CN1319548C - Chinese medicine health tonic for raising antisenility capacity and improving memory - Google Patents
Chinese medicine health tonic for raising antisenility capacity and improving memory Download PDFInfo
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- CN1319548C CN1319548C CNB2003101080363A CN200310108036A CN1319548C CN 1319548 C CN1319548 C CN 1319548C CN B2003101080363 A CNB2003101080363 A CN B2003101080363A CN 200310108036 A CN200310108036 A CN 200310108036A CN 1319548 C CN1319548 C CN 1319548C
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Abstract
The present invention provides a traditional Chinese medicine for enhancing the anti-aging capability of organisms and improving memory, which belongs to the technical field of traditional Chinese medicine health care products. The health care product of the present invention is prepared from the main components: ginseng extract, glossy privet fruit extract, ginkgo biloba extract, soybean phospholipid and supplementary materials. The product of the present invention suits the characteristics of persons in middle and old age because of small dosage and high bioavailability, has the functions of enhancing anti-aging capabilities, improving and preventing the brain disorder of persons in middle and old age, such as the decline of memory, thought slowness, etc. and has good application values.
Description
Technical field
The invention belongs to the Chinese medicine health care product technical field.Be specifically related to a kind of Chinese medicine health care product that improves the defying age ability and improve memory that has.
Background technology
Along with the progress of society and the development of medical science, the world constantly prolongs the average life span.China old people has surpassed 100,000,000.Estimate that the year two thousand twenty reaches 2.8 hundred million, total population 19.3%.Existing in the world now 55 countries have entered the society of the aged.21 century will become the superelevation epoch in age.Therefore, improve the emphasis that the life of elderly person quality problems have become social concerns.Be applicable to old common disease, will become very important research topic in 21 century as health foods such as " senile dementias ".
Summary of the invention
Technical problem to be solved by this invention is the research design defying age and improves the Chinese medicine health care product of memory.
The invention provides a kind of Chinese medicine health care product (Lei Shi board Hui Er is good for capsule) that improves the defying age ability and improve memory that has.
Chinese medicine health care product of the present invention comprises that the Chinese medicine of following component forms as active component, and the consumption of each crude drug is expressed as follows with weight portion: Radix Ginseng extract 25-60, Fructus Ligustri Lucidi extract 10-25, Folium Ginkgo extract 5-15, soybean phospholipid 15-35.
Health product of the present invention are that primary raw material is formed by Radix Ginseng, Fructus Ligustri Lucidi, Folium Ginkgo, soybean phospholipid.This side is through consulting domestic and international pertinent literature, and to the different compatibilities of prescription, has carried out that animal learning memory function influence test back determines.
Radix Ginseng strongly invigorating primordial QI in the side, mend strengthening spleen and lung, the Fructus Alpiniae Oxyphyllae of calming the nerves, can be by the adjusting increased functionality antibody resistance against diseases of exempting from service, also have antioxidation simultaneously, can strengthen old and feeble neurocyte function, promote the growth of neuron membrane, thereby, organ is tending towards old and feeble middle-aged and elderly people has the effect that slow down aging improves memory.
Folium Ginkgo can improve cerebrovascular microcirculation, trophic nerve cell, the old and feeble and impaired neurocyte of protection and reparation.Has certain memory effect that improves.
Fructus Ligustri Lucidi liver and kidney tonifying, its extract can promote nerve growth factor (NGF) and its receptors bind when low concentration.
More than three flavors, have the function of kidney-tonifying and brain tonic, be aided with to have and promote nerve conduction function soybean phospholipid, more apparent slow down aging, improve memory impairments.
Health product of the present invention have carried out functional trial, and its result is as follows:
One, delaying senility function
1. the drosophila survival test method is observed " Lei Shi board Hui Er is good for capsule " influence to life span of drosophila melanogaster.
The drosophila survival result of the test shows: the average life of male fruit bat 0.01%, 0.12% dosage group is significantly higher than matched group (P＜0.05), the highest average life of 0.01% and 0.04% dosage group is significantly higher than matched group (P＜0.05), and the half death time of 0.01%, 0.12% dosage group is significantly higher than matched group (P＜0.05).Male fruit bat 0.01%, 0.04% and the average life of 0.12% dosage group, the highest average life and half death time all are significantly higher than matched group (P＜0.05).Be that the fruit bat result of the test is positive.
2. aged mouse-anti oxidation test method is observed the influence that " Lei Shi board Hui Er is good for capsule " turns into the mouse liver lipid peroxy; Influence to the mouse red blood cell superoxide dismutase.
Aged mouse-anti oxidation test shows: this inspection product high dose group 400mg/kgbw and aged Mus matched group compare, and MDA content significantly reduces (P＜0.01), and the SOD vigor significantly increases (P＜0.01).Be that the antioxidation result of the test is positive.
By evaluation criterion, " Lei Shi board Hui Er is good for capsule " has function in delaying senility.
Two, improve memory effect
" Lei Shi board Hui Er is good for capsule " memory influence to normal mouse has been carried out in this test, adopts the diving tower method; To the improvement effect of the memory acquisition disturbance of mice, adopt the diving tower method; To the improvement effect that obstacle is consolidated in the memory of mice, adopt darkness avoidance test; To the improvement effect of the memory represents obstacle of mice, adopt the water maze method; In addition, to the improvement effect of the memory acquisition disturbance of mice, adopt the diving tower method to carry out replica test.
Observe " Lei Shi board Hui Er is good for capsule ": (1) is to the memory influence of normal mouse, (2) learnt, remember overall process to mice influence.Result's demonstration: 1, compare with the normal control group, the obvious prolongation incubation period 2 (time on insulated platform) of 400mg/kg group and 600mg/kg, errors number obviously reduce (P＜0.05) when step down test is learnt: the errors number of 600mg/kg group obviously reduces (P＜0.05) during test.2, compare with model control group, obviously prolong (P＜0.05) incubation period 2 (time on insulated platform) of 3 dosage groups (200mg/kg, 400mg/kg, 600mg/kg) when testting in step down test, and errors number significantly reduces (P＜0,05); 3, compare with model control group, obviously prolong the incubation period of 200mg/kg group when learning in keeping away dark test, errors number 200mg/kg group and the 400mg/kg obvious minimizing of group (P＜0.05); Each dosage group errors number significantly reduces (P＜0.05) during test; 4, in water maze test, do not have the significance except that when whole process is trained, the reach home difference of time and matched group of 200mg/kg group, when no matter all the other each dosage groups are the 5th omnidistance training or test, compare with the model group matched group, the time that animal is reached home obviously shortens (P＜0.05), errors number obviously reduces (P＜0.05); The wrong animal percentage rate of 200mg/kg group, 600mg/kg group significantly is lower than matched group (P＜0.05) during test; 5, replica test (step down test), 3 dosage group significant prolongations incubation periods 2 (P＜0.05), errors number obviously reduce (P＜0.05) during test, and be consistent with former experimental result.
Result: by the evaluation criterion of " the health food function assessment assessment process and the method for inspection ", 3 indexs of this experiment are all positive, and the repeated trials of memory acquisition disturbance is consistent with former test, illustrates that " Lei Shi board Hui Er is good for capsule " improves significantly to the dysmnesia of mice.
Health product pharmacology of the present invention, toxicological test result are as follows:
Safety toxicity result of the test shows: to large and small Mus acute oral LD50 all greater than 10g/kg.bw, the nontoxic level in true border; Salmonella reversion test, mouse marrow cell micro nuclear test and mouse sperm deformity result of the test are all negative, promptly do not have mutagenic action; 30 days feeding trial results of rat do not see toxic reaction, and the estimation maximum no-effect dose is 2.0g/kg.bw.The function assessment result of the test shows to have slow down aging and improve memory effect.
Another object of the present invention has provided above-mentioned a kind of preparation method that improves the defying age ability and improve the Chinese medicine health care product of memory that has, and this method comprises the following steps:
(1) Radix Ginseng extract preparation: get the Radix Ginseng section, with 70% ethanol extraction three times, filter, merge extractive liquid, reclaims solvent, and is concentrated, 80 ℃ of drying under reduced pressure, promptly;
(2) Fructus Ligustri Lucidi extract preparation: get Fructus Ligustri Lucidi and pulverize, with 50% ethanol extraction three times, each 1: 80 ℃ of drying under reduced pressure, promptly.Extracting solution filters, and filtrate concentrates, 70 ℃ of drying under reduced pressure, promptly;
(3) Semen Ginkgo extrac preparation: get Folium Ginkgo in 80 ℃ of dryings, pulverize, with 70% ethanol extraction three times, filter, merge extractive liquid, reclaims solvent, and is concentrated, 80 ℃ of drying under reduced pressure, promptly;
(4) get after soybean phospholipid and appropriate amount of auxiliary materials fully grind, add the extract that above-mentioned (1), (2), (3) step make, and remaining adjuvant mix homogeneously, granulate, 65 ℃ of dryings, granulate incapsulates, packing, promptly;
The finished product Co-60 irradiation sterilization of 6KGY;
The production environment cleanliness factor is 100,000 grades.
The present invention has following characteristics:
1. component of the present invention has been selected Chinese medicine Radix Ginseng, Fructus Ligustri Lucidi, the Folium Ginkgo of dietotherapeutic and has been aided with soybean phospholipid to carry out prescription according to theory of Chinese medical science.Radix Ginseng strongly invigorating primordial QI among the we is mended strengthening spleen and lung, and the Fructus Alpiniae Oxyphyllae of calming the nerves is regulated the immunologic function system, effects such as antioxidation; Folium Ginkgo can improve cerebrovascular microcirculation, trophic nerve cell, the old and feeble and impaired neurocyte of protection and reparation; Fructus Ligustri Lucidi liver and kidney tonifying, its extract have very strong facilitation to 1-(NGF) receptor when low concentration; Three medicines share, and have the function of kidney-tonifying and brain tonic, are aided with to have to promote nerve conduction function soybean phospholipid, more apparent slow down aging, improve memory impairments.
2. production technology of the present invention was broken in the past and was used as medicine with medical material powder or raw material powder, simple processing technology.Often make the finished product taking dose big, shortcomings such as the interior absorption difference of body.This project according to the contained functional component of each raw material, adopts different ethanol concentration in production technology, extract separately the extractum of effective site and make product again.Overcome deficiency that traditional handicraft causes.Dwindle taking dose, improved bioavailability, particularly be of value to interior absorption of body of middle-aged and elderly people.
3. because each ethanol extraction and soybean phospholipid all have strong hygroscopicity, in preparation process, bring certain difficulty and degeneration, problem such as rotten take place in storage of finished products.Through test and Selection proper supplementary material and consumption.Test and stability test result through every index show that this variety stability is good, meets the requirements.
4. product of the present invention has clear and definite functional component, and " Radix Ginseng total saponins " has effects such as strong, Fructus Alpiniae Oxyphyllae; " ginkgetin " has effects such as microcirculation improvement.Its research data enriches, and mechanism of action is clearer.Radix Ginseng total saponins (in ginsenoside Re 28.2Mg/g) total flavones (in rutin 5.39Mg/g) is through animal and human's body after measured, and animal or human group's result of the test shows, is effective dose.
These health product are equal to other products from prescription, production technology, effect and have compared certain advantage.Radix Ginseng and Semen Ginkgo are ancient Chinese medicines, and through using for many years and modern pharmacology is studied carefully, functional component is clear, and sphere of action has had further expansion, and its effect has obtained people's approval.Product of the present invention is fit to the physiological characteristics of middle-aged and elderly people, and never the same-action point plays slow down aging, improves the neurocyte function, improves the effect of memory.Particularly to having improvement and preventive effect owing to be tending towards disordered brain functioies such as aging, the tired memory decline that causes of cranial nerve, thinking Chi Dun.This will play positive role for prevention and the generation and the development that delay common complaint among the elderly " senile dementia ".
The specific embodiment
Embodiment 1
By per 1000 capsules in weight (gram):
Radix Ginseng extract 90 Fructus Ligustri Lucidi extracts 30
Folium Ginkgo extract 15 soybean phospholipids 36
Microcrystalline Cellulose 66 starch 54
Calcium hydrogen phosphate 9
Preparation method:
(1) Radix Ginseng extract preparation: get the Radix Ginseng section, with 70% ethanol extraction three times, filter, merge extractive liquid, reclaims solvent, and is concentrated, 80 ℃ of drying under reduced pressure, promptly;
(2) Fructus Ligustri Lucidi extract preparation: get Fructus Ligustri Lucidi and pulverize, with 50% ethanol extraction three times, each 1: 80 ℃ of drying under reduced pressure, promptly.Extracting solution filters, and filtrate concentrates, 70 ℃ of drying under reduced pressure, promptly;
(3) Semen Ginkgo extrac preparation: get Folium Ginkgo in 80 ℃ of dryings, pulverize, with 70% ethanol extraction three times, filter, merge extractive liquid, reclaims solvent, and is concentrated, 80 ℃ of drying under reduced pressure, promptly;
(4) get after soybean phospholipid and appropriate amount of auxiliary materials fully grind, add Radix Ginseng extract, Fructus Ligustri Lucidi extract, Folium Ginkgo extract and remaining adjuvant mix homogeneously, granulate, 65 ℃ of dryings incapsulate, packing, promptly;
300 milligrams every, every day 1-2 time, each 2;
The finished product Co-60 irradiation sterilization of 6KGY.The production environment cleanliness factor is 100,000 grades.
Embodiment 2
Per 1000 capsules are (gram) meter by weight:
Radix Ginseng extract 75 Fructus Ligustri Lucidi extracts 30
Folium Ginkgo extract 15 soybean phospholipids 38
Microcrystalline Cellulose 80 starch 55
Calcium hydrogen phosphate 7
Preparation method:
The preparation method of Radix Ginseng, Fructus Ligustri Lucidi, Folium Ginkgo extract and preparation process are all with embodiment 1.
Embodiment 3
Per 1000 capsules are (gram) meter by weight:
Radix Ginseng extract 75 Fructus Ligustri Lucidi extracts 25
Folium Ginkgo extract 20 soybean phospholipids 40
Microcrystalline Cellulose 82 starch 52
Calcium hydrogen phosphate 6
Preparation method:
The preparation method of Radix Ginseng, Fructus Ligustri Lucidi, Folium Ginkgo extract and preparation process are all with embodiment 1.
Claims (2)
1. one kind has the Chinese medicine health care product that improves the defying age ability and improve memory, it is characterized in that Chinese medicine that this Chinese medicine health care product comprises following component is as active component: Radix Ginseng extract 25-60, Fructus Ligustri Lucidi extract 10-25, Folium Ginkgo extract 5-15, soybean phospholipid 15-35 make with following method:
(1) Radix Ginseng extract preparation: get the Radix Ginseng section, with 70% ethanol extraction three times, filter, merge extractive liquid, reclaims solvent, and is concentrated, 80 ℃ of drying under reduced pressure, promptly;
(2) Fructus Ligustri Lucidi extract preparation: get Fructus Ligustri Lucidi and pulverize, with 50% ethanol extraction three times, each 1 hour, 80 ℃ of drying under reduced pressure, promptly.Extracting solution filters, and filtrate concentrates thick, 70 ℃ of drying under reduced pressure, promptly;
(3) Semen Ginkgo extrac preparation: get Folium Ginkgo in 80 ℃ of dryings, pulverize, with 70% ethanol extraction three times, filter, merge extractive liquid, reclaims solvent, and is concentrated, 80 ℃ of drying under reduced pressure, promptly;
(4) get after soybean phospholipid and appropriate amount of auxiliary materials fully grind, add the extract that above-mentioned (1), (2), (3) step make, and remaining adjuvant mix homogeneously, to granulate, 65 ℃ of dryings incapsulate, packing, promptly;
The finished product Co-60 irradiation sterilization of 6KGY.
2. the preparation method with the Chinese medicine health care product that improves defying age ability and improvement memory as claimed in claim 1 is characterized in that this method comprises the following steps:
(1) Radix Ginseng extract preparation: get the Radix Ginseng section, with 70% ethanol extraction three times, filter, merge extractive liquid, reclaims solvent, and is concentrated, 80 ℃ of drying under reduced pressure, promptly;
(2) Fructus Ligustri Lucidi extract preparation: get Fructus Ligustri Lucidi and pulverize, with 50% ethanol extraction three times, each 1 hour, 80 ℃ of drying under reduced pressure, promptly.Extracting solution filters, and filtrate concentrates thick, 70 ℃ of drying under reduced pressure, promptly;
(3) Semen Ginkgo extrac preparation: get Folium Ginkgo in 80 ℃ of dryings, pulverize, with 70% ethanol extraction three times, filter, merge extractive liquid, reclaims solvent, and is concentrated, 80 ℃ of drying under reduced pressure, promptly;
(4) get after soybean phospholipid and appropriate amount of auxiliary materials fully grind, add the extract that above-mentioned (1), (2), (3) step make, and remaining adjuvant mix homogeneously, to granulate, 65 ℃ of dryings incapsulate, packing, promptly;
The finished product Co-60 irradiation sterilization of 6KGY.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2003101080363A CN1319548C (en) | 2003-10-17 | 2003-10-17 | Chinese medicine health tonic for raising antisenility capacity and improving memory |
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| Application Number | Priority Date | Filing Date | Title |
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| CNB2003101080363A CN1319548C (en) | 2003-10-17 | 2003-10-17 | Chinese medicine health tonic for raising antisenility capacity and improving memory |
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| Publication Number | Publication Date |
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| CN1608649A CN1608649A (en) | 2005-04-27 |
| CN1319548C true CN1319548C (en) | 2007-06-06 |
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013173972A1 (en) * | 2012-05-22 | 2013-11-28 | Nestec S.A. | Fructus ligustri lucidi for growth in children |
| CN102886040A (en) * | 2012-11-07 | 2013-01-23 | 广州国宇医药科技有限公司 | Combination for enhancing memory and preparation method thereof |
| CN103623063B (en) * | 2013-11-15 | 2015-10-28 | 天津金耀集团有限公司 | A kind of compositions containing Radix Panacis Quinquefolii, Fructus Ligustri Lucidi extract |
| CN105362738B (en) * | 2015-11-13 | 2019-03-12 | 山东迅达康生物科技有限公司 | Pharmaceutical composition and preparation method thereof for livestock and poultry liver protection shield kidney |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1039724A (en) * | 1988-07-23 | 1990-02-21 | 石富成 | The manufacturing process of soybean phospholipid, protein mixture |
| CN1141185A (en) * | 1996-02-16 | 1997-01-29 | 范凯 | Health-care medicated wine |
| CN1169259A (en) * | 1996-06-27 | 1998-01-07 | 朱炜 | Nutritious powder for strengthening bone and tonifying brain, and preparation method |
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- 2003-10-17 CN CNB2003101080363A patent/CN1319548C/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1039724A (en) * | 1988-07-23 | 1990-02-21 | 石富成 | The manufacturing process of soybean phospholipid, protein mixture |
| CN1141185A (en) * | 1996-02-16 | 1997-01-29 | 范凯 | Health-care medicated wine |
| CN1169259A (en) * | 1996-06-27 | 1998-01-07 | 朱炜 | Nutritious powder for strengthening bone and tonifying brain, and preparation method |
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| CN1608649A (en) | 2005-04-27 |
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