CN102600239B - Medicament for treating thromboangitis obliterans and preparation method thereof - Google Patents

Abstract

The invention discloses a medicament for treating thromboangitis obliterans, which is formed by mixing, crushing and grinding the following components in weight parts: astragalus mongholicus, honeysuckle, Chinese angelica, leech, centipede, bombys batryticatus, earthworm, roasted liquorice, roasted frankincense, myrrh, ground beetle, scorpion, radix salviae miltiorrhizae, hemlock parsley, roasted nux vomica and cassia twig. The medicament has the functions of reinforcing qi and nourishing blood, removing cold-dampness, activating blood circulation to remove stasis, regulating meridians, supporting healthy energy, and removing blood stasis to promote tissue regeneration, and is used for treating vital energy and blood circulation obstruction caused by weak, cold and damp spleen and kidney, venation stasis, and vasculitis at tail ends of four limbs or caused by fire heat generation and yin impairment due to damp stagnation. The medicament has remarkable effect to each phase of the vasculitis, has good treatment effect to deep venous thrombosis, phlebophlogosis and other peripheral vascular diseases, and has high cure rate, quick response, stable curative effect and relapse prevention.

Description

Medicine for the treatment of thromboangiitis obliterans and preparation method thereof

Technical field

The present invention relates to field of traditional Chinese, specifically refer to a kind of medicine for the treatment of thromboangiitis obliterans and preparation method thereof.

Background technology

Its disease of thromboangiitis obliterans is a kind of evil cellulitis disease, and this patient is agonizing, has a delicate constitution, how due to the malpractice death that develops complications.The Chinese medicine and western medicine for the treatment of thromboangiitis obliterans is more at present, but exists curative effect slower, need the regular hour, or therapeutic effect is not good, and is difficult to the defect of radical cure.

Summary of the invention

The object of the invention is provides a kind of rapid-action in order to overcome the deficiency of prior art, effective, and the medicine of the treatment thromboangiitis obliterans that cure rate is high provides a kind of preparation method of this medicine simultaneously.

The technical scheme providing is for achieving the above object:

Treat a medicine for thromboangiitis obliterans, by following raw materials according, mix by weight rear pulverizing pulverize and form:

Radix Astragali 25-30 Flos Lonicerae 50-60 Radix Angelicae Sinensis 15-20 Hirudo 45-50

Scolopendra 10-15 Bombyx Batryticatus 5-10 Pheretima 35-45 Radix Glycyrrhizae Preparata 10-15

Moxibustion Olibanum 15-25 Myrrha 15-25 Eupolyphaga Seu Steleophaga 15-25 Scorpio 15-25

Radix Salviae Miltiorrhizae 25-30 Rhizoma Chuanxiong 15-25 moxibustion Semen Strychni 15-20 Ramulus Cinnamomi 15-20.

The preparation method of medicine for the treatment of thromboangiitis obliterans, by the following step, formed:

A, powder process: get by weight the Radix Astragali, Flos Lonicerae, Radix Angelicae Sinensis, Hirudo, Scolopendra, Bombyx Batryticatus, Pheretima, Radix Glycyrrhizae Preparata, moxibustion Olibanum, Myrrha, Eupolyphaga Seu Steleophaga, Scorpio, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, moxibustion Semen Strychni, Ramulus Cinnamomi, pulverizing after mixing, porphyrize powder, stand-by;

B, preparation: above-mentioned fine powder is stirred, incapsulate.

Thromboangiitis obliterans, belongs to the chronic nonsuppurative inflammation of a kind of middle small artery and vein, is a kind of evil cellulitis disease.The traditional Chinese medical science thinks, necrosis can be divided into for three phases: ischemia phase, malnutrition phase, downright bad phase; In primary disease is main because spleen suffers from a deficiency of the kidney, outer because cold-damp, internal and external reasons is in conjunction with causing that QI and blood is obstructed, venation is retarded by silt, can not nutrition limb end or damp-stagnancy heat-transformation impairment of YIN due to.For this cause of disease, oral this invention medication, accordingly disease and select medicine.The Radix Astragali in medicine, Radix Angelicae Sinensis, Radix Glycyrrhizae have that QI invigorating, consolidating superficial resistance, promoting blood circulation to remove obstruction in the collateral, diuresis, toxin expelling, spleen reinforcing are fostered the spirit of nobility, the effect of expectorant, cough-relieving, relieving spasm to stop pain, then add Hirudo for by blood removing blood stasis, qualcomm meridian; Additional Scorpio, Scolopendra, Pheretima have the effect of the analgesia of relieving dizziness, high fever, infantile convulsions, epilepsy, etc., dispersing pathogen accumulation, heat clearing away arresting convulsion, dredging collateral, Eradicates wind; Coordinate the pain relieving of the Eradicates stasis of blood, the mass dissipating and swelling eliminatings such as Semen Strychni, Radix Salviae Miltiorrhizae, Olibanum, Myrrha, relieving restlessness clears away heart-fire; Flos Lonicerae has the effect of heat clearing away, removing toxic substances, wind-heat dissipating; Make the efficacy of a drug focus of going directly, play treating both the principal and secondary aspects of a disease, get instant result, disease is alleviated rapidly.This Drug therapy feature is: act on rapid, rapid-action; Patient easily accepts, evident in efficacy, cure rate high.And stable curative effect, is difficult for recurrence, and raw material easily obtains, and has no side effect.

In a word, the present invention wants activating blood circulation to dissipate blood stasis, promotes blood circulation, and pain relieving, antiinflammatory again, subsides a swelling, fills blood, and reaches the effect for the treatment of both the principal and secondary aspects of a disease, and the present invention has benefiting QI and nourishing blood, Eradicates cold-damp addiction, blood circulation and removing stasis, conciliation passages through which vital energy circulates, strengthening the body resistance, the effect of the tissue regeneration promoting that goes to become silted up.The vasculitis for the treatment of because spleen, kidney, void, QI and blood due to cold, wet are obstructed, due to venation stasis, limb end or damp-stagnancy heat-transformation impairment of YIN.Comprise: I, II, the various symptoms of III stage angiitis all have unique therapeutic effect; The peripheral vascular diseases such as deep venous thrombosis, phlebitis are also had to good therapeutic effect, and cure rate is high.

Treatment thromboangiitis obliterans thing using method of the present invention: medicine is packed into " 0 " number capsule, each oral five sooner or later.

Below by clinical observation on the therapeutic effect, test and further set forth beneficial effect of the present invention.

This clinical experiment 100 examples, meet the Patients With Thromboangitis Obliterans of Western medicine diagnose standard, all derive from clinic case, age 25-84 year, male's 60 examples wherein, women's 40 examples; Age 25-40 year 40 examples, age 41-84 year 60 examples.

Therapeutic Method: each 5 3.0 grams of oral medicines of the present invention, one month are the course for the treatment of at every day 2 times, is total to the 2-5 course for the treatment of.

Curative effect determinate standard: the symptom change degree of take is curative effect determinate standard.

Observed result: clinical cure 80 examples, effective 15 examples, invalid 5 examples, cure rate 80%, aggregate efficiency 95%.In treatment, only have 5 examples invalid, all cases all have no adverse reaction.To clinical cure personnel random inspection 20 people, follow up a case by regular visits to and within 2 years, have no recurrence.

Refer to 4 routine cases:

Case 1: Li Guiyong, man, 60 years old, Jilin Dunhua peasant.This patient suffered from vasculitis in 2010 and has no improvement through many hospitalizes, and April 5 in 2011, Lai the court was medical, had a medical check-up: painful sickly complexion, right lower extremity is sent out cool, fear of cold, numbness, and have intermittent claudication and foot pain, femoral pulse is normal, dorsal artery of foot, without beating, is diagnosed as the vasculitis I phase, after oral this medicine the 3rd day, symptom is alleviated gradually, transference cure after one course for the treatment of, continues oral this medicine to second course for the treatment of, to consolidate curative effect.Now return to one's perfect health, emotion is optimistic.

Case 2: Zhang Chengguo, male ，39Sui， Muling, Heilongjiang city peasant.Bitterly to our hospital because a left side has a pain in the leg on February 4th, 2010; Main suit: have a large amount of smoking histories; Have a medical check-up: body constitution is become thin, complexion is dark yellow; BP:100mmHG/60mmHG; P:100 beat/min; Left lower limb big toe cyanosis of the skin, middle toe skin rubefaction rest pain, with night for very, lifting affected limb, palor, without pulsation of foot dorsal artery, is diagnosed as the vasculitis II phase; Oral this medicine 1 course for the treatment of+dead point MAILUONING 40ml, symptom takes a turn for the better after one week, can out-of-bed activity, sour swollen symptom alleviates, and serve on 2 courses for the treatment of of this medicine, clinical cure, local blood supply improves, and can normally do manual work.

Case 3: Sun Xingwang, Weifang City, male ，63Sui， Shandong; 2009 because suffering from vasculitis for many years, can not be engaged in physical work, multi-treatment, poor effect.To our hospital on March 17th, 2010; Main suit: have diabetic history 20 years, a large amount of smoking histories 30 years; Have a medical check-up: right lower limb is red, swollen, hot, pain obviously, the necrosis of festering of big toe tip; T:38.5 degree; BP:120mmHG/70mmHG; Left lower limb is sent out cool, is afraid of cold, paroxysmal pain, is diagnosed as the vasculitis III phase; Right lower limb forms gangrene, rancid, hurt like hell because of secondary infection; Therapeutic scheme (1): oral this invention medicine; (2): 0.9% saline+penicillin, 1,800 ten thousand+DIMI 10mg dead points; D-6; (3) 0.9% saline+MAILUONING 50mg dead point; D-6; (4) external autogamy external application of ointment, the outside upper anti-inflammatory ointment of debridement face, within the 3rd day, symptom is controlled; Three courses for the treatment of of this medicine of continuous oral, symptom is improved; Gangrene part comes off, left lower limb transference cure, and establishment side props up blood circulation, improved local blood supply insufficiency symptom, avoided the hardship of amputation.Patient is emotionally stable, mental status is good, the life of taking care of oneself, do work in power.

Case 4: Ma Shuzhen, female, 71 years old, Dunhua yellow mud river, Jilin peasant, on January 3rd, 2009 because human hair combing waste is cool, pain is to our hospital February; Look into: body constitution is become thin, chronic facies, right lower limb limitation of activity, paroxysmal pain, send out cool, acid swollen; Diagnosis: vasculitis I phase.Treatment: 2 courses for the treatment of of oral this medicine, advise patient to strengthen nutrition, function of spleen and stomach regulating, symptom and improve; Discontinuity medication so far, is now taken care of oneself, clinical cure.

The specific embodiment

Embodiment 1

A medicine for the treatment of thromboangiitis obliterans, consists of following traditional Chinese medicine raw:

Radix Astragali 25g Flos Lonicerae 50g Radix Angelicae Sinensis 15g Hirudo 45 g

Scolopendra 10g Bombyx Batryticatus 5g Pheretima 35 g Radix Glycyrrhizae Preparata 10g

Moxibustion Olibanum 15g Myrrha 15g Eupolyphaga Seu Steleophaga 15g Scorpio 15 g

Radix Salviae Miltiorrhizae 25 g Rhizoma Chuanxiong 15g moxibustion Semen Strychni 15g Ramulus Cinnamomi 15g

Preparation method:

A, powder process: by the Radix Astragali, Flos Lonicerae, Radix Angelicae Sinensis, Hirudo, Scolopendra, Bombyx Batryticatus, Pheretima, Radix Glycyrrhizae Preparata, moxibustion Olibanum, Myrrha, Eupolyphaga Seu Steleophaga, Scorpio, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, moxibustion Semen Strychni, Ramulus Cinnamomi, pulverizing after mixing, porphyrize powder, stand-by;

B, preparation: above-mentioned fine powder is stirred, cross 220 mesh sieves, pack " 0 " capsule into.

Embodiment 2

A medicine for the treatment of thromboangiitis obliterans, consists of following traditional Chinese medicine raw:

Radix Astragali 30g Flos Lonicerae 60g Radix Angelicae Sinensis 20g Hirudo 50g

Scolopendra 15g Bombyx Batryticatus 10g Pheretima 45g Radix Glycyrrhizae Preparata 15g

Moxibustion Olibanum 25g Myrrha 25g Eupolyphaga Seu Steleophaga 25g Scorpio 25g

Radix Salviae Miltiorrhizae 30g Rhizoma Chuanxiong 25g moxibustion Semen Strychni 20g Ramulus Cinnamomi 20g

Its preparation method is with embodiment 1.

Embodiment 3

Radix Astragali 30g Flos Lonicerae 50g Radix Angelicae Sinensis 20g Hirudo 50g

Scolopendra 10g Bombyx Batryticatus 5g Pheretima 45g Radix Glycyrrhizae Preparata 10g

Moxibustion Olibanum 20g Myrrha 20g Eupolyphaga Seu Steleophaga 20g Scorpio 20g

Radix Salviae Miltiorrhizae 30g Rhizoma Chuanxiong 20g moxibustion Semen Strychni 15g Ramulus Cinnamomi 15g

Its preparation method is with embodiment 1.

Claims (5)

1. treat a medicine for thromboangiitis obliterans, it is characterized in that by following raw materials according, mixing by weight rear pulverizing pulverize forms:

Radix Astragali 25-30 Flos Lonicerae 50-60 Radix Angelicae Sinensis 15-20 Hirudo 45-50

Scolopendra 10-15 Bombyx Batryticatus 5-10 Pheretima 35-45 Radix Glycyrrhizae Preparata 10-15

Moxibustion Olibanum 15-25 Myrrha 15-25 Eupolyphaga Seu Steleophaga 15-25 Scorpio 15-25

Radix Salviae Miltiorrhizae 25-30 Rhizoma Chuanxiong 15-25 moxibustion Semen Strychni 15-20 Ramulus Cinnamomi 15-20.

2. a kind of medicine for the treatment of thromboangiitis obliterans according to claim 1, is characterized in that by following raw materials according, mixing by weight rear pulverizing pulverize forms:

Radix Astragali 25g Flos Lonicerae 50g Radix Angelicae Sinensis 15g Hirudo 45 g

Scolopendra 10g Bombyx Batryticatus 5g Pheretima 35 g Radix Glycyrrhizae Preparata 10g

Moxibustion Olibanum 15g Myrrha 15g Eupolyphaga Seu Steleophaga 15g Scorpio 15 g

Radix Salviae Miltiorrhizae 25 g Rhizoma Chuanxiong 15g moxibustion Semen Strychni 15g Ramulus Cinnamomi 15g.

3. a kind of medicine for the treatment of thromboangiitis obliterans according to claim 1, is characterized in that by following raw materials according, mixing by weight rear pulverizing pulverize forms:

Radix Astragali 30g Flos Lonicerae 60g Radix Angelicae Sinensis 20g Hirudo 50g

Scolopendra 15g Bombyx Batryticatus 10g Pheretima 45g Radix Glycyrrhizae Preparata 15g

Moxibustion Olibanum 25g Myrrha 25g Eupolyphaga Seu Steleophaga 25g Scorpio 25g

Radix Salviae Miltiorrhizae 30g Rhizoma Chuanxiong 25g moxibustion Semen Strychni 20g Ramulus Cinnamomi 20g.

4. a kind of medicine for the treatment of thromboangiitis obliterans according to claim 1, is characterized in that by following raw materials according, mixing by weight rear pulverizing pulverize forms:

Radix Astragali 30g Flos Lonicerae 50g Radix Angelicae Sinensis 20g Hirudo 50g

Scolopendra 10g Bombyx Batryticatus 5g Pheretima 45g Radix Glycyrrhizae Preparata 10g

Moxibustion Olibanum 20g Myrrha 20g Eupolyphaga Seu Steleophaga 20g Scorpio 20g

Radix Salviae Miltiorrhizae 30g Rhizoma Chuanxiong 20g moxibustion Semen Strychni 15g Ramulus Cinnamomi 15g.

5. a preparation method for the medicine for the treatment of thromboangiitis obliterans as claimed in claim 1, consists of the following step:

A, powder process: get by weight the Radix Astragali, Flos Lonicerae, Radix Angelicae Sinensis, Hirudo, Scolopendra, Bombyx Batryticatus, Pheretima, Radix Glycyrrhizae Preparata, moxibustion Olibanum, Myrrha, Eupolyphaga Seu Steleophaga, Scorpio, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, moxibustion Semen Strychni, Ramulus Cinnamomi, pulverizing after mixing, porphyrize powder, stand-by;

B, preparation: above-mentioned fine powder is stirred, incapsulate.