CN1362163A - Nano Jieshitong medicine for eliminating stone and its preparation - Google Patents
Nano Jieshitong medicine for eliminating stone and its preparation Download PDFInfo
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- CN1362163A CN1362163A CN 01100318 CN01100318A CN1362163A CN 1362163 A CN1362163 A CN 1362163A CN 01100318 CN01100318 CN 01100318 CN 01100318 A CN01100318 A CN 01100318A CN 1362163 A CN1362163 A CN 1362163A
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Abstract
The present invention discloses a nano Jieshitong preparation medicine. It is made up by using 8 Chinese medicinal materials of nano desmodium, nano corn silk, nano pyrrosia, nano prayer-beads, nano poria and others as raw material through the processes of microwave extraction, reduced pressure concentration and supersonic jet spray drying. Its grain fineness is up to 1200-1500 meshes, grain size is 0.1-200 nm, in which most of grain size is less than 100 nm. Said medicine is high in biological utilization rate and obvious in therapeutic effect.
Description
The present invention relates to a kind of clearing away heat-damp and promoting diuresis, Tonglin Paishi, pain easing and hemostasis, cure mainly the logical preparation medicine of nanometer calculus of urinary system infection, cystitis, oedema due to nephritis, lithangiuria, hematuria, pouring drop muddiness, urethra causalgia, the invention still further relates to the method for this medication preparation.
JIESHITONG PIAN is a kind of classical Chinese patent medicine, mainly contains effects such as clearing away heat-damp and promoting diuresis, Tonglin Paishi, pain easing and hemostasis, is used for urinary system infection, cystitis, oedema due to nephritis, lithangiuria, hematuria, pouring drop muddiness, urethra causalgia.But traditional JIESHITONG PIAN disintegrate is slower, absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully, and the nanometer calculus of increase evident in efficacy is led to preparation medicine.
Another object of the present invention provides the preparation method of the logical preparation medicine of this nanometer calculus.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer Herba Desmodii Styracifolii 5-70 part nanometer Stigma Maydis 5-70 part nanometer Folium Pyrrosiae 5-70 part
Nanometer Herba Abri 5-70 part nano Poria 5-50 part nanometer Herba Plantaginis 5-70 part
Nanometer Herba lygodii 5-70 part nanometer Rhizoma Imperatae 5-70 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer Herba Desmodii Styracifolii 10-50 part nanometer Stigma Maydis 10-50 part nanometer Folium Pyrrosiae 10-40 part
Nanometer Herba Abri 10-50 part nano Poria 10-30 part nanometer Herba Plantaginis 10-40 part
Nanometer Herba lygodii 10-40 part nanometer Rhizoma Imperatae 10-50 part
The optimum weight proportioning of medicine of the present invention is:
20 parts of 25 parts of nanometer Folium Pyrrosiaes of 30 parts of nanometer Stigma Maydis of nanometer Herba Desmodii Styracifolii
20 parts of 15 parts of nanometer Herba Plantaginiss of 30 parts of nano Porias of nanometer Herba Abri
30 parts of 20 parts of nanometer Rhizoma Imperataes of nanometer Herba lygodii
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material is because the special construction of nano material---the particle size of material is less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15%-50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, add to concoct according to Chinese Pharmacopoeia one one of version in 2000 and be processed into the common Chinese decoction pieces
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get the logical preparation nano powder of calculus with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made the logical preparation medicine of nanometer calculus is identical.
A kind of important feature of the present invention is, the made drug material of the present invention has reached nanoscale, common JIESHITONG PIAN preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1-200nm, and the overwhelming majority can be crossed the 1200-1500 mesh sieve less than 100nm.
Another important feature of the present invention is, solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that the pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution of the logical preparation medicine of nanometer calculus etc. had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for treatment of conditions such as urinary system infection, lithangiuria, and clinical efficacy significantly is better than traditional JIESHITONG PIAN.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
20 parts of 25 parts of nanometer Folium Pyrrosiaes of 30 parts of nanometer Stigma Maydis of nanometer Herba Desmodii Styracifolii
20 parts of 15 parts of nanometer Herba Plantaginiss of 30 parts of nano Porias of nanometer Herba Abri
30 parts of 20 parts of nanometer Rhizoma Imperataes of nanometer Herba lygodii
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulatedly, make capsule with the fully-automatic capsule racking machine, every capsules content of dispersion is the 0.1-0.6 gram, and the patient takes 1-4 time at every turn.
Embodiment 2:
Prepare nano raw material by preceding method:
20 parts of 25 parts of nanometer Folium Pyrrosiaes of 30 parts of nanometer Stigma Maydis of nanometer Herba Desmodii Styracifolii
20 parts of 15 parts of nanometer Herba Plantaginiss of 30 parts of nano Porias of nanometer Herba Abri
30 parts of 20 parts of nanometer Rhizoma Imperataes of nanometer Herba lygodii
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent powder needle injection standard, do not add any adjuvant, make the logical powder needle injection of nanometer calculus, every injection content is the 5-20 milligram, and each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
20 parts of 25 parts of nanometer Folium Pyrrosiaes of 30 parts of nanometer Stigma Maydis of nanometer Herba Desmodii Styracifolii
20 parts of 15 parts of nanometer Herba Plantaginiss of 30 parts of nano Porias of nanometer Herba Abri
30 parts of 20 parts of nanometer Rhizoma Imperataes of nanometer Herba lygodii
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent membrane standard, filmogen adopts polyvinyl alcohol, make nanometer JIESHITONG PIAN membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: abdominal part, waist.
Claims (6)
1, the logical preparation medicine of a kind of nanometer calculus is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nanometer Herba Desmodii Styracifolii 5-70 part nanometer Stigma Maydis 5-70 part nanometer Folium Pyrrosiae 5-70 part
Nanometer Herba Abri 5-70 part nano Poria 5-50 part nanometer Herba Plantaginis 5-70 part
Nanometer Herba lygodii 5-70 part nanometer Rhizoma Imperatae 5-70 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, the logical preparation medicine of nanometer calculus according to claim 1, wherein the weight proportion of each nano raw material is:
Nanometer Herba Desmodii Styracifolii 10-50 part nanometer Stigma Maydis 10-50 part nanometer Folium Pyrrosiae 10-40 part
Nanometer Herba Abri 10-50 part nano Poria 10-30 part nanometer Herba Plantaginis 10-40 part
Nanometer Herba lygodii 10-40 part nanometer Rhizoma Imperatae 10-50 part
3, the logical preparation medicine of nanometer calculus according to claim 1, wherein the weight proportion of each nano raw material is:
20 parts of 25 parts of nanometer Folium Pyrrosiaes of 30 parts of nanometer Stigma Maydis of nanometer Herba Desmodii Styracifolii
20 parts of 15 parts of nanometer Herba Plantaginiss of 30 parts of nano Porias of nanometer Herba Abri
30 parts of 20 parts of nanometer Rhizoma Imperataes of nanometer Herba lygodii
4, according to claim 1 or the logical preparation medicine of 2 or 3 described nanometer calculus, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or the logical preparation medicine of 2 or 3 described nanometer calculus; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100318 CN1362163A (en) | 2001-01-02 | 2001-01-02 | Nano Jieshitong medicine for eliminating stone and its preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100318 CN1362163A (en) | 2001-01-02 | 2001-01-02 | Nano Jieshitong medicine for eliminating stone and its preparation |
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| CN1362163A true CN1362163A (en) | 2002-08-07 |
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| CN 01100318 Pending CN1362163A (en) | 2001-01-02 | 2001-01-02 | Nano Jieshitong medicine for eliminating stone and its preparation |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102266501A (en) * | 2011-07-25 | 2011-12-07 | 王疆宏 | Jieshitong tea composition and preparation method thereof |
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2001
- 2001-01-02 CN CN 01100318 patent/CN1362163A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102266501A (en) * | 2011-07-25 | 2011-12-07 | 王疆宏 | Jieshitong tea composition and preparation method thereof |
| CN102266501B (en) * | 2011-07-25 | 2012-12-05 | 王疆宏 | Jieshitong tea composition and preparation method thereof |
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