CN1418687A - Medicine composite for treating cough - Google Patents
Medicine composite for treating cough Download PDFInfo
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- CN1418687A CN1418687A CN 02153462 CN02153462A CN1418687A CN 1418687 A CN1418687 A CN 1418687A CN 02153462 CN02153462 CN 02153462 CN 02153462 A CN02153462 A CN 02153462A CN 1418687 A CN1418687 A CN 1418687A
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Abstract
The present invention discloses a Chinese medicine composition for curing cough and its preparation method. It is made of 8 Chinese medicinal materials of Sichuan fritillaria bulb, loquat leaf, aster root, ephedra, scutellaria root, poppy husk and others.
Description
The present invention relates to a kind of pharmaceutical composition for the treatment of cough and preparation method thereof.
The clinical symptom that mainly shows as upper respiratory tract infection of acute bronchitis, as nasal obstruction, sneeze, pharyngalgia, hoarseness etc., cardinal symptom increases the weight of day by day for cough.Chronic bronchitis is because the chronic nonspecific inflammation of trachea, bronchus amount mucosa and surrounding tissue thereof that infection or non-infective agent cause serves as main performance with long-term cough, expectoration or asthma clinically.The human feeling the wind comes from outward, trembles with fear, wets, hot all poison are felt frustrated, and gas is stopped up the then cough that has some setbacks, pathogenic wind toxic, pyretic toxicity heat-transformation, and intrinsic heat is hindered water and is stopped the long-pending expectorant of then giving birth to.Think all poison invasion and attack flesh of exopathogen table, inhibited pulmonary QI then, weakness of the spleen and stomach, then spleen is supported in not semen deposition, and foodstuff essence is from positizing, and then then is converted into and violates on the expectorant in lung, stops amassing with the bringing about the spread of body fluid, and water is general be expectorant, scurries heat-transformation on the evil poison and dries up, and symptoms such as body void is weak occur.The pathogenesis that gets to the bottom of sb.'s illness is a main symptom with wind-heat invading the lung, wind-cold affecting lung, phlegm-heat obstructing in the lung, and the rule of treatment is worked as heat clearing away, and lung qi dispersing is relievingd asthma, and preventing phlegm from forming and stopping coughing is a method.
The object of the invention is to provide a kind of evident in efficacy and pharmaceutical composition with cough-relieving function of having no side effect and preparation method thereof.
Technical solution of the present invention is achieved in that
Bulbus Fritillariae Cirrhosae 5～15 weight portion Folium Eriobotryaes 25～75 weight portions
Radix Asteris 25～75 weight portion Herba Ephedraes 50～150 weight portions
Radix Scutellariae 25～75 weight portion Pericarpium Papaveriss 30～90 weight portions
Radix Glycyrrhizae 25～75 weight portion Mentholums 0.15～0.45 weight portion
Get Herba Ephedrae, use vapor distillation, collect distillate and medicinal liquid, medicinal liquid is standby; Medicinal residues and Bulbus Fritillariae Cirrhosae, Folium Eriobotryae, Radix Asteris, Radix Scutellariae, Pericarpium Papaveris, Radix Glycyrrhizae, decoct with water 2～3 times, 1～3 hour for the first time, 0.5～2 hour for the second time, merge decoction liquor, filter, filtrate with extract medicinal liquid behind the volatile oil and merge and concentrate, the gained clear paste adds ethanol to be made and contains the alcohol amount to 40～80%, leaves standstill 12～48 hours, filter, reclaim ethanol, continue to be condensed into clear paste, add adjuvant, correctives and antibacterial, boil, leave standstill, coarse filtration adds distillate and Mentholum, be adjusted to full dose with distilled water, promptly.
Through laboratory observation, found that pharmaceutical composition of the present invention all has certain inhibitory action to staphylococcus aureus, beta hemolytic streptococcus, streptococcus pneumoniae, colon bacillus, Bacillus proteus and pseudomonas aeruginosa; Has tangible phlegm-dispelling functions; Has tangible antitussive effect; Acetamide alkali and histamine mixed to cause breathe heavily due to the liquid Cavia porcellus and pant obvious prolongation effect is arranged incubation period; Normal mouse temperature all there is not obvious influence; Yeast pyrogenicity rat temperature promptly there is tangible reduction effect, and can continues more than 8 hours; Xylol induced mice ear swelling does not have obvious influence; Rat granuloma hamartoplasia there is the obvious suppression effect, illustrates that pharmaceutical composition of the present invention has remarkable inhibitory action to chronic inflammatory disease.Experimental result shows that medicine of the present invention has heat clearing away, and lung qi dispersing is relievingd asthma, the effect of preventing phlegm from forming and stopping coughing.Be used for cough with copious phlegm or ungratifying ejection of phlegm due to wind-heat invading the lung, the stagnation of fire in the interior, laryngopharynx swelling and pain, fullness in the chest and shortness of breath, cold cough and acute and chronic bronchitis are seen above-mentioned card marquis person.
Pharmaceutical composition of the present invention has dispelling wind and ventilating the lung, relieving cough and resolving phlegm effect such as relieving asthma, and can be used for cold cough, and bringing up phlegm when one coughs due to acute and chronic bronchitis and the wind-heat invading the lung is uncomfortable in chest, treatment of diseases such as dyspnea with rapid and short breath.Experimental example 1: pharmaceutical composition of the present invention is to the phenol red influence of mice trachea excretion
Get body weight 18-22g mice, be subjected to the examination group to irritate extract 0.8g/kg, 2.0g/kg that stomach gives pharmaceutical composition of the present invention respectively, positive controls gives Folium Eriobotryae cough-relieving electuary 2.0g/kg, and the blank group is irritated the stomach normal saline, irritate the long-pending 2ml/100g, successive administration 5 days of being of body of stomach.After the last administration 30 minutes, every Mus lumbar injection 0.25% phenol red normal saline solution 0.5ml.After injecting phenol red 30 minutes, put to death mice, behind literature method flushing pulmonary branches trachea, collect irrigating solution, measure the OD value, the blank group is 0.332 ± 0.059 as a result, is subjected to that the examination group is low, high dose and positive controls be respectively 0.391 ± 0.073,0.398 ± 0.054,0.387 ± 0.061, show that pharmaceutical composition of the present invention can significantly increase the phenol red amount of mice trachea excretion, has obvious phlegm-dispelling functions.Experimental example 2: pharmaceutical composition of the present invention causes the influence of mouse cough to strong aqua ammonia
Get body weight 18-22g mice, be divided into 4 groups at random, the blank group is irritated the stomach normal saline, be subjected to the examination group to irritate extract 0.8g/kg, 2.0g/kg that stomach gives pharmaceutical composition of the present invention respectively, positive controls gives Folium Eriobotryae cough-relieving electuary 2.0g/kg, irritate the long-pending 2ml/100g, successive administration 5 days of being of body of stomach.After the last administration 30 minutes, mice is put in the airtight glass box, quantitatively being sprayed into the strong aqua ammonia aerosol lures and coughs, write down the number of times of coughing in mouse cough incubation period and 3 minutes, the average cough latent period of blank group is 37.9 ± 13.6 seconds as a result, on average the number of times of coughing is 12.7 ± 7.8 times, be subjected to that the examination group is low, high dose and positive controls be respectively 63.5 ± 21.8 seconds, 5.7 ± 6.2 times, 76.1 ± 25.1 seconds, 4.8 ± 4.3 times, 61.0 ± 27.6 seconds, 5.4 ± 4.9 times, show that pharmaceutical composition of the present invention has obvious antitussive effect.
Embodiment 1:
Bulbus Fritillariae Cirrhosae 10g Folium Eriobotryae 50g Radix Asteris 50g Herba Ephedrae 100g
Radix Scutellariae 50g Pericarpium Papaveris 60g Radix Glycyrrhizae 50g Mentholum 0.3g
Get Herba Ephedrae, use vapor distillation, collect distillate and medicinal liquid, medicinal liquid is standby; Medicinal residues and Bulbus Fritillariae Cirrhosae, Folium Eriobotryae, Radix Asteris, Radix Scutellariae, Pericarpium Papaveris, Radix Glycyrrhizae decoct with water secondary, and 2 hours for the first time, 1.5 hours for the second time, merge decoction liquor, filter, the medicinal liquid merging behind filtrate and the extraction volatile oil concentrates, the gained clear paste adds ethanol to be made and contains alcohol amount to 60%, leaves standstill 24 hours, filters, reclaim ethanol, continue to be condensed into clear paste, add Mel 50g, sucrose 100g and sodium benzoate 3g, boil, leave standstill, coarse filtration, add distillate and Mentholum, be adjusted to 1000ml with distilled water, promptly.
Embodiment 2:
Bulbus Fritillariae Cirrhosae 12g Folium Eriobotryae 60g Radix Asteris 60g Herba Ephedrae 90g
Radix Scutellariae 60g Pericarpium Papaveris 60g Radix Glycyrrhizae 60g Mentholum 0.3g
Get Herba Ephedrae, use vapor distillation, collect distillate and medicinal liquid, medicinal liquid is standby; Medicinal residues and Bulbus Fritillariae Cirrhosae, Folium Eriobotryae, Radix Asteris, Radix Scutellariae, Pericarpium Papaveris, Radix Glycyrrhizae, decoct with water secondary, 2 hours for the first time, 1.5 hours for the second time, merge decoction liquor, filter, filtrate with extract medicinal liquid behind the volatile oil and merge and concentrate, the gained clear paste adds ethanol to be made and contains the alcohol amount to 60%, left standstill 24 hours, filter, reclaim ethanol, continue to be condensed into clear paste, measuring temperature is 60 ℃, add Mel 50g, sucrose 100g and sodium benzoate 3g, boil, leave standstill, coarse filtration, add distillate and Mentholum, be adjusted to 1000ml with distilled water, promptly.
Claims (4)
1, a kind of pharmaceutical composition for the treatment of cough is characterized in that this pharmaceutical composition made by following bulk drugs:
25～75 parts of 25～75 portions of Radix Asteriss of 5～15 parts of Folium Eriobotryaes of Bulbus Fritillariae Cirrhosae
30～90 parts of 25～75 parts of Pericarpium Papaveriss of 50～150 parts of Radix Scutellariaes of Herba Ephedrae
0.15～0.45 part of 25～75 parts of Mentholum of Radix Glycyrrhizae
2, a kind of pharmaceutical composition for the treatment of cough as claimed in claim 1 is characterized in that this pharmaceutical composition made by following bulk drugs:
100 parts in 50 portions of Herba Ephedraes of 50 portions of Radix Asteriss of 10 parts of Folium Eriobotryaes of Bulbus Fritillariae Cirrhosae
0.3 part of 50 parts of Mentholum of 60 portions of Radix Glycyrrhizaes of 50 parts of Pericarpium Papaveriss of Radix Scutellariae
3, as claim 1,2 described a kind of preparation of drug combination methods for the treatment of cough, it is characterized in that this method is: get Herba Ephedrae, use vapor distillation, collect distillate and medicinal liquid, medicinal liquid is standby; Medicinal residues and Bulbus Fritillariae Cirrhosae, Folium Eriobotryae, Radix Asteris, Radix Scutellariae, Pericarpium Papaveris, Radix Glycyrrhizae, decoct with water 2～3 times, 1～3 hour for the first time, 0.5～2 hour for the second time, merge decoction liquor, filter, filtrate with extract medicinal liquid behind the volatile oil and merge and concentrate, the gained clear paste adds ethanol to be made and contains the alcohol amount to 40～80%, leaves standstill 12～48 hours, filter, reclaim ethanol, and continue to be condensed into clear paste, add adjuvant, correctives and antibacterial, boil, leave standstill, coarse filtration adds distillate and Mentholum, be adjusted to full dose with distilled water, promptly.
4, a kind of preparation of drug combination method for the treatment of cough as claimed in claim 3 is characterized in that this method is: get Herba Ephedrae, use vapor distillation, collect distillate and medicinal liquid, medicinal liquid is standby; Medicinal residues and Bulbus Fritillariae Cirrhosae, Folium Eriobotryae, Radix Asteris, Radix Scutellariae, Pericarpium Papaveris, Radix Glycyrrhizae decoct with water secondary, and 2 hours for the first time, 1.5 hours for the second time, merge decoction liquor, filter, the medicinal liquid merging behind filtrate and the extraction volatile oil concentrates, the gained clear paste adds ethanol to be made and contains alcohol amount to 60%, leaves standstill 24 hours, filters, reclaim ethanol, and continue to be condensed into clear paste, add Mel, sucrose and sodium benzoate, boil, leave standstill, coarse filtration, add distillate and Mentholum, be adjusted to full dose with distilled water, promptly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB021534624A CN1187074C (en) | 2002-11-29 | 2002-11-29 | Medicine composite for treating cough |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB021534624A CN1187074C (en) | 2002-11-29 | 2002-11-29 | Medicine composite for treating cough |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1418687A true CN1418687A (en) | 2003-05-21 |
| CN1187074C CN1187074C (en) | 2005-02-02 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB021534624A Expired - Lifetime CN1187074C (en) | 2002-11-29 | 2002-11-29 | Medicine composite for treating cough |
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| CN (1) | CN1187074C (en) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1309368C (en) * | 2004-03-17 | 2007-04-11 | 咸阳步长医药科技发展有限公司 | Preparation of Chinese traditional medicine for curing cough and preparation method |
| CN102357183A (en) * | 2011-10-25 | 2012-02-22 | 陕西步长制药有限公司 | Traditional Chinese medicament for curing cough and preparation method thereof |
| CN102357182A (en) * | 2011-10-25 | 2012-02-22 | 陕西步长制药有限公司 | Traditional Chinese medicament for curing cough and preparation method thereof |
| CN102357184A (en) * | 2011-10-25 | 2012-02-22 | 陕西步长制药有限公司 | Traditional Chinese medicine preparation for treating cough and preparation method thereof |
| CN102357181A (en) * | 2011-10-25 | 2012-02-22 | 陕西步长制药有限公司 | Traditional Chinese medicine composition for treating cough and preparation method thereof |
| CN104547496A (en) * | 2014-12-19 | 2015-04-29 | 青岛市市立医院 | Traditional Chinese medicine composition for moistening lung to arrest cough and preparation method thereof |
| CN104815145A (en) * | 2015-04-15 | 2015-08-05 | 苏州市天灵中药饮片有限公司 | Traditional Chinese medicine cough syrup and preparation method thereof |
| CN105125703A (en) * | 2015-08-26 | 2015-12-09 | 江伟明 | Medicine for treating cough and preparing method of medicine |
-
2002
- 2002-11-29 CN CNB021534624A patent/CN1187074C/en not_active Expired - Lifetime
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1309368C (en) * | 2004-03-17 | 2007-04-11 | 咸阳步长医药科技发展有限公司 | Preparation of Chinese traditional medicine for curing cough and preparation method |
| CN102357183A (en) * | 2011-10-25 | 2012-02-22 | 陕西步长制药有限公司 | Traditional Chinese medicament for curing cough and preparation method thereof |
| CN102357182A (en) * | 2011-10-25 | 2012-02-22 | 陕西步长制药有限公司 | Traditional Chinese medicament for curing cough and preparation method thereof |
| CN102357184A (en) * | 2011-10-25 | 2012-02-22 | 陕西步长制药有限公司 | Traditional Chinese medicine preparation for treating cough and preparation method thereof |
| CN102357181A (en) * | 2011-10-25 | 2012-02-22 | 陕西步长制药有限公司 | Traditional Chinese medicine composition for treating cough and preparation method thereof |
| CN102357184B (en) * | 2011-10-25 | 2013-06-12 | 陕西步长高新制药有限公司 | Traditional Chinese medicine preparation for treating cough and preparation method thereof |
| CN102357181B (en) * | 2011-10-25 | 2013-06-12 | 陕西步长高新制药有限公司 | Traditional Chinese medicine composition for treating cough and preparation method thereof |
| CN102357183B (en) * | 2011-10-25 | 2013-06-12 | 陕西步长高新制药有限公司 | Traditional Chinese medicament for curing cough and preparation method thereof |
| CN104547496A (en) * | 2014-12-19 | 2015-04-29 | 青岛市市立医院 | Traditional Chinese medicine composition for moistening lung to arrest cough and preparation method thereof |
| CN104547496B (en) * | 2014-12-19 | 2018-04-24 | 青岛市市立医院 | A kind of Chinese medicine composition to moisten the lung and relieve the cough and preparation method thereof |
| CN104815145A (en) * | 2015-04-15 | 2015-08-05 | 苏州市天灵中药饮片有限公司 | Traditional Chinese medicine cough syrup and preparation method thereof |
| CN105125703A (en) * | 2015-08-26 | 2015-12-09 | 江伟明 | Medicine for treating cough and preparing method of medicine |
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| Publication number | Publication date |
|---|---|
| CN1187074C (en) | 2005-02-02 |
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Owner name: QIYUANYIDE MEDICINES INST., BEIJING Free format text: FORMER OWNER: ZHANG HUIFANG Effective date: 20030812 |
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Effective date of registration: 20030812 Address after: 100027, Beijing, Chaoyang District, East Third Ring Road, Xin 2, di Yang building, room 10, 1007A Applicant after: Beijing Qi Yuan Yi De Pharmaceuticals Research Center Address before: 100027, Beijing, Chaoyang District, East Third Ring Road, Xin 2, di Yang building, room 10, 1007A Applicant before: Zhang Huifang |
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| C14 | Grant of patent or utility model | ||
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Owner name: SHANXI BUCHANG PHARMACEUTICAL CO., LTD. Free format text: FORMER OWNER: XIANYANG BUCHANG PHARMACEUTICAL CO., LTD. Effective date: 20100108 |
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Effective date of registration: 20100108 Address after: Box section 123 West Weiyang road in Xianyang City Patentee after: Shaanxi Buchang Pharmaceuticals Co.,Ltd. Address before: The west section of Xianyang City Weiyang Road No. 123 Patentee before: BUCHANG Group |
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Granted publication date: 20050202 |
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