CN1362105A - Nano Angelicae longhui meidcine and its preparation - Google Patents
Nano Angelicae longhui meidcine and its preparation Download PDFInfo
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- CN1362105A CN1362105A CN 01100154 CN01100154A CN1362105A CN 1362105 A CN1362105 A CN 1362105A CN 01100154 CN01100154 CN 01100154 CN 01100154 A CN01100154 A CN 01100154A CN 1362105 A CN1362105 A CN 1362105A
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Abstract
The present invention discloses a nano Donggui-Longhui preparation medicine. It is made up by using 10 Chinese medicinal materials of nano Radix Angelicae Sinensts, nano gentian, nano gardenia, nano coptis, nano phellodendron and others as raw material through the processes of microwave extraction, reduced pressure concentration and supersonic jet spray drying. Its grain fineness is up to 1200-1500 meshes, grain size is 0.1-200 nm, in which most of grain size is less than 100 nm. Said medicine is high in biological utilization rate and obvious in therapeutic effect.
Description
The present invention relates to a kind of purging liver and gallbladder excess-fire, cure mainly and have a dizzy spell due to the liver and gall excess-fire, mind is not peaceful, and delirium is gone mad, or constipation, and the nano Chinese angelica dragon luxuriant growth preparation medicine of hot urination the invention still further relates to the method for this medication preparation.
Danggui longhui pills, danggui longhui wan is a kind of classical Chinese patent medicine, mainly contains antitumor, anthelmintic, and calm antibiotic, effects such as diarrhea inducing are used for having a dizzy spell due to the liver and gall excess-fire, and mind is not peaceful, and delirium is gone mad, or constipation, hot urination.But traditional danggui longhui pills, danggui longhui wan disintegrate is slower, absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano Chinese angelica of increase evident in efficacy dragon luxuriant growth preparation medicine.
Another object of the present invention provides the preparation method of this nano Chinese angelica dragon luxuriant growth preparation medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
3 parts of 3 parts of nanometer Fructus Gardeniaes of 3 parts of nanometer Radix Gentianaes of nano Chinese angelica
3 parts of 3 parts of nanometer Radix Scutellariaes of 3 parts of nano phellodendron barks of nanometer coptis
Nano rhubarb 3-10 part nano aloe 3-10 part nanometer Radix Aucklandiae 1-5 part
Nano musk 3-10 part
The formula optimization weight proportion scope of medicine of the present invention is:
2 parts of 2 parts of nanometer Fructus Gardeniaes of 2 parts of nanometer Radix Gentianaes of nano Chinese angelica
2 parts of 2 parts of nanometer Radix Scutellariaes of 2 parts of nano phellodendron barks of nanometer coptis
Nano rhubarb 3-7 part nano aloe 3-7 part nanometer Radix Aucklandiae 1-3 part
Nano musk 3-7 part
The optimum weight proportioning of medicine of the present invention is:
1 part of 1 part of nanometer Fructus Gardeniae of 1 part of nanometer Radix Gentianae of nano Chinese angelica
1 part of 1 part of nanometer Radix Scutellariae of 1 part of nano phellodendron bark of nanometer coptis
1.5 parts of 5 parts of nanometer Radix Aucklandiae of 5 parts of nano aloes of nano rhubarb
5 parts of nano musks
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since special construction----the material grains size of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15--50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, be processed into the common Chinese decoction pieces according to process of preparing Chinese medicine of Chinese Pharmacopoeia version in 2000.
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃--and 60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get angelica-Longhui preparation nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nano Chinese angelica dragon luxuriant growth preparation medicine is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common danggui longhui pills, danggui longhui wan preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1--200nm, the overwhelming majority can be crossed the 1200--1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that the powder, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine of nano Chinese angelica dragon luxuriant growth preparation medicine etc. is had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for treatment of conditions such as chronic myelocytic leukemia, biliary tract ascarid, mad disease, cholecystitis, constipation, and clinical efficacy significantly is better than traditional danggui longhui pills, danggui longhui wan.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
1 part of 1 part of nanometer Fructus Gardeniae of 1 part of nanometer Radix Gentianae of nano Chinese angelica
1 part of 1 part of nanometer Radix Scutellariae of 1 part of nano phellodendron bark of nanometer coptis
1.5 parts of 5 parts of nanometer Radix Aucklandiae of 5 parts of nano aloes of nano rhubarb
5 parts of nano musks
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1--0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
1 part of 1 part of nanometer Fructus Gardeniae of 1 part of nanometer Radix Gentianae of nano Chinese angelica
1 part of 1 part of nanometer Radix Scutellariae of 1 part of nano phellodendron bark of nanometer coptis
1.5 parts of 5 parts of nanometer Radix Aucklandiae of 5 parts of nano aloes of nano rhubarb
5 parts of nano musks
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or the described mixed of powder good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard, do not add any adjuvant, make nano Chinese angelica dragon luxuriant growth powder needle injection, every injection content is the 5-20 milligram, each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Be equipped with nano raw material by preceding method:
1 part of 1 part of nanometer Fructus Gardeniae of 1 part of nanometer Radix Gentianae of nano Chinese angelica
1 part of 1 part of nanometer Radix Scutellariae of 1 part of nano phellodendron bark of nanometer coptis
1.5 parts of 5 parts of nanometer Radix Aucklandiae of 5 parts of nano aloes of nano rhubarb
5 parts of nano musks
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make nano Chinese angelica dragon luxuriant growth membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: abdominal part, back, chest.
Claims (6)
1, a kind of nano Chinese angelica dragon luxuriant growth preparation medicine is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
3 parts of 3 parts of nanometer Fructus Gardeniaes of 3 parts of nanometer Radix Gentianaes of nano Chinese angelica
3 parts of 3 parts of nanometer Radix Scutellariaes of 3 parts of nano phellodendron barks of nanometer coptis
Nano rhubarb 3-10 part nano aloe 3-10 part nanometer Radix Aucklandiae 1-5 part
Nano musk 3-10 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nano Chinese angelica dragon luxuriant growth preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
2 parts of 2 parts of nanometer Fructus Gardeniaes of 2 parts of nanometer Radix Gentianaes of nano Chinese angelica
2 parts of 2 parts of nanometer Radix Scutellariaes of 2 parts of nano phellodendron barks of nanometer coptis
Nano rhubarb 3-7 part nano aloe 3-7 part nanometer Radix Aucklandiae 1-3 part
Nano musk 3-7 part
3, nano Chinese angelica dragon luxuriant growth preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
1 part of 1 part of nanometer Fructus Gardeniae of 1 part of nanometer Radix Gentianae of nano Chinese angelica
1 part of 1 part of nanometer Radix Scutellariae of 1 part of nano phellodendron bark of nanometer coptis
1.5 parts of 5 parts of nanometer Radix Aucklandiae of 5 parts of nano aloes of nano rhubarb
5 parts of nano musks
4, according to claim 1 or 2 or 3 described nano Chinese angelica dragon luxuriant growth preparation medicines, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
5, according to the pharmaceutical methods of claim 1 or 2 or 3 described nano Chinese angelica dragon luxuriant growth preparation medicines, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
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| CN 01100154 CN1362105A (en) | 2001-01-04 | 2001-01-04 | Nano Angelicae longhui meidcine and its preparation |
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| CN 01100154 CN1362105A (en) | 2001-01-04 | 2001-01-04 | Nano Angelicae longhui meidcine and its preparation |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101455769B (en) * | 2007-12-14 | 2011-06-29 | 鞍山钢铁集团公司 | Chinese medicine for treating constipation |
| CN102614356A (en) * | 2012-04-20 | 2012-08-01 | 吕宝俊 | Chinese angelica, Chinese gentian and aloe membrane coat tablet and preparation method thereof |
| CN102657786A (en) * | 2012-03-22 | 2012-09-12 | 翟爱玲 | Drinking potion for treating mania |
| CN102961534A (en) * | 2012-12-22 | 2013-03-13 | 陈洪振 | Traditional Chinese medicine composition for treating schizophrenia in stage of attack and preparation method thereof |
| CN103536749A (en) * | 2012-07-08 | 2014-01-29 | 霍继仁 | Medicament for treating cholecystitis |
| EP2661274A4 (en) * | 2011-01-06 | 2014-08-20 | North Texas Medical Ass | Compositions and methods of aloe polysaccharides |
| US9649326B2 (en) | 2010-01-14 | 2017-05-16 | Bespoke Bioscience, Llc | Compositions and methods of aloe polysaccharides |
-
2001
- 2001-01-04 CN CN 01100154 patent/CN1362105A/en active Pending
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101455769B (en) * | 2007-12-14 | 2011-06-29 | 鞍山钢铁集团公司 | Chinese medicine for treating constipation |
| US9649326B2 (en) | 2010-01-14 | 2017-05-16 | Bespoke Bioscience, Llc | Compositions and methods of aloe polysaccharides |
| US10314858B2 (en) | 2010-01-14 | 2019-06-11 | Bespoke Bioscience, Llc | Compositions and methods of Aloe polysaccharides |
| US10918659B2 (en) | 2010-01-14 | 2021-02-16 | Bespoke Bioscience, Llc | Compositions and methods of aloe polysaccharides |
| EP2661274A4 (en) * | 2011-01-06 | 2014-08-20 | North Texas Medical Ass | Compositions and methods of aloe polysaccharides |
| CN102657786A (en) * | 2012-03-22 | 2012-09-12 | 翟爱玲 | Drinking potion for treating mania |
| CN102614356A (en) * | 2012-04-20 | 2012-08-01 | 吕宝俊 | Chinese angelica, Chinese gentian and aloe membrane coat tablet and preparation method thereof |
| CN103536749A (en) * | 2012-07-08 | 2014-01-29 | 霍继仁 | Medicament for treating cholecystitis |
| CN102961534A (en) * | 2012-12-22 | 2013-03-13 | 陈洪振 | Traditional Chinese medicine composition for treating schizophrenia in stage of attack and preparation method thereof |
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