CN1362193A - Namo xinkeshu medicine and its preparation - Google Patents
Namo xinkeshu medicine and its preparation Download PDFInfo
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- CN1362193A CN1362193A CN 01100351 CN01100351A CN1362193A CN 1362193 A CN1362193 A CN 1362193A CN 01100351 CN01100351 CN 01100351 CN 01100351 A CN01100351 A CN 01100351A CN 1362193 A CN1362193 A CN 1362193A
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Abstract
The present invention discloss a nano Xinkeshu preparation medicine. It is made up by uisng the Chinese medicinal materials of nano crataegus, nano salvia, nano pueraria, nano notoginseng and nano saussurea as raw material through the processes of microwave extraction, reduced pressure concentratino and supersonic jet spray drying. Its grain fineness is up to 1200-1500 meshes, grain size is 0.1-200 nm, in which is most of grain size is less than 100 nm. Said medicine is high in biological utilization rate and obvious in therapeutic effect.
Description
The present invention relates to a kind of promoting blood circulation to remove blood stasis, comfortable blood pressure lowering, blood vessel dilating, cholesterol reducing, the nanometer heart that the cures mainly coronary heart disease preparation medicine that can relax the invention still further relates to the method for this medication preparation.
XINKESHU JIAONANG is a kind of classical Chinese patent medicine, mainly contains anoxia enduring, prevents thrombosis, the protection myocardial ischemia, and effects such as blood pressure lowering are used for coronary insufficiency, the hypertension that cardiac insufficiency causes, coronary heart disease.But traditional XINKESHU JIAONANG disintegrate is slower, absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nanometer heart of the increase evident in efficacy preparation medicine that can relax.
The preparation method that another object of the present invention provides this nanometer heart can relax preparation medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer Fructus Crataegi 220-520 part nano red sage 220-520 part nanometer Radix Puerariae 220-520 part
Nanometer Radix Notoginseng 10-40 part nanometer Radix Aucklandiae 10-40 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer Fructus Crataegi 300-450 part nano red sage 300-450 part nanometer Radix Puerariae 300-450 part
Nanometer Radix Notoginseng 20-30 part nanometer Radix Aucklandiae 20-30 part
The optimum weight proportioning of medicine of the present invention is:
375 parts of 375 parts of nanometer Radix Puerariaes of 375 parts of nano red sages of nanometer Fructus Crataegi
25 parts of 25 parts of nanometer Radix Aucklandiae of nanometer Radix Notoginseng
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since special construction-----material grains size of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15%-50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, add to concoct according to Chinese Pharmacopoeia one one of version in 2000 and be processed into the common Chinese decoction pieces
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity in the 30-60 temperature, under 0 to 0.05MPa the pressure, with the instantaneous drying of hypersonic velocity, are promptly made the nanometer prepared slices of Chinese crude drugs.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to 0.05MPa the pressure, with the instantaneous drying of hypersonic velocity jet, the heart preparation nano powder that can relax;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
It is identical that above-mentioned two kinds of methods are made can the relax pharmacological effect of preparation medicine of the nanometer heart.
A kind of important feature of the present invention is: invent made drug material and reached nanoscale, common XINKESHU JIAONANG preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1-200nm, the overwhelming majority can be crossed the 1200-1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the nanometer heart new drug formulation that the powder, tablet, suppository, granule, membrane, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution etc. of preparation medicine has no precedent in the past that can relax.
Pharmaceutical preparation of the present invention can be used for treatment of conditions such as coronary heart disease, angina pectoris, and clinical efficacy is remarkable.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
375 parts of 375 parts of nanometer Radix Puerariaes of 375 parts of nano red sages of nanometer Fructus Crataegi
25 parts of 25 parts of nanometer Radix Aucklandiae of nanometer Radix Notoginseng
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1-0.6 gram, and the patient takes the 1-5 grain at every turn, and is every with 1-4 time.
Embodiment 2:
Prepare nano raw material by preceding method:
375 parts of 375 parts of nanometer Radix Puerariaes of 375 parts of nano red sages of nanometer Fructus Crataegi
25 parts of 25 parts of nanometer Radix Aucklandiae of nanometer Radix Notoginseng
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, make the nanometer heart powder needle injection that can relax, every injection content 5-20 milligram, each consumption is that 1-2 props up, use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
375 parts of 375 parts of nanometer Radix Puerariaes of 375 parts of nano red sages of nanometer Fructus Crataegi
25 parts of 25 parts of nanometer Radix Aucklandiae of nanometer Radix Notoginseng
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, filmogen adopts polyvinyl alcohol, make the nanometer heart membrane that can relax, every membrane area size 2-100 square centimeter, content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: back, chest.
Claims (6)
1, a kind of nanometer heart preparation medicine that can relax is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nanometer Fructus Crataegi 220-520 part nano red sage 220-520 part nanometer Radix Puerariae 220-520 part
Nanometer Radix Notoginseng 10-40 part nanometer Radix Aucklandiae 10-40 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to 0.05MPa the pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, the nanometer heart according to claim 1 preparation medicine that can relax, wherein the weight proportion of each nano raw material is:
Nanometer Fructus Crataegi 300-450 part nano red sage 300-450 part nanometer Radix Puerariae 300-450 part
Nanometer Radix Notoginseng 20-30 part nanometer Radix Aucklandiae 20-30 part
3, the nanometer heart according to claim 1 preparation medicine that can relax, wherein the weight proportion of each nano raw material is:
375 parts of 375 parts of nanometer Radix Puerariaes of 375 parts of nano red sages of nanometer Fructus Crataegi
25 parts of 25 parts of nanometer Radix Aucklandiae of nanometer Radix Notoginseng
4, according to claim 1 or the 2 or 3 described nanometer hearts preparation medicine that can relax, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
5, according to can the relax pharmaceutical methods of preparation medicine of claim 1 or the 2 or 3 described nanometer hearts, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to 0.05MPa the pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100351 CN1362193A (en) | 2001-01-02 | 2001-01-02 | Namo xinkeshu medicine and its preparation |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100351 CN1362193A (en) | 2001-01-02 | 2001-01-02 | Namo xinkeshu medicine and its preparation |
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| CN1362193A true CN1362193A (en) | 2002-08-07 |
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| CN 01100351 Pending CN1362193A (en) | 2001-01-02 | 2001-01-02 | Namo xinkeshu medicine and its preparation |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100339096C (en) * | 2006-05-19 | 2007-09-26 | 山东沃华医药科技股份有限公司 | Preparation of 'Xin Ke Shu' tablet for treating coronary heart disease |
| CN103720810A (en) * | 2012-10-16 | 2014-04-16 | 吉林吉春制药股份有限公司 | Medicine for treating qi-stagnation and blood stasis coronary heart disease and complication of disease and preparation method of medicine |
-
2001
- 2001-01-02 CN CN 01100351 patent/CN1362193A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100339096C (en) * | 2006-05-19 | 2007-09-26 | 山东沃华医药科技股份有限公司 | Preparation of 'Xin Ke Shu' tablet for treating coronary heart disease |
| CN103720810A (en) * | 2012-10-16 | 2014-04-16 | 吉林吉春制药股份有限公司 | Medicine for treating qi-stagnation and blood stasis coronary heart disease and complication of disease and preparation method of medicine |
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