CN1377584A - Atomic iodine aqueous solution and its preparing method - Google Patents
Atomic iodine aqueous solution and its preparing method Download PDFInfo
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- CN1377584A CN1377584A CN 02110037 CN02110037A CN1377584A CN 1377584 A CN1377584 A CN 1377584A CN 02110037 CN02110037 CN 02110037 CN 02110037 A CN02110037 A CN 02110037A CN 1377584 A CN1377584 A CN 1377584A
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Abstract
The present invention relates to inorganic sterilizing chemicals. The aqueous solution of atomic iodine consists of iodine in 0.5-30 wt%, cosolvent cyclodextrin derivative and water. It is compounded through preparation of ethanol alcohol solution of iodine and saturated water solution of cyclodextrin derivative at 35-70 deg.c, mixing, and diluting with water to the said iodine content. The macro molecule of cyclodextrin as cosolvent can raise the solution degree of iodine, convert insoluble iodine into water soluble micron level iodine and thus increase the stability of medicine. The present invnetion has strong sterilization, no irritation to skin, mucous membrane and other sensitive parts and no toxic side effect, and is used as substitute of iodine tincture and iodoform.
Description
Technical field
The invention belongs to the sterilizing article category that contains inorganic active ingredient, especially a kind of atomic iodine aqueous solution and compound method thereof.
Background technology
The magma activity of proteins group of iodine energy oxidizing bacteria also can make protein denaturation in conjunction with its amino, thereby the very strong effect of killing common bacteria, fungi, virus and protozoon is arranged.The ethanolic solution (Tincture of iodine, the tincture of iodine promptly is commonly called as the tincture of iodine) that is made into iodine traditionally uses, and because of its solvent is an ethanol, the tool excitant can not be used for the alcohol autopath; The Iodophor (Iodophor) that is become with the iodine complexing by surfactant is unsettled water-soluble sterilization, washing agent, can be used as the regeneration product of the tincture of iodine, but has fulsome iodine smelly; Patent Office of the People's Republic of China is in the ZL93101603.7 " Solutio iodum-polyoxinolum aromaticum " of bulletin on June 25th, 1997, adding benzaldehyde on the basis of commercially available Iodophor is a kind of improvement as flavouring, but the dodecyl polyoxyethylene sodium sulphate consumption of its use is big (content can reach 5～55% in the finished product) too, it belongs to anionic surfactant, and document promptly has report to the toxicity of surfactant in the seventies.
Summary of the invention
The regeneration product that the purpose of this invention is to provide the tincture of iodine, Iodophor, promptly nontoxic, stable atom iodine solution and compound method thereof.
Technical scheme of the present invention is: develop a kind of atomic iodine aqueous solution, it is characterized in that it mainly is made up of iodine, cosolvent cyclodextrine derivatives and water, wherein content of iodine is 0.5～30W/W.
The compound method of above-mentioned atomic iodine aqueous solution is characterized in that comprising the steps:
1. under 35～70 ℃ of conditions, prepare the ethanolic solution of iodine with the absolute ethyl alcohol of meltage;
2. under 35～70 ℃ of conditions, prepare the saturated aqueous solution of cosolvent cyclodextrine derivatives;
3. under 35～70 ℃, stirring condition, mix both and make into homogeneous phase;
4. thin up reaches 0.5～30%W/W to content of iodine.
The compound method of above-mentioned atomic iodine aqueous solution is characterized in that to stirring, in the atomic iodine aqueous solution of homogeneous phase, adding the flavouring benzaldehyde of solution weight 0.01～0.1%;
The compound method of above-mentioned atomic iodine aqueous solution is characterized in that described cyclodextrine derivatives is meant alpha-cyclodextrin, beta-schardinger dextrin-or gamma-cyclodextrin;
The compound method of above-mentioned atomic iodine aqueous solution is characterized in that described cyclodextrine derivatives is meant the alpha-cyclodextrin of replacement, the beta-schardinger dextrin-of replacement or the gamma-cyclodextrin of replacement.
According to the literature: cyclodextrin is that starch is used by the basophilia bacillus that separates in the soil, cultivates the alkali starch enzymatic hydrolysis obtain and gets.It is a kind of glucose oligosaccharide in the form of a ring.Under normal conditions, cyclodextrin is by the interconnective structure of 1 → 4 key ring-type.
Cyclodextrin is novel " comprising " material of present a kind of food more likely and medicine.Commercially available common have α, β, three kinds of cyclodextrin of γ are made of 6,7,8 glucose molecules respectively.Beta cyclodextrin is the most commonly used, and its hole directly is 0.6～1nm, with medicine with suitable processing after, medicine (for example, iodine) can be contained in its circulus and form the former shape inclusion of ultra micro, because of its ultra microstructure is molecularity, dispersion effect is better.
Advantage of the present invention is:
1. the macrocycle molecule of cyclodextrin can improve drug solubility, forms a large amount of internal voids behind the great amount of hydroxy group dehydrating condensation in its molecular structure, and non-water-soluble iodine is converted into " micron order " stable water-soluble;
2. cyclodextrin can strengthen stability of drug, and as volatilization prevention, anti-distillation because stability increases, is placed in room temperature and still can be stablized constant in six months;
3. the cosolvent cyclodextrin that adopts of the present invention, similar glucose matrix, to sensitive parts such as skin, mucous membranes, also having no stimulates;
4. cyclodextrin itself is with sweet taste slightly, can hide the stink of iodine effectively.
Commonly used have HP-(Hydroxypropyl-β-Cyclodextrin), hydroxyethyl-(Hydroxyethyl-β-Cyclodextrin), methyl-beta-schardinger dextrin-(Methyl-β-Cyclodextrin), 2, a series of cyclodextrine derivatives such as 6-dimethyl-, sulfonic group beta-schardinger dextrin-, glucosyl group beta-schardinger dextrin-, nano based beta-schardinger dextrin-, polymeric cyclodextrins, sulfonic group alpha-cyclodextrin, glucosyl group gamma-cyclodextrin, beta-schardinger dextrin-, alpha-cyclodextrin, gamma-cyclodextrin, nanoparticle.
After measured, the resistance of commercially available iodophor solution is 5～7 * 1K Ω; The atomic iodine aqueous solution resistance that the present invention makes is 50～70 * 1K Ω; Much larger than the Iodophor of ionic state, conduct electricity hardly.Iodine is comprised in a large amount of cavitys of cyclodextrine derivatives formation, makes iodine form atomic state, and particle reaches micron order, and solvability heightens, and sterilizing power heightens.
If with the regeneration product of atomic iodine aqueous solution as the tincture of iodine, Iodophor, not only sterilizing power heightens, and have no side effect, and cost is lower, is suitable for promoting.
The present invention is good sterilization, sterilization, deodorization, analgesia and radioactive substance antipoison.Can be used for external skin sterilization, anticorrosion, or as the decontaminant of body lotion, tableware, toy etc.
Embodiment
Embodiment one preparation 2% (W/W) atomic iodine aqueous solution iodine: cosolvent: water=1: 5: surplus.
Cosolvent adopts beta-schardinger dextrin-, its key technical indexes: the appearance white powder, nontoxic, do not have smell, little sweet; Content 〉=99%; Moisture≤0.5%; Residue on ignition≤0.3%; Content of beary metal (in Pb)≤0.00001%; Arsenic (As) content≤0.00001%.The new big smart Fine chemical industry of Shan East Co., Ltd product.
Comprise the steps:
1. 5g iodine porphyrize in mortar is under 65～70 ℃, with the ethanolic solution (use 10ml approximately, its amount is with in the control process for preparation, and iodine is degree of being dissolved as fully) of the ethanol preparation iodine of meltage;
2. under 65～70 ℃ of conditions, the 5g beta-schardinger dextrin-is dissolved in the 50ml water saturated aqueous solution of preparation cosolvent beta-schardinger dextrin-;
3. under 65～70 ℃, stirring condition, the ethanolic solution of iodine is poured in the saturated aqueous solution of cosolvent beta-schardinger dextrin-, stirred 20min and make into homogeneous phase;
3. thin up reaches 250ml to total amount.Sampling, conventional chemical assay, every 1ml 0.1N sodium thiosulfate and 12.69mgI
2Quite.Content of iodine 2% (W/W) in the solution.Lucifuge, sealed glass jars packing.
Embodiment two preparation 30% (W/W) atomic iodine aqueous solution iodine: cosolvent: water=1: 1: surplus.
Cosolvent adopts alpha-cyclodextrin, and the water yield is added the benzaldehyde of solution weight 0.01% by the amount of calculation increase and decrease, and is surplus with example one.
Embodiment three preparation 20% (W/W) atomic iodine aqueous solution iodine: cosolvent: water=1: 4: surplus.
Cosolvent adopts gamma-cyclodextrin, and the water yield is added the benzaldehyde of solution weight 0.1% by the amount of calculation increase and decrease, and is surplus with example one.
Embodiment four preparation 1% (W/W) atomic iodine aqueous solution iodine: cosolvent: water=1: 10: surplus.
Cosolvent adopts HP-, and the water yield is by the amount of calculation increase and decrease, and is surplus with embodiment one.
Embodiment five preparation 15% (W/W) atomic iodine aqueous solution iodine: cosolvent: water=1: 8: surplus.
Cosolvent adopts hydroxyethyl-, and the water yield is by the amount of calculation increase and decrease, and is surplus with embodiment one.
Embodiment six preparation 30% (W/W) atomic iodine aqueous solution iodine: cosolvent: water=1: 6: surplus.55～60℃；
Adopt methyl-beta-schardinger dextrin-, the water yield is added the benzaldehyde of solution weight 0.05% by the amount of calculation increase and decrease, and is surplus with example one.
Embodiment seven preparation 20% (W/W) atomic iodine aqueous solution iodine: cosolvent: water=1: 3: surplus.
Cosolvent adopts 2, the 6-dimethyl-, and the water yield is by the amount of calculation increase and decrease, and is surplus with embodiment six.
Embodiment eight preparation 10% (W/W) atomic iodine aqueous solution iodine: cosolvent: water=1: 15: surplus.
Adopt the sulfonic group beta-schardinger dextrin-, the water yield is added the benzaldehyde of solution weight 0.03% by the amount of calculation increase and decrease, and is surplus with example six.
Embodiment nine preparation 15% (W/W) atomic iodine aqueous solution iodine: cosolvent: water=1: 7: surplus.
Adopt the glucosyl group beta-schardinger dextrin-, the water yield is added the benzaldehyde of solution weight 0.02% by the amount of calculation increase and decrease, and is surplus with example six.
Embodiment ten preparation 10% (W/W) atomic iodine aqueous solution iodine: cosolvent: water=1: 5: surplus.60～65℃；
Cosolvent adopts the nano based beta-schardinger dextrin-, and the water yield is by the amount of calculation increase and decrease, and is surplus with embodiment one.
Embodiment 11 preparation 15% (W/W) atomic iodine aqueous solution iodine: cosolvent: water=1: 2: surplus.
Adopt polymeric cyclodextrins, the water yield is added the benzaldehyde of solution weight 0.06% by the amount of calculation increase and decrease, and is surplus with example ten.
Embodiment 12 preparation 30% (W/W) atomic iodine aqueous solution iodine: cosolvent: water=1: 1: surplus.
Cosolvent adopts alpha-cyclodextrin, and the water yield is by the amount of calculation increase and decrease, and is surplus with embodiment ten.
Embodiment 13 preparation 20% (W/W) atomic iodine aqueous solution iodine: cosolvent: water=1: 5: surplus.
Adopt gamma-cyclodextrin, the water yield is added the benzaldehyde of solution weight 0.08% by the amount of calculation increase and decrease, and is surplus with example ten.
Embodiment 14 preparation 3% (W/W) atomic iodine aqueous solution iodine: cosolvent: water=1: 15: surplus.
Cosolvent adopts HP-, and the water yield is by the amount of calculation increase and decrease, and is surplus with embodiment ten.
Embodiment 15 preparation 25% (W/W) atomic iodine aqueous solution iodine: cosolvent: water=1: 10: surplus.50～55 ℃; Adopt hydroxyethyl-, the water yield is added the benzaldehyde of solution weight 0.01% by the amount of calculation increase and decrease, and is surplus with example one.
Embodiment 16 preparation 30% (W/W) atomic iodine aqueous solution iodine: cosolvent: water=1: 5: surplus.
Cosolvent adopts methyl-beta-schardinger dextrin-, and the water yield is by the amount of calculation increase and decrease, and is surplus with embodiment 15.
Embodiment 17 preparation 20% (W/W) atomic iodine aqueous solution iodine: cosolvent: water=1: 6: surplus.
Adopt 2,6-dimethyl-, water add the benzaldehyde of solution weight 0.1% by the amount of calculation increase and decrease, and be surplus with example one.
Embodiment 18 preparation 10% (W/W) atomic iodine aqueous solution iodine: cosolvent: water=1: 15: surplus.
Cosolvent adopts the sulfonic group beta-schardinger dextrin-, and the water yield is by the amount of calculation increase and decrease, and is surplus with embodiment 15.
Embodiment 19 preparation 15% (W/W) atomic iodine aqueous solution iodine: cosolvent: water=1: 9: surplus.
Cosolvent adopts the glucosyl group beta-schardinger dextrin-, and the water yield is by the amount of calculation increase and decrease, and is surplus with embodiment 15.
Embodiment 20 preparation 20% (W/W) atomic iodine aqueous solution iodine: cosolvent: water=1: 5: surplus.45～50 ℃; Cosolvent adopts the nano based beta-schardinger dextrin-, and the water yield is by the amount of calculation increase and decrease, and is surplus with embodiment one.
Embodiment 21 preparation 15% (W/W) atomic iodine aqueous solution iodine: cosolvent: water=1: 2: surplus.
Adopt polymeric cyclodextrins, the water yield is added the benzaldehyde of solution weight 0.01% by the amount of calculation increase and decrease, and is surplus with example 20.
Embodiment 22 preparation 25% (W/W) atomic iodine aqueous solution iodine: cosolvent: water=1: 10: surplus.50～55 ℃; Adopt hydroxyethyl-, the water yield is added the benzaldehyde of solution weight 0.01% by the amount of calculation increase and decrease, and is surplus with example one.
Embodiment 23 preparation 30% (W/W) atomic iodine aqueous solution iodine: cosolvent: water=1: 5: surplus.
Cosolvent adopts methyl-beta-schardinger dextrin-, and the water yield is by the amount of calculation increase and decrease, and is surplus with embodiment 22.
Embodiment 24 preparation 25% (W/W) atomic iodine aqueous solution iodine: cosolvent: water=1: 10: surplus.Adopt hydroxyethyl-, the water yield is added the benzaldehyde of solution weight 0.01% by the amount of calculation increase and decrease, and is surplus with example 22.
Embodiment 25 preparation 30% (W/W) atomic iodine aqueous solution iodine: cosolvent: water=1: 5: surplus.40～45 ℃; Cosolvent adopts methyl-beta-schardinger dextrin-, and the water yield is by the amount of calculation increase and decrease, and is surplus with embodiment one.
Embodiment 26 preparation 20% (W/W) atomic iodine aqueous solution iodine: cosolvent: water=1: 6: surplus.Adopt 2,6-dimethyl-, water add the benzaldehyde of solution weight 0.1% by the amount of calculation increase and decrease, and be surplus with example 25.
Embodiment 27 preparation 10% (W/W) atomic iodine aqueous solution iodine: cosolvent: water=1: 15: surplus.
Cosolvent adopts the sulfonic group beta-schardinger dextrin-, and the water yield is by the amount of calculation increase and decrease, and is surplus with embodiment one.
Embodiment 28 preparation 15% (W/W) atomic iodine aqueous solution iodine: cosolvent: water=1: 9: surplus.35～40 ℃; Cosolvent adopts the glucosyl group beta-schardinger dextrin-, and the water yield is by the amount of calculation increase and decrease, and is surplus with embodiment one.
Embodiment 29 preparation 20% (W/W) atomic iodine aqueous solution iodine: cosolvent: water=1: 5: surplus.Cosolvent adopts the nano based beta-schardinger dextrin-, and the water yield is by the amount of calculation increase and decrease, and is surplus with embodiment 28.
Claims (5)
1. atomic iodine aqueous solution is characterized in that it mainly is made up of iodine, cosolvent cyclodextrine derivatives and water, and wherein content of iodine is 0.5～30% W/W.
2. the compound method according to the described atomic iodine aqueous solution of claim 1 is characterized in that comprising the steps:
1. under 35～70 ℃ of conditions, prepare the ethanolic solution of iodine with the absolute ethyl alcohol of meltage;
2. under 35～70 ℃ of conditions, prepare the saturated aqueous solution of cosolvent cyclodextrine derivatives;
3. under 35～70 ℃, stirring condition, mix both and make into homogeneous phase;
4. thin up reaches 0.5～30% W/W to content of iodine.
3. compound method according to the described atomic iodine aqueous solution of claim 2 is characterized in that to stirring, in the atomic iodine aqueous solution of homogeneous phase, adding the flavouring benzaldehyde of solution weight 0.01～0.1%.
4. the compound method according to claim 2 or 3 described atomic iodine aqueous solutions is characterized in that described cyclodextrine derivatives is meant alpha-cyclodextrin, beta-schardinger dextrin-or gamma-cyclodextrin.
5. the compound method according to claim 2 or 3 described atomic iodine aqueous solutions is characterized in that described cyclodextrine derivatives is meant the alpha-cyclodextrin of replacement, the beta-schardinger dextrin-of replacement or the gamma-cyclodextrin of replacement.
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| CN 02110037 CN1216537C (en) | 2002-02-28 | 2002-02-28 | Atomic iodine aqueous solution and its preparing method |
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| CN1216537C CN1216537C (en) | 2005-08-31 |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100591358C (en) * | 2008-02-01 | 2010-02-24 | 山东省农业科学院家禽研究所 | Method for preparing highly water-soluble cydiodine |
| CN102827770A (en) * | 2012-08-20 | 2012-12-19 | 三峡大学 | Color developing method for screening amylase producing strain |
| CN103247212A (en) * | 2012-02-10 | 2013-08-14 | 天津市天堰医教科技开发有限公司 | Simulated iodine tincture |
| WO2014023718A1 (en) * | 2012-08-07 | 2014-02-13 | Dräger Safety AG & Co. KGaA | Disinfectant containing a complex of iodine and cyclodextrin |
| CN104012572A (en) * | 2014-06-10 | 2014-09-03 | 山东省农业科学院家禽研究所 | Disinfection powder and preparation method thereof |
| CN114917267A (en) * | 2022-04-25 | 2022-08-19 | 杭州西子卫生消毒药械有限公司 | Iodine-containing disinfectant for skin and preparation method thereof |
-
2002
- 2002-02-28 CN CN 02110037 patent/CN1216537C/en not_active Expired - Fee Related
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100591358C (en) * | 2008-02-01 | 2010-02-24 | 山东省农业科学院家禽研究所 | Method for preparing highly water-soluble cydiodine |
| CN103247212A (en) * | 2012-02-10 | 2013-08-14 | 天津市天堰医教科技开发有限公司 | Simulated iodine tincture |
| WO2014023718A1 (en) * | 2012-08-07 | 2014-02-13 | Dräger Safety AG & Co. KGaA | Disinfectant containing a complex of iodine and cyclodextrin |
| GB2517107A (en) * | 2012-08-07 | 2015-02-11 | Draeger Safety Ag & Co Kgaa | Disinfectant containing a complex of iodine and cyclodextrin |
| GB2517107B (en) * | 2012-08-07 | 2019-04-24 | Draeger Safety Ag & Co Kgaa | Disinfectant containing a complex of iodine and cyclodextrin |
| CN102827770A (en) * | 2012-08-20 | 2012-12-19 | 三峡大学 | Color developing method for screening amylase producing strain |
| CN104012572A (en) * | 2014-06-10 | 2014-09-03 | 山东省农业科学院家禽研究所 | Disinfection powder and preparation method thereof |
| CN114917267A (en) * | 2022-04-25 | 2022-08-19 | 杭州西子卫生消毒药械有限公司 | Iodine-containing disinfectant for skin and preparation method thereof |
| CN114917267B (en) * | 2022-04-25 | 2023-04-11 | 杭州西子卫生消毒药械有限公司 | Iodine-containing disinfectant for skin and preparation method thereof |
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| CN1216537C (en) | 2005-08-31 |
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