CN1326746A

CN1326746A - Montmorilonite as component of animal medicine and fodder additive

Info

Publication number: CN1326746A
Application number: CN00109391A
Authority: CN
Inventors: 翟永功
Original assignee: Wang Yingdian; Zuo Mingxue
Current assignee: Wang Yingdian; Zuo Mingxue
Priority date: 2000-06-01
Filing date: 2000-06-01
Publication date: 2001-12-19

Abstract

The present invention relates to the application of montmorillonite as the component of the animal remedy for preventing and treating diarrhea and other gastrointestinal trace diseases. The animal remedy include Chinese animal remedy, animal remedy supplementary material, carrier, and controlled releasing agent. Montmorillonite is a kind of silicate mineral comprising regularly stacked structural units of two tetrahedron layers and one sandwiched octahedron layer.

Description

Montmorillonitum is as veterinary drug and feed additive composition

The present invention relates to the composition of a kind of mineral Montmorillonitum, be used for the treatment of and prevent acute and chronic diarrhoeal diseases and other gastroenteropathy as veterinary drug, veterinary drug preparation, veterinary drug adjuvant, animal feed additive; As pharmaceutical carrier, feed adhesive and controlled release fertilizer agent.With the composition of Montmorillonitum, be pharmacy allusion quotation collection, Compendium of Material Medica, " all not on the books in Chinese pharmacopoeia, " the veterinary drug pharmacopeia " since ancient times as veterinary drug, veterinary drug preparation, veterinary drug adjuvant, animal feed additive.This patent relates to the pharmaceutical characteristic of Montmorillonitum to animal diarrhoeal diseases and other gastrointestinal mucosa disease, is to determine by the textual criticism of mineral drug kind, mineral drug component analysis and mineral drug evaluation, animal pharmacology and clinical test results.

Prior art: at the animal intestines and stomach tract disease, the especially prevention of diarrhoeal diseases and treatment mainly is to use antibiotic at present.The clinical antibiotic utilization rate of animal almost is 100% at present.Since nineteen twenty-nine Fleming finds penicillin, constantly there is new antibiotic to come out, kind of antibiotic surplus oneself finds 4000 at present is used for clinical not down over one hundred kind.Antibiotic application is controlled most of bacteroidal diseases.Except that clinical practice, also have many antibiotic to be used to feed additive.Because long-term a large amount of use antibiotic, even abuse of antibiotics, thereby produce many side effect.At first, poultry life-time service antibiotic can make pathogen sport Resistant strain, develops immunity to drugs, and simultaneously, also can cause humans and animals body normal flora imbalance, and the formation of the organism immune response of drawing up, the serious superinfection that causes, even cause death.Its this, antibiotic is residual in animal body, remains in meat.Antibiotic in the food such as milk, egg can not make its deactivation fully through heat treated, and the people takes in the food that this class contains residual antibiotic for a long time, can cause chronic poisoning, and human body is produced harm.

In view of this, the European Community only uses penicillin, tetracycline, oxytetracycline, chlortetracycline from the mid-1970s is just alert, and oleandomycin, erythromycin, neomycin etc. are as animal feed additive; Japan successively bans use of that penicillin, streptomycin, monensin, Salinomycin, oxytetracycline, the thunder mycin of pounding, gram cypress are mould, kanamycin, examine letter mycin, lasalocid etc. as feed additive; The former Soviet Union bans use of tetracycline, streptomycin, penicillin, neomycin, and other antibiotic that is used for the treatment of purpose on medical science and the veterinary is as feed additive.In the U.S., because the past is not tight to the use restriction of feeding antibiotic, particularly not tight to medical antibiotic restriction, nearly making, 25% Salmonella develops immunity to drugs to multiple antibiotic, therefore, have to take to forbid or limit the use of some antibiotic in recent years as feed additive.

Purpose: along with Chinese economic development and accession to the WTO (WTO), the livestock products market of China also will walk with world's pace, and the use of antibiotic in herding is produced also will be restricted.Therefore, natural new veterinary drug, veterinary drug preparation and the feed additive that develop noresidue, has no side effect just becomes the focus of this area research.This is not only the demand that animal produces, and the more important thing is the requirement of human health.

Technical scheme: Montmorillonitum is a kind of natural minerals; with it is veterinary drug, veterinary drug preparation and the feed additive of main component development; the toxin that has the virus in the digestive tract, pathogenic bacteria and generation thereof has the extremely strong effect of fixing, draw up; gastrointestinal mucosal there is very strong barrier protection function; its unique chemical constituent that contains can interact with the mucous glycoprotein in the intestinal mucosa cell, strengthens the barrier protection function of intestinal mucosa.Simultaneously, Montmorillonitum can play the enhancing drug effect and reduce medicine to gastrointestinal tract mucous stimulation as the controlled release fertilizer agent of other gastrointestinal drug and other feed additive.

Technological merit: with the Montmorillonitum is veterinary drug, veterinary drug preparation and the feed additive of main component, does not enter blood circulation in the treatment of diarrhoeal diseases and other gastroenteropathy, has no side effect, drug residue free; Montmorillonitum can reduce the zest medicine to the gastrointestinal side effect.Therefore, Montmorillonitum is a kind of brand-new green veterinary drug and feed additive.

Technology path: select natural montmorillonite mineral raw material,, can obtain the Montmorillonitum of medicinal standard by certain process for separating and purifying.For some particular components of purification, used chemical drugs and reagent also all are very common common drugs.The discrimination method of Montmorillonitum also is that sensation, fracture, hardness, proportion of character, appearance color, gloss, hands tongue according to mineral etc. done general discriminating, and then application modern analysis means, its chemical composition and structure are analyzed, measured its distinctive physical and chemical performance simultaneously.

Description of drawings: the crystal structure sketch map of the X of main chemical composition Fig. 1 Montmorillonitum of table 1 Montmorillonitum-x ray diffration pattern x Fig. 2 Montmorillonitum

Claims

1, a kind of mineral Montmorillonitum is used to prepare veterinary drug, veterinary drug preparation, veterinary drug adjuvant, animal feed additive, it is characterized in that:

(1) a kind of layered clay mineral has the dioctahedron architectural feature;

(2) the dioctahedron layer thickness has certain variation;

(3) basic chemical composition is an aluminosilicate;

(4) outward appearance is earthy, the tool soapy feeling;

(5) have intensive water absorption and dilatancy;

(6) toxin to antibacterial, virus and generation thereof has fixing, the effect of adsorbing, draw up, and mucosa is had the barrier protection effect;

2, the mineral Montmorillonitum of putting down in writing according to claim 1, its English name: montmorillonite, another name: montmorillonitic clay, Montmorillonitum family, it is characterized in that said dioctahedron is formed structural units's layer by two tetrahedral layers and an octahedral layer that is clipped in the middle in (1), repeat to stack into crystal regularly from level to level by this Institutional Layer again, form the dioctahedron structure;

3, according to claim 1,2 mineral of being put down in writing, it is characterized in that said dioctahedron structure sheaf has certain thickness in (2), layer thickness can change basal spacing d because of the content of intermediary water, the kind difference of interlayer ion ₀₀₁=1.200～1.800nm;

4,, it is characterized in that said basic chemical composition is an aluminosilicate in (3), its main chemical compositions: SiO according to claim 1,2,3 mineral of being put down in writing ₂40.0～80.0%, AL ₂O ₃12.0～25.0%, Fe ₂O ₃1.00-5.00% in addition, often contains multiple elements such as P, K, Na, Ca, Mg, Al, Fe, Mn, Cu, Zn, Li, Ti, V, Cr;

5, according to claim 1,2,3,4 mineral of being put down in writing, it is characterized in that said Montmorillonitum outward appearance often is earthy in (4), sometimes be tiny scale aggregate, be white in color, but, often be light gray, tone such as greyish white, pink, light green because of often containing multiple elements such as P, K, Na, Ca, Mg, Al, Fe, Mn, Cu, Zn, Li, Ti, V, Cr; Tarnish when dry, very soft, the tool soapy feeling; Have intensive water absorption and dilatancy; Be suspended state and gelatinized in the aqueous solution or become pastel;

6,, it is characterized in that in (6) said Montmorillonitum harmful pathogenic bacteria of in gastrointestinal tract, fixing and draw up according to claim 1,2,3,4,5 mineral of being put down in writing; Repair and the protection mucosa, have the effect of prevention and treatment diarrhoeal diseases and other gastroenteropathy; Simultaneously, can be used as veterinary drug adjuvant, feed additive, comprise carrier, binding agent and controlled release fertilizer agent.