, which is characterized by comprising the following steps: weighing the raw material components according to the proportion, drying, crushing into fine powder, sieving and mixing uniformly to obtain the composition.
5. A method for preparing the traditional Chinese medicine composition of any one of claims 1 to 3, which is characterized by comprising the following steps: weighing the raw material components according to the proportion, and then decocting with 6-12 times of water for 1-3 times, 1-3 hours each time; mixing the medicinal liquids, and filtering; centrifuging the filtrate, and collecting the supernatant; concentrating the supernatant into extract; or further concentrating the supernatant, drying, and pulverizing into dry extract powder.
6. The preparation method of claim 5, wherein the raw material components of the traditional Chinese medicine composition are firstly crushed into medicinal material coarse powder, water is added to the medicinal material coarse powder and mixed uniformly to obtain a suspension, and the suspension is soaked and decocted.
7. The preparation method according to claim 5, wherein the raw material components of the Chinese medicinal composition are crushed into medicinal material coarse powder; adding 6-12 times of water into the crude powder, uniformly mixing to obtain a suspension, soaking for 10min, decocting for 2 times, each time for 1h, combining liquid medicines, filtering, centrifuging the filtrate, and collecting a supernatant; concentrating the supernatant in water bath, spray drying at 70 ℃, and sieving with a 120-mesh sieve to obtain dry extract powder.
8. A traditional Chinese medicine preparation for treating pulmonary abscess, which is characterized by comprising an effective amount of the traditional Chinese medicine composition of any one of claims 1 to 3 or the traditional Chinese medicine composition prepared by the method of any one of claims 4 to 7 and a pharmaceutically acceptable carrier.
9. Use of the Chinese medicinal composition of any one of claims 1 to 3 or the Chinese medicinal composition prepared by the method of any one of claims 4 to 7 or the Chinese medicinal preparation of claim 8 in the preparation of a medicament for treating pulmonary abscess.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105079389A (en) * | 2015-08-25 | 2015-11-25 | 湖南中医药大学 | Traditional Chinese medicine combination for treating chronic prostatitis and preparation method thereof |
| CN105558125A (en) * | 2014-10-17 | 2016-05-11 | 江门市禾盛生物技术有限公司 | Millettia speciosa and honeysuckle tea and preparation method thereof |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105558125A (en) * | 2014-10-17 | 2016-05-11 | 江门市禾盛生物技术有限公司 | Millettia speciosa and honeysuckle tea and preparation method thereof |
| CN105079389A (en) * | 2015-08-25 | 2015-11-25 | 湖南中医药大学 | Traditional Chinese medicine combination for treating chronic prostatitis and preparation method thereof |
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