CN1358526A - 一种治疗骨质疏松症的中药 - Google Patents
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Abstract
一种治疗骨质疏松症的药物,它是由淫羊藿、珍珠层粉两味药组成,其重量比为淫羊藿∶珍珠层粉=1∶0.01－0.10。该中药可用于各种不同原因引起的骨质疏松症,能显著增加骨密度。具有药源来源广泛、药物成本低廉、服用方便等优点。
Description
本发明涉及一种治疗骨质疏松症的药物组合物，具体的说是一种治疗骨质疏松症的中药。
骨质疏松症是以骨量减少，骨的微观结构退化为特征的，致使骨的脆性增加，是一种常见的老年代谢性疾病。随着人口的老龄化，骨质疏松症以及引起的骨折发生率迅速增加，已经成为威胁老年人健康的重大疾病之一。其发病率随年龄的增加，男性约为20％，而绝经期妇女可高大50％以上。(李恩，蔡辉.骨质疏松症发病的整体观与中西医治疗的辨证观。中国全科医学2001(4)2：91-93)目前，对该病的治疗西医主要以雌激素、钙剂、降钙素、双磷酸盐及氟制剂等，由于这些药物存在价格昂贵，长期使用药疗不满意，副作用较大等原因。(CN1038813C)因此，人们越来越重视中医药在治疗骨质疏松症方面的研究。
本发明的目的是在于克服上述西药现有技术不足，提供一种以中医理论为基础的中药，此药物有治疗骨质疏松症，增加骨密度等作用。
本发明的解决方案是基于祖国的中医理论。中医认为，原发性骨质疏松症的主要原因是肾虚。《素问·五藏生成篇》中说：“肾之合骨也，其荣发”。“肾主骨，藏精，精生髓营骨”，“肝主筋”。钙的缺乏对骨质疏松是“标”不是“本”，治疗应当重在治“源”，而兼顾其“流”。此方淫羊藿，补肝肾，坚筋骨，重在“源本”的调节。淫羊藿主要有效成分为淫羊藿苷，有明显抑制破骨细胞活性，同时又能促进成骨细胞的功能，使钙化骨形成增加。肝肾同源，肾虚日久致肝阴不足，肝阳上亢。珍珠层粉平肝潜阳，清肝明目。同时珍珠层粉含大量生物活性钙，易于吸收，故可治其“标”以补其“流”。二药配伍共凑“源流”皆补，标本皆治之功。
本发明药物是由淫羊藿与珍珠层粉两味药组成，其重量比为：
淫羊藿∶珍珠层粉＝1∶0.01 0.10
以上两味中，淫羊藿为小檗科植物淫羊藿Epimedium brevicornum Maxin.、箭叶淫羊藿Epimedium sagittatum(sieb.et Zucc.)Maxim.、柔毛淫羊藿Epimediumpubescens Maxim.、巫山淫羊藿Epimedium wushanense T.S.Ying、或朝鲜淫羊藿Epimedium koreanum Nakai的干燥地上部分。珍珠为珍珠贝科动物马氏珍珠贝Pteria martensii(Dunker)、蚌科动物三角帆蚌Hyriopsis cumingii(Lea)或褶纹冠蚌Cristaria plicata(leach)等双壳类动物受刺激形成的珍珠。
将上述两组分制成本发明药物的生产方法是：
1、将淫羊藿药材粉碎成粗粉后，加水煎煮二次(每次1.5小时)，收集药液过滤去渣，浓缩，然后用乙醇调节至含醇量为60％进行醇沉，静置，取上清液过滤，回收乙醇并浓缩至比重1.10(70℃测定)，将此浸膏液喷雾干燥，得干浸膏粉。
2、珍珠层粉为珍珠壳内层部分加工而成的粉末，采自四川省珍珠制药厂。
3、将珍珠层粉、淫羊藿浸膏粉按上述比例配好后，混合均匀，填充胶囊，即得。
本发明与上述西药相比具有下述优点：
1、药源来源广泛，药物成本低廉。例如：进口降钙素连用三月，其费用可高达2000元，而本发明药物连用三月，其费用为270元左右。
2、治疗范围广。本中药可用于各种不同原因引起的骨质疏松症，还可治疗妇女更年期综合症。
3、服用方便。本发明剂型为胶囊剂，用量与用法为1日2次，早晚各1粒。
4、各种毒、副作用小。例如长期使用双磷酸盐制剂可引起下肢疼痛综合症；降钙素注射后，病人有潮热感，雌激素的长期使用可能导致女性子宫癌、乳腺癌发病率的升高。而本药则无这些毒、副作用，动物实验也证实了这一点。
5、疗效可靠。使用本中药治疗了部分骨质疏松病人，90％的病人治疗后腰疼痛症状明显好转，骨密度显著增加。
6、制备工艺简单，易操作。本工艺中淫羊藿提取浸膏粉，然后与珍珠层粉混匀，装胶囊，即得。工艺简单，易操作。
实施例1
按下述配比称取淫羊藿与珍珠层粉
淫羊藿∶珍珠层粉＝1∶0.025生产方法如下：
1、将淫羊藿药材粉碎成粗粉后，加水煎煮二次(每次1.5小时)，收集药液过滤去渣，浓缩，然后用乙醇调节至含醇量为60％进行醇沉，静置，取上清液过滤，回收乙醇并浓缩至比重1.10(70℃测定)，将此浸膏液喷雾干燥，得干浸膏粉。
2、珍珠层粉为珍珠壳内层部分加工而成的粉末，采自四川省珍珠制药厂。
3、将珍珠层粉、淫羊藿浸膏粉按上述比例配好后，混合均匀，填充胶囊，即得.
实施例2按下述配比称取淫羊藿与珍珠层粉淫羊藿∶珍珠层粉＝1∶0.055生产方法同实施例1
实施例3按下述配比称取淫羊藿与珍珠层粉淫羊藿∶珍珠层粉＝1∶0.09生产方法同实施例1
Claims (1)
1、一种治疗骨质疏松症的药物，其特征在于：由淫羊藿、珍珠层粉两味药组成，其重量比为：
淫羊藿∶珍珠层粉＝1∶0.01-0.10
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101380359B (zh) * | 2008-10-20 | 2011-01-12 | 浙江省中医药研究院 | 健骨胶囊及其制备方法 |
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| CN101380359B (zh) * | 2008-10-20 | 2011-01-12 | 浙江省中医药研究院 | 健骨胶囊及其制备方法 |
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Effective date of registration: 20080912 Address after: No 36, Shu West Road, Chengdu, Sichuan, Jinniu District Patentee after: Chengdu Kanghong Pharmaceuticals Group Co., Ltd. Address before: No 36, Shu West Road, Chengdu, Sichuan, Jinniu District Patentee before: Chengdu Kanghong Sci-Tech Industry (Group) Co., Ltd. |
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| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20210225 Address after: 611930 No.89 Hualong Road, Tianpeng Town, Pengzhou City, Chengdu City, Sichuan Province Patentee after: Sichuan Jishengtang Pharmaceutical Co.,Ltd. Address before: 610036 No. 36 Shu West Road, Chengdu, Sichuan, Jinniu District Patentee before: CHENGDU KANGHONG PHARMACEUTICAL GROUP Co.,Ltd. |
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| CX01 | Expiry of patent term | ||
| CX01 | Expiry of patent term |
Granted publication date: 20040929 |