CN1418623A - 柠檬苦素制备治疗痔疮药物的用途 - Google Patents
柠檬苦素制备治疗痔疮药物的用途 Download PDFInfo
- Publication number
- CN1418623A CN1418623A CN 02145371 CN02145371A CN1418623A CN 1418623 A CN1418623 A CN 1418623A CN 02145371 CN02145371 CN 02145371 CN 02145371 A CN02145371 A CN 02145371A CN 1418623 A CN1418623 A CN 1418623A
- Authority
- CN
- China
- Prior art keywords
- limonin
- parts
- starch
- hemorrhoid
- weight proportion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 208000014617 hemorrhoid Diseases 0.000 title claims abstract description 35
- 239000003814 drug Substances 0.000 title claims abstract description 11
- VHLJDTBGULNCGF-UHFFFAOYSA-N Limonin Natural products CC1(C)OC2CC(=O)OCC23C4CCC5(C)C(CC(=O)C6OC56C4(C)C(=O)CC13)c7cocc7 VHLJDTBGULNCGF-UHFFFAOYSA-N 0.000 claims abstract description 70
- KBDSLGBFQAGHBE-MSGMIQHVSA-N limonin Chemical compound C=1([C@H]2[C@]3(C)CC[C@H]4[C@@]([C@@]53O[C@@H]5C(=O)O2)(C)C(=O)C[C@@H]2[C@]34COC(=O)C[C@@H]3OC2(C)C)C=COC=1 KBDSLGBFQAGHBE-MSGMIQHVSA-N 0.000 claims abstract description 70
- 238000002360 preparation method Methods 0.000 claims abstract description 16
- 239000002775 capsule Substances 0.000 claims abstract description 9
- 239000007924 injection Substances 0.000 claims abstract description 7
- 238000002347 injection Methods 0.000 claims abstract description 7
- 235000020357 syrup Nutrition 0.000 claims abstract description 6
- 239000006188 syrup Substances 0.000 claims abstract description 6
- 239000002552 dosage form Substances 0.000 claims abstract description 3
- 239000003826 tablet Substances 0.000 claims abstract description 3
- 229920002472 Starch Polymers 0.000 claims description 28
- 235000019698 starch Nutrition 0.000 claims description 28
- 239000008107 starch Substances 0.000 claims description 28
- 239000000203 mixture Substances 0.000 claims description 17
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 14
- 239000012153 distilled water Substances 0.000 claims description 14
- 239000008101 lactose Substances 0.000 claims description 14
- 239000002002 slurry Substances 0.000 claims description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 14
- 239000002994 raw material Substances 0.000 claims description 11
- 150000002629 limonins Chemical class 0.000 claims description 10
- 229940031703 low substituted hydroxypropyl cellulose Drugs 0.000 claims description 10
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims description 8
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 7
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 7
- 229930006000 Sucrose Natural products 0.000 claims description 7
- 235000020374 simple syrup Nutrition 0.000 claims description 7
- 239000005720 sucrose Substances 0.000 claims description 7
- 239000007788 liquid Substances 0.000 claims description 6
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims description 4
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims description 4
- 239000008280 blood Substances 0.000 abstract description 7
- 210000004369 blood Anatomy 0.000 abstract description 6
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 230000036039 immunity Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 12
- 238000005303 weighing Methods 0.000 description 10
- 239000008187 granular material Substances 0.000 description 8
- 238000000034 method Methods 0.000 description 5
- 208000024891 symptom Diseases 0.000 description 5
- 206010013786 Dry skin Diseases 0.000 description 4
- 208000032843 Hemorrhage Diseases 0.000 description 4
- 230000008034 disappearance Effects 0.000 description 4
- 238000001035 drying Methods 0.000 description 4
- 238000002156 mixing Methods 0.000 description 4
- 239000007779 soft material Substances 0.000 description 4
- 206010030113 Oedema Diseases 0.000 description 3
- 208000002193 Pain Diseases 0.000 description 3
- 230000000740 bleeding effect Effects 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 201000007772 internal hemorrhoid Diseases 0.000 description 3
- 210000004877 mucosa Anatomy 0.000 description 3
- 230000036407 pain Effects 0.000 description 3
- 108090000386 Fibroblast Growth Factor 1 Proteins 0.000 description 2
- 102100031706 Fibroblast growth factor 1 Human genes 0.000 description 2
- 206010020565 Hyperaemia Diseases 0.000 description 2
- 208000003251 Pruritus Diseases 0.000 description 2
- 230000008033 biological extinction Effects 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 208000008035 Back Pain Diseases 0.000 description 1
- 241000207199 Citrus Species 0.000 description 1
- 206010053567 Coagulopathies Diseases 0.000 description 1
- 235000005956 Cosmos caudatus Nutrition 0.000 description 1
- 244000293323 Cosmos caudatus Species 0.000 description 1
- 108090000379 Fibroblast growth factor 2 Proteins 0.000 description 1
- 102000003974 Fibroblast growth factor 2 Human genes 0.000 description 1
- 102100037362 Fibronectin Human genes 0.000 description 1
- 108010067306 Fibronectins Proteins 0.000 description 1
- 235000003143 Panax notoginseng Nutrition 0.000 description 1
- 241000180649 Panax notoginseng Species 0.000 description 1
- 208000012287 Prolapse Diseases 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 210000002255 anal canal Anatomy 0.000 description 1
- 230000036592 analgesia Effects 0.000 description 1
- 230000001093 anti-cancer Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 210000000436 anus Anatomy 0.000 description 1
- 235000020971 citrus fruits Nutrition 0.000 description 1
- 230000035602 clotting Effects 0.000 description 1
- 230000013872 defecation Effects 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 208000035861 hematochezia Diseases 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 230000002439 hemostatic effect Effects 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 229910052957 realgar Inorganic materials 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000017423 tissue regeneration Effects 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
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- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims (7)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 02145371 CN1213749C (zh) | 2002-11-21 | 2002-11-21 | 柠檬苦素制备治疗痔疮药物的用途 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 02145371 CN1213749C (zh) | 2002-11-21 | 2002-11-21 | 柠檬苦素制备治疗痔疮药物的用途 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1418623A true CN1418623A (zh) | 2003-05-21 |
CN1213749C CN1213749C (zh) | 2005-08-10 |
Family
ID=4750876
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN 02145371 Expired - Lifetime CN1213749C (zh) | 2002-11-21 | 2002-11-21 | 柠檬苦素制备治疗痔疮药物的用途 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN1213749C (zh) |
-
2002
- 2002-11-21 CN CN 02145371 patent/CN1213749C/zh not_active Expired - Lifetime
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Publication number | Publication date |
---|---|
CN1213749C (zh) | 2005-08-10 |
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Date | Code | Title | Description |
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C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
ASS | Succession or assignment of patent right |
Owner name: ZHEJIANG PROVINCE NANYANG PHARMACEUTICAL CO., LTD. Free format text: FORMER OWNER: CHEN SHAOYIN Effective date: 20100301 |
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C41 | Transfer of patent application or patent right or utility model | ||
COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 317600 QINGMA XIAOPUZHU VILLAGE, ZHUGANG TOWN, YUHUAN COUNTY, ZHEJIANG PROVINCE TO: 317604 DAMAIYU ECONOMIC DEVELOPMENT ZONE, YUHUAN COUNTY, TAIZHOU CITY, ZHEJIANG PROVINCE |
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TR01 | Transfer of patent right |
Effective date of registration: 20100301 Address after: 317604 Yuhuan County Economic Development Zone, Taizhou barley island, Zhejiang Patentee after: Zhejiang South Ocean Pharmaceutical Co.,Ltd. Address before: 317600 Zhejiang province Yuhuan County Zhugang Tsing Ma Xiaopu bamboo village Patentee before: Chen Shaoyin |
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DD01 | Delivery of document by public notice |
Addressee: Ma Yuefeng Document name: Notification of Passing Examination on Formalities |
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EE01 | Entry into force of recordation of patent licensing contract |
Application publication date: 20030521 Assignee: Hangzhou Nanyang Pharmaceutical Co.,Ltd. Assignor: Zhejiang South Ocean Pharmaceutical Co.,Ltd. Contract record no.: 2013330000100 Denomination of invention: Prepn. of obakulactone contd. medicine for treating hemorrhoid, and its use Granted publication date: 20050810 License type: Exclusive License Record date: 20130424 |
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LICC | Enforcement, change and cancellation of record of contracts on the licence for exploitation of a patent or utility model | ||
EM01 | Change of recordation of patent licensing contract |
Change date: 20130628 Contract record no.: 2013330000100 Assignee after: ZHEJIANG SUPOR SOUTHOCEAN PHARMACEUTICAL Co.,Ltd. Assignee before: Hangzhou Nanyang Pharmaceutical Co.,Ltd. |
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LICC | Enforcement, change and cancellation of record of contracts on the licence for exploitation of a patent or utility model | ||
TR01 | Transfer of patent right | ||
TR01 | Transfer of patent right |
Effective date of registration: 20170601 Address after: 311200, Zhejiang, Hangzhou province Hangzhou large Jiangdong industrial agglomeration, No. 829 Fu Hang Road Patentee after: HANGZHOU SUPOR SOUTH OCEAN PHARMACEUTICAL CO.,LTD. Address before: 317604 Yuhuan County Economic Development Zone, Taizhou barley island, Zhejiang Patentee before: Zhejiang South Ocean Pharmaceutical Co.,Ltd. |
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DD01 | Delivery of document by public notice | ||
DD01 | Delivery of document by public notice |
Addressee: Zhejiang South Ocean Pharmaceutical Co.,Ltd. Document name: Notification of Passing Examination on Formalities |
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CP03 | Change of name, title or address | ||
CP03 | Change of name, title or address |
Address after: 310000 No. 829, changfuhang Road, Qianjin Street, Qiantang District, Hangzhou City, Zhejiang Province Patentee after: Zhejiang sukean Pharmaceutical Co.,Ltd. Address before: No.829, changfuhang Road, dajiangdong Industrial Cluster District, Hangzhou, Zhejiang 311200 Patentee before: HANGZHOU SUPOR SOUTH OCEAN PHARMACEUTICAL CO.,LTD. |
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CX01 | Expiry of patent term | ||
CX01 | Expiry of patent term |
Granted publication date: 20050810 |