CN1309368C - Preparation of Chinese traditional medicine for curing cough and preparation method - Google Patents
Preparation of Chinese traditional medicine for curing cough and preparation method Download PDFInfo
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- CN1309368C CN1309368C CNB2004100220686A CN200410022068A CN1309368C CN 1309368 C CN1309368 C CN 1309368C CN B2004100220686 A CNB2004100220686 A CN B2004100220686A CN 200410022068 A CN200410022068 A CN 200410022068A CN 1309368 C CN1309368 C CN 1309368C
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- 238000002360 preparation method Methods 0.000 title claims abstract description 32
- 239000003814 drug Substances 0.000 title claims abstract description 27
- 206010011224 Cough Diseases 0.000 title claims description 18
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- 238000011282 treatment Methods 0.000 claims abstract description 10
- 238000000034 method Methods 0.000 claims abstract description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 55
- 239000007788 liquid Substances 0.000 claims description 36
- 239000000341 volatile oil Substances 0.000 claims description 33
- 239000008187 granular material Substances 0.000 claims description 18
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- 239000000843 powder Substances 0.000 claims description 13
- 238000004821 distillation Methods 0.000 claims description 12
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- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 claims description 11
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- -1 add water-wet Substances 0.000 claims description 10
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- 239000003826 tablet Substances 0.000 claims description 7
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- 230000000694 effects Effects 0.000 abstract description 5
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- 238000010579 first pass effect Methods 0.000 abstract description 2
- 238000007254 oxidation reaction Methods 0.000 abstract description 2
- 241001662414 Aster tataricus Species 0.000 abstract 1
- 206010006458 Bronchitis chronic Diseases 0.000 abstract 1
- 244000061508 Eriobotrya japonica Species 0.000 abstract 1
- 235000009008 Eriobotrya japonica Nutrition 0.000 abstract 1
- 241000935235 Fritillaria meleagris Species 0.000 abstract 1
- 240000001090 Papaver somniferum Species 0.000 abstract 1
- 235000008753 Papaver somniferum Nutrition 0.000 abstract 1
- 240000004534 Scutellaria baicalensis Species 0.000 abstract 1
- 235000017089 Scutellaria baicalensis Nutrition 0.000 abstract 1
- 238000010521 absorption reaction Methods 0.000 abstract 1
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- 230000000638 stimulation Effects 0.000 abstract 1
- 241000699670 Mus sp. Species 0.000 description 6
- 235000008504 concentrate Nutrition 0.000 description 6
- BELBBZDIHDAJOR-UHFFFAOYSA-N Phenolsulfonephthalein Chemical compound C1=CC(O)=CC=C1C1(C=2C=CC(O)=CC=2)C2=CC=CC=C2S(=O)(=O)O1 BELBBZDIHDAJOR-UHFFFAOYSA-N 0.000 description 4
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- 238000011084 recovery Methods 0.000 description 4
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 description 4
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- 239000008194 pharmaceutical composition Substances 0.000 description 3
- 210000003437 trachea Anatomy 0.000 description 3
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 2
- 206010013952 Dysphonia Diseases 0.000 description 2
- 208000010473 Hoarseness Diseases 0.000 description 2
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- 239000004615 ingredient Substances 0.000 description 2
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- 241000721047 Danaus plexippus Species 0.000 description 1
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- 206010057190 Respiratory tract infections Diseases 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
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- HFHDHCJBZVLPGP-RWMJIURBSA-N alpha-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO HFHDHCJBZVLPGP-RWMJIURBSA-N 0.000 description 1
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- 230000001088 anti-asthma Effects 0.000 description 1
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Abstract
The present invention relates to a traditional Chinese medicine preparation for treating tussis and a preparing method thereof. The traditional Chinese medicine preparation is prepared from the following medicines of fritillary bulb, loquat leaf, tatarian aster, herba ephedrae, baikal skullcap root, poppy shell, etc. The traditional Chinese medicine preparation has the exact treatment effect on acute or chronic bronchitis, rhinobyon, sternutation, pharyngalgia, raucedo, etc. The tablet preparation provided by the present invention has accurate a dosage, little difference of the contents of objects contained in the tablet preparation and stable quality. Moreover, the medicines which are easily form the oxidization, the deterioration and the deliquescence are protected by coating so that light rays, air, moisture, etc. have less influence on the medicines. The granular preparation has little stimulation to the gstrointestinal tract, high medicine carrying quantity and good taste so that the granular preparation is good for acceptance. The capsule preparation has rapid absorption, high biological availability and wide application range. The injection preparation has high biological availability, rapid taking effect and no first pass effect so that the injection preparation is suitable for patients who can not carry out the oral administration.
Description
Technical field: the present invention relates to a kind of Chinese medicine preparation for the treatment of cough and preparation method thereof, belong to technical field of Chinese medicine.
Technical background: the clinical symptom that mainly shows as upper respiratory tract infection of acute bronchitis, as nasal obstruction, sneeze, pharyngalgia, hoarseness etc., cardinal symptom increases the weight of day by day for cough.Prevent and treat purpose in order to reach, a large amount of research has been done by many inventors and medicine enterprise, and the product of some treatments also is provided; It is 02153462 patent application that the applicant has once submitted " a kind of pharmaceutical composition for the treatment of cough and preparation method thereof ", application number with employee comrade's Zhang Huifang name to Patent Office of the People's Republic of China.In this part patent application document, because the dosage form of finishing only is syrup, its easy moldy metamorphism, and contained volatile oil is effective ingredient in its preparation in the Herba Ephedrae, but owing to have incomplete place in its technology, make loss of volatile oil in the Herba Ephedrae, thereby drug effect is reduced; Although so the medicine that this part application provides can be treated the disease of being narrated, the effect of finding them in actual use is not special ideal.
Summary of the invention: the object of the invention is to provide Chinese medicine preparation of a kind of evident in efficacy and treatment cough with cough-relieving function of having no side effect and preparation method thereof, to solve the problem that prior art exists.
The present invention is achieved in that according to components by weight percent and calculates: get Bulbus Fritillariae Cirrhosae 5～15 weight portions, Folium Eriobotryae 25～75 weight portions, Radix Asteris 25～75 weight portions, Herba Ephedrae 50～150 weight portions, Radix Scutellariae 25～75 weight portions, Pericarpium Papaveris 30～90 weight portions, Radix Glycyrrhizae 25～75 weight portions, Mentholum 0.15～0.45 weight portion and be prepared into tablet, granule, soft capsule, capsule, drop pill, pill, medicated wine, tincture, extractum, ejection preparation, comprise: common injection, injectable powder, lyophilized injectable powder, infusion solution, other special preparations; Comprise sustained-release preparation, membranous patch, gel etc.Say accurately: its dosage form is tablet, granule, soft capsule, capsule, pill.Preparation method of the present invention is to get Herba Ephedrae, uses vapor distillation, collects distillate and medicinal liquid, and medicinal liquid is standby; Medicinal residues and Bulbus Fritillariae Cirrhosae, Folium Eriobotryae, Radix Asteris, Radix Scutellariae, Pericarpium Papaveris, Radix Glycyrrhizae, decoct with water 2～3 times, 1～3 hour for the first time, 0.5～2 hour for the second time, merge decoction liquor, filter, the medicinal liquid merging behind filtrate and the extraction volatile oil concentrates, the gained clear paste adds ethanol to be made and contains alcohol amount to 40～80%, left standstill 12～48 hours, and filtered, reclaim ethanol, and continue to be condensed into thick paste, vacuum drying gets dry extract, and is ground into fine powder, volatile oil is sneaked into after measuring beta-cyclodextrin inclusion compounds with 8 times, and the reuse diverse ways is made different preparations.Its method for preparing tablet thereof is: get Herba Ephedrae, use vapor distillation, collect distillate and medicinal liquid, medicinal liquid is standby; Medicinal residues and Bulbus Fritillariae Cirrhosae, Folium Eriobotryae, Radix Asteris, Radix Scutellariae, Pericarpium Papaveris, Radix Glycyrrhizae, decoct with water 2～3 times, 1～2 hour for the first time, 0.5～1 hour for the second time, merge decoction liquor, filter, filtrate with extract medicinal liquid behind the volatile oil and merge and concentrate, the gained clear paste adds ethanol to be made and contains the alcohol amount to 40～60%, left standstill 12～24 hours, filter, reclaim ethanol, and continue to be condensed into thick paste, vacuum drying, get dry extract, be ground into fine powder, add water-wet, granulate, volatile oil is sneaked into after measuring beta-cyclodextrin inclusion compounds with 8 times, tabletting, promptly.Its process for producing granula is: get Herba Ephedrae, use vapor distillation, collect distillate and medicinal liquid, medicinal liquid is standby; Medicinal residues and Bulbus Fritillariae Cirrhosae, Folium Eriobotryae, Radix Asteris, Radix Scutellariae, Pericarpium Papaveris, Radix Glycyrrhizae, decoct with water 2～3 times, 2～3 hours for the first time, 1～2 hour for the second time, merge decoction liquor, filter, filtrate with extract medicinal liquid behind the volatile oil and merge and concentrate, the gained clear paste adds ethanol to be made and contains the alcohol amount to 60～80%, leaves standstill 24～48 hours, filter, reclaim ethanol, and continue to be condensed into thick paste, vacuum drying, get dry extract, be ground into fine powder, add water-wet, granulate, volatile oil is sneaked into after measuring beta-cyclodextrin inclusion compounds with 8 times, promptly.Its capsule preparation method thereof is: get Herba Ephedrae, use vapor distillation, collect distillate and medicinal liquid, medicinal liquid is standby; Medicinal residues and Bulbus Fritillariae Cirrhosae, Folium Eriobotryae, Radix Asteris, Radix Scutellariae, Pericarpium Papaveris, Radix Glycyrrhizae, decoct with water 2～3 times, 1～3 hour for the first time, 0.5～2 hour for the second time, merge decoction liquor, filter, filtrate with extract medicinal liquid behind the volatile oil and merge and concentrate, the gained clear paste adds ethanol to be made and contains the alcohol amount to 40～80%, left standstill 12～48 hours, filter, reclaim ethanol, and continue to be condensed into thick paste, vacuum drying, get dry extract, be ground into fine powder, add water-wet, granulate, volatile oil is sneaked into after measuring beta-cyclodextrin inclusion compounds with 8 times, filling, promptly.
According to traditional Chinese medical science traditional theory, Bulbus Fritillariae Cirrhosae, the Herba Ephedrae diaphoresis diuretic of relievining asthma, monarch drug in the side of being, relieving cough and reducing sputum; Folium Eriobotryae, Radix Asteris, Pericarpium Papaveris expectorant cough suppressant and anti-asthmatic are ministerial drug in the side; The Radix Scutellariae invigorating the spleen and replenishing QI is adjuvant drug in the side; Radix Glycyrrhizae, Mentholum reduce phlegm, and Synergistic is an accessory drugs.The present invention selects tablet, granule, capsule, soft capsule, drop pill, pill etc. for use; Wherein: tablet dose is accurate, and the content content difference is little, steady quality, and some easy oxidation deterioration and deliquescent medicine can be protected by coating, and light, air, moisture etc. are less to its influence; Granule, GI irritation is little; Drug loading is big, and mouthfeel is good, is beneficial to acceptance; Capsule absorbs fast, the bioavailability height, and the use crowd is wide; Injection bioavailability height, onset speed is fast, no first pass effect, be applicable to can not be oral the patient; Sustained-release preparation is easy to use, provides balance persistent effective blood drug concentration, needing to be particularly useful for the patient of long-term prescription.The present invention is directed to prior art simultaneously, the volatile oil that the Herba Ephedrae distillation extraction is gone out carries out enclose with cyclodextrin, can prevent the volatilization of volatile oil; Improve stability of drug; Also can cover the bad smell of volatile oil simultaneously.The present invention has more definite therapeutic effect for acute bronchitis, nasal obstruction, sneeze, pharyngalgia, hoarseness etc.
Effectively controlled in order to confirm method provided by the invention, the preparation good effect, the applicant carries out a series of experiments:
Experimental example 1: to the phenol red influence of mice trachea excretion
Get body weight 18-22g mice, be subjected to the examination group to irritate the extract 2.0g/kg that stomach gives tablet of the present invention, granule, capsule respectively, positive controls gives oral liquid 2.0g/kg, irritates the long-pending 2ml/100g, successive administration 5 days of being of body of stomach.After the last administration 30 minutes, every Mus lumbar injection 0.25% phenol red normal saline solution 0.5ml.After injecting phenol red 30 minutes, put to death mice, behind literature method flushing pulmonary branches trachea, collect irrigating solution, measure the OD value, matched group is 0.312 ± 0.054 as a result, is subjected to examination group tablet, granule, capsule to be respectively 0.395 ± 0.113,0.387 ± 0.341,0.379 ± 0.235, show that pharmaceutical composition of the present invention can significantly increase the phenol red amount of mice trachea excretion, has obvious phlegm-dispelling functions.
Experimental example 2: strong aqua ammonia is caused the influence of mouse cough
Get body weight 18-22g mice, be divided into 4 groups at random, irritate stomach respectively and give tablet of the present invention, granule, capsule, positive controls gives oral liquid, irritates the long-pending 2ml/100g, successive administration 5 days of being of body of stomach.After the last administration 30 minutes, mice is put in the airtight glass box, quantitatively being sprayed into the strong aqua ammonia aerosol lures and coughs, write down the number of times of coughing in mouse cough incubation period and 3 minutes, the average cough latent period of matched group is 61.6 ± 13.4 seconds as a result, on average the number of times of coughing is 5.7 ± 4.8 times, be respectively by examination group tablet, granule, capsule 63.5 ± 12.5 seconds, 4.6 ± 3.1 times, 66.1 ± 21.2 seconds, 4.7 ± 3.2 times, 61.0 ± 27.6 seconds, 5.4 ± 4.9 times, show that pharmaceutical composition of the present invention is similar to oral liquid, obvious antitussive effect is all arranged.
Experimental example 3: adjuvant screening
The volatile oil of epheday intermedia of the present invention is its effective ingredient, and is diffusing for preventing waving of volatile oil, improves stability of drug, covers the bad smell of volatile oil, better brings into play drug effect, and selecting the cyclodextrin parcel is its key technology.Certainly adopt other auxiliary material also can produce product, but situation about reflecting after the actual fabrication is that the auxiliary material that the present invention selected is ideal.
Inclusion rate=[amount of volatile oil/volatile oil addition in the clathrate] * 100%
Recovery rate=[clathrate actual amount/(cyclodextrin amount+volatile oil addition)] * 100%
Cyclodextrin: oil 4: 16: 18: 1
Inclusion rate % recovery rate % inclusion rate % recovery rate % inclusion rate % recovery rate %
Beta-schardinger dextrin-72.5 92.2 73.2 92.2 76.7 94.5
Alpha-cyclodextrin 72.3 93.0 73.4 92.0 71.3 92.3
Gamma-cyclodextrin 73.1 91.3 71.9 91.5 72.4 90.2
White dextrin 67.7 82.2 68.3 87.2 64.3 81.3
Yellow starch gum 60.1 80.1 62.7 82.1 65.3 84.2
By experiment, adopt the selected adjuvant prepared preparation steady quality of the present invention, good effect.
Concrete embodiment:
Embodiments of the invention 1:
Get 5 parts of Bulbus Fritillariae Cirrhosaes, 25 parts of Folium Eriobotryaes, 25 parts of Radix Asteriss, 50 parts in Herba Ephedrae, 25 parts of Radix Scutellariaes, 30 parts of Pericarpium Papaveriss, 25 parts in Radix Glycyrrhizae, 0.15 part of Mentholum, get Herba Ephedrae, use vapor distillation, collect distillate and medicinal liquid, medicinal liquid is standby; Medicinal residues and Bulbus Fritillariae Cirrhosae, Folium Eriobotryae, Radix Asteris, Radix Scutellariae, Pericarpium Papaveris, Radix Glycyrrhizae decoct with water 2～3 times, 1 hour for the first time, 0.5 hour for the second time, merge decoction liquor, filter, medicinal liquid behind filtrate and the extraction volatile oil merges concentrated, the gained clear paste adds ethanol to be made and contains alcohol amount to 40%, leaves standstill 12 hours, filters, reclaim ethanol, and continuing to be condensed into thick paste, vacuum gets dry extract in dry, be ground into fine powder, add water-wet, granulate, volatile oil is sneaked into after measuring beta-cyclodextrin inclusion compounds with 8 times, tabletting, promptly get tablet, oral, every day 3 times, each 3.
Embodiments of the invention 2:
Get 15 parts of Bulbus Fritillariae Cirrhosaes, 75 parts of Folium Eriobotryaes, 75 parts of Radix Asteriss, 150 parts in Herba Ephedrae, 75 parts of Radix Scutellariaes, 90 parts of Pericarpium Papaveriss, 75 parts in Radix Glycyrrhizae, 0.45 part of Mentholum, get Herba Ephedrae, use vapor distillation, collect distillate and medicinal liquid, medicinal liquid is standby; Medicinal residues and Bulbus Fritillariae Cirrhosae, Folium Eriobotryae, Radix Asteris, Radix Scutellariae, Pericarpium Papaveris, Radix Glycyrrhizae decoct with water 3 times, and 3 hours for the first time, 2 hours for the second time, merge decoction liquor, filter, the medicinal liquid merging behind filtrate and the extraction volatile oil concentrates, the gained clear paste adds ethanol to be made and contains alcohol amount to 80%, leaves standstill 48 hours, filters, reclaim ethanol, and continue to be condensed into thick paste, vacuum drying, get dry extract, be ground into fine powder, add water-wet, granulate, volatile oil is sneaked into after measuring beta-cyclodextrin inclusion compounds with 8 times, promptly.
Embodiments of the invention 3:
10 parts of Bulbus Fritillariae Cirrhosaes, 50 parts of Folium Eriobotryaes, 50 parts of Radix Asteriss, 100 parts in Herba Ephedrae, 60 parts of 50 parts of Pericarpium Papaveriss of Radix Scutellariae, 50 parts in Radix Glycyrrhizae, 0.3 part of Mentholum are got Herba Ephedrae, use vapor distillation, collect distillate and medicinal liquid, and medicinal liquid is standby; Medicinal residues and Bulbus Fritillariae Cirrhosae, Folium Eriobotryae, Radix Asteris, Radix Scutellariae, Pericarpium Papaveris, Radix Glycyrrhizae decoct with water 3 times, and 2 hours for the first time, 1 hour for the second time, merge decoction liquor, filter, filtrate with extract medicinal liquid behind the volatile oil and merge and concentrate, the gained clear paste adds ethanol to be made and contains the alcohol amount to 60%, left standstill 24 hours, and filtered, reclaim ethanol, and continuing to be condensed into thick paste, vacuum drying gets dry extract, be ground into fine powder, add water-wet, granulate, volatile oil is sneaked into after measuring beta-cyclodextrin inclusion compounds with 8 times, filling, promptly.
Claims (4)
1, a kind of Chinese medicine preparation for the treatment of cough calculates according to components by weight percent: Bulbus Fritillariae Cirrhosae 5～15 weight portions, Folium Eriobotryae 25～75 weight portions, Radix Asteris 25～75 weight portions, Herba Ephedrae 50～150 weight portions, Radix Scutellariae 25～75 weight portions, Pericarpium Papaveris 30～90 weight portions, Radix Glycyrrhizae 25～75 weight portions, Mentholum 0.15～0.45 weight portion are prepared into tablet, granule, soft capsule, capsule, drop pill or gel; It is characterized in that: get Herba Ephedrae, use vapor distillation, collect distillate and medicinal liquid, medicinal liquid is standby; Medicinal residues and Bulbus Fritillariae Cirrhosae, Folium Eriobotryae, Radix Asteris, Radix Scutellariae, Pericarpium Papaveris, Radix Glycyrrhizae, decoct with water 2～3 times, 1～3 hour for the first time, 0.5～2 hour for the second time, merge decoction liquor, filter, the medicinal liquid merging behind filtrate and the extraction volatile oil concentrates, the gained clear paste adds ethanol to be made and contains alcohol amount to 40～80%, left standstill 12～48 hours, and filtered, reclaim ethanol, and continue to be condensed into thick paste, vacuum drying gets dry extract, and is ground into fine powder, volatile oil is sneaked into after measuring beta-cyclodextrin inclusion compounds with 8 times, and the reuse diverse ways is made different preparations.
2, according to the Chinese medicine preparation of the described treatment cough of claim 1, it is characterized in that: method for preparing tablet thereof is: get Herba Ephedrae, use vapor distillation, collect distillate and medicinal liquid, medicinal liquid is standby; Medicinal residues and Bulbus Fritillariae Cirrhosae, Folium Eriobotryae, Radix Asteris, Radix Scutellariae, Pericarpium Papaveris, Radix Glycyrrhizae, decoct with water 2～3 times, 1～2 hour for the first time, 0.5～1 hour for the second time, merge decoction liquor, filter, filtrate with extract medicinal liquid behind the volatile oil and merge and concentrate, the gained clear paste adds ethanol to be made and contains the alcohol amount to 40～60%, left standstill 12～24 hours, filter, reclaim ethanol, and continue to be condensed into thick paste, vacuum drying, get dry extract, be ground into fine powder, add water-wet, granulate, volatile oil is sneaked into after measuring beta-cyclodextrin inclusion compounds with 8 times, tabletting, promptly.
3, according to the Chinese medicine preparation of the described treatment cough of claim 1, it is characterized in that: process for producing granula is: get Herba Ephedrae, use vapor distillation, collect distillate and medicinal liquid, medicinal liquid is standby; Medicinal residues and Bulbus Fritillariae Cirrhosae, Folium Eriobotryae, Radix Asteris, Radix Scutellariae, Pericarpium Papaveris, Radix Glycyrrhizae, decoct with water 2～3 times, 2～3 hours for the first time, 1～2 hour for the second time, merge decoction liquor, filter, filtrate with extract medicinal liquid behind the volatile oil and merge and concentrate, the gained clear paste adds ethanol to be made and contains the alcohol amount to 60～80%, leaves standstill 24～48 hours, filter, reclaim ethanol, and continue to be condensed into thick paste, vacuum drying, get dry extract, be ground into fine powder, add water-wet, granulate, volatile oil is sneaked into after measuring beta-cyclodextrin inclusion compounds with 8 times, promptly.
4, according to the Chinese medicine preparation of the described treatment cough of claim 1, it is characterized in that: capsule preparation method thereof is: get Herba Ephedrae, use vapor distillation, collect distillate and medicinal liquid, medicinal liquid is standby; Medicinal residues and Bulbus Fritillariae Cirrhosae, Folium Eriobotryae, Radix Asteris, Radix Scutellariae, Pericarpium Papaveris, Radix Glycyrrhizae, decoct with water 2～3 times, 1～3 hour for the first time, 0.5～2 hour for the second time, merge decoction liquor, filter, filtrate with extract medicinal liquid behind the volatile oil and merge and concentrate, the gained clear paste adds ethanol to be made and contains the alcohol amount to 40～80%, left standstill 12～48 hours, filter, reclaim ethanol, and continue to be condensed into thick paste, vacuum drying, get dry extract, be ground into fine powder, add water-wet, granulate, volatile oil is sneaked into after measuring beta-cyclodextrin inclusion compounds with 8 times, filling, promptly.
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| CN102357183B (en) * | 2011-10-25 | 2013-06-12 | 陕西步长高新制药有限公司 | Traditional Chinese medicament for curing cough and preparation method thereof |
| CN102357182A (en) * | 2011-10-25 | 2012-02-22 | 陕西步长制药有限公司 | Traditional Chinese medicament for curing cough and preparation method thereof |
| CN102357184B (en) * | 2011-10-25 | 2013-06-12 | 陕西步长高新制药有限公司 | Traditional Chinese medicine preparation for treating cough and preparation method thereof |
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