CN1418689A - Medicine composition for treating diabetes, and its prepn. method - Google Patents
Medicine composition for treating diabetes, and its prepn. method Download PDFInfo
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- CN1418689A CN1418689A CN 02153464 CN02153464A CN1418689A CN 1418689 A CN1418689 A CN 1418689A CN 02153464 CN02153464 CN 02153464 CN 02153464 A CN02153464 A CN 02153464A CN 1418689 A CN1418689 A CN 1418689A
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- 206010012601 diabetes mellitus Diseases 0.000 title claims abstract description 20
- 239000003814 drug Substances 0.000 title claims abstract description 8
- 239000000203 mixture Substances 0.000 title claims abstract description 7
- 229940079593 drug Drugs 0.000 title claims description 5
- 238000000034 method Methods 0.000 title claims 5
- 238000002360 preparation method Methods 0.000 claims abstract description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 15
- 239000000843 powder Substances 0.000 claims description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 11
- 241000237903 Hirudo Species 0.000 claims description 10
- 239000009636 Huang Qi Substances 0.000 claims description 10
- 239000000706 filtrate Substances 0.000 claims description 10
- 239000008194 pharmaceutical composition Substances 0.000 claims description 10
- 239000006071 cream Substances 0.000 claims description 5
- 230000006837 decompression Effects 0.000 claims description 5
- 238000001035 drying Methods 0.000 claims description 5
- 238000002156 mixing Methods 0.000 claims description 5
- 238000010992 reflux Methods 0.000 claims description 5
- 238000004064 recycling Methods 0.000 claims description 4
- 235000019640 taste Nutrition 0.000 claims description 4
- 235000005903 Dioscorea Nutrition 0.000 claims description 3
- 241000234273 Dioscorea Species 0.000 claims description 3
- 235000000504 Dioscorea villosa Nutrition 0.000 claims description 3
- 241000219780 Pueraria Species 0.000 claims description 3
- 241001530126 Scrophularia Species 0.000 claims description 3
- 229920002472 Starch Polymers 0.000 claims description 3
- 235000004879 dioscorea Nutrition 0.000 claims description 3
- 235000019698 starch Nutrition 0.000 claims description 3
- 239000008107 starch Substances 0.000 claims description 3
- 239000002671 adjuvant Substances 0.000 claims description 2
- 239000000890 drug combination Substances 0.000 claims 2
- 229920001353 Dextrin Polymers 0.000 claims 1
- 239000004375 Dextrin Substances 0.000 claims 1
- 239000012141 concentrate Substances 0.000 claims 1
- 235000019425 dextrin Nutrition 0.000 claims 1
- 244000247747 Coptis groenlandica Species 0.000 abstract 1
- 235000002991 Coptis groenlandica Nutrition 0.000 abstract 1
- 240000006509 Gynostemma pentaphyllum Species 0.000 abstract 1
- 235000002956 Gynostemma pentaphyllum Nutrition 0.000 abstract 1
- 241001038563 Pseudostellaria Species 0.000 abstract 1
- 235000017276 Salvia Nutrition 0.000 abstract 1
- 240000007164 Salvia officinalis Species 0.000 abstract 1
- 229940107666 astragalus root Drugs 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 description 17
- 239000008280 blood Substances 0.000 description 17
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 14
- 239000008103 glucose Substances 0.000 description 14
- HIMXGTXNXJYFGB-UHFFFAOYSA-N alloxan Chemical compound O=C1NC(=O)C(=O)C(=O)N1 HIMXGTXNXJYFGB-UHFFFAOYSA-N 0.000 description 12
- 230000000694 effects Effects 0.000 description 8
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 6
- 201000010099 disease Diseases 0.000 description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
- 241000283973 Oryctolagus cuniculus Species 0.000 description 4
- 102000004877 Insulin Human genes 0.000 description 3
- 108090001061 Insulin Proteins 0.000 description 3
- 241000699670 Mus sp. Species 0.000 description 3
- 229940125396 insulin Drugs 0.000 description 3
- 210000002966 serum Anatomy 0.000 description 3
- 210000002784 stomach Anatomy 0.000 description 3
- 230000008485 antagonism Effects 0.000 description 2
- 230000023852 carbohydrate metabolic process Effects 0.000 description 2
- 235000021256 carbohydrate metabolism Nutrition 0.000 description 2
- 230000004089 microcirculation Effects 0.000 description 2
- 210000003462 vein Anatomy 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 1
- 230000003064 anti-oxidating effect Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 201000001421 hyperglycemia Diseases 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 230000037356 lipid metabolism Effects 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 238000007410 oral glucose tolerance test Methods 0.000 description 1
- ICFJFFQQTFMIBG-UHFFFAOYSA-N phenformin Chemical group NC(=N)NC(=N)NCCC1=CC=CC=C1 ICFJFFQQTFMIBG-UHFFFAOYSA-N 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000003716 rejuvenation Effects 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
Abstract
The present invention discloses a Chinese medicine composition for curing diabetes and its preparation method. It is made of 11 Chinese medicinal medicinal materials of pseudostellaria root, salvia root, coptis, astragalus root, gynostemma pentaphylla and others.
Description
The present invention relates to a kind of pharmaceutical composition for the treatment of diabetes and preparation method thereof.
Diabetes are commonly encountered diseases, frequently-occurring disease, annual morbidity is about 9,300,000, diabetes have the tendency of extension and rejuvenation now, China's new trouble diabetes number every year is with 1,250,000, every day is with 3500 people's speed increase, the growth that this is surprising makes diabetes formally clamp-on the row of ten big representative national diseases.Diabetes are second killers in the modern disease, and its harm to human body is only second to cancer, cause serious body and mind infringement and burden on society.Therefore, actively develop the study on prevention of diabetes, become an important topic of current sanitary work.
The object of the invention is to provide a kind of Chinese medicine and preparation method thereof of the treatment diabetes that have no side effect of evident in efficacy, taking convenience.
Technical solution of the present invention is achieved in that
Bulk drugs as described below:
27～81 parts of 90～270 portions of Rhizoma Coptidis of 90～270 parts of Radix Salviae Miltiorrhizaes of Radix Pseudostellariae
90～270 parts of 90～270 portions of Rhizoma Dioscoreaes of 90～270 portions of Herb Gynostemmae Pentaphylli of the Radix Astragali
9～27 parts of 27～81 portions of Hirudos of 60～180 portions of Radix Scrophulariaes of Rhizoma Atractylodis
60～180 parts of 60～180 parts of Radix Puerariaes of Fructus Malvae
With 60～90% alcohol reflux 2～3 times, each 1～3 hour, filter, decompression filtrate recycling ethanol, clear paste is standby; Other gets Radix Pseudostellariae, the Radix Astragali, Herb Gynostemmae Pentaphylli, Rhizoma Dioscoreae, Fructus Malvae and decocts with water 2～3 times, and 1～3 hour for the first time, 0.5～1.5 hour for the second time, filter, the merging filtrate concentrating under reduced pressure, gained clear paste and above-mentioned clear paste merge, continue to be condensed into thick paste, drying under reduced pressure, dried cream powder is broken, with Hirudo fine powder mix homogeneously, add adjuvant, fully mixing incapsulates, promptly.
Through laboratory observation, take that the blood sugar increasing to alloxan model rabbit has tangible reduction effect behind the pharmaceutical composition of the present invention, with model control group utmost point significant difference is arranged relatively, the obvious blood sugar increasing that causes of antagonism glucose, and can obviously reduce area under the AUC blood glucose district line; Blood sugar increasing to the STZ-DM rat has tangible reduction effect, with model control group utmost point significant difference is arranged more all; STZ-DM rat carbohydrate metabolism is improved significantly, and the blood sugar increasing that glucose is caused has tangible reduction effect, with model control group utmost point significant difference is arranged relatively; Blood lipid dysbolism to the STZ-DM rat improves significantly, and shows the reduction of blood CHO, TG, LDL level, the rising of HDL level; Make to 30 minutes serum insulin levels behind the glucose load to raise rapidly, and, have certain effect for the carbohydrate metabolism that improves the STZ-DM rat apparently higher than the modeling matched group; The blood glucose that alloxan is caused diabetic mice has tangible reduction effect; The body weight, the endurance decline that alloxan are caused diabetic mice improve significantly, and can significantly reduce fasting blood glucose level; Certain antioxidation is arranged; The auricular microcirculation obstacle that alloxan is caused diabetic mice improves significantly, and can shorten the recovery time that 1%Adr causes microcirculation disturbance; Blood glucose to normal rat does not have tangible reduction effect, to the also not significantly influence of serum insulin levels of normal rat; Blood lipid metabolism to normal rat does not have remarkable influence.
Pharmaceutical composition of the present invention has replenishing YIN and removing heat, and effects such as heat clearing and blood circulation promoting can be used for deficiency of both QI and YIN, and the diabetes due to the venation block is the treatment of diabetes and other diseases.
Experimental example 1: rabbit vein injection alloxan causes insulin to hang down the mo(u)ld bottom half hyperglycemia model, select fasting to can't help the water 3-8 hour rabbit of serum glucose value more than 180mg/dl, be divided into water matched group, the high, medium and low dosage group of pharmaceutical composition of the present invention at random, the insoral group.Successive administration 20 days, fasting 6h before the test, 12h behind the last medicine, ear edge vein exploitating blood is done oral glucose tolerance test, be that the 2.0g/kg glucose is irritated stomach, and, calculate on an empty stomach and glucose is irritated behind the stomach area (Area Under Curve) under 60 minutes blood glucose district lines respectively in 0,30,60,120 minutes repetition measurement blood sugar levels of oral glucose.The result shows: pharmaceutical composition of the present invention has tangible reduction effect to the blood sugar increasing of alloxan model rabbit, high, in, dosage group and model control group more all have utmost point significant difference, low dose group and model control group more all have significant difference.Drug regimen object height of the present invention, middle dosage group be the blood sugar increasing that causes of antagonism glucose obviously, and presents certain dose-dependence.And can obviously reduce area under the AUC blood glucose district line.
Embodiment 1:
Radix Pseudostellariae 180g Radix Salviae Miltiorrhizae 180g Rhizoma Coptidis 54g Radix Astragali 180g
Herb Gynostemmae Pentaphylli 180g Rhizoma Dioscoreae 180g Rhizoma Atractylodis 120g Radix Scrophulariae 54g
Hirudo 18g Fructus Malvae 120g Radix Puerariae 120g
It is standby that the water intaking trematodiasis is ground into fine powder; Get Radix Salviae Miltiorrhizae, Rhizoma Coptidis, Rhizoma Atractylodis, Radix Scrophulariae, the Radix Puerariae five tastes, with 80% alcohol reflux secondary, each 1.5 hours, filter, decompression filtrate recycling ethanol, clear paste is standby; Other gets Radix Pseudostellariae, the Radix Astragali, Herb Gynostemmae Pentaphylli, Rhizoma Dioscoreae, Fructus Malvae and decocts with water secondary, and 1.5 hours for the first time, 1 hour for the second time, filter, the merging filtrate concentrating under reduced pressure, gained clear paste and above-mentioned clear paste merge, continue to be condensed into thick paste, drying under reduced pressure, dried cream powder is broken, with Hirudo fine powder mix homogeneously, add starch to 400g, fully mixing incapsulates, make 1000, promptly.
Embodiment 2:
Radix Pseudostellariae 200g Radix Salviae Miltiorrhizae 200g Rhizoma Coptidis 60g Radix Astragali 200g
Herb Gynostemmae Pentaphylli 200g Rhizoma Dioscoreae 200g Rhizoma Atractylodis 150g Radix Scrophulariae 60g
Hirudo 20g Fructus Malvae 120g Radix Puerariae 120g
It is standby that the water intaking trematodiasis is ground into fine powder; Get Radix Salviae Miltiorrhizae, Rhizoma Coptidis, Rhizoma Atractylodis, Radix Scrophulariae, the Radix Puerariae five tastes, with 80% alcohol reflux secondary, each 1.5 hours, filter, decompression filtrate recycling ethanol, clear paste is standby; Other gets Radix Pseudostellariae, the Radix Astragali, Herb Gynostemmae Pentaphylli, Rhizoma Dioscoreae, Fructus Malvae and decocts with water secondary, and 1.5 hours for the first time, 1 hour for the second time, filter, the merging filtrate concentrating under reduced pressure, gained clear paste and above-mentioned clear paste merge, continue to be condensed into thick paste, drying under reduced pressure, dried cream powder is broken, with Hirudo fine powder mix homogeneously, add starch to 400g, fully mixing incapsulates, make 1000, promptly.
Claims (4)
1, a kind of pharmaceutical composition for the treatment of diabetes is characterized in that this pharmaceutical composition made by following bulk drugs:
27～81 parts of 90～270 portions of Rhizoma Coptidis of 90～270 parts of Radix Salviae Miltiorrhizaes of Radix Pseudostellariae
90～270 parts of 90～270 portions of Rhizoma Dioscoreaes of 90～270 portions of Herb Gynostemmae Pentaphylli of the Radix Astragali
9～27 parts of 27～81 portions of Hirudos of 60～180 portions of Radix Scrophulariaes of Rhizoma Atractylodis
60～180 parts of 60～180 parts of Radix Puerariaes of Fructus Malvae
2, a kind of pharmaceutical composition for the treatment of diabetes as claimed in claim 1 is characterized in that this pharmaceutical composition made by following bulk drugs:
54 parts of 180 portions of Rhizoma Coptidis of 180 parts of Radix Salviae Miltiorrhizaes of Radix Pseudostellariae
180 parts of 180 portions of Rhizoma Dioscoreaes of 180 portions of Herb Gynostemmae Pentaphylli of the Radix Astragali
18 parts of 54 portions of Hirudos of 120 portions of Radix Scrophulariaes of Rhizoma Atractylodis
120 parts of 120 parts of Radix Puerariaes of Fructus Malvae
3, as claim 1,2 described a kind of preparation of drug combination methods for the treatment of diabetes, it is characterized in that this method is: it is standby that the water intaking trematodiasis is ground into fine powder; Get Radix Salviae Miltiorrhizae, Rhizoma Coptidis, Rhizoma Atractylodis, Radix Scrophulariae, the Radix Puerariae five tastes, with 60～90% alcohol reflux 2～3 times, each 1～3 hour, filter, filtrate decompression concentrates and reclaims ethanol, and clear paste is standby; Other gets Radix Pseudostellariae, the Radix Astragali, Herb Gynostemmae Pentaphylli, Rhizoma Dioscoreae, Fructus Malvae and decocts with water 2～3 times, and 1～3 hour for the first time, 0.5～1.5 hour for the second time, filter merging filtrate, concentrating under reduced pressure, gained clear paste and above-mentioned clear paste merge, and continue to be condensed into thick paste, drying under reduced pressure, dried cream powder is broken, with Hirudo fine powder mix homogeneously, add adjuvant, fully mixing, incapsulate, promptly.
4, a kind of preparation of drug combination method for the treatment of diabetes as claimed in claim 3 is characterized in that this method is: it is standby that the water intaking trematodiasis is ground into fine powder; Get Radix Salviae Miltiorrhizae, Rhizoma Coptidis, Rhizoma Atractylodis, Radix Scrophulariae, the Radix Puerariae five tastes, with 80% alcohol reflux secondary, each 1.5 hours, filter, decompression filtrate recycling ethanol, clear paste is standby; Other gets Radix Pseudostellariae, the Radix Astragali, Herb Gynostemmae Pentaphylli, Rhizoma Dioscoreae, Fructus Malvae and decocts with water secondary, and 1.5 hours for the first time, 1 hour for the second time, filter, the merging filtrate concentrating under reduced pressure, gained clear paste and above-mentioned clear paste merge, continue to be condensed into thick paste, drying under reduced pressure, dried cream powder is broken, with Hirudo fine powder mix homogeneously, add starch or dextrin, fully mixing incapsulates, promptly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 02153464 CN1224407C (en) | 2002-11-29 | 2002-11-29 | Medicine composition for treating diabetes, and its prepn. method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 02153464 CN1224407C (en) | 2002-11-29 | 2002-11-29 | Medicine composition for treating diabetes, and its prepn. method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1418689A true CN1418689A (en) | 2003-05-21 |
| CN1224407C CN1224407C (en) | 2005-10-26 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 02153464 Expired - Lifetime CN1224407C (en) | 2002-11-29 | 2002-11-29 | Medicine composition for treating diabetes, and its prepn. method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1224407C (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100379441C (en) * | 2005-12-20 | 2008-04-09 | 湖南九典制药有限公司 | Sugar downbearing network vessel freeing Chinese medicinal preparation |
| CN101890098B (en) * | 2009-05-21 | 2012-03-14 | 中国中医科学院广安门医院 | Medicament for treating type II diabetic cardiopathy and preparation method thereof |
| CN101336974B (en) * | 2008-08-07 | 2012-05-23 | 华中科技大学同济医学院附属同济医院 | Blood sugar and fat reducing traditional Chinese medicine with function of comprehensively adjusting body metabolism and preparation method thereof |
| CN102526420A (en) * | 2011-12-31 | 2012-07-04 | 陕西步长制药有限公司 | Traditional Chinese medicine preparation for treating diabetes and preparation method thereof |
| CN102526422A (en) * | 2011-12-31 | 2012-07-04 | 陕西步长制药有限公司 | Chinese medicinal formulation for treating diabetes and preparation method of same |
| CN102526421A (en) * | 2011-12-31 | 2012-07-04 | 陕西步长制药有限公司 | Chinese medicinal formulation for treating diabetes and preparation method of same |
-
2002
- 2002-11-29 CN CN 02153464 patent/CN1224407C/en not_active Expired - Lifetime
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100379441C (en) * | 2005-12-20 | 2008-04-09 | 湖南九典制药有限公司 | Sugar downbearing network vessel freeing Chinese medicinal preparation |
| CN101336974B (en) * | 2008-08-07 | 2012-05-23 | 华中科技大学同济医学院附属同济医院 | Blood sugar and fat reducing traditional Chinese medicine with function of comprehensively adjusting body metabolism and preparation method thereof |
| CN101890098B (en) * | 2009-05-21 | 2012-03-14 | 中国中医科学院广安门医院 | Medicament for treating type II diabetic cardiopathy and preparation method thereof |
| CN102526420A (en) * | 2011-12-31 | 2012-07-04 | 陕西步长制药有限公司 | Traditional Chinese medicine preparation for treating diabetes and preparation method thereof |
| CN102526422A (en) * | 2011-12-31 | 2012-07-04 | 陕西步长制药有限公司 | Chinese medicinal formulation for treating diabetes and preparation method of same |
| CN102526421A (en) * | 2011-12-31 | 2012-07-04 | 陕西步长制药有限公司 | Chinese medicinal formulation for treating diabetes and preparation method of same |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1224407C (en) | 2005-10-26 |
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