CN1379857A - 用于伸展聚合物的方法和装置 - Google Patents

用于伸展聚合物的方法和装置 Download PDF

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Publication number
CN1379857A
CN1379857A CN00814266A CN00814266A CN1379857A CN 1379857 A CN1379857 A CN 1379857A CN 00814266 A CN00814266 A CN 00814266A CN 00814266 A CN00814266 A CN 00814266A CN 1379857 A CN1379857 A CN 1379857A
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China
Prior art keywords
polymkeric substance
passage
integrating device
elongated structure
channel
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Pending
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CN00814266A
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English (en)
Chinese (zh)
Inventor
E·Y·陈
L·C·格莱克
P·S·维尔曼
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US Genomics Inc
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US Genomics Inc
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
    • B01F25/43—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
    • B01F25/431—Straight mixing tubes with baffles or obstructions that do not cause substantial pressure drop; Baffles therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
    • B01F25/43—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
    • B01F25/432—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction with means for dividing the material flow into separate sub-flows and for repositioning and recombining these sub-flows; Cross-mixing, e.g. conducting the outer layer of the material nearer to the axis of the tube or vice-versa
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
    • B01F25/43—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
    • B01F25/433—Mixing tubes wherein the shape of the tube influences the mixing, e.g. mixing tubes with varying cross-section or provided with inwardly extending profiles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502746—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0663—Stretching or orienting elongated molecules or particles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0694—Creating chemical gradients in a fluid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0681—Filter
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0883—Serpentine channels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/08—Regulating or influencing the flow resistance
    • B01L2400/084—Passive control of flow resistance
    • B01L2400/086—Passive control of flow resistance using baffles or other fixed flow obstructions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • B01L3/502776—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for focusing or laminating flows
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/44—Resins; Plastics; Rubber; Leather
    • G01N33/442—Resins; Plastics

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  • Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Physics & Mathematics (AREA)
  • Fluid Mechanics (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CN00814266A 1999-08-13 2000-08-11 用于伸展聚合物的方法和装置 Pending CN1379857A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14902099P 1999-08-13 1999-08-13
US60/149,020 1999-08-13

Publications (1)

Publication Number Publication Date
CN1379857A true CN1379857A (zh) 2002-11-13

Family

ID=22528446

Family Applications (1)

Application Number Title Priority Date Filing Date
CN00814266A Pending CN1379857A (zh) 1999-08-13 2000-08-11 用于伸展聚合物的方法和装置

Country Status (7)

Country Link
EP (1) EP1210578A4 (ja)
JP (1) JP2003507026A (ja)
CN (1) CN1379857A (ja)
AU (1) AU6771100A (ja)
CA (1) CA2381361A1 (ja)
IL (1) IL148088A0 (ja)
WO (1) WO2001013088A1 (ja)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103203256A (zh) * 2006-07-19 2013-07-17 博纳基因技术有限公司 纳米口装置阵列：它们的制备以及在大分子分析中的应用
US8722327B2 (en) 2007-03-28 2014-05-13 Bionano Genomics, Inc. Methods of macromolecular analysis using nanochannel arrays
CN102369059B (zh) * 2008-06-06 2014-09-24 博纳基因技术有限公司 集成分析装置及相关制造方法和分析技术
CN104272089A (zh) * 2012-03-05 2015-01-07 松下电器产业株式会社 传感器设备
CN101151377B (zh) * 2004-05-13 2015-04-01 纳米生物技术股份有限公司 纳米-pcr:进行核酸扩增和检测的方法及装置
US9181578B2 (en) 2008-11-18 2015-11-10 Bionano Genomics, Inc. Polynucleotide mapping and sequencing
US9536041B2 (en) 2008-06-30 2017-01-03 Bionano Genomics, Inc. Methods and devices for single-molecule whole genome analysis
CN111417468A (zh) * 2017-11-30 2020-07-14 艾仕得涂料系统有限责任公司 利用高转移效率施涂器施加的涂料组合物及其方法和系统
CN112473418A (zh) * 2020-11-06 2021-03-12 中国石油大学(北京) 一种连续油管用超干二氧化碳泡沫发生装置及其应用
CN113617402A (zh) * 2021-07-07 2021-11-09 福建农林大学 产生剪切和拉伸组合流场的微流芯片、装置及其应用方法

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7056661B2 (en) 1999-05-19 2006-06-06 Cornell Research Foundation, Inc. Method for sequencing nucleic acid molecules
US6927065B2 (en) 1999-08-13 2005-08-09 U.S. Genomics, Inc. Methods and apparatus for characterization of single polymers
AU2002227156A1 (en) 2000-12-01 2002-06-11 Visigen Biotechnologies, Inc. Enzymatic nucleic acid synthesis: compositions and methods for altering monomer incorporation fidelity
EP2801624B1 (en) 2001-03-16 2019-03-06 Singular Bio, Inc Arrays and methods of use
US8423294B2 (en) 2001-09-18 2013-04-16 Pathogenetix, Inc. High resolution linear analysis of polymers
GB0125436D0 (en) * 2001-10-23 2001-12-12 Deltadot Ltd Analysis of temperature-dependent molecular configurations
WO2003106693A2 (en) 2002-01-01 2003-12-24 Princeton University Gradient structures interfacing microfluidics and nanofluidics, methods for fabrication and uses thereof
US7282330B2 (en) 2002-05-28 2007-10-16 U.S. Genomics, Inc. Methods and apparati using single polymer analysis
EP1546380A4 (en) 2002-05-28 2007-02-14 Us Genomics Inc METHODS AND APPARATUSES FOR ANALYZING SIMPLE POLYMERS
AU2003251986A1 (en) * 2002-07-17 2004-02-02 U.S.Genomics, Inc. Methods and compositions for analyzing polymers using chimeric tags
JP2006522940A (ja) * 2003-04-10 2006-10-05 ユー．エス． ジェノミクス， インコーポレイテッド マイクロチャネルにおけるポリマーの操作
US20070026456A1 (en) * 2003-09-02 2007-02-01 Nec Corporation Method of biomolecule analysis and method of identifying biomolecule therewith
US7977048B2 (en) 2004-01-13 2011-07-12 Pathogenetix, Inc. Detection and quantification of analytes in solution using polymers
US7595160B2 (en) 2004-01-13 2009-09-29 U.S. Genomics, Inc. Analyte detection using barcoded polymers
AP2773A (en) * 2004-05-13 2013-09-30 Nanobiosym Inc NANO-PCR: Methods and devices for nucleic acid amplification and detection
US7170050B2 (en) 2004-09-17 2007-01-30 Pacific Biosciences Of California, Inc. Apparatus and methods for optical analysis of molecules
ES2402939T3 (es) * 2005-12-23 2013-05-10 Nanostring Technologies, Inc. Composiciones que comprenden macromoléculas inmovilizadas y orientadas y métodos para su preparación
CA2646309C (en) 2006-04-21 2016-07-26 Nanobiosym, Inc. Single-molecule platform for drug discovery: methods and apparatuses for drug discovery, including discovery of anticancer and antiviral agents
US7858305B2 (en) 2006-06-30 2010-12-28 The Invention Science Fund I, Llc Method of combing a nucleic acid
JP5086335B2 (ja) * 2007-03-02 2012-11-28 株式会社セイシン企業 フローセル及びそれを備えた粒子形状分析装置
CN101772697B (zh) * 2007-06-07 2013-08-21 技术研究及发展基金有限公司 用于聚集颗粒的系统和方法
US8367424B2 (en) 2007-10-15 2013-02-05 Rohm Co., Ltd. Microchip and method of using the same
EP3425060B1 (en) 2008-03-28 2021-10-27 Pacific Biosciences of California, Inc. Compositions and methods for nucleic acid sequencing
WO2011108540A1 (ja) 2010-03-03 2011-09-09 国立大学法人大阪大学 ヌクレオチドを識別する方法および装置、ならびにポリヌクレオチドのヌクレオチド配列を決定する方法および装置
GB201111237D0 (en) * 2011-06-30 2011-08-17 Isis Innovation Nanochip
US11053535B2 (en) 2011-09-12 2021-07-06 The University Of North Carolina At Chapel Hill Devices with a fluid transport nanochannel intersected by a fluid sensing nanochannel and related methods
EP2570488A1 (en) * 2011-09-16 2013-03-20 Centre National de la Recherche Scientifique (C.N.R.S) Method for longitudinal macromolecule spreading and method for analyzing macromolecules
EP3591408A1 (en) * 2012-02-10 2020-01-08 The University of North Carolina at Chapel Hill Devices with fluidic nanofunnels, associated methods, fabrication and analysis systems
WO2013158860A1 (en) * 2012-04-18 2013-10-24 Pathogenetix, Inc. Devices and methods for nucleic acid preparation and analysis
WO2014027580A1 (ja) 2012-08-17 2014-02-20 国立大学法人大阪大学 試料の分析方法
AU2014223620B2 (en) 2013-02-28 2017-09-14 The University Of North Carolina At Chapel Hill Nanofluidic devices with integrated components for the controlled capture, trapping, and transport of macromolecules and related methods of analysis
JP2014173934A (ja) * 2013-03-07 2014-09-22 Toshiba Corp 半導体マイクロ分析チップ及びその製造方法
EP2971181B1 (en) 2013-03-13 2019-02-20 The University of North Carolina At Chapel Hill Nanofluidic devices for the rapid mapping of whole genomes and related systems and methods of analysis
US10933417B2 (en) 2013-03-15 2021-03-02 Nanobiosym, Inc. Systems and methods for mobile device analysis of nucleic acids and proteins
CN104368250B (zh) * 2013-08-13 2017-12-22 北京慧荣和科技有限公司 气体或气溶胶混合或稀释装置
KR20160079780A (ko) 2013-09-18 2016-07-06 퀀텀 바이오시스템즈 가부시키가이샤 생체분자를 서열화하는 디바이스들, 시스템들 및 방법들
JP2015077652A (ja) 2013-10-16 2015-04-23 クオンタムバイオシステムズ株式会社 ナノギャップ電極およびその製造方法
KR20160130380A (ko) * 2014-01-24 2016-11-11 퀀텀 바이오시스템즈 가부시키가이샤 생체분자를 서열화하기 위한 디바이스, 시스템 및 방법
US10438811B1 (en) 2014-04-15 2019-10-08 Quantum Biosystems Inc. Methods for forming nano-gap electrodes for use in nanosensors
WO2015170782A1 (en) 2014-05-08 2015-11-12 Osaka University Devices, systems and methods for linearization of polymers
WO2016182811A1 (en) 2015-05-11 2016-11-17 The University Of North Carolina At Chapel Hill Fluidic devices with nanoscale manifolds for molecular transport, related systems and methods of analysis
WO2020124263A1 (en) * 2018-12-21 2020-06-25 Nanorial Technologies Ltd. Apparatus, methods, and systems for mixing, dispersing substances

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3123249B2 (ja) * 1991-09-10 2001-01-09 株式会社日立製作所 Ｄｎａ分子の長さ計測方法および計測装置
US5538898A (en) * 1995-03-16 1996-07-23 International Business Machines Corporation Method suitable for identifying a code sequence of a biomolecule
US5846832A (en) * 1995-09-20 1998-12-08 The Board Of Trustees Of The Leland Stanford Junior University Apparatus and method for shear breakage of polynucleotides
CA2301309A1 (en) * 1997-08-13 1999-02-25 Cepheid Microstructures for the manipulation of fluid samples
IL141310A0 (en) * 1998-08-13 2002-03-10 Us Genomics Inc Optically characterizing polymers

Cited By (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101151377B (zh) * 2004-05-13 2015-04-01 纳米生物技术股份有限公司 纳米-pcr:进行核酸扩增和检测的方法及装置
CN103203256B (zh) * 2006-07-19 2015-09-23 博纳基因技术有限公司 纳米口装置阵列:它们的制备以及在大分子分析中的应用
CN103203256A (zh) * 2006-07-19 2013-07-17 博纳基因技术有限公司 纳米口装置阵列：它们的制备以及在大分子分析中的应用
US9845238B2 (en) 2006-07-19 2017-12-19 Bionano Genomics, Inc. Nanonozzle device arrays: their preparation and use for macromolecular analysis
US11529630B2 (en) 2006-07-19 2022-12-20 Bionano Genomics, Inc. Nanonozzle device arrays: their preparation and use for macromolecular analysis
US9061901B2 (en) 2006-07-19 2015-06-23 Bionano Genomics, Inc. Nanonozzle device arrays: their preparation and use for macromolecular analysis
US9310376B2 (en) 2007-03-28 2016-04-12 Bionano Genomics, Inc. Methods of macromolecular analysis using nanochannel arrays
US10000804B2 (en) 2007-03-28 2018-06-19 Bionano Genomics, Inc. Methods of macromolecular analysis using nanochannel arrays
US8722327B2 (en) 2007-03-28 2014-05-13 Bionano Genomics, Inc. Methods of macromolecular analysis using nanochannel arrays
CN102369059B (zh) * 2008-06-06 2014-09-24 博纳基因技术有限公司 集成分析装置及相关制造方法和分析技术
US9536041B2 (en) 2008-06-30 2017-01-03 Bionano Genomics, Inc. Methods and devices for single-molecule whole genome analysis
US10435739B2 (en) 2008-06-30 2019-10-08 Bionano Genomics, Inc. Methods and devices for single-molecule whole genome analysis
US11939627B2 (en) 2008-06-30 2024-03-26 Bionano Genomics, Inc. Methods and devices for single-molecule whole genome analysis
US10995364B2 (en) 2008-06-30 2021-05-04 Bionano Genomics, Inc. Methods and devices for single-molecule whole genome analysis
US9181578B2 (en) 2008-11-18 2015-11-10 Bionano Genomics, Inc. Polynucleotide mapping and sequencing
US10000803B2 (en) 2008-11-18 2018-06-19 Bionano Genomics, Inc. Polynucleotide mapping and sequencing
CN104272089A (zh) * 2012-03-05 2015-01-07 松下电器产业株式会社 传感器设备
US9829486B2 (en) 2012-03-05 2017-11-28 Panasonic Intellectual Property Management Co., Ltd. Sensor device
US11649371B2 (en) 2017-11-30 2023-05-16 Axalta Coating Systems Ip Co., Llc Method of forming a coating composition for application to a substrate utilizing a high transfer efficiency applicator
US11655391B2 (en) 2017-11-30 2023-05-23 Axalta Coating Systems Ip Co., Llc Coating compositions for application utilizing a high transfer efficiency applicator and methods and systems thereof
CN111417468B (zh) * 2017-11-30 2022-04-12 艾仕得涂料系统有限责任公司 利用高转移效率施涂器施加的涂料组合物及其方法和系统
US11453802B2 (en) 2017-11-30 2022-09-27 Axalta Coating Systems Ip Co., Llc Method of applying a coating composition to a substrate
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