CN100591358C - Method for preparing highly water-soluble cydiodine - Google Patents
Method for preparing highly water-soluble cydiodine Download PDFInfo
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- CN100591358C CN100591358C CN200810014514A CN200810014514A CN100591358C CN 100591358 C CN100591358 C CN 100591358C CN 200810014514 A CN200810014514 A CN 200810014514A CN 200810014514 A CN200810014514 A CN 200810014514A CN 100591358 C CN100591358 C CN 100591358C
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- cydiodine
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Abstract
The invention discloses a preparation method of a high water-soluble cydiodine, which belongs to pharmacy technology field. Quickly putting the iodine solution into Beta- cyclodextrin saturated solution and then mixing constantly until the solution cools to below 40 DEG C. Then naturally precipitating the cooled cydiodine solution and pouring the supernatant out and leaving the sediment when the precipitation completes. Or separating the cooled cydiodine solution via centrifugation to separate the sediment and water, and then putting the sediment to the oven to bake to powder and then sift out; in addition, spray drying the cooled west ground solution to get dry powder of cydiodine is also feasible. Put the dry cydiodine powder to the oven to bake for a certain period and then mixing well,and the high water-soluble cydiodine will be formed. The high water-soluble cydiodine prepared by the method has the advantages of having fast coating speed, high water-soluble, good disinfect effectand stable quality.
Description
Technical field
The present invention relates to the preparation method of highly water-soluble cydiodine, belong to the pharmaceutical technology field.
Background technology
Infectious disease is one of the key factor in harm humans and animals and plants Jiankang.In order to eliminate infection, we not only will kill the pathogenic microorganism of invading body, but also will eliminate the pathogenic microorganism in the environment, and protecting human and vegeto-animal Jiankang, and this task must be finished by sterilization.Sterilization can be eliminated pathogenic microorganism from the infectious disease source, the propagation of blocking-up pathogenic microorganism, thus play the human or vegeto-animal purpose of protection.Sterilization can be undertaken by physical method, also can be undertaken by chemical method, and in face of big disease transmission, chemical disinfection is the main means of disinfectant.Chemical disinfection promptly is to use chemical reagent to carry out disinfection.Sterilization in the market is a lot of with the chemical reagent kind, mainly comprises classes such as aldehydes, peroxide, chlorinated product, alkylation gas, alcohols, quaternary ammonium salts, Operand, soda acid, heavy metal.Wherein, Operand is so that its Disinfection Effect is good, toxic and side effects is low, zest is little, noresidue and do not have advantages such as eco-toxicity and be widely used.Iodine is a kind of wide spectrum, disinfectant efficiently, has powerful osmosis, direct halogen preteins, cause microbial death, it can kill most of microbe, as antibacterial, virus, fungus, protozoacide and bacterial spore etc., and iodine is little to the killing action concentration difference of multiple microorganism.The exploitation iodine disinfectant at first will solve two problems, dissolubility in the first water, and it two is the molecularities that keep iodine.This mainly is because iodine is water insoluble, and iodine must just have disinfective action with molecularity.Be suitable for environment disinfected in the market, and the Operand that is widely used has only povidone iodine class (the indefinite form conjugate of iodine and surfactant), and other multiple Operand, as iodine glycerol, iodoform, iodine trichloride and chiniofon etc., mainly because of the high sterilization that is used for utensil or skin, mucosa etc. of cost more.The molecularity of good water solubility, maintenance iodine, and Operand with low cost is the target of iodine disinfectant exploitation.
Cydiodine is a kind of novel Operand of developing the external seventies in last century, and said preparation utilizes beta-schardinger dextrin-with low cost, and (β-Cyclodextrin, abbreviation β-CYD) as carrier, iodine is wrapped quilt with molecularity has formed β-CYD-I
2Clathrate, i.e. cydiodine (β-CyclodextrinInclusion Compound of Iodion is called for short the Cydiodion-cydiodine).Cydiodine physics, chemical property are stable, can be used for sterilization, anticorrosion, deodorization and oral cavity and mucosa antibacterial etc.In Japan, ratified three patents in 1976 about cydiodine preparation and purposes, comprise Japan.Kokai 7688625 (1976), 76 101123 (1976) and 76 101124 (1976) etc., the preparation method of cydiodine is in the patent: the 50g beta-schardinger dextrin-is joined the I by 12g
2, the I that forms of 8g KI and 200ml water
2Wrap quilt in the-KI aqueous solution, encrusting substance can be used for sterilization, deodorization.Nineteen eighty-three Japan Jpn.KokaiTokkyo Koho JP83 152808 (1983) patents in preparation technology and patent in 1976 of cydiodine similar.In " compound xidi iodine sucked tablet and preparation method thereof " patent (publication number CN 1049099A) of China's Military Medical Science Institute's acquisition in 1991, cydiodine is by I
2-KI drips of solution is added in the beta-schardinger dextrin-solution and obtains, and wherein the potassium iodide content ratio is 3.0%-15%, and content of iodine is than being 1.5%-15%.China Chen Wen in 2006 political affairs have obtained the patent (patent No. ZL0349607.9) of " preparation method of compound xidi iodine sucked tablet " again, and wherein cydiodine is that alcoholic solution by iodine is added drop-wise in the water of beta-schardinger dextrin-or the Diluted Alcohol solution and prepares.In addition, the beta-schardinger dextrin-bag is all longer by the process of iodine in the above patent, promptly just obtains cydiodine after bag is kept certain hour under the temperature.
More than these patented methods can both prepare steady quality, the higher cydiodine of content of iodine, but the prepared cydiodine dissolubility of these methods is all very low, 20 ℃ of 100ml water dissolution amounts are no more than 0.01g, belong to the slightly solubility material.All there is other shortcoming in the cydiodine of above simultaneously these method preparations again and is not suitable for extensive environment disinfected use.In the patent as four patents of Japan and China Military Medical Science Institute, I
2Aqueous solution by KI as cosolvent, the consumption of KI and I
2Usage ratio all very high, KI is 2/3rds of an iodine consumption in the patent of Japan, KI is 0.2～10 times of iodine consumption in the patent of China Military Medical Science Institute, because price and the I of KI
2Close, KI does not have bactericidal action in cydiodine, and low dose of use can be carried dissolubility in the periodic water, but heavy dose of only the use can increase the cost of cydiodine, thereby is not suitable for large-area environment disinfected.And ethanol is only used in the dissolving of iodine in the patent that China Chen Wen political affairs obtain, not only dissolubility is low for cydiodine by this prepared, go back owing to there is not the hydrotropy of potassium iodide simultaneously, the iodine molecule stability that cydiodine discharges in water is also relatively poor, and generation is volatilized and caused concentration reduction in the water easily.
By above patent as can be seen: with I
2With the beta-schardinger dextrin-bag be to calculate at 1: 1 by ratio, the iodine molecule theoretical content is about 18.27% in the cydiodine, because dissolubility all is lower than 0.01g in the cydiodine water of above patent preparation, even the iodine molecule of the water-soluble back of the cydiodine quilt that wraps all dissociates, the concentration of the iodine molecule in the cydiodine solution does not reach 18.27mg/L, and iodine is to the killing concentration and all will be higher than 50mg/L of most of antibacterials, so the cydiodine of above patented method preparation can't use as extensive sterilization.So, cydiodine is developed as dissolubility in the water that disinfectant products at first must improve cydiodine.
Summary of the invention
Purpose of the present invention just is to improve the dissolubility of cydiodine in water, and reduces the cydiodine production cost, and cydiodine can be used as a kind of disinfectant cheaply.
The preparation method of highly water-soluble cydiodine of the present invention is achieved through the following technical solutions:
(1) wraps by technology: beta-schardinger dextrin-is added water be mixed with saturated solution, I
2Be dissolved in KI and form iodine solution in the alcoholic solution, iodine solution is added in the beta-schardinger dextrin-saturated solution fast, naturally cool to below 40 ℃ under constantly stirring then;
(2) dewatering process: with the natural sedimentation of refrigerative cydiodine solution, precipitation is poured out supernatant after fully and is stayed precipitation, perhaps with cooled cydiodine solution by centrifuging with precipitate and separated form water, and then precipitate be placed in the baking box to do roastingly to powdery, sieve; Also refrigerative cydiodine solution directly can be carried out spray drying in addition and obtain the cydiodine dried powder;
(3) high-temperature process: will be drying become pulverous cydiodine and be placed into and do mix homogeneously behind the roasting certain hour in the baking box, can obtain highly water-soluble cydiodine.
Concrete steps are as follows:
1, component and proportioning
Beta-schardinger dextrin-: m part;
I
2: n part, with the beta-schardinger dextrin-mol ratio be 1: 1, i.e. n: m=253.8: 1135;
KI:1%n～15% n part;
50%～99% alcoholic solution: n～20n part;
Beta-schardinger dextrin-solution: beta-schardinger dextrin-m part adds water and is mixed with saturated solution under 50～100 ℃;
Iodine solution: with n part I
2And 1%n～15%n part KI is dissolved in and forms the high concentration iodine solution in 50%～99% alcoholic solution of n～20n part.
2, technological process
(1) bag is by technology
Iodine solution is added in the beta-schardinger dextrin-saturated solution fast, under constantly stirring, naturally cools to below 40 ℃ in the room temperature then.
(2), dewatering process
With cooled cydiodine solution dehydrates, be dried to powdery.Dewatering process has following method:
1. natural sedimentation method: more than refrigerative cydiodine solution natural sedimentation 24h, precipitation is poured out supernatant after fully, and then with precipitate be placed in the baking box 40 ℃～100 ℃ do roasting to the powdery crushing screening;
2. centrifuging: cooled cydiodine solution is centrifugal by centrifuge, with precipitate and separated form water, again precipitate is placed in the baking box 40 ℃～100 ℃ do roasting to the powdery crushing screening;
3. spray drying method: refrigerative cydiodine solution is directly carried out spray drying, and the spray dryer hot blast temperature is set at 100 ℃～200 ℃, and the material outlet temperature is set at below 100 ℃, and cydiodine is once sprayed into dried powder in spray dryer.
(3), high-temperature process
Will be drying become powdered cydiodine and be placed in baking box or other heating vessel, be heated to 100 ℃～200 ℃ and keep certain hour, the cydiodine that obtains is highly water-soluble cydiodine.
The cydiodine available iodine content of above method preparation is more than 16%, and dissolubility is greater than dissolving 0.1g (dissolving back iodine concentration is greater than 160mg/L) in the 100ml water during less than 3%, 20 ℃ for KI content, and the iodine response rate is more than 90%.
In the present invention, I
2Dissolving use the alcoholic solution of 50%～99% high concentration, and the KI that uses low dosage is as cosolvent, the iodine solution that is made into can reach higher concentration, as 80% alcoholic solution under the situation of 2.5g KI hydrotropy, can dissolve the above iodine of 30g in the time of 60 ℃, the KI of low dosage not only can guarantee cheaply cydiodine but also have the hydrotropy effect, can reduce the volatilization of iodine molecule after making cydiodine water-soluble.Beta-schardinger dextrin-solution is saturated solution in this patent, course of reaction is for mixing the back natural cooling rather than keep a period of time under reaction temperature, this is because the forming process of cydiodine is a reversible course of reaction, under uniform temp since the dissolubility of cydiodine well below beta-schardinger dextrin-, the cydiodine that generates in the reaction constantly precipitation is separated out, and reduction along with reaction temperature, beta-schardinger dextrin-concentration is in nearly saturation all the time, and bag is constantly carried out until the cooling balance towards the generation direction of cydiodine by the reaction meeting.After reaction is cooled to below 40 ℃, because the cydiodine dissolubility is low and molecular weight is big, can precipitate rapidly when leaving standstill, so dewatering process can at first adopt natural sedimentation method or centrifugal method with cydiodine and separated form water, and then the cydiodine of post precipitation is carried out low temperature do and roastingly can form exsiccant preparation.Dewatering process also can carry out a step by spray drying method and be dried to powder.After the processing of dried cydiodine by temperature more than 100 ℃, the cydiodine that obtains is highly water-soluble cydiodine.
Utilize the highly water-soluble cydiodine of the inventive method preparation to have the following advantages: wrap fast by speed, water solublity is high, Disinfection Effect good and steady quality etc., specifies as follows:
Bag is fast by speed: bag is that iodine solution and beta-schardinger dextrin-mix and the back natural cooling process by process in the inventive method, and need not kept certain hour under the temperature at bag, so bag is very fast by speed, is suitable for large-scale production.
Dissolubility: in the time of 20 ℃, 100ml water can dissolve more than the highly water-soluble cydiodine 0.10g of the inventive method preparation, and cydiodine dissolving back forms clarification, transparent, yellow homogeneous solution.Available iodine content calculates with 16% in the cydiodine, and iodine concentration can surpass 160mg/L, is higher than the disinfection concentration commonly used (50～100mg/L) of iodine far away.
Disinfection Effect: detect according to " disinfectant technical specification " (2002 editions) prescriptive procedure, with the Na that is up to the standards
2S
2O
3, Tween80 and lecithin PBS solution (wherein three's concentration is respectively 0.5%, 4% and 0.2%) is as neutralizer, the highly water-soluble cydiodine of the inventive method preparation is to the quantitative sterilization effect of staphylococcus aureus ATCC 6538, escherichia coli 8099 and Candida albicans ATCC10231.When effective iodine concentration is that the bactericidal effect data of 100mg/L cydiodine solution see the following form.
Stability: the highly water-soluble cydiodine of the inventive method preparation, in 25 ℃ ± 2 ℃, the environment of relative humidity 60% ± 5%, to deposit 12 months, available iodine content reduces and is no more than 8%; Deposited 6 months in 40 ℃ ± 2 ℃, the environment of relative humidity 75% ± 5%, available iodine content reduces and is no more than 7%; Cydiodine effect duration of the inventive method preparation was above 1 year.
The specific embodiment
Example one:
Take by weighing beta-schardinger dextrin-300g, adding to has in the glass reaction of the 1000ml water still, be heated with stirring to 88 ℃～90 ℃ dissolvings fully after, keep temperature standby.Take by weighing iodine 67.1g, KI 5g, add in the 200ml90% alcoholic solution, be heated to 60 ℃ of all dissolvings.Then under agitation, iodine solution is added in the beta-schardinger dextrin-saturated solution fast, stops heating then, and under constantly stirring, make reactor naturally cool to 30 ℃.Then reactant liquor is poured in the beaker room temperature leave standstill deposit 24h and make the cydiodine natural sedimentation after, supernatant is removed, then precipitate is put in the enamel tray, put into 55 ℃ of baking boxs and do roasting to powder.Put into enamel tray again after powder sieved and evenly shakeout, put into baking box then, and kept 40 minutes after oven temperature is raised to 120 ℃, the cydiodine mix homogeneously with doing after roasting can obtain highly water-soluble cydiodine.
Example two:
Take by weighing beta-schardinger dextrin-200g, adding to has in the glass reaction of the 1000ml water still, be heated with stirring to 70 ℃～72 ℃ dissolvings fully after, keep temperature standby.Take by weighing iodine 44.7g, KI 6g, add in the 300ml95% alcoholic solution, be heated to 50 ℃ of all dissolvings.Under agitation, stop heating after being added to iodine solution in the beta-schardinger dextrin-saturated solution fast, and under constantly stirring, make reactor naturally cool to 35 ℃.With the reactant liquor rotating speed be the continuous high speed centrifuge of 15000rps centrifugal after, the centrifugal precipitate that obtains is put in the enamel tray, put into 50 ℃ of baking boxs and do roasting to powder.Put into enamel tray again after powder sieved and evenly shakeout, put into baking box then, and kept 30 minutes after oven temperature is raised to 130 ℃, the cydiodine mix homogeneously with doing after roasting can obtain highly water-soluble cydiodine.
Example three:
Take by weighing beta-schardinger dextrin-500g, adding to has in the glass reaction of the 1500ml water still, be heated with stirring to 80 ℃～82 ℃ dissolvings fully after, keep temperature standby.Take by weighing iodine 111.8g, KI 15g, add in the 350ml80% alcoholic solution, be heated to 60 ℃ of all dissolvings.Under agitation, stop heating after being added to iodine solution in the beta-schardinger dextrin-saturated solution fast, and under constantly stirring, make reactor naturally cool to 30 ℃.Then reactant liquor is carried out spray drying, the spray dryer hot blast temperature is made as 160 ℃, and the material outlet temperature is 70 ℃, once is spray dried to cydiodine Powdered.Cydiodine is put into enamel tray more evenly shakeout, put into baking box then, and kept 15 minutes after oven temperature is raised to 140 ℃, with the cydiodine mix homogeneously of doing after roasting.
Claims (3)
1, a kind of preparation method of highly water-soluble cydiodine is characterized in that, technological process is as follows: take by weighing beta-schardinger dextrin-300g, adding to has in the glass reaction of the 1000ml water still, be heated with stirring to 88 ℃～90 ℃ dissolvings fully after, keep temperature standby; Take by weighing iodine 67.1g, KI5g, add in 200ml 90% alcoholic solution, be heated to 60 ℃ of all dissolvings; Then under agitation, iodine solution is added in the beta-schardinger dextrin-saturated solution fast, stops heating then, and under constantly stirring, make reactor naturally cool to 30 ℃; Then reactant liquor is poured in the beaker room temperature leave standstill deposit 24h and make the cydiodine natural sedimentation after, supernatant is removed, then precipitate is put in the enamel tray, putting into 55 ℃ of baking boxs does roasting to powder, put into enamel tray again after powder sieved and evenly shakeout, put into baking box then, and kept 40 minutes after oven temperature is raised to 120 ℃, cydiodine mix homogeneously with doing after baking can obtain highly water-soluble cydiodine.
2, a kind of preparation method of highly water-soluble cydiodine is characterized in that, technological process is as follows: take by weighing beta-schardinger dextrin-200g, adding to has in the glass reaction of the 1000ml water still, be heated with stirring to 70 ℃～72 ℃ dissolvings fully after, keep temperature standby; Take by weighing iodine 44.7g, KI6g, add in 300ml 95% alcoholic solution, be heated to 50 ℃ of all dissolvings; Under agitation, stop heating after being added to iodine solution in the beta-schardinger dextrin-saturated solution fast, and under constantly stirring, make reactor naturally cool to 35 ℃; With the reactant liquor rotating speed be the continuous high speed centrifuge of 15000rps centrifugal after, the centrifugal precipitate that obtains is put in the enamel tray, put into 50 ℃ of baking boxs and do roasting to powder; Put into enamel tray again after powder sieved and evenly shakeout, put into baking box then, and kept 30 minutes after oven temperature is raised to 130 ℃, the cydiodine mix homogeneously with doing after roasting can obtain highly water-soluble cydiodine.
3, a kind of preparation method of highly water-soluble cydiodine is characterized in that, technological process is as follows: take by weighing beta-schardinger dextrin-500g, adding to has in the glass reaction of the 1500ml water still, be heated with stirring to 80 ℃～82 ℃ dissolvings fully after, keep temperature standby; Take by weighing iodine 111.8g, KI15g, add in 350ml 80% alcoholic solution, be heated to 60 ℃ of all dissolvings; Under agitation, stop heating after being added to iodine solution in the beta-schardinger dextrin-saturated solution fast, and under constantly stirring, make reactor naturally cool to 30 ℃; Then reactant liquor is carried out spray drying, the spray dryer hot blast temperature is made as 160 ℃, the material outlet temperature is 70 ℃, once be spray dried to cydiodine Powdered, cydiodine is put into enamel tray more evenly shakeout, put into baking box then, and kept 15 minutes after oven temperature is raised to 140 ℃, cydiodine mix homogeneously with doing after baking can obtain highly water-soluble cydiodine.
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| CN103393717B (en) * | 2013-07-23 | 2015-04-22 | 何元龙 | Method for preparing high-water-solubility cydiodine with low cost |
| CN104012572A (en) * | 2014-06-10 | 2014-09-03 | 山东省农业科学院家禽研究所 | Disinfection powder and preparation method thereof |
| CN114292753B (en) * | 2021-12-23 | 2023-06-16 | 南京大学 | Method for separating cells and discharging nanoparticles from cells |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1049099A (en) * | 1990-08-16 | 1991-02-13 | 中国人民解放军军事医学科学院毒物药物研究所 | Compound xidi iodine sucked tablet and preparation method thereof |
| CN1377584A (en) * | 2002-02-28 | 2002-11-06 | 周颖 | Atomic iodine aqueous solution and its preparing method |
| CN1513475A (en) * | 2003-07-14 | 2004-07-21 | 陈文政 | Process for preparing buccal lozenge contg. compound sede-iodine |
| JP2007063131A (en) * | 2005-08-04 | 2007-03-15 | Nippo Kagaku Kk | Gargle |
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- 2008-02-01 CN CN200810014514A patent/CN100591358C/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1049099A (en) * | 1990-08-16 | 1991-02-13 | 中国人民解放军军事医学科学院毒物药物研究所 | Compound xidi iodine sucked tablet and preparation method thereof |
| CN1377584A (en) * | 2002-02-28 | 2002-11-06 | 周颖 | Atomic iodine aqueous solution and its preparing method |
| CN1513475A (en) * | 2003-07-14 | 2004-07-21 | 陈文政 | Process for preparing buccal lozenge contg. compound sede-iodine |
| JP2007063131A (en) * | 2005-08-04 | 2007-03-15 | Nippo Kagaku Kk | Gargle |
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