CN1298342C

CN1298342C - Medicine for treating thromboangiitis and its preparing method

Info

Publication number: CN1298342C
Application number: CNB2005100126250A
Authority: CN
Inventors: 任进才; 任东东
Original assignee: Individual
Current assignee: Individual
Priority date: 2005-06-22
Filing date: 2005-06-22
Publication date: 2007-02-07
Anticipated expiration: 2025-06-22
Also published as: CN1709317A

Abstract

The present invention relates to a Chinese patent drug for treating thrombus occlusion type angitis, which takes nux vomica, centipedes, stiff silkworms, earthworms, long-noded pit vipers, garter snakes, leeches, cockroaches, pangolins and myrrh as raw materials. The nux vomica is dipped in oil to be broiled; the pangolins are mixed with other components according to proportion after fried fiercely by fine stone sand and then are pulverized into fine powder which is encapsulated to make into capsules. After observed clinically, the present invention has obvious therapeutic effect on acute and chronic thrombus occlusion type angitis of various stages.

Description

Medicine of treatment thromboangiitis obliterans and preparation method thereof

Affiliated technical field

The present invention relates to the vasculitic medicine of a kind of treatment, particularly relate to a kind of Chinese patent medicine for the treatment of thromboangiitis obliterans.

Background technology

Thromboangiitis obliterans is chronic general vascular disorder, is a kind of periodicity, segmental inflammatory disorders of artery and vein, mainly involve extremity in, small artery and vein, see so that lower limb more more.Its clinical manifestation is afraid of cold for suffering from the limb far-end, and feeling of numbness is arranged, and foot and shank have the pain of delocalization, continue intermittent claudication then to occur, and toes have rest pain, the aggravation at night.Primary disease is more common in north cold area, especially is mainly in male person between twenty and fifty, is the great disease of a kind of hazardness, the lighter's amputation maimed person, and weight person's threat to life is the very thorny difficult problem of medical circle.

Western medicine is still not fully aware of for the pathogeny of thromboangiitis obliterans, do not have effective medicine and Therapeutic Method yet, adopt blood vessel dilating, thrombolytic, hormone, alleviating vascular spasm class medicine to treat more, cure the symptoms, not the disease, symptom can only be eased mostly, can not effect a radical cure.Can also adopt surgical operation is method treatments such as lumbar sympathectomy, artery reconstruction, or physiotherapy, but effect is all very not remarkable yet, causes the relapse rate of primary disease and amputation rate higher.

Motherland's medical science thinks, the cause of disease of thromboangiitis obliterans mainly is because the YIN-cold endogenous dampness, fire-transformation with the passing of time, and fire-toxin is held under the arm wet, the living expectorant of fighting mutually, the stagnation of phlegm venation, blood vessels are obstructed, failure of skin and muscle to be nourished, muscles and bones mistake is grown, so the rotten muscle of meat is mashed, bone decreases and comes off, and controls suitable clearing away phlegm collateral dredging, hard masses softening and resolving.Typing determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs such as YANGHE TANG, Radix Angelicae Pubescentis et Herba Taxilli Decoction, XUEFUZHUYU TANG, TAOREN SIWU TANG, SIMIAOYONGAN TANG, Gu Butang, decoction of ten powerful tonics, RENSHEN YANGRONG TANG, attached osmanthus eight flavor balls, ZHIBAI DIHUANG WAN are adopted in present Chinese traditional treatment more, though tcm therapy is remarkable to the therapeutic effect of thromboangiitis obliterans than doctor trained in Western medicine, but owing to fail to catch the main pathogenesis cause of disease of primary disease, so whole curative effect still can not be satisfied with.

Summary of the invention

The purpose of this invention is to provide a kind of cold heat radiation that removes, treating the poisonous disease with poisonous drugs, the clearing away phlegm collateral dredging, the treatment thromboangiitis obliterans Chinese Traditional Medicines of bone are protected in hard masses softening and resolving, nourishing muscle and tendon.

The preparation method of this medicine is provided, and is another goal of the invention of the present invention.

Solution of the present invention is based on motherland's medical science to pathogenetic understanding of thromboangiitis obliterans and Therapeutic Principle, with reference to modern pharmacology research, filters out from motherland's medicine treasure-house and removes the Chinese medicine that cold heat radiation, eliminating blood stasis and smoothing collaterals, nourishing muscle and tendon protect bone and make.

Medicine of the present invention specifically is to be made by the raw material of following weight ratio:

Semen Strychni 5～20 Scolopendras 5～20

Bombyx Batryticatus 2～8 Pheretimas 5～20

Agkistrodon 2～8 Zaocys 2～8

Hirudo 2～8 Eupolyphaga Seu Steleophaga 5～20

Squama Manis 2～8 Myrrhas 5～20.

Preparing the preferred raw material weight ratio of medicine of the present invention is:

Semen Strychni 10～15 Scolopendras 5～10

Bombyx Batryticatus 2～5 Pheretimas 5～10

Agkistrodon 2～5 Zaocys 2～5

Hirudo 2～5 Eupolyphaga Seu Steleophaga 5～10

Squama Manis 2～5 Myrrhas 10～15.

Above-mentioned each component can be made said dosage form on any pharmaceutics, and the preferred dosage form of the present invention is a capsule.

Above-mentioned each component is made medicine production method of the present invention is:

1, gets Semen Strychni and go in 150 ℃ of oil to fry, pull out, dry behind the oil strain to coke yellow;

2, get Squama Manis and fry, make its expansion be yellow with microlith sand big gun;

3, above-mentioned two medicines and all the other components are pressed the proportioning mix homogeneously, be ground into 100～120 order fine powders, in incapsulating, make capsule.

Thromboangiitis obliterans, the traditional Chinese medical science is called necrosis, this cause of disease YIN-cold endogenous dampness, fire-transformation with the passing of time, fire-toxin is held under the arm wet, the living expectorant of fighting mutually, the stagnation of phlegm venation, blood vessels are obstructed, failure of skin and muscle to be nourished, muscles and bones mistake is grown, so skin lesion, meat corruption, muscle rot, bone takes off.In the prescription of the present invention, the expectorant poison of Semen Strychni heat-clearing and toxic substances removing, activating collaterals to relieve pain, the venation of dispelling, Scolopendra detoxicating and resolving stagnation of pathogens, removing obstruction in the collateral to relieve pain, two medicines share monarch drug for it, cold heat clearing away poison, temperatureization severe pathogenic cold, simultaneously using both cold and hot drugs, the heat radiation of dispeling cold, expectorant poison are all unimpeded except that, venation, QI and blood square tube, general rule not bitterly; Agkistrodon is treated malignant boil and blood vessel dilating, and the Zaocys collateral dredging is treated skin ulcer, the Bombyx Batryticatus dissipating phlegm and resolving masses, Pheretima softening the hard mass heat radiation knot, more than four flavor insects medicines be ministerial drug, be all the key medicine of Liver Channel, with its suppressing the hyperactive liver eliminating stagnation, liver governing tendons so share to increase the merit of principal agent resolving mass and removing the obstruction of the collateral; Hirudo removing blood stasis, XIAOSHUANTONG knot, current blood vessels ， Eupolyphaga Seu Steleophaga removing blood stasis, continuous muscle protect bone, broken heavily fortified point is attacked knot, and two medicines share adjuvant drug for it; Squama Manis eliminating stasis and resolving masses, detumescence and apocenosis, Myrrha loose, and blood is subsided a swelling, the analgesic therapy granulation promoting, and two medicines share, and the eliminating stagnation granulation promoting is thought messenger drug.More than all medicine compatibilities, simultaneously using both cold and hot drugs, treating the poisonous disease with poisonous drugs, the clearing away phlegm collateral dredging, hard masses softening and resolving, bone is protected in nourishing muscle and tendon, all has very notable therapeutic effect for each phase thromboangiitis obliterans of acute and chronic, phlebitis and various thrombosis sexually transmitted disease (STD) disease.

For showing the therapeutic effect of medicine of the present invention to thromboangiitis obliterans, the present invention has carried out clinical observation on the therapeutic effect to 200 routine thromboangiitis obliterans patients, wherein, in respect of first phase patient 100 examples, the second stage of patient's 78 examples, three phase patients, 22 examples.

Among the 100 routine clinical first phase patients, male's 73 examples, women's 27 examples, age, the course of disease to more than 30 years, was the ischemia phase more than half a year between 23～85 years old, catch cold and freeze history, conscious foot numbness sends out pain cool, the bloated fatiguability of shank acid during walking, vola expand firmly and feel the bloated firmly sense in vola, and symptom gradually increases the weight of, intermittent claudication takes place, wherein suffer from faint 68 examples of main drive arteriopalmus, arteriopalmus 32 examples that disappear, and all with the migration superficial phlebitis.

Take medicine of the present invention after 7 days, the conscious pain of 78 routine patients obviously alleviates, and 22 routine conditions of patients are stable.After continuing to take medicine 40 days, 88 routine patient's pain disappear, and local skin is ruddy, walks lamely to disappear, and arteriopalmus strengthens, and the migration superficial phlebitis disappears, and clinical cure is followed up a case by regular visits to two not recurrences every year; 12 routine patients continue the clinical observation of taking medicine.

Among 100 clinical two, the three phase patients of example, malnutrition phase patient 78 examples, suffering from limb before taking medicine has tangible numbness to be afraid of cold to send out cool sensation, pain is obvious when static, night, the pain increased, often embraces foot and sit, and must not sleep peacefully, suffering from the main drive arteriopalmus disappears, local no sweating, the toenail poor growth thickens distortion, the xerosis cutis flushing, and with the Calf muscle atrophy.Downright bad phase patient 22 examples are suffered from limb generation ulcer 18 examples, gangrenous 4 examples, and the patient once used Western medicine blood vessel dilating medicine and hormone therapy, DeGrain, except that 2 examples add with the antibiotic with infection, the local debridement of changing dressings of all the other equal routines, no special treatment.

More than among 100 clinical two, the three phase patients of example, take medicine of the present invention after 40 days, 86 routine patient's pain reliefs, can fall asleep 4～5 hours night, inactive narcotic analgesic medicine.After taking medicine 120 days, among the downright bad phase patient of 22 examples, 19 routine sloughs come off, wound healing, and pain disappears, and sb.'s illness took a favorable turn for 2 examples, 1 routine invalid amputation; The equal pain of 78 routine malnutrition phase patients disappears, ulcer healing, and arteriopalmus recovers, and skin is ruddy, toenail gloss, the fine hair demutation, clinical cure is followed up a case by regular visits to not recurrence in 2 years.

200 routine clinical observation patients are carried out comprehensive statistics, clinical cure rate 92.5%, effective percentage 99.5%, concrete statistical data sees Table 1.

Table 1 clinical drug therapeutic effect statistics of the present invention

The course of treatment	Effect	Clinical manifestation (number)
		Clinical manifestation (number)			The ischemia phase	The malnutrition phase	The downright bad phase
		100	78	22	The ischemia phase	The malnutrition phase	The downright bad phase
		100	78	22	40 days	Clinical cure	88
Effectively	12	86				Clinical cure	88
Effectively	12	86		Invalid			14
120 days	Clinical cure		78	Invalid			14		19
	Clinical cure		78	Effectively			2		19
	Invalid			Effectively			2	1

The specific embodiment

Embodiment 1:

Take by weighing raw material (Kg) by following proportioning:

Semen Strychni 1.2 Scolopendras 0.6 Bombyx Batryticatus 0.3

Pheretima 0.6 Agkistrodon 0.3 Zaocys 0.3

Hirudo 0.3 Eupolyphaga Seu Steleophaga 0.6 Squama Manis 0.3

Myrrha 1.2

Concrete production method is that elder generation puts into 150 ℃ oil with Semen Strychni, fries and goes its toxicity, when waiting to explode to coke yellow, pulls oil strain out, dries; With microlith sand big gun Squama Manis(parched), make its expansion be yellow; All the other medicines are given birth to usefulness, with above ten flavor Chinese medicine mix homogeneously, are ground into 120 purpose fine powders, in incapsulating by every 0.5g, make capsule.

Embodiment 2:

Take by weighing raw material (Kg) by following proportioning:

Semen Strychni 1.0 Scolopendras 0.8 Bombyx Batryticatus 0.5

Pheretima 0.8 Agkistrodon 0.5 Zaocys 0.5

Hirudo 0.5 Eupolyphaga Seu Steleophaga 0.5 Squama Manis 0.2

Myrrha 1.0

Production method is with embodiment 1.

Claims

1, a kind of medicine for the treatment of thromboangiitis obliterans is characterized in that making active component raw material and is made up of the component of following weight proportioning:

Semen Strychni 5～20 Scolopendras 5～20

Bombyx Batryticatus 2～8 Pheretimas 5～20

Agkistrodon 2～8 Zaocys 2～8

Hirudo 2～8 Eupolyphaga Seu Steleophagas 5～20

Squama Manis 2～8 Myrrhas 5～20.

2, the medicine of treatment thromboangiitis obliterans according to claim 1 is characterized in that the weight proportion of each raw material is

Semen Strychni 10～15 Scolopendras 5～10

Bombyx Batryticatus 2～5 Pheretimas 5～10

Agkistrodon 2～5 Zaocys 2～5

Hirudo 2～5 Eupolyphaga Seu Steleophagas 5～10

Squama Manis 2～5 Myrrhas 10～15.

3, the medicine of treatment thromboangiitis obliterans according to claim 1 and 2 is characterized in that said medicament is a said dosage form on any pharmaceutics.

4, the medicine of treatment thromboangiitis obliterans according to claim 3 is characterized in that said medicament is a capsule.

5, the preparation method of the medicine of the described treatment thromboangiitis obliterans of claim 4 is characterized in that getting earlier Semen Strychni and goes in 150 ℃ of oil to fry to coke yellow, pulls out, dries behind the oil strain; Squama Manis is fried with microlith sand big gun, made its expansion be yellow; Above-mentioned two medicines and all the other components are pressed the proportioning mix homogeneously, be ground into 100～120 order fine powders, in incapsulating, make capsule.