CN1397554A - 新颖的n－苄基哌嗪化合物、它们的制备方法和含有它们的药物组合物 - Google Patents
新颖的n－苄基哌嗪化合物、它们的制备方法和含有它们的药物组合物 Download PDFInfo
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- CN1397554A CN1397554A CN02124182A CN02124182A CN1397554A CN 1397554 A CN1397554 A CN 1397554A CN 02124182 A CN02124182 A CN 02124182A CN 02124182 A CN02124182 A CN 02124182A CN 1397554 A CN1397554 A CN 1397554A
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- methyl
- piperazinyl
- phenoxy group
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- 239000003706 n methyl dextro aspartic acid receptor stimulating agent Substances 0.000 description 1
- PSHKMPUSSFXUIA-UHFFFAOYSA-N n,n-dimethylpyridin-2-amine Chemical compound CN(C)C1=CC=CC=N1 PSHKMPUSSFXUIA-UHFFFAOYSA-N 0.000 description 1
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- 239000012188 paraffin wax Substances 0.000 description 1
- QWSRZFHYFOVUDW-UHFFFAOYSA-N pentanoic acid;dihydrochloride Chemical compound Cl.Cl.CCCCC(O)=O QWSRZFHYFOVUDW-UHFFFAOYSA-N 0.000 description 1
- 210000004303 peritoneum Anatomy 0.000 description 1
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- 238000001556 precipitation Methods 0.000 description 1
- UUMZDXBZTGNJDF-UHFFFAOYSA-N propanamide;dihydrochloride Chemical compound Cl.Cl.CCC(N)=O UUMZDXBZTGNJDF-UHFFFAOYSA-N 0.000 description 1
- FXSZGKYGUFCBQY-UHFFFAOYSA-N propanoic acid;dihydrochloride Chemical compound Cl.Cl.CCC(O)=O FXSZGKYGUFCBQY-UHFFFAOYSA-N 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 229940107700 pyruvic acid Drugs 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
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- 210000000664 rectum Anatomy 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000012312 sodium hydride Substances 0.000 description 1
- 229910000104 sodium hydride Inorganic materials 0.000 description 1
- 238000002798 spectrophotometry method Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 230000035882 stress Effects 0.000 description 1
- 239000006190 sub-lingual tablet Substances 0.000 description 1
- 229940098466 sublingual tablet Drugs 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
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- 229940095064 tartrate Drugs 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/092—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings with aromatic radicals attached to the chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Hospice & Palliative Care (AREA)
- Surgery (AREA)
- Urology & Nephrology (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0109454 | 2001-07-16 | ||
| FR0109454A FR2827284B1 (fr) | 2001-07-16 | 2001-07-16 | Nouveaux derives de n-benzylpiperazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1397554A true CN1397554A (zh) | 2003-02-19 |
Family
ID=8865549
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN02124182A Pending CN1397554A (zh) | 2001-07-16 | 2002-07-16 | 新颖的n－苄基哌嗪化合物、它们的制备方法和含有它们的药物组合物 |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US6686360B2 (enExample) |
| EP (1) | EP1277746B1 (enExample) |
| JP (1) | JP2003096057A (enExample) |
| KR (1) | KR100498867B1 (enExample) |
| CN (1) | CN1397554A (enExample) |
| AR (1) | AR034779A1 (enExample) |
| AT (1) | ATE295358T1 (enExample) |
| AU (1) | AU2002300150B2 (enExample) |
| BR (1) | BR0202686A (enExample) |
| CA (1) | CA2394010A1 (enExample) |
| DE (1) | DE60204083T2 (enExample) |
| DK (1) | DK1277746T3 (enExample) |
| EA (1) | EA005165B1 (enExample) |
| ES (1) | ES2241973T3 (enExample) |
| FR (1) | FR2827284B1 (enExample) |
| HU (1) | HUP0202293A3 (enExample) |
| MX (1) | MXPA02006900A (enExample) |
| NO (1) | NO20023409L (enExample) |
| NZ (1) | NZ520173A (enExample) |
| PL (1) | PL355066A1 (enExample) |
| PT (1) | PT1277746E (enExample) |
| SI (1) | SI1277746T1 (enExample) |
| ZA (1) | ZA200205666B (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8174436B2 (en) | 2002-07-08 | 2012-05-08 | American Underwater Products, Inc. | Dive computer with global positioning system receiver |
| US9443039B2 (en) | 2002-07-08 | 2016-09-13 | Pelagic Pressure Systems Corp. | Systems and methods for dive computers with remote upload capabilities |
| US20070010529A1 (en) * | 2003-05-19 | 2007-01-11 | Kanji Takahashi | Nitrogenous heterocyclic compounds and medical use thereof |
| FR2883876B1 (fr) * | 2005-03-30 | 2007-05-04 | Servier Lab | Derives d'indanyl-piperazines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| US7797124B2 (en) | 2006-12-28 | 2010-09-14 | American Underwater Products, Inc. | Dive computer with free dive mode and wireless data transmission |
| US9821893B2 (en) * | 2014-10-06 | 2017-11-21 | Pelagic Pressure Systems Corp. | System and methods for configurable dive masks with multiple interfaces |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2661176B1 (fr) * | 1990-04-20 | 1992-06-12 | Adir | Nouveau procede de preparation de la 1-(2,3,4-trimethoxybenzyl) piperazine en amination reductive. |
| JPH04356473A (ja) * | 1991-05-31 | 1992-12-10 | Wako Pure Chem Ind Ltd | ベンジルピペラジン誘導体の新規製造法 |
| FR2681324B1 (fr) * | 1991-09-18 | 1993-10-29 | Adir Cie | Nouveaux derives de la trimetazidine, leur procede de preparation et les compositions pharmaceutiques les contenant. |
| FR2703048B1 (fr) * | 1993-03-24 | 1996-01-05 | Adir | Nouveaux composes n-benzylpiperazine, leur procede de preparation et les compositions pharmaceutiques les renfermant. |
| FR2757164B1 (fr) * | 1996-12-16 | 1999-01-22 | Adir | Nouveaux derives de n-benzylpiperazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| US6479495B1 (en) * | 1997-09-29 | 2002-11-12 | Aventis Pharmaceuticals Inc. | Aminoalkylphenol derivatives and related compounds |
-
2001
- 2001-07-16 FR FR0109454A patent/FR2827284B1/fr not_active Expired - Fee Related
-
2002
- 2002-07-12 MX MXPA02006900A patent/MXPA02006900A/es active IP Right Grant
- 2002-07-12 BR BR0202686-4A patent/BR0202686A/pt not_active Application Discontinuation
- 2002-07-15 HU HU0202293A patent/HUP0202293A3/hu unknown
- 2002-07-15 NZ NZ520173A patent/NZ520173A/en not_active IP Right Cessation
- 2002-07-15 NO NO20023409A patent/NO20023409L/no unknown
- 2002-07-15 AR ARP020102635A patent/AR034779A1/es unknown
- 2002-07-15 EA EA200200682A patent/EA005165B1/ru not_active IP Right Cessation
- 2002-07-15 JP JP2002205661A patent/JP2003096057A/ja active Pending
- 2002-07-15 KR KR10-2002-0041113A patent/KR100498867B1/ko not_active Expired - Fee Related
- 2002-07-16 CA CA002394010A patent/CA2394010A1/fr not_active Abandoned
- 2002-07-16 AU AU2002300150A patent/AU2002300150B2/en not_active Ceased
- 2002-07-16 EP EP02291784A patent/EP1277746B1/fr not_active Expired - Lifetime
- 2002-07-16 SI SI200230129T patent/SI1277746T1/xx unknown
- 2002-07-16 DE DE60204083T patent/DE60204083T2/de not_active Expired - Lifetime
- 2002-07-16 ZA ZA200205666A patent/ZA200205666B/xx unknown
- 2002-07-16 ES ES02291784T patent/ES2241973T3/es not_active Expired - Lifetime
- 2002-07-16 CN CN02124182A patent/CN1397554A/zh active Pending
- 2002-07-16 AT AT02291784T patent/ATE295358T1/de active
- 2002-07-16 DK DK02291784T patent/DK1277746T3/da active
- 2002-07-16 PT PT02291784T patent/PT1277746E/pt unknown
- 2002-07-16 US US10/195,948 patent/US6686360B2/en not_active Expired - Fee Related
- 2002-07-16 PL PL02355066A patent/PL355066A1/xx not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| PT1277746E (pt) | 2005-07-29 |
| AR034779A1 (es) | 2004-03-17 |
| NZ520173A (en) | 2004-02-27 |
| CA2394010A1 (fr) | 2003-01-16 |
| EP1277746A2 (fr) | 2003-01-22 |
| SI1277746T1 (enExample) | 2005-08-31 |
| AU2002300150B2 (en) | 2007-10-11 |
| ES2241973T3 (es) | 2005-11-01 |
| NO20023409L (no) | 2003-01-17 |
| HUP0202293A2 (hu) | 2003-04-28 |
| KR100498867B1 (ko) | 2005-07-04 |
| DE60204083T2 (de) | 2006-03-16 |
| FR2827284B1 (fr) | 2003-10-31 |
| HUP0202293A3 (en) | 2004-04-28 |
| ZA200205666B (en) | 2003-03-27 |
| DK1277746T3 (da) | 2005-08-29 |
| US20030158207A1 (en) | 2003-08-21 |
| PL355066A1 (en) | 2003-01-27 |
| FR2827284A1 (fr) | 2003-01-17 |
| BR0202686A (pt) | 2003-05-06 |
| EP1277746A3 (fr) | 2003-08-13 |
| EP1277746B1 (fr) | 2005-05-11 |
| KR20030007187A (ko) | 2003-01-23 |
| EA200200682A1 (ru) | 2003-02-27 |
| ATE295358T1 (de) | 2005-05-15 |
| HU0202293D0 (enExample) | 2002-09-28 |
| NO20023409D0 (no) | 2002-07-15 |
| EA005165B1 (ru) | 2004-12-30 |
| JP2003096057A (ja) | 2003-04-03 |
| MXPA02006900A (es) | 2010-11-17 |
| US6686360B2 (en) | 2004-02-03 |
| DE60204083D1 (de) | 2005-06-16 |
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