CN1408368A - Method for preparing nano pilose antler suspension - Google Patents
Method for preparing nano pilose antler suspension Download PDFInfo
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- CN1408368A CN1408368A CN01128902A CN01128902A CN1408368A CN 1408368 A CN1408368 A CN 1408368A CN 01128902 A CN01128902 A CN 01128902A CN 01128902 A CN01128902 A CN 01128902A CN 1408368 A CN1408368 A CN 1408368A
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- pilose antler
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- cornu cervi
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/32—Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane
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Abstract
The present invention provides a preparation process of a kind of pilose antler suspension. By means of alcohol-water composite extraction process, the steriod compounds, phosphatide compounds, glycolipid compounds, amino acids, trace elements and other effective components are extracted as far as possible. Then, under stirring and supersonic vibration, alcohol extractive liquid of pilose antler is dropped slowly into water extractive liquid of pilose antler with surfactant in the amount of 0.1-1.0 wt% of pilos antler weight. The product has nano pilose antler grains capable of being absorbed directly via intestinal mucous membrane in relatively high absorptivity.
Description
The invention belongs to the Chinese medicine preparation field, specifically is the method for Cornu Cervi Pantotrichum being made nano suspending liquid.
Cornu Cervi Pantotrichum is a kind of Chinese medicine of preciousness, for still being ossified young horn with fine hair on the stag head of vertebrates Cervidae Cervus nippon Temminck or Cervus elaphus linnaeus etc.Cornu Cervi Pantotrichum mainly contains estradiol, estrone, cholesterol, lecithin, cephalin, lipid sphyngomyelin, glycolipid reaches the nearly aminoacid more than 15 kinds, is many with glycine, glutamic acid and lysine wherein.In addition, also have polysaccharide and various trace elements, mainly contain calcium, phosphorus, magnesium etc.The common instructions of taking of Cornu Cervi Pantotrichum is to take orally or flood into medicated wine with Chinese liquor behind the pulverization to take.These two kinds of instructions of taking all can not reach the purpose of effective ingredient in the abundant absorption Cornu Cervi Pantotrichum, this is because estradiol, estrone, cholesterol, lecithin, cephalin, lipid sphyngomyelin and glycolipid etc. are all water insoluble, its still in vivo digestion and absorption, must rely on Digestive system in enzyme fully contact, because they and water are immiscible, therefore hindered and the contacting of enzyme, greatly reduced the absorption by human body rate.
The present invention adopts the alcohol-water composite extraction method, the steroid in the Cornu Cervi Pantotrichum (as estradiol, estrone etc.) phospholipids compounds (as lecithin, cephalin, lipid sphyngomyelin etc.), glycolipid compound and effective ingredient such as aminoacid and various trace elements can be extracted to greatest extent; (number of patent application: 01108482.0) be made into nano pilose antler suspension, its warp is less than 100 nanometers for " the nano alcohol-soluble particle preparation method of Chinese medicine " that adopts the inventor to propose then.According to reported in literature, straight can directly absorb without digestion by intestinal mucosa through grease particle less than 500 nanometers, thereby improved greatly precious Chinese medicine-Cornu Cervi Pantotrichum-absorption rate.
The objective of the invention is to improve the absorbance of human body to precious Chinese medicine Cornu Cervi Pantotrichum.The inventive method is reliable, and is easy to operate, need not complex device, and required energy consumption is low, do not produce environmental pollution.
The objective of the invention is to realize by following technical proposals:
1, the preparation of Cornu Cervi Pantotrichum alcohol extract is the Cornu Cervi Pantotrichum pulverization, adds the dehydrated alcohol lixiviate at room temperature 7 days of 10 times of Cornu Cervi Pantotrichum weight, and every day was with supersonic vibration 30 minutes.Adopt for the second time heat extraction (making further stripping such as lipid sphyngomyelin, cephalin and glycolipid), heating-up temperature is 40～60 ℃, and the time is 12 hours, and the supersonic vibration secondary is 30 minutes at every turn.Merge leaching alcohol liquid twice, rectification is smart to divide (but also fractional distillation in case of necessity reduces the pure content in the extracting solution).
2, the preparation of Cornu Cervi Pantotrichum decocting liquid is with the filtering residue of alcohol extract, amount of water is 30～200 times of Cornu Cervi Pantotrichum filtering residue weight, and the pH value of modulating aqueous solution with vinegar is 5～6 (making the fully stripping of amino acid whose trace element), and decocting temperature is 80～98 ℃, decocting time is 2～5 hours, gets filtrate for later use.
3, add surfactant and add surfactant in Cornu Cervi Pantotrichum decocting in water filtrate, the surfactant that is added must be the surfactant that meets food sanitation standard.Anionic surfactant can be selected sodium lauryl sulphate, CSL, soap etc. for use; Nonionic surfactant can be selected glycerol monosterate, Si Pan, tween etc. for use; Cosurfactant can be selected lauryl alcohol, hexadecanol etc. for use.Anionic surfactant/non-ionic surface active agent is a mol ratio 3～4: 1 anionic surfactant/cosurfactant is mole 1: 1～3
The consumption of concrete anionic surfactant is 0.05～0.35% of a Cornu Cervi Pantotrichum consumption
4, change solvent under stirring and supersonic vibration condition, the Radix Panacis Quinquefolii alcohol extract is added drop-wise in the Cornu Cervi Pantotrichum water decoction that contains surfactant, rate of addition is 1～2 of a per second.Dropwise and, promptly form the nano-antler water slurry through the depositing of certain hour.Measure through Wuhan University's transmissioning electric mirror determining and the compound new technique of material National Key Laboratory laser particle size analyzer, prepared grain diameter is less than 100 nanometers.
Claims (5)
1, the preparation method of nano pilose antler suspension, it is characterized in that be with the alcohol extract of Cornu Cervi Pantotrichum stir and the supersonic vibration condition under, slowly drip or the spraying adding contains in the Cornu Cervi Pantotrichum water decoction of surfactant, temperature is at 0～78 ℃, deposit through certain hour, obtain nano pilose antler suspension.
2, the preparation method of nano pilose antler suspension according to claim 1, it is characterized in that described alcohol extract is to adopt ethanol merceration and hot dipping secondary dipping process to extract, the hot dipping temperature is 40～60 ℃, in order to accelerate leaching velocity, has also added supersonic vibration.
3, the preparation method of nano pilose antler suspension according to claim 1 is characterized in that described Cornu Cervi Pantotrichum water decoction is to adopt vinegar synthetic, and its pH value is 5～6, and decocting temperature is 80～98 ℃.
4, the preparation method of nano pilose antler suspension according to claim 1 is characterized in that described surfactant is that anionic can mix use with nonionic, and can to add aliphatic alcohol be cosurfactant.
5, the preparation method of nano pilose antler suspension according to claim 1 also can be used for other similar nanometer Chinese medicines of preparation property, as nano pilose antler suspension, nano deerhorn colloidal suspension liquid, nanometer Hippocampus suspension.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN01128902A CN1408368A (en) | 2001-09-27 | 2001-09-27 | Method for preparing nano pilose antler suspension |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN01128902A CN1408368A (en) | 2001-09-27 | 2001-09-27 | Method for preparing nano pilose antler suspension |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1408368A true CN1408368A (en) | 2003-04-09 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN01128902A Pending CN1408368A (en) | 2001-09-27 | 2001-09-27 | Method for preparing nano pilose antler suspension |
Country Status (1)
| Country | Link |
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| CN (1) | CN1408368A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007124618A1 (en) * | 2006-04-28 | 2007-11-08 | Lizhong Wang | Insulin-like growth factor-enriched nano-products of hairy antler and process for preparation thereof |
| CN101647568B (en) * | 2009-09-03 | 2012-09-05 | 辽宁鹿源参茸饮片有限公司 | Spotted deer antler liquid and preparation method thereof |
-
2001
- 2001-09-27 CN CN01128902A patent/CN1408368A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007124618A1 (en) * | 2006-04-28 | 2007-11-08 | Lizhong Wang | Insulin-like growth factor-enriched nano-products of hairy antler and process for preparation thereof |
| CN101647568B (en) * | 2009-09-03 | 2012-09-05 | 辽宁鹿源参茸饮片有限公司 | Spotted deer antler liquid and preparation method thereof |
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| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |