CN1380882A - 作为抗肿瘤剂的c10酯取代的紫杉烷 - Google Patents

作为抗肿瘤剂的c10酯取代的紫杉烷 Download PDF

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Publication number
CN1380882A
CN1380882A CN01800568A CN01800568A CN1380882A CN 1380882 A CN1380882 A CN 1380882A CN 01800568 A CN01800568 A CN 01800568A CN 01800568 A CN01800568 A CN 01800568A CN 1380882 A CN1380882 A CN 1380882A
Authority
CN
China
Prior art keywords
pyridyl
furyl
thienyl
taxane
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN01800568A
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English (en)
Chinese (zh)
Inventor
R·A·霍尔顿
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Florida State University Research Foundation Inc
Original Assignee
Florida State University Research Foundation Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Florida State University Research Foundation Inc filed Critical Florida State University Research Foundation Inc
Publication of CN1380882A publication Critical patent/CN1380882A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D83/00—Containers or packages with special means for dispensing contents
    • B65D83/14—Containers for dispensing liquid or semi-liquid contents by internal gaseous pressure, i.e. aerosol containers comprising propellant
    • B65D83/75—Aerosol containers not provided for in groups B65D83/16 - B65D83/74
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Mechanical Engineering (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN01800568A 2000-02-02 2001-02-02 作为抗肿瘤剂的c10酯取代的紫杉烷 Pending CN1380882A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17978200P 2000-02-02 2000-02-02
US60/179,782 2000-02-02

Publications (1)

Publication Number Publication Date
CN1380882A true CN1380882A (zh) 2002-11-20

Family

ID=22657972

Family Applications (1)

Application Number Title Priority Date Filing Date
CN01800568A Pending CN1380882A (zh) 2000-02-02 2001-02-02 作为抗肿瘤剂的c10酯取代的紫杉烷

Country Status (25)

Country Link
EP (1) EP1165553B1 (enExample)
JP (1) JP2003522172A (enExample)
CN (1) CN1380882A (enExample)
AT (1) ATE432928T1 (enExample)
AU (1) AU782150B2 (enExample)
BG (1) BG64889B1 (enExample)
BR (1) BR0104354A (enExample)
CA (1) CA2368274C (enExample)
CZ (1) CZ20013430A3 (enExample)
DE (1) DE60138853D1 (enExample)
GE (1) GEP20043323B (enExample)
HU (1) HUP0600302A2 (enExample)
IL (1) IL145638A (enExample)
MX (1) MXPA01009905A (enExample)
NO (1) NO327910B1 (enExample)
NZ (1) NZ514382A (enExample)
PL (1) PL202957B1 (enExample)
RO (1) RO121270B1 (enExample)
RU (1) RU2262506C2 (enExample)
SK (1) SK13692001A3 (enExample)
TR (1) TR200102858T1 (enExample)
TW (1) TWI299732B (enExample)
UA (1) UA75039C2 (enExample)
WO (1) WO2001057032A1 (enExample)
ZA (1) ZA200108055B (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6649632B2 (en) 2000-02-02 2003-11-18 Fsu Research Foundation, Inc. C10 ester substituted taxanes
CA2354471A1 (en) * 2001-07-31 2003-01-31 Florida State University Research Foundation, Inc. C10 ester substituted taxanes
SG129990A1 (en) * 2001-08-01 2007-03-20 Univ Florida State Res Found C10 ester substituted taxanes
SV2006002010A (es) 2004-02-13 2006-08-23 Univ Florida State Res Found Taxanos sustituidos con esteres de ciclopentilo en c10
WO2006088767A2 (en) * 2005-02-14 2006-08-24 Florida State University Research Foundation, Inc. C10 cyclopropyl ester substituted taxane compositions
US8242166B2 (en) 2008-03-31 2012-08-14 Florida State University Research Foundation, Inc. C(10) ethyl ester and C(10) cyclopropyl ester substituted taxanes

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2601675B1 (fr) * 1986-07-17 1988-09-23 Rhone Poulenc Sante Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent
US5243045A (en) * 1991-09-23 1993-09-07 Florida State University Certain alkoxy substituted taxanes and pharmaceutical compositions containing them
US5250683A (en) * 1991-09-23 1993-10-05 Florida State University Certain substituted taxanes and pharmaceutical compositions containing them
IL108443A0 (en) * 1993-01-29 1994-04-12 Univ Florida State C7 taxane derivatives and pharmaceutical compositions containing them
CA2158863C (en) * 1993-03-22 2006-12-19 Robert A. Holton Taxanes having a pyridyl substituted side-chain
EP0690711B1 (en) * 1993-03-22 2000-08-16 Florida State University Taxanes having an amino substituted side-chain
PT1228759E (pt) * 1993-03-22 2005-04-29 Univ Florida State Composicoes farmaceuticas contendo um taxano possuindo uma cadeia lateral substituida com furilo ou tienilo
US5475011A (en) * 1993-03-26 1995-12-12 The Research Foundation Of State University Of New York Anti-tumor compounds, pharmaceutical compositions, methods for preparation thereof and for treatment
US6100411A (en) * 1994-10-28 2000-08-08 The Research Foundation Of State University Of New York Taxoid anti-tumor agents and pharmaceutical compositions thereof
WO1996013495A1 (en) * 1994-10-28 1996-05-09 The Research Foundation Of State University Of New York Taxoid derivatives, their preparation and their use as antitumor agents
CA2255615C (en) * 1996-05-22 2006-08-29 Neuromedica, Inc. Compositions comprising conjugates of cis-docosahexaenoic acid and docetaxel
US5795909A (en) * 1996-05-22 1998-08-18 Neuromedica, Inc. DHA-pharmaceutical agent conjugates of taxanes
AU758418B2 (en) * 1997-12-19 2003-03-20 Kabushiki Kaisha Yakult Honsha Taxane derivatives
JP2003026673A (ja) * 1999-03-05 2003-01-29 Asahi Kasei Corp 骨形成促進剤

Also Published As

Publication number Publication date
HUP0600302A2 (en) 2006-07-28
TR200102858T1 (tr) 2002-12-23
RU2262506C2 (ru) 2005-10-20
PL351380A1 (en) 2003-04-07
ATE432928T1 (de) 2009-06-15
BG64889B1 (bg) 2006-08-31
IL145638A (en) 2011-05-31
IL145638A0 (en) 2002-06-30
GEP20043323B (en) 2004-02-10
AU3480901A (en) 2001-08-14
SK13692001A3 (sk) 2002-07-02
NZ514382A (en) 2004-05-28
JP2003522172A (ja) 2003-07-22
TWI299732B (en) 2008-08-11
EP1165553B1 (en) 2009-06-03
RO121270B1 (ro) 2007-02-28
PL202957B1 (pl) 2009-08-31
CZ20013430A3 (cs) 2002-04-17
BR0104354A (pt) 2002-01-02
EP1165553A1 (en) 2002-01-02
NO20014754D0 (no) 2001-10-01
AU782150B2 (en) 2005-07-07
BG105965A (en) 2002-07-31
UA75039C2 (en) 2006-03-15
NO327910B1 (no) 2009-10-19
NO20014754L (no) 2001-11-29
ZA200108055B (en) 2003-12-01
CA2368274C (en) 2009-10-13
CA2368274A1 (en) 2001-08-09
MXPA01009905A (es) 2003-08-20
DE60138853D1 (de) 2009-07-16
WO2001057032A1 (en) 2001-08-09

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